PhD ceremony: A.W. van Zijl, 16.15 uur, Academiegebouw, Broerstraat 5, Groningen
Thesis: Enantioselective copper catalyzed allylic alkylation using Grignard reagents: applications in synthesis
Promotor(s): prof. B.L. Feringa, prof. A.J. Minnaard
Faculty: Mathematics and Natural Sciences
Enantioselective copper catalyzed allylic alkylation is a powerful carbon-carbon bond forming reaction. In this thesis the development of a new catalyst for the use of Grignard reagents in this reaction is described. This catalyst is based on copper and the ligand Taniaphos. The high regio- and enantioselectivity obtained, in particular with the introduction of a CH3 group, makes the new catalyst complementary to those reported previously for this reaction.
In addition, the enantioselective copper catalyzed allylic alkylation was applied in the synthesis of relevant organic compounds, such as building blocks containing two functional groups, pheromones and heterocyclic compounds. This demonstrates that this reaction can make a valuable contribution to the possibilities that synthetic organic chemists have. In part due to this work, they might decide on applying asymmetric catalytic methods instead of older and less efficient methods, when they wish to synthesize chiral compounds, such as for instance medicinal compounds.
Moniek Tromp and Marleen Kamperman share a lot in common. Both are young professors of chemistry at the
Zernike Institute for Advanced Materials (ZIAM).Both joined the UG in 2018. Both are engaged in developing new materials. Both enjoy promoting science...
After two years of hard work, the Groningen Top Dutch Solar Racing team has arrived in Australia. The team consists of students of the Hanze University of Applied Sciences, University of Groningen, and secondary vocational education (MBO) and is currently...
Kick-off Young Science and Engineering Network (YSEN)