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Cognitive functioning of children treated for acute lymphoblastic leukaemia with chemotherapy-only

08 April 2009

PhD ceremony: mw. N.C.A.J. Jansen, 16.15 uur, Academiegebouw, Broerstraat 5, Groningen

Thesis: Cognitive functioning of children treated for acute lymphoblastic leukaemia with chemotherapy-only

Promotor(s): prof. W.A. Kamps, prof. J.M. Bouma

Faculty: Medical Sciences


Acute lymphoblastic leukaemia (ALL) is the most common form of malignancy in children. With the introduction of ‘chemotherapy-only’ protocols which replaced irradiation by intrathecal and high dose systemic chemotherapy, the number of patients with cognitive deterioration has dramatically decreased with stable or even improved survival rates. There is no consensus concerning possible more subtle negative effects of chemotherapy on intellectual development and specific neuropsychological functions such as attention, memory, and visual motor abilities. In 1999, the nationwide study presented in this thesis was therefore initiated by the Paediatric Oncology Centre of the University Medical Centre Groningen. Main objective was to assess potential early and late negative late effects of chemotherapy-only on cognitive functioning in children treated for ALL.


Last modified:15 September 2017 3.39 p.m.
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