Cellular Chemistry

Faculteit Science and Engineering
Jaar 2020/21
Vakcode WBCH021-05
Vaknaam Cellular Chemistry
Niveau(s) bachelor
Voertaal Engels
Periode semester II a
ECTS 5
Rooster rooster.rug.nl

Uitgebreide vaknaam Cellular Chemistry
Leerdoelen Upon completion of the course the students should be able to:
1 describe and explain the dimensions of cells and components in cells and to describe the rates of a number of cellular processes
2 describe and explain the basic functioning of a modern light microscope, the principles of photochemistry and the advanced microscopy methods FRET and FRAP
3 describe and explain the underlying principles and functioning of flow cytometry and microfluidics as techniques for single cell analysis
4 describe and explain the processes of DNA replication
5 describe and explain the processes of the cell cycle and its regulation
6 describe and explain the general principles of transcription and translation
7 describe and explain the mechanisms of protein transport into organelles & general principles of cell signalling
8 describe and explain the building blocks of the cytoskeleton and their functions
9 describe and explain the origin and consequences of molecular noise
10 analyse the literature and identify the most recent findings in a chosen topic of the course
Omschrijving This course aims to provide insight in the field of cell biology from a chemical and quantitative perspective. Specifically, students will acquire solid knowledge about a number of important dynamic and spatial processes in cells and will learn about experimental methods to study these processes.

Topics
- Overall construction plans for cells: numbers, dimensions and architecture of cells
- Light microscopy as technique to study spatial and dynamic processes in cells; photochemistry of fluorescent proteins
- Theme ‘space’: incl. (i) intracellular compartments and protein sorting, (ii) intracellular vesicular traffic, (iii) cell communication, (iv) cytoskeleton and self-assembly
- Theme ‘time’: incl. (i) DNA replication, (ii) advanced transcription and translation, (iii) cell cycle, (iv) stochastic effects in cells
Because optical microscopy is essential for the tracking of processes and molecules in a cell, a few hours will be devoted to hands-on experience in fluorescence microscopy.
Uren per week
Onderwijsvorm Hoorcollege (LC), Werkcollege (T)
(Total hours of lectures: 13 x 45 min, tutorials: 13 x 45 min, practicals: 5 hours)
Toetsvorm Schriftelijk tentamen (WE)
Vaksoort bachelor
Coördinator prof. dr. B. Poolman
Docent(en) prof. dr. B. Poolman ,prof. dr. I.J. van der Klei
Verplichte literatuur
Titel Auteur ISBN Prijs
Chapters from:
Molecular Biology of the Cell, 6th edition, Alberts et al
Chapters 12, 13, 15, 16, 17, 18, 20
Chapters from:
Physical Biology of the Cell, 2nd edition, Phillips et al
Chapters 13, 14
Entreevoorwaarden The chemistry students have all the basics to follow this course (biochemistry incl practicum, DNA, bioenergetics and metabolism). The bio-knowledge of the physics students is less broad at this stage, but this is not considered a problem. This course completes the chemistry students’ overview about the chemistry-oriented bio-subjects in their bachelor curriculum, from which point on they can continue a chemistry or biology Master.
Opmerkingen The result of the writing exam determines the mark of this course. The written exam is an open question-closed book exam. The questions range from simply know-how questions to more complex ones where students have to explain more complex concepts. The questions are assembled from a larger pool of questions. Every year, the exam consists of new and old questions. Questions are graded according to a scheme of predefined answers.

This course was registered last year with course code CHCC-12
Opgenomen in
Opleiding Jaar Periode Type
BSc Chemistry  ( Chemistry of life) 3 semester II a verplicht
BSc Courses for Exchange Students: Chemistry - Chemical Engineering - semester II a
BSc Physics  (Track: Biophysics and Medical Physics ) 3 semester II a verplicht