Neurobiology of Psychiatric Disorders

Faculteit Science and Engineering
Jaar 2019/20
Vakcode WMBM18001
Vaknaam Neurobiology of Psychiatric Disorders
Niveau(s) master
Voertaal Engels
Periode semester I b
ECTS 5
Rooster rooster.rug.nl

Uitgebreide vaknaam Neurobiology of Psychiatric Disorders
Leerdoelen The current classification scheme for the diagnosis of psychiatric disorders, such as Schizophrenia and Autism, separates each into non-overlapping diagnostic categories. These diagnostic categories are sufficient to provide the basis for general clinical management, but do not describe the underlying neurobiology that gives rise to individual symptoms. The ability to precisely link these symptoms to underlying neurobiology would not only facilitate the development of better treatments, it would also allow physicians to provide patients with a better understanding of the complexities and management of their illness. To realize this ambition, a paradigm shift is needed to build an understanding of how neuropsychiatric diagnoses can be based on variation in quantitative biological parameters. The main difficulty in the construction of biologically valid diagnoses is the lack of objective biomarkers. Moreover, the uncertain relationship between diagnosis and underlying etiology has created difficulties for etiological research and made the generation of appropriate disease models and development of targeted treatments very difficult. As etiological research progresses, there has been a rethinking of these diagnostic boundaries and their usefulness in treatment and classification of neuropsychiatric disorders. For example, there is more etiological overlap between psychiatric and neurodegenerative disorders than previously thought, and that they may better be described as domains of cross-disorder-related traits (rather than separable categories) that can be translated to rodent models. This course will make students familiar with the basic principles, and provide insights into newly emerging developments in the field by linking psychiatry to neurobiology. Driven by advances in technologies and by knowledge on neural circuitry function, precision medicine approaches are under way to tackle cross-diagnostic overlap and clinical heterogeneity in psychiatric disorders.
Omschrijving At the end of the course students are able to:
1) assess the relationship between psychiatric disorders and dysfunctional neural circuits (in the light of an emerging paradigm shift)
2) evaluate the use of current technological advances that provide quantitative biological parameters to map brain disorders (e.g., through genetics, neuro-imaging techniques).
3) clarify, and evaluate the use of novel approaches to understand brain circuit development in relation to psychiatric disorders (e.g., RDOC, evolutionary principles).
4) evaluate new treatment strategies based on neurobiological principles (e.g., precision medicine).
5) compose and assess a relevant research proposal using the above mentioned principles.
Uren per week
Onderwijsvorm Hoorcollege (LC), Opdracht (ASM), Werkcollege (T)
Toetsvorm Opdracht (AST), Presentatie (P)
(The final score is composed of a judgment of the oral presentation (45%), the written project proposal (45%), the review of project proposals (10%).)
Vaksoort master
Coördinator prof. dr. M.J.H. Kas
Docent(en) dr. E.H. Bos ,dr. S.F. de Boer ,prof. dr. W.H.I.M. Drinkenburg ,prof. dr. M.J.H. Kas ,prof. dr. I.E.C. Sommer
Verplichte literatuur
Titel Auteur ISBN Prijs
The presented material is made available as handouts to the students and a list of general review articles on important subjects is posted on Nestor
Entreevoorwaarden No specific prior knowledge is required to participate in the course unit.

The course is open to: MSc Behavioural and Cognitive Neurosciences, MSc Biology, MSc Biomedical Sciences, MSc Medical Pharmaceutical Sciences.
Opmerkingen Capacity: maximum 40 students.This is a MSc. Biomedical Sciences course unit: see student portal for priority regulations.
Opgenomen in
Opleiding Jaar Periode Type
MSc Behavioural and Cognitive Neurosciences: Behavioural Neurosciences  (Electives: courses from other programmes) 2 semester I b keuze
MSc Behavioural and Cognitive Neurosciences: Cognitive Neuroscience & Modelling  (Electives: courses from other programmes) 2 semester I b keuze
MSc Behavioural and Cognitive Neurosciences: Molecular & Clinical Neurosciences  (Electives: courses from other programmes) 2 semester I b keuze
MSc Biomedical Sciences: Biology of Ageing  (Electives (10 ECTS)) - semester I b keuze
MSc Biomedical Sciences: Biology of Cancer and Immune System  (Electives ) - semester I b keuze
MSc Biomedical Sciences: Biology of Food and Nutrition  (Electives (10 ECTS)) - semester I b keuze
MSc Biomedical Sciences: Neuroscience  ( Masters Courses) - semester I b verplicht
MSc Biomedical Sciences: Research  (Electives) - semester I b keuze
MSc Biomedical Sciences: Science, Business and Policy  (Electives (10 ECTS)) - semester I b keuze
MSc Medical Pharmaceutical Sciences: Pharmaceutical Design and Engineering  (Other possible Electives) - semester I b keuze
MSc Medical Pharmaceutical Sciences: Pharmaco-epidemiology  (Other possible Electives) - semester I b keuze
MSc Medical Pharmaceutical Sciences: Research  (Electives) - semester I b keuze
MSc Medical Pharmaceutical Sciences: Science, Business and Policy  (Electives (10 ECTS)) - semester I b keuze
MSc Medical Pharmaceutical Sciences: Toxicology and Drug Disposition  (Electives ) - semester I b keuze