Skip to ContentSkip to Navigation
About usNews and EventsNews articles

Neuron-glia interactions in the CNS. Implication of CXCR3-signaling in excitotoxicity- induced neurodegeneration

14 December 2009

Promotie: H.R.J. van Weering, 13.15 uur, Academiegebouw, Broerstraat 5, Groningen
Proefschrift: Neuron-glia interactions in the CNS. Implication of CXCR3-signaling in excitotoxicity- induced neurodegeneration
Promotor(s): prof.dr. H.W.G.M. Boddeke, prof.dr. K.P.H. Biber
Faculteit: Medische Wetenschappen
Contact: via de persvoorlichters van het UMCG, tel. 050-361 2200, e-mail: voorlichting bvl.umcg.nl

Neuron-glia interactions in the CNS. Implication of CXCR3-signaling in excitotoxicity- induced neurodegeneration

In this thesis we provide evidence that microglia have a profound neuroprotective role in a paradigm known as glutamate-induced neurodegeneration (excitotoxicity) and that local expression of chemotactic cytokines (chemokines) considerably affects the degree of neuronal cell death in this paradigm. More specifically, we demonstrate that chemokines CXCL10 and CCL21 directly affect neuronal survival under excitotoxic conditions, most likely through modulation of microglia activation. Moreover, we provide evidence that the effects of these two chemokines in this paradigm are mediated through the same chemokine receptor, namely CXCR3. Finally, we demonstrate that CXCL10 and CCL21 induce calcium transients and proliferation in astrocytes in vitro, suggesting also a role for these chemokines in the activation of astrocytes.  

Last modified:15 September 2017 3.39 p.m.
printView this page in: Nederlands

More news

  • 11 October 2019

    Down Under with Top Dutch (update)

    After two years of hard work, the Groningen Top Dutch Solar Racing team has arrived in Australia. The team consists of students of the Hanze University of Applied Sciences, University of Groningen, and secondary vocational education (MBO) and is currently...

  • 08 October 2019

    Making a splash in whale research

    He disliked genetics as an undergraduate and never really wanted to work with whales. Yet, Per Palsbøll became a worldwide expert in the genetics of marine mammals, heading a research programme spanning the entire globe. Introducing the concept of...

  • 03 October 2019

    New criteria for bank loans and stock exchanges listings could protect depleted marine resources from seafood sector

    Two reforms in the finance sector have the potential to accelerate action towards a sustainable seafood industry, according to new research published in the journal Science Advances. Compiling data on 160 publicly listed seafood companies and 3000...