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Small heat shock proteins. Implications for neurodegeneration and longevity

01 July 2009

PhD ceremony: M.J. Vos, 13.15 uur, Academiegebouw, Broerstraat 5, Groningen

Thesis: Small heat shock proteins. Implications for neurodegeneration and longevity

Promotor(s): prof. H.H. Kampinga

Faculty: Medical Sciences

 

Aging in general, as well as several age-related diseases, are characterized by a gradual decrease in proper cell functioning. Cells continuously have to deal with protein renewal, degradation and folding. The main hazard of these processes is the formation of partly- or incorrectly folded proteins which tend to form toxic aggregates and disturb cellular functions. Fortunately, cells contain a special group of proteins devoted to support the process of protein folding.These chaperones can be divided into several families, each with their own characteristic function within the folding network. In this thesis is focused on the small heat shock protein (sHSP) family. Using both cellular studies and studies in fruit flies, the individual contribution of each sHSP member to protein folding and reduction of aggregation of proteins known to cause neurological disorders such as Huntington’s disease was determined.

 

Last modified:15 September 2017 3.38 p.m.
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