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Experimental models of retinal angiogenesis the effects of angiopoietin-2 and TNFα modulation

15 June 2009

PhD ceremony: F.M. Gräfin vom Hagen, 16.15 uur, Academiegebouw, Broerstraat 5, Groningen

Thesis: Experimental models of retinal angiogenesis the effects of angiopoietin-2 and TNFα modulation

Promotor(s): prof. G. Molema, prof. H.P. Hammes, prof. R.O.B. Gans

Faculty: Medical Sciences


Many patients with diabetic are at risk to develop diabetic retinopathy. The prevention depends on the efficient normalization of blood glucose levels and blood pressure. However, in the standard clinical setting this is difficult to achieve. In this thesis is shown that Ang2 mediates pathologic retinal angiogenesis and postnatal retinal vascular development. Furthermore, angiogenic and inflammatory factors cooperate at the incipience of pathological retinal angiogenesis. Local application of a combination of antiangiogenic and anti-inflammatory drugs is a future option to treat proliferative retinopathies.


Last modified:15 September 2017 3.39 p.m.
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