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Biocatalysis and Green Chemistry
| Faculteit | Science and Engineering |
| Jaar | 2021/22 |
| Vakcode | WMCH027-05 |
| Vaknaam | Biocatalysis and Green Chemistry |
| Niveau(s) | master |
| Voertaal | Engels |
| Periode | semester I b (12-11-2019 till 21-12-2019) |
| ECTS | 5 |
| Rooster | rooster.rug.nl |
| Uitgebreide vaknaam | Biocatalysis and Green Chemistry | ||||||||||||||||
| Leerdoelen | At the end of the course, the student is able to: 1) demonstrate knowledge of the diversity of reactions allowed by enzymatic catalysis, including the catalytic properties of serine hydrolases,redox enzymes, and other groups of enzymes included in the course syllabus 2) understand and be able to explain the use of enzymes for catalyzing important reactions such as hydrolysis, group transfer, oxidation, and conjugation 3) be able to explain the catalytic mechanism of important enzymes, including acid-base catalysis, covalent catalysis and the role of metals and cofactors 4) be able to evaluate and explain the relations between enzyme properties and application in different areas, such as production of enantiopure compounds, development of sustainable processes, and processing of biomass components 5) be able to present in a coherent and convincing way in a written report, scientific approaches that can be used to develop new biocatalytic processes, including the formulation of a critical justification and the design of a work flow. |
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| Omschrijving | Catalysis is the key technology in the development of green processes for synthetic chemistry. Enzymes are versatile and often highly selective catalysts that operate under mild conditions in water. The possibility to use enzymes in synthetic chemistry is attractive because of their wide reaction scope and the possibility to tailor enzyme properties for specific conversions. This course aims provide an understanding of enzyme-catalyzed reactions, including mechanisms of important enzymes, the basis and analysis of chemo-, regio- and stereoselectivity of enzymes, and the relationship between enzyme properties and their application in biocatalysis. Various classes of enzymes are discussed, such as hydrolases, transferases, oxidoreductases, and C-C bond forming enzymes, as well as enzymes used for polymerization and modification of materials and enzymes for carbohydrate processing (amylases, cellulases, chitinases). Enzymes used in synthetic biology, fermentation pathways. Specific topics in this course are: • biocatalysis: regio- and stereoselectivity of enzymes; chemoselectivity, enzyme kinetics, mechanisms • lipases, proteases and acylases in biocatalysis: mechanism, hydrolysis, synthesis, kinetic description • pyridoxal enzymes (transaminations), thiamine and lysine enzymes (transketolases, aldolases), C-C bond formation • enzymatic carbohydrate conversion for food and fuels, amylases, cellulases and related enzymes • redox enzymes, incl. monooxygenases, oxidases, and reductases • enzyme engineering and immobilization • use of enzymes in materials science, polymerization reactions for surface modification • synthetic biology. Design and engineering of fermentation pathways, diols, platform chemicals • biocatalyst development, design of new processes |
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| Uren per week | |||||||||||||||||
| Onderwijsvorm | Hoorcollege (LC), Opdracht (ASM), Werkcollege (T) | ||||||||||||||||
| Toetsvorm |
Presentatie (P), Schriftelijk tentamen (WE), Verslag (R)
(The final grade is calculated as follows: 50% written exam and 50% report. The written exam and the report require a 6 or higher to receive a final pass and grade.) |
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| Vaksoort | master | ||||||||||||||||
| Coördinator | prof. dr. ir. M.W. Fraaije | ||||||||||||||||
| Docent(en) | prof. dr. ir. M.W. Fraaije ,Prof. Dr. K.U. Loos | ||||||||||||||||
| Verplichte literatuur |
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| Entreevoorwaarden | The course unit requires prior knowledge about biochemistry, bioenergetics, molecular biology and organic chemistry, all studied in the first or second years of the BSc program Chemistry (track Life or Sustainability) or Biology (track Molecular Biology). | ||||||||||||||||
| Opmerkingen | This course was registered last year with course code MLGBB04 | ||||||||||||||||
| Opgenomen in |