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Lipid transfer proteins: consequences for cellular cholesterol efflux and cardiovascular risk in diabetes mellitus

11 February 2009

PhD ceremony: R. de Vries, 13.15 uur, Academiegebouw, Broerstraat 5, Groningen

Thesis: Lipid transfer proteins: consequences for cellular cholesterol efflux and cardiovascular risk in diabetes mellitus

Promotor(s): prof. B.H.R. Wolffenbuttel

Faculty: Medical Sciences

 

Type 1 and type 2 diabetes mellitus are accompanied by an increased cardiovascular risk. One of the reasons for this increase is an altered cholesterol metabolism. The reverse cholesterol transport process, in which cholesterol from the peripheral vascular cells is transported back to the liver, is an important protecting mechanism against atherosclerosis. High density lipoprotein (HDL), plays an important role because HDL-particles are able to take up cholesterol from cells and transport it to the liver. This thesis studies the ability of HDL from diabetic patients to stimulate cholesterol efflux from model cells. It is also shown that an increased PLTP-activity contributes to an increased vascular wall thickness and thereby may be disadvantageous.

 

Last modified:15 September 2017 3.39 p.m.
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