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Microorganisms and inflammation in the long term aseptic loosening process of total hip implants

14 May 2008

PhD ceremony: mw. C.S.M. Hoenders, 14.45 uur, Academiegebouw, Broerstraat 5

Thesis: Microorganisms and inflammation in the long term aseptic loosening process of total hip implants

Promotor(s): prof. M.J.A. van Luyn, prof. S.K. Bulstra

Faculty: Medical Sciences


Replacement of the hip joint by a hip implant is known as an effective treatment of for instance osteoarthritis of the hip. Despite the high success rate, 5% of all replaced hips loosen after 10-15 years. This usually results in replacement of the hip implant which means that the patient has to undergo another surgery and revalidation period. Apart from the considerable consequences for the patient, this intervention also accounts for high costs of healthcare budget.

In this thesis, several factors, such as obesity, old age, long operatingtime and dementia, have been identified to increase the risk of hip implant loosening and hip implant infection. Beside these factors, the mechanism leading to loosening was studied. It was demonstrated that bacteria are involved in this loosening process while it is generally believed that no bacteria are present in this process. To be able to detect these bacteria in very low numbers, more sensitive techniques were used.

More insight in the loosening mechanism will create possibilities to intervene in the process and less patients will need re-operation because they can also be helped with a less invasive treatment. In further research, new treatment possibilities will be studied and options for the prevention of hip implant loosening will be further explored.

Last modified:15 September 2017 3.37 p.m.

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