Proton therapy in the presence of motion
The success of radiation therapy critically depends on the ability to deposit a sufficient dose in the tumor to sterilize it while at the same time minimizing the dose in the surrounding healthy tissue to reduce the risk of clinically relevant complications. Proton therapy has physical advantages over the conventional photon therapy, as most of the dose is deposited at the end of the proton range (Bragg peak). This requires millimeter accuracy of the Bragg peak localization in order to avoid too high dose in healthy tissue and too low dose in the tumor. In practice, errors occur due to range uncertainties, positioning errors, organ motion and anatomical changes during the course of treatment. The correct delivery verification of the radiation dose is therefore essential to ensure high treatment quality. The treatment of moving tumors (e.g. in the lungs) with particle therapy is a real challenge as the motion can easily result in too low dose in the tumor and an associated too high dose in the surrounding healthy tissue. The verification is therefore even more important than for static tumors and faces the same challenge as the complex irradiation strategies for moving tumors that are currently being developed.
|Last modified:||25 September 2014 4.24 p.m.|