Nanomedicine and nanosafety

Faculteit Science and Engineering
Jaar 2019/20
Vakcode WMFA15001
Vaknaam Nanomedicine and nanosafety
Niveau(s) master
Voertaal Engels
Periode semester II a

Uitgebreide vaknaam Nanogeneeskunde (drug targeting, drug delivery, organ-on-a-chip) en nanoveiligheid
Leerdoelen At the end of the course, the student is able to
1. describe biological properties of nano-sized materials and their general behavior at cell and organism level in relation to both their applications in medicine (drug targeting, drug delivery, and organ-on-a-chip devices) and the potential risks of nanotechnologies (nanosafety)
2. analyze properties of nanomedicines in comparison to conventional drugs and compare characteristics of the main different classes of nanomedicines
3. identify challenges in different aspects of drug delivery and drug targeting and analyse potential solutions currently under investigation to address them including challenges in the synthesis of nano-sized drug carriers and targeted drugs, modification of nanomedicine properties when applied in biological conditions, behavior of nanomedicines and other nanomaterials at cell and organism level (barriers to drug delivery)
4. evaluate literature on current challenges and latest developments in the different aspects mentioned in objectives 1-3
Omschrijving This course covers the following topics:
• nanomedicine for drug delivery and drug targeting
• nanomedicine applications other than drug delivery and drug targeting (organ-on-a-chip devices, tissue regeneration, stem cell differentiation and assisted surgery)
• overview of main classes of nanomedicines, such as lipid based drug carriers, polymer based drug carriers, inorganic nanoparticles, antibodies and immunoconjugates, biomimetic materials, viral based nanocarriers
• drug carriers and targeted drugs currently on the market and in clinical trials
• challenges in nanomaterial design for successful targeting and barriers to drug delivery;
• methods to characterize nano-sized drug carriers after synthesis and once applied in biological environments (size, charge, stability in biological fluids such as blood);
• behavior of nano-sized materials at cellular and and organism level (uptake, distribution, final fate, eventual effects on cellular functions);
• potential risks and safety concerns for nanomedicines and nano-sized materials not intended to be in contact with humans and living organisms (other nanotechnologies).
Uren per week
Onderwijsvorm Hoorcollege (LC), Werkcollege (T)
(Lectures: 20 hours; tutorials: 8 hours; symposium: 4 hours (mandatory attendance))
Toetsvorm Opdracht (AST), Presentatie (P), Schriftelijk tentamen (WE)
(The exam consists of open-ended questions. The group project is a literature study, the conclusions of which will be presented to the group. Each of these parts has to be graded minimally with a 6/10 The assessment of group project is based on: 1. The scientific quality of the content (problem statement, 15% of project grade and Literature quality and relevance, 20%) 2. Structure and layout of the slides (15%) 3. Verbal skills (10%) 4. Presentation behavior (5%) 5. Presentation of scientific content (15%) 6. Response to questions (20%))
Vaksoort master
Coördinator prof. dr. A. Salvati
Docent(en) Gastdocent(en) ,prof. dr. A. Salvati ,prof. dr. E.M.J. Verpoorte
Verplichte literatuur
Titel Auteur ISBN Prijs
A list of literature will be provided by the lecturer.
Opmerkingen A minimum of 10 students and a maximum of 30 students can take this course. This course is also open to other MSc students (e.g. Nanoscience, Chemistry or MPDI). However, due to the limited capacity of the course, priority will be given to MSc students Pharmacy and MPS.
Opgenomen in
Opleiding Jaar Periode Type
MSc Chemistry: Erasmus Mundus Theoretical Chemistry and Computing Modelling  (Electives) - semester II a keuze
MSc Courses for Exchange Students: Pharmacy - semester II a verplicht
MSc Farmacie  (Keuzevakken) - semester II a keuze
MSc Medical Pharmaceutical Sciences: Pharmaceutical Design and Engineering  ( Suggest Electives) - semester II a keuze
MSc Medical Pharmaceutical Sciences: Pharmaco-epidemiology  (Other possible Electives) - semester II a keuze
MSc Medical Pharmaceutical Sciences: Research  (Electives) - semester II a keuze
MSc Medical Pharmaceutical Sciences: Science, Business and Policy  (Electives (10 ECTS)) - semester II a keuze
MSc Medical Pharmaceutical Sciences: Toxicology and Drug Disposition  ( Master Courses) - semester II a keuzegroep
MSc Nanoscience  (Optional Courses) - semester II a keuze