Radioisotopes in Experimental Biology

Faculteit Science and Engineering
Jaar 2019/20
Vakcode MLAA03
Vaknaam Radioisotopes in Experimental Biology
Niveau(s) master
Voertaal Engels
Periode semester I b (02-12-2019 till 21-12-2019)
ECTS 5
Rooster rooster.rug.nl

Uitgebreide vaknaam Radioisotopes in Experimental Biology
Leerdoelen At the end of the course, the student is able to:
1. reproduce the specific characteristics of the 3 main types of ionizing (radioactive) radiation, how to measure it and how to work safely with radioactive substances taken in to account the specific laws and legislations
2. reproduce more specific information on the most commonly used radioisotopes in biological experiments, how they are
used in experiments and the biological effects of ionizing radiation
3. perform an example of a biological labelling experiment and explain the use/choice of radioisotopes in a biological experiment, clarify the necessary specific safety precautions
4. apply the obtained knowledge in a experiment set-up with radioisotopes and summarize the experiment and results in a written report.
Omschrijving RPO Dispersible Radioactive Materials-D is the minimum expert level which allows you to work with radioisotopes at the university and university hospital (UMCG). It is an official expert level supervised and regulated by the Dutch Government. The University of Groningen is one of the few official recognized institutes were you can obtain certificates of the official radiation expert levels. At the end of the 1st week you will HAVE to pass the RPO DRM-D test to be allowed to participate in the remainder of the course.

NOTE: For the course an additional registration is needed
apart from Progress for participating in an official RPO DRM-D course.

Topics will include:
• Radioisotope detection using X-ray film
• The (advanced liquid) scintillation counter
• In vitro labeling of nucleic acids and proteins
• Subcellular localization of biological molecules
• Radioisotopes and immunoassay
• Pharmacological techniques
• Biological effect of radiation

The final part of the course consist of chronobiological research question regarding Melatonin using a Radioimmunoessay (RIA). The students will be their own research subjects. The results will be discussed in a concluding tutorial.
Uren per week
Onderwijsvorm Hoorcollege (LC), Practisch werk (PRC), Werkcollege (T)
(All practicals (including experiment week 3) are mandatory, absence will result in not passing the course)
Toetsvorm Meerkeuze toets (MC), Schriftelijk tentamen (WE), Verslag (R)
(Multiple choice test after week 1, to obtain certification. Minimal passing grade is 5.5 (out of 10). This exam has to be passed in order to continue with the remainder of the course. A final written exam: minimal 5 out of 10 to pass. Both exams and the assessment of the practical part contribute each 1/3 to the finale grade: the final grade is the average of these 3 grades.)
Vaksoort master
Coördinator drs. E.J. Bunskoeke
Docent(en) drs. M. Blaauw ,drs. E.J. Bunskoeke ,prof. dr. R.P. Coppes ,dr. M.H.K. Linskens , E.I. Zuidersma, MSc.
Verplichte literatuur
Titel Auteur ISBN Prijs
Syllabus
Both the theory book RPO DRM-D as the syllabus can be obtained in the office of the course coordinator (5174.028).
The participants will be informed when the course materials are available.
€  35,00
Radiation Protection Officer - Dispersible Radioactive Materials - level D (University of Groningen, 2018) (Fee is paid upon entry in GARP.) Dr. F. Pleiter and Dr. H.F. Boersma ca. €  10,00
https://www.rug.nl/education/other-study-opportunities/radiation-protection/strts-vrs-d/
Entreevoorwaarden The course unit assumes no specific prior knowledge except a bachelor degree in an area of life-sciences (e.g. Biology, LS&T,
Pharmacy, Medical Biology, Chemistry with biochemisty, etc.).
Opmerkingen Location: Linnaeusborg (Center of Life Sciences), Zernike
During the curriculum year the course will be taught once in December.
Capacity: minimum 4, maximum 24 students for the 5 ECTS course. First come, first serve.
Further information will be provided one month prior to the course.
(Master students who are only interested in obtaining the RPO DRM-D certificate have to contact the course coordinator for information about the other radiation courses.)
Opgenomen in
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