Skip to ContentSkip to Navigation
About usNews and EventsNews articles

Small heat shock proteins. Implications for neurodegeneration and longevity

01 July 2009

PhD ceremony: M.J. Vos, 13.15 uur, Academiegebouw, Broerstraat 5, Groningen

Thesis: Small heat shock proteins. Implications for neurodegeneration and longevity

Promotor(s): prof. H.H. Kampinga

Faculty: Medical Sciences


Aging in general, as well as several age-related diseases, are characterized by a gradual decrease in proper cell functioning. Cells continuously have to deal with protein renewal, degradation and folding. The main hazard of these processes is the formation of partly- or incorrectly folded proteins which tend to form toxic aggregates and disturb cellular functions. Fortunately, cells contain a special group of proteins devoted to support the process of protein folding.These chaperones can be divided into several families, each with their own characteristic function within the folding network. In this thesis is focused on the small heat shock protein (sHSP) family. Using both cellular studies and studies in fruit flies, the individual contribution of each sHSP member to protein folding and reduction of aggregation of proteins known to cause neurological disorders such as Huntington’s disease was determined.


Last modified:15 September 2017 3.38 p.m.
printView this page in: Nederlands

More news

  • 22 May 2019

    The North of the Netherlands goes down under during Solar Challenge

    Students of Hanze University of Applied Sciences (UAS), University of Groningen and Noorderpoort will be competing in the Bridgestone World Solar Challenge in Australia for the first time, with their own uniquely built and designed solar car called...

  • 20 May 2019

    Forthcoming honorary doctor Titia de Lange: Splicing ropes and aging

    Titia de Lange has dedicated most of her working life to researching long telomeres – the ends of chromosomes. She was awarded an honorary doctorate in June for her ground-breaking research. De Lange’s first experiment as a PhD student, under the supervision...

  • 15 May 2019

    Academy Medal for Trudy Dehue

    Trudy Dehue, scientific sociologist, author and emeritus professor of the University of Groningen, will receive the Academy Medal from the Royal Netherlands Academy of Arts and Sciences (KNAW). The Academy Medal is awarded every other year to individuals...