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Walvoort, Dr Marthe

Marthe Walvoort
Marthe Walvoort

Marthe Walvoort is an assistant professor of Chemistry at the University of Groningen. She researches the function and workings of carbohydrate molecules, which are not only present in food, but also in paper or on the outside of bacteria and viruses. Walvoort studies these molecules by reproducing them in the lab. In contrast to the reproduction of DNA and protein chains, this technique is still in its infancy. Much of Walvoort’s work revolves around developing new methods for producing carbohydrate chains.

Bacteria often use sugars to infect other cells, which means that the knowledge generated by Walvoort’s research could lead to new ways of neutralizing bacteria. Another focus area is the development of carbohydrate chains to promote the growth of ‘good’ rather than ‘bad’ bacteria, helping to curb the need for antibiotics in the future.

At the end of her degree programme in chemistry in Leiden, Walvoort spent a year carrying out research in Oxford. She was then awarded a PhD in Chemistry in Leiden (cum laude (with distinction)) and worked at Massachusetts Institute of Technology (MIT) as a postdoc researcher from 2012 to 2015.

Walvoort is a Rosalind Franklin Fellow at the University of Groningen and one of the founders of the Young Academy Groningen.

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Publications

2019

Verkhnyatskaya, S. A., de Vries, A. H., Douma-de Vries, E., Sneep, R. J. L., & Walvoort, M. T. C. (2019). Direct and Regioselective Di-alpha-fucosylation on the Secondary Rim of beta-Cyclodextrin: Cover Profile. Chemistry, 25(27), 6649-6649. https://doi.org/10.1002/chem.201901257
Verkhnyatskaya, S. A., de Vries, A. H., Douma-de Vries, E., Sneep, E. J. L., & Walvoort, M. T. C. (2019). Direct and Regioselective Di-alpha-fucosylation on the Secondary Rim of beta-Cyclodextrin. Chemistry, 25(27), 6722-6727. https://doi.org/10.1002/chem.201806090
Verkhnyatskaya, S., Ferrari, M., de Vos, P., & Walvoort, M. T. C. (2019). Shaping the Infant Microbiome With Non-digestible Carbohydrates. Frontiers in Microbiology, 10, [343]. https://doi.org/10.3389/fmicb.2019.00343

2018

Leeuwenburgh, V., Bhattacharya, A., Urzua, C., Walvoort, M., Jalving, H., de Jong, S., & Fehrmann, R. (2018). The metabolic landscape browser: a novel tool for understanding pan-cancer metabolic processes through variance in gene expression data. European Journal of Cancer, 103(Suppl.1), E106-E106. [318 (PB-079)].

2017

Lukose, V., Walvoort, M. T. C., & Imperiali, B. (2017). Bacterial phosphoglycosyl transferases: initiators of glycan biosynthesis at the membrane interface. Glycobiology, 27(9), 820-833. https://doi.org/10.1093/glycob/cwx064
Bdira, F. B., Kallemeijn, W. W., Oussoren, S. V., Scheij, S., Bleijlevens, B., Florea, B. I., ... Aerts, J. M. F. G. (2017). Stabilization of Glucocerebrosidase by Active Site Occupancy. ACS chemical biology, 12(7), 1830-1841. https://doi.org/10.1021/acschembio.7b00276

2016

Walvoort, M. T. C., Testa, C., Eilam, R., Aharoni, R., Nuti, F., Rossi, G., ... Papini, A. M. (2016). Antibodies from multiple sclerosis patients preferentially recognize hyperglucosylated adhesin of non-typeable Haemophilus influenzae. Scientific Reports, 6, [39430]. https://doi.org/10.1038/srep39430
Walvoort, M. T. C., Lukose, V., & Imperiali, B. (2016). A Modular Approach to Phosphoglycosyltransferase Inhibitors Inspired by Nucleoside Antibiotics. Chemistry : a European Journal, 22(11), 3856-3864. https://doi.org/10.1002/chem.201503986
Das, D., Walvoort, M. T. C., Lukose, V., & Imperiali, B. (2016). A Rapid and Efficient Luminescence-based Method for Assaying Phosphoglycosyltransferase Enzymes. Scientific Reports, 6, [33412]. https://doi.org/10.1038/srep33412

2015

Zhang, Q., van Rijssel, E. R., Walvoort, M. T. C., Overkleeft, H. S., van der Marel, G. A., & Codee, J. D. C. (2015). Acceptor Reactivity in the Total Synthesis of Alginate Fragments Containing -L-Guluronic Acid and -D-Mannuronic Acid. Angewandte Chemie - International Edition, 54(26), 7670-7673. https://doi.org/10.1002/anie.201502581

2014

Baker, P., Ricer, T., Moynihan, P. J., Kitova, E. N., Walvoort, M. T. C., Little, D. J., ... Howell, P. L. (2014). P. aeruginosa SGNH Hydrolase-Like Proteins AlgJ and AlgX Have Similar Topology but Separate and Distinct Roles in Alginate Acetylation. PLoS Pathogens, 10(8), [e1004334]. https://doi.org/10.1371/journal.ppat.1004334
Wolfram, F., Kitova, E. N., Robinson, H., Walvoort, M. T. C., Codee, J. D. C., Klassen, J. S., & Howell, P. L. (2014). Catalytic Mechanism and Mode of Action of the Periplasmic Alginate Epimerase AlgG. The Journal of Biological Chemistry, 289(9), 6006-6019. https://doi.org/10.1074/jbc.M113.533158

2013

Ronnols, J., Walvoort, M. T. C., van der Marel, G. A., Codee, J. D. C., & Widmalm, G. (2013). Chair interconversion and reactivity of mannuronic acid esters. Organic & Biomolecular Chemistry, 11(46), 8127-8134. https://doi.org/10.1039/c3ob41747f
Frihed, T. G., Walvoort, M. T. C., Codee, J. D. C., van der Marel, G. A., Bols, M., & Pedersen, C. M. (2013). Influence of O6 in Mannosylations Using Benzylidene Protected Donors: Stereoelectronic or Conformational Effects? Journal of Organic Chemistry, 78(6), 2191-2205. https://doi.org/10.1021/jo302455d

2012

Walvoort, M. T. C., van der Marel, G. A., Overkleeft, H. S., & Codee, J. D. C. (2012). On the reactivity and selectivity of donor glycosides in glycochemistry and glycobiology: trapped covalent intermediates. Chemical Science, 4(3), 897-906. https://doi.org/10.1039/c2sc21610h
Walvoort, M. T. C., Volbeda, A. G., Reintjens, N. R. M., van den Elst, H., Plante, O. J., Overkleeft, H. S., ... Codee, J. D. C. (2012). Automated Solid-Phase Synthesis of Hyaluronan Oligosaccharides. Organic letters, 14(14), 3776-3779. https://doi.org/10.1021/ol301666n
Walvoort, M. T. C., van den Elst, H., Plante, O. J., Kroeck, L., Seeberger, P. H., Overkleeft, H. S., ... Codee, J. D. C. (2012). Automated Solid-Phase Synthesis of beta-Mannuronic Acid Alginates. Angewandte Chemie - International Edition, 51(18), 4393-4396. https://doi.org/10.1002/anie.201108744
Walvoort, M. T. C., Kallemeijn, W. W., Willems, L. I., Witte, M. D., Aerts, J. M. F. G., van der Marel, G. A., ... Overkleeft, H. S. (2012). Tuning the leaving group in 2-deoxy-2-fluoroglucoside results in improved activity-based retaining beta-glucosidase probes. Chemical Communications, 48(84), 10386-10388. https://doi.org/10.1039/c2cc35653h

2011

Walvoort, M. T. C., Moggre, G-J., Lodder, G., Overkleeft, H. S., Codee, J. D. C., & van der Marel, G. A. (2011). Stereoselective Synthesis of 2,3-Diamino-2,3-dideoxy-beta-D-mannopyranosyl Uronates. Journal of Organic Chemistry, 76(18), 7301-7315. https://doi.org/10.1021/jo201179p
Walvoort, M. T. C., de Witte, W., van Dijk, J., Dinkelaar, J., Lodder, G., Overkleeft, H. S., ... van der Marel, G. A. (2011). Mannopyranosyl Uronic Acid Donor Reactivity. Organic letters, 13(16), 4360-4363. https://doi.org/10.1021/ol2016862
Witte, M. D., Walvoort, M. T. C., Li, K-Y., Kallemeijn, W. W., Donker-Koopman, W. E., Boot, R. G., ... Overkleeft, H. S. (2011). Activity-Based Profiling of Retaining beta-Glucosidases: A Comparative Study. ChemBioChem, 12(8), 1263-1269. https://doi.org/10.1002/cbic.201000773
Codee, J. D. C., Walvoort, M. T. C., de Jong, A-R., Lodder, G., Overkleeft, H. S., & van der Marel, G. A. (2011). Mannuronic Acids: Reactivity and Selectivity. Journal of carbohydrate chemistry, 30(7-9), 438-457. https://doi.org/10.1080/07328303.2011.624284
Codee, J. D. C., Christina, A. E., Walvoort, M. T. C., Overkleeft, H. S., & Van der Marel, G. A. (2011). Uronic Acids in Oligosaccharide and Glycoconjugate Synthesis. In B. FraserReid, & JC. Lopez (Eds.), REACTIVITY TUNING IN OLIGOSACCHARIDE ASSEMBLY (pp. 253-289). (Topics in Current Chemistry; Vol. 301). Springer. https://doi.org/10.1007/128_2010_111

2010

Walvoort, M. T. C., Lodder, G., Overkleeft, H. S., Codee, J. D. C., & van der Marel, G. A. (2010). Mannosazide Methyl Uronate Donors. Glycosylating Properties and Use in the Construction of beta-ManNAcA-Containing Oligosaccharides. Journal of Organic Chemistry, 75(23), 7990-8002. https://doi.org/10.1021/jo101779v
Walvoort, M. T. C., Dinkelaar, J., van den Bos, L. J., Lodder, G., Overkleeft, H. S., Codee, J. D. C., & van der marel, G. A. (2010). The impact of oxacarbenium ion conformers on the stereochemical outcome of glycosylations. Carbohydrate Research, 345(10), 1252-1263. https://doi.org/10.1016/j.carres.2010.02.027

2009

Walvoort, M. T. C., Lodder, G., Mazurek, J., Overkleeft, H. S., Codee, J. D. C., & van der Marel, G. A. (2009). Equatorial Anomeric Triflates from Mannuronic Acid Esters. Journal of the American Chemical Society, 131(34), 12080-+. https://doi.org/10.1021/ja905008p
Last modified:09 January 2019 3.06 p.m.
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