Chemical Biology

Faculteit Science and Engineering
Jaar 2020/21
Vakcode WBCH036-05
Vaknaam Chemical Biology
Niveau(s) bachelor
Voertaal Engels
Periode semester II b

Uitgebreide vaknaam Chemical Biology
Leerdoelen At the end of the course, the student is able to:
1. explain how synthetic (poly)peptides, nucleic acids and carbohydrates are synthesized and he/she can propose synthetic routes for these compounds;
2. summarize the limitations of chemistry in living systems;
3. apply their knowledge of ligation techniques for the construction of modified biomolecules;
4. describe how a cell synthesizes polypeptides and how genomic factors control protein synthesis, incl. initiation and termination of synthesis;
5. design new proteins using computational design and directed evolution and new protein functionalities through, the incorporation into polypeptides of unnatural amino acids;
6. Describe how DNA can be used to design nanoscale object, and to perform basic computational tasks
7. Describe how to sequence DNA with first, second and third generation sequencing technologies
Omschrijving Chemical biology is a multidisciplinary field, which investigates biological phenomena using chemical tools that are difficult to study using traditional molecular biology tools. One of these phenomena is the regulation of the activity of biomolecules (proteins, nucleic acids and carbohydrates) by posttranslational modification. Molecular biology methods and newly developed synthetic methods to obtain homogeneously modified biomolecules in vitro and in living systems will be discussed. The possibilities and limitations of these synthetic strategies will be taught, incl. new biochemical and synthetic strategies to tackle molecular interactions in the cell at high spatial and temporal resolution. Another important development of chemical biology is the designing, engineering and re-programming of biological systems. Hence, it will be explained how the synthesis of proteins is controlled by the cell. Further, new methodologies to design proteins, to incorporate non-natural amino acids into proteins, and to edit a genome will be described. Finally, it will also be explained how DNA can be used to design nanoscale structures and to perform basic computational tasks.
Uren per week
Onderwijsvorm Hoorcollege (LC), Werkcollege (T)
(Total hours of lectures: 30 hours, Tutorials: 20 hours, Self study: 90 hours.)
Toetsvorm Schriftelijk tentamen (WE)
(Final grade: Written exam with open questions (100%).)
Vaksoort bachelor
Coördinator prof. dr. G. Maglia, PhD.
Docent(en) prof. dr. G. Maglia, PhD. ,prof. dr. M.D. Witte
Verplichte literatuur
Titel Auteur ISBN Prijs
Primary literature available through Nestor

JM Berg, JL Tymoczko and L Stryer 987-1-4292-0494-1
Organic Chemistry P. Vollhardt and N. Schore
Entreevoorwaarden The course unit assumes prior knowledge acquired from Biochemistry, year 1; Molecules, Reactivity and Function, Organic Chemistry 1, year 1 and Organic Chemistry 2, year 2.
Opmerkingen The student will be evaluated on their ability to answer the questions as practiced in tutorials and their ability to apply this knowledge to solve new (related and unrelated) problems. The exam and marking scheme will be added. A typical exam contains 100 points and a student should at least have scored 55 points to pass.

The course unit is often followed by, or prepares students for, the track practical Chemical Biology, the Bachelor project, and ultimately also the MSc Chemistry (track Chemical Biology) in which the learning objectives attained are required as prior knowledge.

This course was registered last year with course code CHCB-11
Opgenomen in
Opleiding Jaar Periode Type
BSc Chemistry  ( Chemistry of Life) 2 semester II b verplicht
BSc Physics 2 semester II b verplicht BMP