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Theoretical models in bioanalytical method development

17 April 2009

PhD ceremony: G. Hendriks, 16.15 uur, Academiegebouw, Broerstraat 5, Groningen

Thesis: Theoretical models in bioanalytical method development

Promotor(s): prof. D.R.A. Uges, prof. J.P. Franke

Faculty: Mathematics and Natural Sciences

 

Gert Hendriks presents in his thesis four new models of bioanalytical techniques used for the determination of drugs in body fluids:

1) A new method for modelling retention times in a gradient LC-system. This method takes the distortion of the gradient profile, caused by dead volumes in the LC-system, into account.

2) A new algorithm that shows the possibility of using a more extended range in extraction pH in liquid-liquid extraction of ionisable analytes. It is demonstrated that varying the pH within this range, highly affects the extraction selectivity.

3) The acid-base behaviour of human plasma is elucidated over a wide pH range. With these parameters the resulting pH of a mixture of plasma and a buffer solution can be calculated resulting in a better controlled sample preparation.

4) A new method for modelling the analyte recovery behaviour in solid phase extraction (SPE) systems. By using a new introduced tool, the elution behaviour of the analytes can be visualised. The results from these tests can be used to model the extraction and elution behaviour of the analytes. This model results in an accurate description of the wash SPE elution conditions by predicting the analyte recovery at different wash and elution conditions.

 

Last modified:15 September 2017 3.38 p.m.
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