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The impact of cerebral injury in donation and transplantation. A central role of the intestine

23 December 2009

Promotie: L.G. Koudstaal, 14.45 uur, Academiegebouw, Broerstraat 5, Groningen
Proefschrift: The impact of cerebral injury in donation and transplantation. A central role of the intestine
Promotor(s): prof.dr. R.J. Ploeg, prof.dr. H. van Goor
Faculteit: Medische Wetenschappen
Contact: via de persvoorlichters van het UMCG, tel. 050-361 2200, e-mail: voorlichting@bvl.umcg.nl

The impact of cerebral injury in donation and transplantation. A central role of the intestine

The aim of this thesis was to study the role of the intestine in brain death induced injury. Both experimental and clinical studies were focussed on inflammation in relationship with intestinal permeability.

Inflammation, apoptosis and enhanced intestinal permeability are demonstrated. Furthermore, this thesis shows that the anti- a pro-inflammatory proteins angiopoietin-1 and the pro-inflammatory angiopoietin-2 is modulated progressively towards inflammation during the period of brain death prior to organ recovery. Serum angiopoietin-2 concentration was independently significantly associated with graft survival: higher values in donor serum were predictive of a lower risk.

Last modified:15 September 2017 3.39 p.m.
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