Skip to ContentSkip to Navigation
About usNews and EventsNews articles

Cardiovascular late effects in adult survivors of childhood cancer

10 December 2008

PhD ceremony: mw. C.A.J. Brouwer, 13.15 uur, Academiegebouw, Broerstraat 5, Groningen

Thesis: Cardiovascular late effects in adult survivors of childhood cancer

Promotor(s): prof. W.A. Kamps, prof. J.A. Gietema, prof. E.G.E. de Vries

Faculty: Medical Sciences

 

One of the most important causes of morbidity and mortality in childhood cancer survivors is cardiovascular damage. The aim of this thesis is to gain insight in the prevalence of (sub)clinical cardiac and/or vascular damage and cardiovascular risk factors in childhood cancer survivors in association with previous cancer treatment. The studies described in this thesis show an increased prevalence of cardiac and vascular damage and cardiovascular risk factors in the survivors compared with the healthy controls. Especially, the finding of diastolic dysfunction (disturbed relaxation of the left chamber of the heart) is remarkable and not described before in such a large cohort of survivors by load-independent echocardiography parameters. Diastolic dysfunction in childhood cancer survivors is associated with previous chest irradiation and with a higher dose of anthracyclines (a specific group of cytostatics). Subclinical vascular damage is associated with previous irradiation, especially when delivered on the neck. Furthermore, the survivors had more often an unfavourable cardiovascular risk profile compared with the controls. This was mainly indicated by a higher prevalence of the metabolic syndrome, which is a clustering of cardiovascular risk factors. Additionally, survivors treated with cranial irradiation are at risk to develop overweight, while anthracycline-treated survivors are at risk to develop underweight. Our finding of a higher prevalence of cardiovascular risk factors in childhood cancer survivors compared with controls is important, because the presence of risk factors may serve as potential intervention targets in the prevention and/or early treatment of (sub)clinical cardiovascular disease.

 

Last modified:15 September 2017 3.37 p.m.

More news

  • 23 April 2019

    From paperclip to patent

    How is it possible that an albatross doesn’t crash and die when it lands? And how come its large wings don’t break due to air resistance? That is what you would expect, according to the laws of aerodynamics. However, Professor Eize Stamhuis has discovered...

  • 16 April 2019

    A thorough characterization of structural variants in human genomes

    Human genomes vary quite a bit from individual to individual. These differences include single nucleotide changes, or “spelling mistakes” in the DNA sequence, but even more variation comes from structural variants, which include additions, deletions...

  • 02 April 2019

    ‘Sense of loss drives voting behaviour’

    ‘Everybody here loves that academia has returned to Friesland. We teach, carry out research and think along about solutions to problems that are relevant for Friesland,’ says Caspar van den Berg, Professor of Global and Local Governance at the UG Campus...