Supramolecular chemistry

Faculteit Science and Engineering
Jaar 2019/20
Vakcode CHC3133E
Vaknaam Supramolecular chemistry
Niveau(s) master
Voertaal Engels
Periode semester II a

Uitgebreide vaknaam Supramolecular chemistry
Leerdoelen At the end of this course, student is able to
1: explain the different types of noncovalent interactions and show how to quantify these
2: explain that the simultaneous action of several noncovalent interactions can give rise to different forms of cooperativity (chelate and allosteric).
3: recognise the most common synthetic receptors and self-assembled structures and materials, including self-assembled monolayers and polymers.
4: explain the basic kinetics of self-replicating molecules.
5: explain the principles and applications of dynamic combinatorial chemistry.
explain the concepts and challenges in supramolecular catalysis.
7: contrast the difference between systems under thermodynamic control, kinetic control and systems that are far-from-equilibrium.
discriminate between self-assembled and self-organized systems
enumerate the non-covalent and covalent interactions that comprise self-assembled monolayers
predict whether or not a molecule will form a self-assembled monolayer under specific conditions
Omschrijving This course is an introduction to supramolecular chemistry in which recent examples are used to elaborate on the background and most important principles. First, the most important non-covalent interactions will be explained. We will then see how these interactions can act in concert to give rise to well-defined supramolecular structures, including: host-guest chemistry, self-assembled structures and materials. This will be followed by a treatment of the interplay between noncovalent chemistry and covalent chemistry as seen in dynamic covalent chemistry, dynamic combinatorial chemistry, supramolecular catalysis and self-replication. After that far-from-equilibrium systems will be introduced, including far-from-equilibrium self-assembly, molecular motors. Further topics that will be treated include nanoparticles, self-assembled monolayers, the supramolecular chemistry of polymers, using recent examples from the literature that exemplify the phenomena involved and the utility and constraints of using molecules in bottom-up fabrication.
Uren per week
Onderwijsvorm Hoorcollege (LC), Opdracht (ASM), Practisch werk (PRC)
(Total hours of lectures: 20 hours, homework assignments: 120 hours, tutorials: 3 hours, literature presentations: 2 hours.)
Toetsvorm Practisch werk (PR), Presentatie (P), Schriftelijk tentamen (WE)
(Grade contributiion: 70% written exam, 20% presentation, 10% practical work. See remarks.)
Vaksoort master
Coördinator prof. dr. S. Otto
Docent(en) prof. dr. R.C. Chiechi ,Prof. Dr. K.U. Loos ,prof. dr. S. Otto ,dr. M.C.A. Stuart
Verplichte literatuur
Titel Auteur ISBN Prijs
The handouts and readers compiled specifically for this course are mandatory literature.
Entreevoorwaarden The course unit assumes prior knowledge acquired from Organic Chemistry 2 and Physical Chemistry 2, from the Bachelor Chemistry degree program.
Opmerkingen Max number of points is 100. Mark = number of points / 10, rounded off to the nearest 0.5 mark (except between 5 and 6, where rounding takes place to the nearest integer mark).
Marking of literature presentations is based on the student's understanding of the content and conclusions, connection to the context and critical analysis of contents and their implications for the field.
Pass mark: 6

The practical course is mandatory. If the student misses this component for a valid reason (s)he will have to do a similar practical assignment at a later moment.
Opgenomen in
Opleiding Jaar Periode Type
MSc Chemistry: Advanced Materials  ( Core Programme) - semester II a keuzegroep
MSc Chemistry: Advanced Materials  (Electives) - semester II a keuze
MSc Chemistry: Catalysis and Green Chemistry  (Electives) - semester II a keuze
MSc Chemistry: Chemical Biology  (Electives) - semester II a keuze
MSc Chemistry: Erasmus Mundus Theoretical Chemistry and Computing Modelling  (Electives) - semester II a keuze
MSc Chemistry: Science, Business and Policy  (Electives) - semester II a keuze
MSc Courses for Exchange Students: Chemistry - Chemical Engineering - semester II a Chemistry
MSc Nanoscience  (Optional Courses) - semester II a keuze
MSc Physics: Advanced Materials  ( Compulsory courses) - semester II a keuzegroep