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Protein secretion and disulfide bond handling in Bacillus subtilis

07 January 2009

PhD ceremony: R.H.M. Kouwen, 14.45 uur, Academiegebouw, Broerstraat 5, Groningen

Thesis: Protein secretion and disulfide bond handling in Bacillus subtilis

Promotor(s): prof. J.M. van Dijl

Faculty: Medical Sciences


This thesis describes research into the mechanisms of protein secretion by B. subtilis, with a strong focus on the secretion of proteins containing disulfide bonds. The mechanisms of disulfide bond formation and breakage have been studied, and differences with other bacteria, such as the important pathogen Staphylococcus aureus have been explored. Furthermore, the efficiency in export and folding of both native and foreign proteins containing disulfide bonds in B. subtilis have been studied.


Last modified:15 September 2017 3.38 p.m.
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