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Ultrasound and microbubble targeted delivery. Exploring the mechanism and its therapeutic potential

09 November 2009

Microbubbles are tiny bubbles which consist out of a shell surrounding a gas-core and are used as a contrast agent in echography. It has been demonstrated that ultrasound and microbubbles can be used for local delivery of plasmid DNA and drugs into cells. This thesis describes the optimal circumstances for the intracellular delivery of plasmid DNA to endothelial cells. In the future, this technique may lead to the development of new therapeutic strategies to treat cardiovascular disease.

Last modified:15 September 2017 3.39 p.m.
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