Receptor Pharmacology

Uitgebreide vaknaam	Receptor Pharmacology
Leerdoelen	At the end of the course, the student is able to: 1) Explain the relationship between ligand binding and effect 2) Explain the mode of action of receptor systems, including ligand-gated ion channels, G protein coupled receptors, receptor tyrosine kinases, cytokine receptors and nuclear receptors 3) Explain the molecular mechanism of neurotransmission and the associated physiological effects in the autonomous and somatic nervous system; 4) Explain the role of histamine and autacoids in inflammation; 5) Explain the role of the dopaminergic and serotonergic receptors in the central nervous system 6) Describe the effects of drugs working on the systems described under 3-5 in relation to specific human diseases.
Omschrijving	Earlier on in year 1, the student has become acquainted with the most important principles in physiology, including defense mechanisms and immunology, and is able to understand and explain these principles in the therapeutic approach to pathologies using pharmacological interventions. In the receptor pharmacology course, more attention will be given to the underlying mechanisms that play a role in physiology and pathophysiology. It concerns a deepening of the therapeutic approach to diseases by pharmaceutical companies. The following topics are covered in this course: 1. General pharmacology including central definitions in pharmacology: agonism, antagonism, inverse agonism, receptor reserve, receptor regulation (desensitization); signal transduction mechanisms: G protein-coupled receptors, ligand-gated ion channels, kinase-linked receptors, nuclear receptors, crosstalk between signal transduction mechanisms; 2. Immunopharmacology including histamine and autacoids and their receptors, non-steroidal anti-inflammatory drugs (NSAIDS) and corticosteroids. 3. The basic principles of neurotransmission: pre- and post-synaptic receptors, co-transmission; local anesthetics. 4. The cholinergic and adrenergic system and their role in (para)sympathetic regulation and skeletal muscle physiology. 5. An introduction into neuropharmacology, including dopaminergic and serotonergic receptor systems. This course is in line with the learning outcomes xxxxx of the Bachelor's degree in Pharmacy (TER Appendix I).
Uren per week
Onderwijsvorm	Hoorcollege (LC) (Hoorcolleges: 42 uur; zelfstudie: 98 uur)
Toetsvorm	Meerkeuze toets (MC), Schriftelijk tentamen (WE) (The entire course unit will be assessed by means of an examination comprising 40 multiple-choice questions and 2 essay questions. The multiple-choice questions will count for 2/3 of the final mark and the essay questions for 1/3. Students will have 3 hours to complete the examination. To assess all learning outcomes in a balanced manner, all chapters and lecture files must be addressed in the examination.)
Vaksoort	propedeuse
Coördinator	prof. dr. R. Gosens
Docent(en)	Prof. Dr. A.M. Dolga ,prof. dr. R. Gosens ,Prof. Dr. M. Schmidt
Verplichte literatuur	Titel Auteur ISBN Prijs Rang & Dale's Pharmacology (9th edition) Rang HP, Dale MM, Ritter JM, Flower RJ, Henderson G Lecture files (via Nestor)
Entreevoorwaarden	The course unit assumes prior knowledge from the Physiology and Pharmacology course unit (WBFA020-05). This course unit is an entry requirement for the Pharmacology Practical (WBFA019-05).
Opmerkingen	Random chance + realistic knowledge rate / 100 * ((multiple-choice questions - random chance) + essay question 1 + essay question 2) Mark: If the score < pass mark: mark = 1.0 + 4.5 * (score - random chance) / pass mark - random chance If the score > pass mark: mark + 5.5 4.5 * (score - random chance) / number of questions - pass mark) Determination of the final mark for the course unit: the knowledge percentage is set at 55% and the pass mark is subsequently calculated, corrected for random chance. Marks over or equal to 5.5 are a pass and all marks below 5.5 are a fail. The average mark will be rounded off to the nearest whole or half mark; a mark of 5.5 will not be given. Students who fail the examination must take a resit. Dit vak had vorig jaar vakcode WPFA18007
Opgenomen in	Opleiding Jaar Periode Type BSc Farmacie  (hoofdprogramma) 1 semester II b verplicht