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Organ preservation and viability in kidney and liver transplantation; experimental and clinical studies

12 November 2008

PhD ceremony: M.H.J. Maathuis, 16.15 uur, Academiegebouw, Broerstraat 5, Groningen

Thesis: Organ preservation and viability in kidney and liver transplantation; experimental and clinical studies

Promotor(s): prof. R.J. Ploeg, prof. G. Rakhorst

Faculty: Medical Sciences

 

Kidney and liver transplantations are routinely performed nowadays to treat end stage organ diseases. However, the increasing gap between demand and supply, has necessitated the transplantation community to expand donor criteria and accept donor organs which sustained more damage. Organ preservation should maintain organ viability after an organ has been disconnected from the circulation in the donor. At this moment static cold storage (4°C) using the University of Wisconsin (UW) solution is the most widely used method of organ preservation. Improving organ preservation might be a successful strategy to transplant damaged organs with excellent function after transplantation.

A novel and now clinically available preservation solution (IGL-1) was studied in an animal model but did not show any advantage over the UW solution. An alternative method for organ preservation is hypothermic machine perfusion (HMP). Using this method, the organ is connected to a perfusion device. The Groningen Machine Perfusion system was studied in a porcine model and improved kidney and liver preservation. In a clinical trial, deceased donor kidneys demonstrated a better function after transplantation following HMP preservation when compared to CS. Even more improvement can be expected from normothermic (37°C) machine preservation. Due to the complexity of the technique, more research is necessary before clinical application can be considered.

 

Last modified:15 September 2017 3.37 p.m.

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