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Frijlink, prof.dr. Erik

Erik Frijlink
Erik Frijlink

Erik Frijlink (1960, Meppel) is sinds 1998 hoogleraar Farmaceutische Technologie en Biofarmacie aan de Rijksuniversiteit Groningen. Daarvoor was hij hoofd van de afdeling Farmaceutische Ontwikkeling van Solvay Pharmaceuticals. Zijn onderzoeksgroep richt zich op geavanceerde technologie voor verbeterde toediening van medicijnen. Zijn groep heeft internationaal een prominente plaats verworven op dit terrein. Wereldwijd zijn al meer dan 300.000 mensen met door hem ontwikkelde technieken behandeld.

Frijlink leidt een internationaal consortium dat zoekt naar een universeel griepvaccin. Het onderzoek wordt uitgevoerd door twaalf internationale partners. De Europese Unie steunt het onderzoek met een subsidie van zes miljoen euro. Frijlink denkt dat het niet lang meer duurt voor er een vaccin is dat mensen beschermt tegen alle vormen van griep. Zo'n vaccin zou de jaarlijkse seizoensprik overbodig maken. Frijlink verwacht vooral veel van middelen die via een inhalator kunnen worden toegediend. Dat zou effectiever kunnen zijn dan een injectie. Hij ontwikkelde zelf al een een innovatieve poederinhalator tegen astma en COPD. Deze nieuwe inhalator, de Novolizer, biedt ten opzichte van bestaande inhalatoren vele voordelen.

Frijlink is genomineerd voor de Huibregtsenprijs 2016. Uit het juryrapport: "Het werk van Frijlink is exemplarisch voor baanbrekend onderzoek dat tegelijkertijd van groot belang is voor onze maatschappij. Het koppelt wetenschappelijke excellentie aan maatschappelijke relevantie en is tevens een van de weinige voorbeelden van hoe een vinding op een Nederlandse universiteit leidt tot een aanmerkelijke licentiestroom."

Eerder in het nieuws

Artikel NOS
Artikel NOS

2019

Frijlink, H. W. (2019). Wisselen van medicijnen. In Wisselen van medicijnen (pp. 1-116)

2018

Grasmeijer, N., Tiraboschi, V., Woerdenbag, H. J., Frijlink, H. W., & Hinrichs, W. L. J. (2019). Identifying critical process steps to protein stability during spray drying using a vibrating mesh or a two-fluid nozzle. European Journal of Pharmaceutical Sciences, 128, 152-157. DOI: 10.1016/j.ejps.2018.11.027
Tomar, J., Biel, C., de Haan, C. A. M., Rottier, P. J. M., Petrovsky, N., Frijlink, H. W., ... Peeters, B. (2018). Passive inhalation of dry powder influenza vaccine formulations completely protects chickens against H5N1 lethal viral challenge. European Journal of Pharmaceutics and Biopharmaceutics, 133, 85-95. DOI: 10.1016/j.ejpb.2018.10.008
Beugeling, M., Grasmeijer, N., Born, P. A., van der Meulen, M., van der Kooij, R. S., Schwengle, K., ... Hinrichs, W. L. J. (2018). The mechanism behind the biphasic pulsatile drug release from physically mixed poly(DL-lactic(-co-glycolic) acid)-based compacts. International Journal of Pharmaceutics, 551(1-2), 195-202. DOI: 10.1016/j.ijpharm.2018.09.025
Gareb, B., Dijkstra, G., Kosterink, J. G. W., & Frijlink, H. W. (2018). Development of novel zero-order release budesonide tablets for the treatment of ileo-colonic inflammatory bowel disease and comparison with formulations currently used in clinical practice. International Journal of Pharmaceutics. DOI: 10.1016/j.ijpharm.2018.11.019
Ruigrok, M. J. R., Xian, J-L., Frijlink, H. W., Melgert, B. N., Hinrichs, W. L. J., & Olinga, P. (2018). siRNA-mediated protein knockdown in precision-cut lung slices. European Journal of Pharmaceutics and Biopharmaceutics, 133, 339-348. DOI: 10.1016/j.ejpb.2018.11.005
Tomar, J., Patil, H. P., Bracho, G., Tonnis, W. F., Frijlink, H. W., Petrovsky, N., ... Hinrichs, W. L. J. (2018). Advax augments B and T cell responses upon influenza vaccination via the respiratory tract and enables complete protection of mice against lethal influenza virus challenge. Journal of Controlled Release, 288, 199-211. DOI: 10.1016/j.jconrel.2018.09.006
Weerts, Z. Z. R. M., Keszthelyi, D., Vork, L., Aendekerk, N. C. P., Frijlink, H. W., Brouwers, J. R. B. J., ... Masclee, A. A. M. (2018). A Novel Ileocolonic Release Peppermint Oil Capsule for Treatment of Irritable Bowel Syndrome: A Phase I Study in Healthy Volunteers. Advances in therapy. DOI: 10.1007/s12325-018-0802-1
Kanojia, G., Raeven, R. H. M., van der Maas, L., Bindels, T. H. E., van Riet, E., Metz, B., ... Kersten, G. F. A. (2018). Development of a thermostable spray dried outer membrane vesicle pertussis vaccine for pulmonary immunization. Journal of controlled release : official journal of the Controlled Release Society, 286, 167-178. DOI: 10.1016/j.jconrel.2018.07.035
Tian, Y., Visser, J. C., Klever, J. S., Woerdenbag, H. J., Frijlink, H. W., & Hinrichs, W. L. J. (2018). Orodispersible films based on blends of trehalose and pullulan for protein delivery. European Journal of Pharmaceutics and Biopharmaceutics. DOI: 10.1016/j.ejpb.2018.09.016
Sibum, I., Hagedoorn, P., de Boer, A. H., Frijlink, H. W., & Grasmeijer, F. (2018). Challenges for pulmonary delivery of high powder doses. International Journal of Pharmaceutics, 548(1), 325-336. DOI: 10.1016/j.ijpharm.2018.07.008
Amssoms, K., Born, P. A., Beugeling, M., De Clerck, B., Van Gulck, E., Hinrichs, W. L. J., ... Baert, L. (2018). Ovalbumin-containing core-shell implants suitable to obtain a delayed IgG1 antibody response in support of a biphasic pulsatile release profile in mice. PLoS ONE, 13(8), e0202961. [0202961]. DOI: 10.1371/journal.pone.0202961
Yska, J. P., Punter, R. J., Woerdenbag, H. J., Emous, M., Frijlink, H. W., Wilffert, B., & Van Roon, E. N. (2018). A gastrointestinal simulation system for dissolution of oral solid dosage forms before and after Roux-en-Y gastric bypass. European Journal of Hospital Pharmacy: Science and Practice. DOI: 10.1136/ejhpharm-2017-001360
Lexmond, A. J., Singh, D., Frijlink, H. W., Clarke, G. W., Page, C. P., Forbes, B., & van den Berge, M. (2018). Realising the potential of various inhaled airway challenge agents through improved delivery to the lungs. Pulmonary Pharmacology & Therapeutics, 49, 27-35. DOI: 10.1016/j.pupt.2018.01.004
Akkerman, O. W., Grasmeijer, F., de Lange, W. C. M., Kerstjens, H. A. M., de Vries, G., Bolhuis, M. S., ... van der Werf, T. S. (2018). Cross border, highly individualised treatment of a patient with challenging extensively drug-resistant tuberculosis. European Respiratory Journal, 51(3), [1702490]. DOI: 10.1183/13993003.02490-2017
Lexmond, A. J., Boudewijn, I. M., Hagedoorn, P., Schokker, S., Cox, C. A., Vonk, J. M., ... van den Berge, M. (2018). Bronchial Provocation Testing Can Be Improved by Using Dry Powder Adenosine Instead of Nebulized Adenosine Monophosphate. American Journal of Respiratory and Critical Care Medicine, 197(3), 391-394. DOI: 10.1164/rccm.201704-0715LE
Kauppinen, A., Broekhuis, J., Grasmeijer, N., Tonnis, W., Ketolainen, J., Frijlink, H. W., & Hinrichs, W. L. J. (2018). Efficient production of solid dispersions by spray drying solutions of high solid content using a 3-fluid nozzle. European Journal of Pharmaceutics and Biopharmaceutics, 123, 50-58. DOI: 10.1016/j.ejpb.2017.11.009
van Dijk, F., Teekamp, N., Beljaars, L., Post, E., Zuidema, J., Steendam, R., ... Olinga, P. (2018). Pharmacokinetics of a sustained release formulation of PDGFβ-receptor directed carrier proteins to target the fibrotic liver. Journal of Controlled Release, 269, 258-265. DOI: 10.1016/j.jconrel.2017.11.029
Bhide, Y., Tomar, J., Dong, W., de Vries-Idema, J., Frijlink, H. W., Huckriede, A., & Hinrichs, W. L. J. (2018). Pulmonary delivery of influenza vaccine formulations in cotton rats: Site of deposition plays a minor role in the protective efficacy against clinical isolate o H1N1pdm virus. Drug Delivery, 25(1), 533-545. DOI: 10.1080/10717544.2018.1435748
Ruigrok, M., Maggan, N., Frijlink, H. W., Melgert, B., Olinga, P., & Hinrichs, W. (2018). siRNA-mediated RNA interference in precision-cut tissue slices prepared from mouse lung. Poster session presented at 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Granada, Spain.
Ruigrok, M., Xian, J. L., Frijlink, H. W., Melgert, B., Hinrichs, W., & Olinga, P. (2018). siRNA-mediated protein knockdown in precision-cut lung slices. Poster session presented at AAPS PharmSci360, Washington, United States.

2017

Teekamp, N., Van Dijk, F., Broesder, A., Evers, M., Zuidema, J., Steendam, R., ... Hinrichs, W. L. J. (2017). Polymeric microspheres for the sustained release of a protein-based drug carrier targeting the PDGFβ-receptor in the fibrotic kidney. International Journal of Pharmaceutics, 534(1-2), 229-236. DOI: 10.1016/j.ijpharm.2017.09.072
Teekamp, N., Tian, Y., Visser, J. C., Olinga, P., Frijlink, H. W., Woerdenbag, H. J., & Hinrichs, W. L. J. (2017). Addition of Pullulan to Trehalose Glasses Improves the Stability of β-Galactosidase at High Moisture Conditions. Carbohydrate Polymers, 176, 374-380. DOI: 10.1016/j.carbpol.2017.08.084
Ruigrok, M. J. R., Maggan, N., Willaert, D., Frijlink, H. W., Melgert, B. N., Olinga, P., & Hinrichs, W. L. J. (2017). siRNA-mediated RNA interference in precision-cut tissue slices prepared from mouse lung and kidney. The AAPS Journal, 19(6), 1855-1863. DOI: 10.1208/s12248-017-0136-y
Mensink, M., Hinrichs, W., Frijlink, H. W., & van der Voort Maarschalk, K. (2017). Kleine, flexibele suikers meest geschikt voor stabilisatie eiwit. Pharmaceutisch Weekblad, 43.
Mensink, M. A., S ̌ib í k, J., Frijlink, H. W., Maarschalk, K. V. D. V., Hinrichs, W. L. J., & Zeitler, J. A. (2017). Thermal Gradient Mid- and Far-Infrared Spectroscopy as Tools for Characterization of Protein Carbohydrate Lyophilizates. Molecular pharmaceutics, 14(10), 3550-3557. DOI: 10.1021/acs.molpharmaceut.7b00568
van Dijk, F., Teekamp, N., Beljaars, L., Post, E., Kim, Y. O., Frijlink, E., ... Olinga, P. (2017). Therapeutic proteins in the treatment of liver fibrosis: The antifibrotic potential of a sustained release formulation for a PDGF beta-receptor targeted rho-kinase inhibitor. Hepatology, 66, 217A.
Visser, J. C., Weggemans, O. A. F., Boosman, R. J., Loos, K. U., Frijlink, H. W., & Woerdenbag, H. J. (2017). Increased drug load and polymer compatibility of bilayered orodispersible films. European Journal of Pharmaceutical Sciences, 107, 183-190. DOI: 10.1016/j.ejps.2017.07.010
van der Wiel, E., Lexmond, A. J., van den Berge, M., Postma, D. S., Hagedoorn, P., Frijlink, H. W., ... Ten Hacken, N. H. T. (2017). Targeting the small airways with dry powder adenosine: A challenging concept. European clinical respiratory journal, 4(1), [1369328]. DOI: 10.1080/20018525.2017.1369328
Cox, C. A., Boudewijn, I. M., Vroegop, S. J., Schokker, S., Lexmond, A. J., Frijlink, E. W., ... van den Berge, M. (2017). Extrafine compared to non-extrafine particle ICS in smokers and ex-smokers with asthma. European Respiratory Journal, 50. DOI: 10.1183/1393003.congress-2017.PA521
Lexmond, A. J., Boudewijn, I., Hagedoorn, P., Schokker, S., Cox, C., Vonk, J., ... van den Berge, M. (2017). An improved bronchial provocation test with dry powder adenosine instead of nebulised adenosine monophosphate (AMP). European Respiratory Journal, 50(Suppl. 61). DOI: 10.1183/1393003.congress-2017.PA4756
Cox, C. A., Boudewijn, I. M., Vroegop, S. J., Schokker, S., Lexmond, A. J., Frijlink, H. W., ... van den Berge, M. (2017). Extrafine compared to non-extrafine particle inhaled corticosteroids in smokers and ex-smokers with asthma. Respiratory Medicine, 130, 35-42. DOI: 10.1016/j.rmed.2017.07.005
Lexmond, A. J., Hagedoorn, P., Frijlink, H. W., Rottier, B. L., & de Boer, A. H. (2017). Prerequisites for a dry powder inhaler for children with cystic fibrosis. PLoS ONE, 12(8), [e0183130]. DOI: 10.1371/journal.pone.0183130
Sibum, I., Grasmeijer, F., Hagedoorn, P., & Frijlink, H. W. (2017). Characterisation of jet-milled and spray dried isoniazid for pulmonary administration. Journal of aerosol medicine and pulmonary drug delivery, 30(4), A2.
Patil, H. P., Herrera Rodriguez, J., de Vries-Idema, J., Meijerhof, T., Frijlink, H. W., Hinrichs, W. L. J., & Huckriede, A. (2017). Adjuvantation of Pulmonary-Administered Influenza Vaccine with GPI-0100 Primarily Stimulates Antibody Production and Memory B Cell Proliferation. Vaccines, 5(3). DOI: 10.3390/vaccines5030019
Mensink, M. A., Frijlink, H. W., van der Voort Maarschalk, K., & Hinrichs, W. L. J. (2017). How sugars protect proteins in the solid state and during drying (review): Mechanisms of stabilization in relation to stress conditions. European Journal of Pharmaceutics and Biopharmaceutics, 114, 288-295. DOI: 10.1016/j.ejpb.2017.01.024
van Doorn, E., Pleguezuelos, O., Liu, H., Fernandez, A., Bannister, R., Stoloff, G., ... Hak, E. (2017). Evaluation of the immunogenicity and safety of different doses and formulations of a broad spectrum influenza vaccine (FLU-v) developed by SEEK: study protocol for a single-center, randomized, double-blind and placebo-controlled clinical phase IIb trial. BMC Infectious Diseases, 17(1), [241]. DOI: 10.1186/s12879-017-2341-9
de Boer, A., Hagedoorn, P., Hoppentocht, M., Buttini, F., Grasmeijer, F., & Frijlink, H. W. (2017). Dry powder inhalation: past, present and future. Expert Opinion on Drug Delivery, 14(4), 499-512. DOI: 10.1080/17425247.2016.1224846
Visser, J., Eugresya, G., Hinrichs, W., Tjandrawinata, R., Avanti, C., Frijlink, H. W., & Woerdenbag, H. (2017). Development of orodispersible films with selected Indonesian medicinal plant extracts. Journal of Herbal Medicine, 7, 37-46. DOI: 10.1016/j.hermed.2016.10.002
van Doorn, E., Liu, H., Ben-Yedidia, T., Hassin, S., Visontai, I., Norley, S., ... Hak, E. (2017). Evaluating the immunogenicity and safety of a BiondVax-developed universal influenza vaccine (Multimeric-001) either as a standalone vaccine or as a primer to H5N1 influenza vaccine: Phase IIb study protocol. Medicine, 96(11), [e6339]. DOI: 10.1097/MD.0000000000006339
Jacobs, M. S., Luinstra, M., Moes, J. R., Chan, T. C. Y., Minovic, I., Frijlink, H. W., & Woerdenbag, H. J. (2017). Ready-to-use parenteral amiodarone: A feasibility study towards a long-term stable product formulation. European Journal of Hospital Pharmacy: Science and Practice, 24(2), 110-114. DOI: 10.1136/ejhpharm-2015-000860
Visser, J. C., Woerdenbag, H. J., Hanff, L. M., & Frijlink, H. W. (2017). Personalized Medicine in Pediatrics: The Clinical Potential of Orodispersible Films. Aaps pharmscitech, 104(5), 1292-1300. DOI: 10.1208/s12249-016-0515-1
Kanojia, G., Have, R. T., Soema, P. C., Frijlink, H., Amorij, J-P., & Kersten, G. (2017). Developments in the formulation and delivery of spray dried vaccines. Human vaccines & immunotherapeutics, 13(10), 2364-2378. DOI: 10.1080/21645515.2017.1356952, 10.1080/21645515.2017.1359363
Van Dijk, F., Teekamp, N., Beljaars, L., Post, E., Schuppan, D., Kim, Y. O., ... Olinga, P. (2017). Towards clinical use of targeted therapies for liver fibrosis: development of a sustained release formulation for therapeutic proteins. Journal of Hepatology, 66(1), S44-S44.

2016

Liu, H., Frijlink, H. W., Huckriede, A., van Doorn, E., Schmidt, E., Leroy, O., ... Hak, E. (2016). Influenza Vaccine Research funded by the European Commission FP7-Health-2013-Innovation-1 project. Vaccine, 34(48), 5845-5854. DOI: 10.1016/j.vaccine.2016.10.040
Grasmeijer, N., Frijlink, H. W., & Hinrichs, W. L. J. (2016). Model to predict inhomogeneous protein-sugar distribution in powders prepared by spray drying. Journal of Aerosol Science, 101, 22-33. DOI: 10.1016/j.jaerosci.2016.07.012
Tomar, J., Born, P. A., Frijlink, H. W., & Hinrichs, W. L. J. (2016). Dry influenza vaccines: towards a stable, effective and convenient alternative to conventional parenteral influenza vaccination. Expert review of vaccines, 15(11), 1431-1447. DOI: 10.1080/14760584.2016.1182869
Kanojia, G., ten Have, R., Bakker, A., Wagner, K., Frijlink, H. W., Kersten, G. F. A., & Amorij, J-P. (2016). The Production of a Stable Infliximab Powder: The Evaluation of Spray and Freeze-Drying for Production. PLoS ONE, 11(10), [e0163109]. DOI: 10.1371/journal.pone.0163109
Kanojia, G., Willems, G., Frijlink, H. W., Kesrten, G., Soema, P., & Amorij, J-P. (2016). A Design of Experiment approach to predict product and process parameters for a spray dried influenza vaccine. International Journal of Pharmaceutics, 511(2), 1098-1111. DOI: 10.1016/j.ijpharm.2016.08.022
Hagedoorn, P., Grasmeijer, F., Hoppentocht, M., Akkerman, O., Frijlink, H., & De Boer, A. (2016). In vitro evaluation of the Twincer colistin dry powder inhaler as a non-cough-inducing alternative to Colobreathe. European Respiratory Journal, 48(Suppl.60). DOI: 10.1183/13993003.congress-2016.PA2561
Mensink, M. A., Nethercott, M. J., Hinrichs, W. L. J., Maarschalk, K. V. D. V., Frijlink, H. W., Munson, E. J., & Pikal, M. J. (2016). Influence of Miscibility of Protein-Sugar Lyophilizates on Their Storage Stability. Aaps journal, 18(5), 1225-1232. DOI: 10.1208/s12248-016-9937-7
Kanojia, G., Frijlink, H. W., Kersten, G., Soema, P., & Amorij, J-P. (2016). A Design of Experiment Approach to Predict Process and Product Parameters for a Spray Dried Influenza Vaccine.
Ruigrok, M., Frijlink, H. W., & Hinrichs, W. (2016). Pulmonary administration of small interfering RNA: The route to go? Journal of Controlled Release, 235, 14-23. DOI: 10.1016/j.jconrel.2016.05.054
Weerts, Z. Z. R. M., Keszthelyi, D., Frijlink, H. W., Brouwers, J. R. B. J., Vork, L., Jonkers, D. M. A. E., & Masclee, A. A. M. (2016). A randomized, phase I, double-blind, crossover study on pharmacokinetics of peppermint oil capsules in healthy volunteers: Enteric-coating versus colon-targeted-delivery. Neurogastroenterology and motility, 28, 101. DOI: 10.1111/nmo.12881
Bloemers, J., van Rooij, K., de Leede, L., Frijlink, H. W., Koppeschaar, H. P. F., Olivier, B., & Tuiten, A. (2016). Single dose sublingual testosterone and oral sildenafil versus a dual-route/dual-release fixed-dose combination tablet: a pharmacokinetic comparison. British Journal of Clinical Pharmacology, 81(6), 1091-1102. DOI: 10.1111/bcp.12887
Gareb, B., Eissens, A. C., Kosterink, J. G. W., & Frijlink, H. (2016). Development of a zero-order sustained-release tablet containing mesalazine and budesonide intended to treat the distal gastrointestinal tract in inflammatory bowel disease. European Journal of Pharmaceutics and Biopharmaceutics, 103, 32-42. DOI: 10.1016/j.ejpb.2016.03.018
Luinstra, M., Grasmeijer, F., Hagedoorn, P., & Frijlink, H. W. (2016). A LEVODOPA WITH L-LEUCINE INHALATION POWDER FOR USE IN PARKINSON'S DISEASE. Journal of aerosol medicine and pulmonary drug delivery, 29(3), A15-A15.
Hoppentocht, M., Akkerman, O. W., Hagedoorn, P., Alffenaar, J-W. C., van der Werf, T. S., Kerstjens, H. A. M., ... de Boer, A. H. (2016). Evaluation of Inhaled Dry Powder Tobramycin Free Base in Non-Cystic Fibrosis Bronchiectasis Patients. Journal of aerosol medicine and pulmonary drug delivery, 29(3), A22-A23.
Maurer, J. M., Hofman, S., Schellekens, R. C. A., Tonnis, W. F., Dubois, A. O. T., Woerdenbag, H. J., ... Frijlink, H. W. (2016). Development and potential application of an oral ColoPulse infliximab tablet with colon specific release: A feasibility study. International Journal of Pharmaceutics, 505(1-2), 175-186. DOI: 10.1016/j.ijpharm.2016.03.027
Cremers, T., Flik, G., Frijlink, H. W., & Woerdenbag, H. J. (2016). Body Sculpting (Patent No. WO2016060564.)
Krampe, R., Visser, C., Frijlink, H. W., Breitkreutz, J., Woerdenbag, H. J., & Preis, M. (2016). Oromucosal film preparations: points to consider for patient centricity and manufacturing processes. Expert Opinion on Drug Delivery, 13(4), 493-506. DOI: 10.1517/17425247.2016.1118048
Hoppentocht, M., Akkerman, O. W., Hagedoorn, P., Alffenaar, J-W. C., van der Werf, T. S., Kerstjens, H. A. M., ... de Boer, A. H. (2016). Tolerability and Pharmacokinetic Evaluation of Inhaled Dry Powder Tobramycin Free Base in Non-Cystic Fibrosis Bronchiectasis Patients. PLoS ONE, 11(3), [e0149768]. DOI: 10.1371/journal.pone.0149768
Grasmeijer, N., Frijlink, H. W., & Hinrichs, W. L. J. (2016). An adaptable model for growth and/or shrinkage of droplets in the respiratory tract during inhalation of aqueous particles. Journal of Aerosol Science, 93, 21-34. DOI: 10.1016/j.jaerosci.2015.11.011
Frijlink, H. W., Grasmeijer, N., Hinrichs, W. L. J., Amssoms, K. I. E., & Baert, L. E. C. (2016). Compacted Solid Dosage Form (Patent No. WO2016020308.)
Teekamp, N., van Dijk, F., Beljaars, E., Hinrichs, W., Poelstra, K., Frijlink, H. W., & Olinga, P. (2016). Biodegradable microspheres for the sustained release of PDGF-receptor directed PPB-HSA targeted to the fibrotic kidney. Poster session presented at Congress on Innovation in Drug Delivery, Antibes, France.
Teekamp, N., van Dijk, F., Beljaars, E., Hinrichs, W., Steendam, R., Zuidema, J., ... Olinga, P. (2016). Biodegradable microspheres for the sustained release of PDGF-receptor directed pPB-HSA targeted to the fibrotic kidney. Abstract from FIGON Dutch Medicine Days, Ede, Netherlands.
Hagedoorn, P., de Boer, A., & Frijlink, H. W. (2016). Het belang van inhalatietechnologie voor een optimale luchtwegbehandeling. Nederlands tijdschrift voor allergie & astma, 4, 130-136.
Frijlink, H. W. (2016). Pulmonary delivery of antibiotics in tuberculosis. Figon DMD Book of Abstracts, [ABS-2016-10250].

2015

Mensink, M. A., Frijlink, H. W., van der Voort Maarschalk, K., & Hinrichs, W. L. J. (2015). Inulin, a flexible oligosaccharide. II: Review of its pharmaceutical applications. Carbohydrate Polymers, 134, 418-428. DOI: 10.1016/j.carbpol.2015.08.022
de Boer, A. H., Hagedoorn, P., & Frijlink, H. W. (2015). IPC No. A61M 15/00 (2006.01). A breath actuated dry powder inhaler (Patent No. WO2015187025.)
Mensink, M. A., Van Bockstal, P-J., Pieters, S., De Meyer, L., Frijlink, H. W., van der Voort Maarschalk, K., ... De Beer, T. (2015). In-line near infrared spectroscopy during freeze-drying as a tool to measure efficiency of hydrogen bond formation between protein and sugar, predictive of protein storage stability. International Journal of Pharmaceutics, 792-800. DOI: 10.1016/j.ijpharm.2015.11.030
Teekamp, N., Olinga, P., Hinrichs, W., & Frijlink, H. W. (2015). Protein Stability during Hot Melt Extrusion: The Effect of Extrusion Temperature, Hydrophilicity of Polymers and Sugar Glass Pre-stabilization. Poster session presented at Biopharmacy Day 2015, Leuven, Belgium.
Luinstra, M., Grasmeijer, F., Hagedoorn, P., Moes, J. R., Frijlink, H. W., & De Boer, A. H. (2015). A levodopa dry powder inhaler for the treatment of Parkinson's disease patients in off periods. European Journal of Pharmaceutics and Biopharmaceutics, 97, 22-29. DOI: 10.1016/j.ejpb.2015.10.003
Teekamp, N., Olinga, P., Frijlink, H. W., & Hinrichs, W. (2015). Protein Stability during Hot Melt Extrusion: The Effect of Extrusion Temperature, Hydrophilicity of Polymers and Sugar Glass Pre-stabilization. Poster session presented at AAPS Annual Meeting and Exposition, Orlando, United States.
Mensink, M. A., Frijlink, H. W., Maarschalk, K. V. D. V., & Hinrichs, W. L. J. (2015). Inulin, a flexible oligosaccharide I: Review of its physicochemical characteristics. Carbohydrate Polymers, 130, 405-419. DOI: 10.1016/j.carbpol.2015.05.026
Luinstra, M., Rutgers, W., Dijkstra, H., Grasmeijer, F., Hagedoorn, P., Vogelzang, J., ... De Boer, A. (2015). Inhalation manoeuvre performed by Parkinson's patients during an off period. European Respiratory Journal, 46(Supl. 59). DOI: 10.1183/13993003.congress2015.PA1586
De Boer, A. H., Gjaltema, D., Hagedoorn, P., & Frijlink, H. W. (2015). Can 'extrafine' dry powder aerosols improve lung deposition? European Journal of Pharmaceutics and Biopharmaceutics, 96, 143-151. DOI: 10.1016/j.ejpb.2015.07.016
Maurer, J. M., Schellekens, R. C. A., van Rieke, H. M., Wanke, C., Iordanov, V., Stellaard, F., ... Kosterink, J. G. W. (2015). Gastrointestinal pH and Transit Time Profiling in Healthy Volunteers Using the IntelliCap System Confirms Ileo-Colonic Release of ColoPulse Tablets. PLoS ONE, 10(7), [e0129076]. DOI: 10.1371/journal.pone.0129076
Luinstra, M., Rutgers, A. W. F., Dijkstra, H., Grasmeijer, F., Hagedoorn, P., Vogelzang, J. M. J., ... De Boer, A. H. (2015). Can patients with Parkinson's disease use dry powder inhalers during off periods? PLoS ONE, 10(7), [e0132714]. DOI: 10.1371/journal.pone.0132714
Luinstra, M., Rutgers, W. A. W. F., Dijkstra, H., Grasmeijer, F., Hagedoorn, P., Vogelzang, J., ... De Boer, A. H. (2015). The ability of Parkinson's disease patients to use dry powder inhalers during off periods. Movement Disorders, 30, 101. DOI: 10.1002/mds.26295
Patil, H. P., Murugappan, S., de Vries-Idema, J., Meijerhof, T., de Haan, A., Frijlink, H. W., ... Huckriede, A. (2015). Comparison of adjuvants for a spray freeze-dried whole inactivated virus influenza vaccine for pulmonary administration. European Journal of Pharmaceutics and Biopharmaceutics, 93, 231-241. DOI: 10.1016/j.ejpb.2015.04.004
Visser, J. C., Dohmen, W. M. C., Hinrichs, W. L. J., Breitkreutz, J., Frijlink, H. W., & Woerdenbag, H. J. (2015). Quality by design approach for optimizing the formulation and physical properties of extemporaneously prepared orodispersible films. International Journal of Pharmaceutics, 485(1-2), 70-76. DOI: 10.1016/j.ijpharm.2015.03.005
Stanković, M., Hiemstra, C., De Waard, H., Zuidema, J., Steendam, R., Frijlink, H. W., & Hinrichs, W. L. J. (2015). Protein release from water-swellable poly(d,l-lactide-PEG)-b-poly(ϵ-caprolactone) implants. International Journal of Pharmaceutics, 480(1-2), 73-83. DOI: 10.1016/j.ijpharm.2015.01.007
Tonnis, W. F., Mensink, M. A., de Jager, A., Maarschalk, K. V. D. V., Frijlink, H. W., & Hinrichs, W. L. J. (2015). Size and molecular flexibility of sugars determine the storage stability of freeze-dried proteins. Molecular pharmaceutics, 12(3), 684-694. DOI: 10.1021/mp500423z
Tonnis, W. F., Huckriede, A. L. W., Hinrichs, W. L. J., & Frijlink, H. W. (2015). Pulmonary administration of subunit vaccines. In C. Foged, T. Rades, Y. Perrie, & S. Hook (Eds.), Subunit Vaccine Delivery (pp. 307-329). (Advances in Delivery Science and Technology). Springer. DOI: 10.1007/978-1-4939-1417-3_16
Stanković, M., Frijlink, H. W., & Hinrichs, W. L. J. (2015). Polymeric formulations for drug release prepared by hot melt extrusion: application and characterization. Drug Discovery Today, 20(7), 812-823. DOI: 10.1016/j.drudis.2015.01.012
Hoppentocht, M., Akkerman, O. W., Hagedoorn, P., Frijlink, H. W., & de Boer, A. H. (2015). The Cyclops for pulmonary delivery of aminoglycosides; A new member of the Twincer™ family. European Journal of Pharmaceutics and Biopharmaceutics, 90, 8-15. DOI: 10.1016/j.ejpb.2015.01.012
Murugappan, S., Frijlink, H. W., Petrovsky, N., & Hinrichs, W. L. J. (2015). Enhanced pulmonary immunization with aerosolized inactivated influenza vaccine containing delta inulin adjuvant. European Journal of Pharmaceutical Sciences, 66, 118-122. DOI: 10.1016/j.ejps.2014.10.008
Teekamp, N., Duque , L. F., Frijlink, H. W., Hinrichs, W. L., & Olinga, P. (2015). Production methods and stabilization strategies for polymer-based nanoparticles and microparticles for parenteral delivery of peptides and proteins. Expert Opinion on Drug Delivery, 12(8), 1311-1331. DOI: 10.1517/17425247.2015.1003807
Visser, C., Woerdenbag, H. J., Crediet, S., Gerrits, E., Lesschen, M. A., Hinrichs, W. L. J., ... Frijlink, H. W. (2015). Orodispersible films in individualized pharmacotherapy: The development of a formulation for pharmacy preparations. International Journal of Pharmaceutics, 478(1), 155-163. DOI: 10.1016/j.ijpharm.2014.11.013
Grasmeijer, F., Grasmeijer, N., Hagedoorn, P., Frijlink, H. W., & de Boer, A. H. (2015). Recent advances in the fundamental understanding of adhesive mixtures for inhalation. Current Pharmaceutical Design.
Frijlink, H. W., Bouwhuis, M., & Brouwers, J. (2015). Toedieningsvormen opioiden voor doorbraakpijn. MFM-Tijdschrift over praktijkgerichte farmacotherapie, 5(3), 14-20.
Frijlink, H. W., Touw, D., & Woerdenbag, H. (2015). Biopharmaceutics. In Practical Pharmaceutics, An international guideline for the preparation care and use of medicinal products (pp. 323-346). Springer. DOI: 10.1007/978-3-319-15814-3_16

2014

Peeters, B., Tonnis, W. F., Murugappan, S., Rottier, P., Koch, G., Frijlink, H. W., ... Hinrichs, W. L. J. (2014). Pulmonary immunization of chickens using non-adjuvanted spray-freeze dried whole inactivated virus vaccine completely protects against highly pathogenic H5N1 avian influenza virus. Vaccine, 32(48), 6445-6450. DOI: 10.1016/j.vaccine.2014.09.048
Tonnis, W. F., Bagerman, M., Weij, M., Sjollema, J., Frijlink, H. W., Hinrichs, W. L. J., & de Boer, A. H. (2014). A novel aerosol generator for homogenous distribution of powder over the lungs after pulmonary administration to small laboratory animals. European Journal of Pharmaceutics and Biopharmaceutics, 88(3), 1056-1063. DOI: 10.1016/j.ejpb.2014.10.011
Yska, J. P., Punter, R. J., Woerdenbag, H. J., Apers, J. A., Emous, M., Totte, E., ... van Roon, E. N. (2014). A GASTROINTESTINAL SIMULATION SYSTEM (GISS) FOR DISSOLUTION OF DRUGS BEFORE AND AFTER ROUX-EN-Y GASTRIC BYPASS: FIRST RESULTS. British Journal of Clinical Pharmacology, 78(4), 774-774. DOI: 10.1111/bcp.12400
Gjaltema, D., Hagedoorn, P., Frijlink, H. W., & De Boer, A. H. (2014). Are extra-fine particles from dry powder inhalers likely to improve lung deposition? European Respiratory Journal, 44.
Lexmond, A. J., van der Wiel, E., Hagedoorn, P., Bult, W., Frijlink, H. W., ten Hacken, N. H. T., & de Boer, A. H. (2014). Adenosine dry powder inhalation for bronchial challenge testing, part 2: Proof of concept in asthmatic subjects. European Journal of Pharmaceutics and Biopharmaceutics, 88(1), 148-152. DOI: 10.1016/j.ejpb.2014.04.008
Hoppentocht, M., Hoste, C., Hagedoorn, P., Frijlink, H. W., & de Boer, A. H. (2014). In vitro evaluation of the DP-4M PennCentury™ insufflator. European Journal of Pharmaceutics and Biopharmaceutics, 88(1), 153-159. DOI: 10.1016/j.ejpb.2014.06.014
Hoppentocht, M., Hagedoorn, P., Frijlink, H. W., & de Boer, A. H. (2014). Technological and practical challenges of dry powder inhalers and formulations. Advanced Drug Delivery Reviews, 75, 18-31. DOI: 10.1016/j.addr.2014.04.004
Rosas, J. G., de Waard, H., De Beer, T., Vervaet, C., Remon, J. P., Hinrichs, W. L. J., ... Blanco, M. (2014). NIR spectroscopy for the in-line monitoring of a multicomponent formulation during the entire freeze-drying process. Journal of Pharmaceutical and Biomedical Analysis, 97, 39-46. DOI: 10.1016/j.jpba.2014.04.010
Hoppentocht, M., Hagedoorn, P., Frijlink, H. W., & de Boer, A. H. (2014). DESIGN AND DEVELOPMENT OF A DISPOSABLE HIGH DOSE DRY POWDER INHALER FOR AMINOGLYCOSIDES. Journal of aerosol medicine and pulmonary drug delivery, 27(4), A22.
Grasmeijer, F., Hagedoorn, P., Frijlink, H. W., & de Boer, A. H. (2014). THE INTERPLAY BETWEEN VARIABLES IN THE FORMULATION AND DISPERSION OF ADHESIVE MIXTURES FOR INHALATION. Journal of aerosol medicine and pulmonary drug delivery, 27(4), A27.
Demoly, P., Hagedoorn, P., de Boer, A. H., & Frijlink, H. W. (2014). The clinical relevance of dry powder inhaler performance for drug delivery. Respiratory Medicine, 108(8), 1195-1203. DOI: 10.1016/j.rmed.2014.05.009
Thanh Nguyen, . N. V., Willemsz, T., Frijlink, H., & Maarschalk, K. V. D. V. (2014). Numerical study of agglomerate abrasion in a tumbling mixer. Chemical Engineering Science, 114, 21-29. DOI: 10.1016/j.ces.2014.03.015
Hagedoorn, P., Frijlink, H., & De Boer, A. (2014). Inhalatoren bij astma en COPD. Huisarts en Wetenschap, 57(7), 382. DOI: 10.1007/s12445-014-0194-7
Stankovic, M., Tomar, J., Hiemstra, C., Steendam, R., Frijlink, H. W., & Hinrichs, W. L. J. (2014). Tailored protein release from biodegradable poly(ε-caprolactone-PEG)- b-poly(ε-caprolactone) multiblock-copolymer implants. European Journal of Pharmaceutics and Biopharmaceutics, 87(2), 329-337. DOI: 10.1016/j.ejpb.2014.02.012
Fussell, A. L., Grasmeijer, F., Frijlink, H. W., de Boer, A. H., & Offerhaus, H. L. (2014). CARS microscopy as a tool for studying the distribution of micronised drugs in adhesive mixtures for inhalation. Journal of Raman Spectroscopy, 45(7), 495-500. DOI: 10.1002/jrs.4515
Lexmond, A. J., Kruizinga, T. J., Hagedoorn, P., Rottier, B. L., Frijlink, H. W., & de Boer, A. H. (2014). Effect of inhaler design variables on paediatric use of dry powder inhalers. PLoS ONE, 9(6), [e99304]. DOI: 10.1371/journal.pone.0099304
Grasmeijer, F., Frijlink, H. W., & de Boer, A. (2014). A proposed definition of the 'activity' of surface sites on lactose carriers for dry powder inhalation. European Journal of Pharmaceutical Sciences, 56(1), 102-104. DOI: 10.1016/j.ejps.2014.02.012
Van Rooij, K., De Leede, L., Frijlink, H. W., Bloemers, J., Poels, S., Koppeschaar, H., ... Tuiten, A. (2014). Pharmacokinetics of a Prototype Formulation of Sublingual Testosterone and a Buspirone Tablet, Versus an Advanced Combination Tablet of Testosterone and Buspirone in Healthy Premenopausal Women. Drugs in R&D, 14(2), 125-132. DOI: 10.1007/s40268-014-0047-7
Tonnis, W. F., Amorij, J-P., Vreeman, M. A., Frijlink, H. W., Kersten, G. F., & Hinrichs, W. L. J. (2014). Improved storage stability and immunogenicity of hepatitis B vaccine after spray-freeze drying in presence of sugars. European Journal Pharmaceutical Sciences, 55(1), 36-45. DOI: 10.1016/j.ejps.2014.01.005
Murugappan, S., Patil, H. P., Frijlink, H. W., Huckriede, A., & Hinrichs, W. L. J. (2014). Simplifying influenza vaccination during pandemics: sublingual priming and intramuscular boosting of immune responses with heterologous whole inactivated influenza vaccine. Aaps journal, 16(2), 342-349. DOI: 10.1208/s12248-014-9565-z
Patil, H. P., Murugappan, S., Ter Veer, W., Meijerhof, T., De Haan, A., Frijlink, H. W., ... Huckriede, A. (2014). Evaluation of monophosphoryl lipid A as adjuvant for pulmonary delivered influenza vaccine. Journal of controlled release : official journal of the Controlled Release Society, 174(1), 51-62. DOI: 10.1016/j.jconrel.2013.11.013
Grasmeijer, F., Lexmond, A. J., van den Noort, M., Hagedoorn, P., Hickey, A. J., Frijlink, H. W., & de Boer, A. (2014). New mechanisms to explain the effects of added lactose fines on the dispersion performance of adhesive mixtures for inhalation. PLoS ONE, 9(1), [e87825]. DOI: 10.1371/journal.pone.0087825
Avanti, C., Saluja, V., Van Streun, E. L. P., Frijlink, H. W., & Hinrichs, W. L. J. (2014). Stability of lysozyme in aqueous extremolyte solutions during heat shock and accelerated thermal conditions. PLoS ONE, 9(1), [e86244]. DOI: 10.1371/journal.pone.0086244
Hoppentocht, M., Hagedoorn, P., Frijlink, H. W., & de Boer, A. H. (2014). Developments and strategies for inhaled antibiotic drugs in tuberculosis therapy: A critical evaluation. European Journal of Pharmaceutics and Biopharmaceutics, 86(1), 23-30. DOI: 10.1016/j.ejpb.2013.10.019
Lexmond, A. J., Hagedoorn, P., Van Der Wiel, E., Hacken, ten, N., Frijlink, H. W., & De Boer, A. H. (2014). Adenosine dry powder inhalation for bronchial challenge testing, part 1: Inhaler and formulation development and in vitro performance testing. European Journal of Pharmaceutics and Biopharmaceutics, 86(1), 105-114. DOI: 10.1016/j.ejpb.2013.06.027

2013

Woerdenbag, H., Visser, C., & Frijlink, H. (2013). Pharmacy preparations, customized quality in Dutch clinical care. 19-22. Pharma Indochina VIII. ASEAN Pharmacy - Integration for development, Hanoi, Viet Nam.
Lexmond, A. J., Hagedoorn, P., Frijlink, H. W., & de Boer, A. H. (2013). Challenging the two-minute tidal breathing challenge test. Journal of aerosol medicine and pulmonary drug delivery, 26(6), 380-386. DOI: 10.1089/jamp.2012.1021
Murugappan, S., Patil, H. P., Kanojia, G., ter Veer, W., Meijerhof, T., Frijlink, H. W., ... Hinrichs, W. L. J. (2013). Physical and immunogenic stability of spray freeze-dried influenza vaccine powder for pulmonary delivery: Comparison of inulin, dextran, or a mixture of dextran and trehalose as protectants. European Journal of Pharmaceutics and Biopharmaceutics, 85(3 PART A), 716-725. DOI: 10.1016/j.ejpb.2013.07.018
Grasmeijer, F., Hagedoorn, P., Frijlink, H. W., & de Boer, A. H. (2013). The effect of mixing time on drug agglomeration and detachment for adhesive mixtures containing fine lactose carriers. Journal of aerosol medicine and pulmonary drug delivery, 26(5), 7. DOI: 10.1089/jamp.2013.ab01
Tonnis, W. F., Lexmond, A. J., Frijlink, H. W., De Boer, A. H., & Hinrichs, W. L. J. (2013). Devices and formulations for pulmonary vaccination. Expert Opinion on Drug Delivery, 10(10), 1383-1397. DOI: 10.1517/17425247.2013.810622
Grasmeijer, N., de Waard, H., Hinrichs, W. L. J., & Frijlink, H. W. (2013). A user-friendly model for spray drying to aid pharmaceutical product development. PLoS ONE, 8(9), [e74403]. DOI: 10.1371/journal.pone.0074403
Gjaltema, D., Hagedoorn, P., Grasmeijer, F., Huijbers, B. G., Frijlink, H. W., & De Boer, A. H. (2013). Comparative in vitro performance of the new drug aclidinium in a novel multidose dry powder inhaler. European Respiratory Journal, 42.
Teekamp, N., Hagedoorn, P., Huijbers, B. G., Gjaltema, D., Frijlink, H. W., & De Boer, A. H. (2013). Comparison of the in vitro performance of originator and generic drug-combination dry powder inhalers. European Respiratory Journal, 42.
Grasmeijer, F., Hagedoorn, P., Frijlink, H. W., & de Boer, A. H. (2013). Drug content effects on the dispersion performance of adhesive mixtures for inhalation. PLoS ONE, 8(8), [e71339]. DOI: 10.1371/journal.pone.0071339
Siissalo, S., De Waard, H., De Jager, M. H., Hayeshi, R., Frijlink, H. W., Hinrichs, W. L. J., ... De Graaf, I. A. M. (2013). Nanoparticle formulation of a poorly soluble cannabinoid receptor 1 antagonist improves absorption by rat and human intestine. Drug Metabolism and Disposition, 41(8), 1557-1565. DOI: 10.1124/dmd.112.049585
Stankovic, M., de Waard, H., Steendam, R., Hiemstra, C., Zuidema, J., Frijlink, H. W., & Hinrichs, W. L. J. (2013). Low temperature extruded implants based on novel hydrophilic multiblock copolymer for long-term protein delivery. European Journal of Pharmaceutical Sciences, 49(4), 578-587. DOI: 10.1016/j.ejps.2013.05.011
Grasmeijer, F., Hagedoorn, P., Frijlink, H. W., & de Boer, A. (2013). Mixing time effects on the dispersion performance of adhesive mixtures for inhalation. PLoS ONE, 8(7), [e69263]. DOI: 10.1371/journal.pone.0069263
Willemsz, T. A., Nguyen, T. T., Hooijmaijers, R., Frijlink, H. W., Vromans, H., & van der Voort Maarschalk, K. (2013). Quantitative characterization of agglomerate abrasion in a tumbling blender by using the Stokes number approach. Aaps pharmscitech, 14(1), 183-188. DOI: 10.1208/s12249-012-9909-x
Avanti, C., Hinrichs, W. L. J., Casini, A., Eissens, A. C., van Dam, A., Kedrov, A., ... Permentier, H. P. (2013). The formation of oxytocin dimers is suppressed by the zinc-aspartate-oxytocin complex. Journal of Pharmaceutical Sciences, 102(6), 1734-1741. DOI: 10.1002/jps.23546
Grasmeijer, N., Stankovic, M., de Waard, H., Frijlink, H. W., & Hinrichs, W. L. J. (2013). Unraveling protein stabilization mechanisms: Vitrification and water replacement in a glass transition temperature controlled system. Biochimica et biophysica acta-Proteins and proteomics, 1834(4), 763-769. DOI: 10.1016/j.bbapap.2013.01.020
Schellekens, R. C. A., Stellaard, F., Woerdenbag, H. J., Frijlink, H. W., & Kosterink, J. G. W. (2013). Erratum: Applications of stable isotopes in clinical pharmacology (vol 72, pg 879, 2011). British Journal of Clinical Pharmacology, 75(4), 1171. DOI: 10.1111/bcp.12107
Avanti, C., Oktaviani, N. A., Hinrichs, W. L. J., Frijlink, H. W., & Mulder, F. A. A. (2013). Aspartate buffer and divalent metal ions affect oxytocin in aqueous solution and protect it from degradation. International Journal of Pharmaceutics, 444(1-2), 139-145. DOI: 10.1016/j.ijpharm.2013.01.051
Frijlink, H., de Boer, A., & Hagedoorn, P. (2013). Inhalatietechniek vertaald in naar de praktijk. Respiratory News International, 4, 8. [1].
Tonnis, W. F., Lexmond, A. J., Frijlink, H. W., de Boer, A. H., & Hinrichs, W. L. J. (2013). Rebuttal from the authors. Expert Opinion on Drug Delivery, 10(11), 1594-1595.
Maurer, J. M., Schellekens, R. C. A., Van Rieke, H. M., Stellaard, F., Wutzke, K. D., Buurman, D. J., ... Kosterink, J. G. W. (2013). ColoPulse tablets perform comparably in healthy volunteers and Crohn's patients and show no influence of food and time of food intake on bioavailability. Journal of controlled release : official journal of the Controlled Release Society, 172(3), 618-624. DOI: 10.1016/j.jconrel.2013.09.021

2012

Bloemers, J. M. M., Eissens, A. C., Frijlink, H. W., & Jozef, L. G. (2012). Drug Delivery system (Patent No. WO2012158030.)
Grasmeijer, F., Hagedoorn, P., Frijlink, H. W., & de Boer, A. H. (2012). Characterisation of high dose aerosols from dry powder inhalers. International Journal of Pharmaceutics, 437(1-2), 242-249. DOI: 10.1016/j.ijpharm.2012.08.020
Tonnis, W. F., Kersten, G. F., Frijlink, H. W., Hinrichs, W. L. J., de Boer, A. H., & Amorij, J-P. (2012). Pulmonary Vaccine Delivery: A Realistic Approach? Journal of aerosol medicine and pulmonary drug delivery, 25(5), 249-260. DOI: 10.1089/jamp.2011.0931
Willemsz, T. A., Hooijmaijers, R., Rubingh, C. M., Frijlink, H. W., Vromans, H., & van der Voort Maarschalk, K. (2012). The Stokes number approach to support scale-up and technology transfer of a mixing process. Aaps pharmscitech, 13(3), 928-933. DOI: 10.1208/s12249-012-9818-z
Maurer, M. J. M., Schellekens, R. C. A., Wutzke, K. D., Dijkstra, G., Woerdenbag, H. J., Frijlink, H. W., ... Stellaard, F. (2012). A non-invasive, low-cost study design to determine the release profile of colon drug delivery systems: A feasibility study. Pharmaceutical Research, 29(8), 2070-2078. DOI: 10.1007/s11095-012-0735-3
Tran, T. N., Nguyen, T. T., Willemsz, T. A., van Kessel, G., Frijlink, H. W., & van der Voort Maarschalk, K. (2012). A density-based segmentation for 3D images, an application for X-ray micro-tomography. Analytica Chimica Acta, 725, 14-21. DOI: 10.1016/j.aca.2012.03.008
Srinarong, P., Pham, B. T., Holen, M., van der Plas, A., Schellekens, R. C. A., Hinrichs, W. L. J., & Frijlink, H. W. (2012). Preparation and physicochemical evaluation of a new tacrolimus tablet formulation for sublingual administration. Drug Development and Industrial Pharmacy, 38(4), 490-500. DOI: 10.3109/03639045.2011.613075
Marriott, C., & Frijlink, H. W. (2012). Lactose as a carrier for inhalation products: breathing new life into an old carrier. Preface. Advanced Drug Delivery Reviews, 64(3), 217-219. DOI: 10.1016/j.addr.2011.11.003
Willemsz, T. A., Tran, T. N., van der Hoeven, M., Hooijmaijers, R., Frijlink, H. W., Vromans, H., & Maarschalk, K. V. D. V. (2012). A statistical method for velocity detection in moving powder beds using image analysis. AIChE Journal, 58(3), 690-696. DOI: 10.1002/aic.12624
Willemsz, T. A., Hooijmaijers, R., Rubingh, C. M., Tran, T. N., Frijlink, H. W., Vromans, H., & van der Voort Maarschalk, K. (2012). Kinetic energy density and agglomerate abrasion rate during blending of agglomerates into powders. European Journal Pharmaceutical Sciences, 45(1-2), 211-215. DOI: 10.1016/j.ejps.2011.11.012
Reperant, L. A., van de Bildt, M. W. G., van Amerongen, G., Leijten, L. M. E., Watson, S., Palser, A., ... Frijlink, H. (2012). Marked endotheliotropism of highly pathogenic avian influenza virus H5N1 following intestinal inoculation in cats. Journal of Virology, 86(2), 1158-1165. DOI: 10.1128/JVI.06375-11
Avanti, C., Permentier, H. P., van Dam, A., Poole, R., Jiskoot, W., Frijlink, H. W., & Hinrichs, W. L. J. (2012). A new strategy to stabilize oxytocin in aqueous solutions: II. Suppression of cysteine-mediated intermolecular reactions by a combination of divalent metal ions and citrate. Molecular pharmaceutics, 9(3), 554-562. DOI: 10.1021/mp200622z

2011

De Waard, H., Hinrichs, W. L. J., & Frijlink, H. W. (2011). Lagere dosering lipofiele geneesmiddelen door nanokristallen: Sproeivriesdrogen verb etert oplosgedrag. Pharmaceutisch Weekblad, 146(51-52), 28-31.
Nguyen, T. T., Tran, T. N., Willemsz, T. A., Frijlink, H. W., Ervasti, T., Ketolainen, J., & Maarschalk, K. V. D. V. (2011). A density based segmentation method to determine the coordination number of a particulate system. Chemical Engineering Science, 66(24), 6385-6392. DOI: 10.1016/j.ces.2011.08.044
Hagedoorn, P., Gruben, K., Frijlink, H. W., & De Boer, A. H. (2011). The effect of lactose carrier properties on the fine particle dose from dry powder inhalers in dependence of the inhaler design. Journal of aerosol medicine and pulmonary drug delivery, 24(6), 320. DOI: 10.1089/jamp.2011.ab01
Schellekens, R. C. A., Stellaard, F., Woerdenbag, H. J., Frijlink, H. W., & Kosterink, J. G. W. (2011). Applications of stable isotopes in clinical pharmacology. British Journal of Clinical Pharmacology, 72(6), 879-897. DOI: 10.1111/j.1365-2125.2011.04071.x
Grasmeijer, F., Hagedoorn, P., Frijlink, H. W., & De Boer, A. H. (2011). Characterisation of high dose dry powder aerosols by cascade impaction and laser diffraction analysis. Journal of aerosol medicine and pulmonary drug delivery, 24(6), 318.
de Waard, H., Hessels, M. J. T., Boon, M., Sjollema, K. A., Hinrichs, W. L. J., Eissens, A. C., & Frijlink, H. W. (2011). CLSM as quantitative method to determine the size of drug crystals in a solid dispersion. Pharmaceutical Research, 28(10), 2567-2574. DOI: 10.1007/s11095-011-0484-8
Srinarong, P., de Waard, H., Frijlink, H. W., & Hinrichs, W. L. J. (2011). Improved dissolution behavior of lipophilic drugs by solid dispersions: the production process as starting point for formulation considerations. Expert Opinion on Drug Delivery, 8(9), 1121-1140. DOI: 10.1517/17425247.2011.598147
de Waard, H., Grasmeijer, N., Hinrichs, W. L. J., De Beer, T., & Frijlink, H. W. (2011). Controlled crystallization during freeze-drying: A process suitable for large-scale production of drug nanocrystals. Pharmaceutical Technology Europe, 35(8), 58-62.
Frijlink, H. W., Hoppentocht, M., & De Boer, A. H. (2011). Aerosol therapy in tuberculosis: Is it useful and is it feasible. Journal of aerosol medicine and pulmonary drug delivery, 24(3), 3. DOI: 10.1089/jamp.2011.00A1
Srinarong, P., Hämäläinen, S., Visser, M. R., Hinrichs, W. L. J., Ketolainen, J., & Frijlink, H. W. (2011). Surface-active derivative of inulin (Inutec® SP1) is a superior carrier for solid dispersions with a high drug load. Journal of Pharmaceutical Sciences, 100(6), 2333-2342. DOI: 10.1002/jps.22471
Avanti, C., Amorij, J-P., Setyaningsih, D., Hawe, A., Jiskoot, W., Visser, J., ... Frijlink, H. W. (2011). A new strategy to stabilize oxytocin in aqueous solutions: I. The effects of divalent metal ions and citrate buffer. Aaps journal, 13(2), 284-290. DOI: 10.1208/s12248-011-9268-7
De Boer, A. H., Hagedoorn, P. H., & Frijlink, H. W. F. (2011). Do misconceptions hinder effective inhalation therapy with dry powder inhalers? Journal of aerosol medicine and pulmonary drug delivery, 24(3), 44. DOI: 10.1089/jamp.2011.00A1
De Boer, A. H., Hagedoorn, P. H., & Frijlink, H. W. F. (2011). New applications for the twincer disposable high dose dry powder inhaler. Journal of aerosol medicine and pulmonary drug delivery, 24(3), 44. DOI: 10.1089/jamp.2011.00A1
Hoppentocht, M., Abdulla, A., Frijlink, H. W., De Boer, A. H., & Van Doorne, H. (2011). The development and application of an in vitro model to determine the susceptibility of P. aeruginosa in biofilms to various antibiotics. Journal of aerosol medicine and pulmonary drug delivery, 24(3), 18-19. DOI: 10.1089/jamp.2011.00A1
Grasmeijer, F., Hagedoorn, P., Frijlink, H. W., & De Boer, A. H. (2011). Investigations into the mechanisms of drug particle detachment from carriers in adhesive mixtures for inhalation. Journal of aerosol medicine and pulmonary drug delivery, 24(3), 44. DOI: 10.1089/jamp.2011.00A1
de Waard, H., Frijlink, H. W., & Hinrichs, W. L. J. (2011). Bottom-up preparation techniques for nanocrystals of lipophilic drugs. Pharmaceutical Research, 28(5), 1220-1223. DOI: 10.1007/s11095-010-0323-3
Woerdenbag, H. J., Dillingh, J. H., Wanders, J. T. M., Boer, E. J., Frijlink, H. W., Kosterink, J. G. W., & Schellekens, R. C. A. (2011). Elastomeer-infuuspompen getest voor de praktijk. Pharmaceutisch Weekblad, 146(15), 58-64.
Hagedoorn, P., Frijlink, H. W., & De Boer, A. H. (2011). Longdepositie na pulmonale geneesmiddeltoediening bij COPD: Ontwerp inhalator bepaalt effectiviteit. Pharmaceutisch Weekblad, 146(9-10 (special issue)), 32-35.
Audouy, S. A. L., van der Schaaf, G., Hinrichs, W. L. J., Frijlink, H. W., Wilschut, J., & Huckriede, A. (2011). Development of a dried influenza whole inactivated virus vaccine for pulmonary immunization. Vaccine, 29(26), 4345-4352. DOI: 10.1016/j.vaccine.2011.04.029

2010

de Waard, H., De Beer, T., Hinrichs, W. L. J., Vervaet, C., Remon, J-P., & Frijlink, H. W. (2010). Controlled Crystallization of the Lipophilic Drug Fenofibrate During Freeze-Drying: Elucidation of the Mechanism by In-Line Raman Spectroscopy. Aaps journal, 12(4), 569-575. DOI: 10.1208/s12248-010-9215-z
Saluja, V., Visser, M. R., ter Veer, W., van Roosmalen, M. L., Leenhouts, K., Hinrichs, W. L. J., ... Frijlink, H. W. (2010). Influenza antigen-sparing by immune stimulation with Gram-positive enhancer matrix (GEM) particles. Vaccine, 28(50), 7963-7969. DOI: 10.1016/j.vaccine.2010.09.066
Saluja, V., Visser, M. R., van Roosmalen, M. L., Leenhouts, K., Huckriede, A., Hinrichs, W. L. J., & Frijlink, H. W. (2010). Gastro-intestinal delivery of influenza subunit vaccine formulation adjuvanted with Gram-positive enhancer matrix (GEM) particles. European Journal of Pharmaceutics and Biopharmaceutics, 76(3), 470-474. DOI: 10.1016/j.ejpb.2010.08.003
Amorij, J. P., Hinrichs, W. L. J., Frijlink, H. W., Wilschut, J. C., & Huckriede, A. (2010). Needle-free influenza vaccination. Lancet Infectious Diseases, 10(11), 740.
Schellekens, R. C. A., Baltink, J. H., Woesthuis, E. M., Stellaard, F., Kosterink, J. G. W., Woerdenbag, H. J., & Frijlink, H. W. (2010). Film coated tablets (ColoPulse technology) for targeted delivery in the lower intestinal tract: influence of the core composition on release characteristics. Pharmaceutical development and technology, 17(1), 40-47. DOI: 10.3109/10837450.2010.513986
Amorij, J-P., Hinrichs, W. L. J., Frijlink, H. W., Wilschut, J. C., & Huckriede, A. (2010). Needle-free influenza vaccination. Lancet Infectious Diseases, 10(10), 699-711. DOI: 10.1016/S1473-3099(10)70157-2
Saluja, V., Hinrichs, W. L. J., & Frijlink, H. W. (2010). Dried influenza vaccines: Over the counter vaccines. Human vaccines, 6(10), 854-856.
Schellekens, R. C. A., Stellaard, F., Olsder, G. G., Woerdenbag, H. J., Frijlink, H. W., & Kosterink, J. G. W. (2010). Oral ileocolonic drug delivery by the colopulse-system: A bioavailability study in healthy volunteers. Journal of controlled release : official journal of the Controlled Release Society, 146(3), 334-340. DOI: 10.1016/j.jconrel.2010.05.028
Srinarong, P., Kouwen, S., Visser, M. R., Hinrichs, W. L. J., & Frijlink, H. W. (2010). Effect of drug-carrier interaction on the dissolution behavior of solid dispersion tablets. Pharmaceutical development and technology, 15(5), 460-468. DOI: 10.3109/10837450903286529
Nguyen, T. T., Rambanapasi, C., de Boer, A. H., Frijlink, H. W., Ven, P. M. V. D., de Vries, J., ... Maarschalk, K. V. D. V. (2010). A centrifuge method to measure particle cohesion forces to substrate surfaces: The use of a force distribution concept for data interpretation. International Journal of Pharmaceutics, 393(1-2), 88-95. DOI: 10.1016/j.ijpharm.2010.04.016
Laksmana, F. L., Kok, P. J. A. H., Frijlink, H. W., Vromans, H., & Maarschalk, K. V. D. V. (2010). Gas Permeation Related to the Moisture Sorption in Films of Glassy Hydrophilic Polymers. Journal of Applied Polymer Science, 116(6), 3310-3317. DOI: 10.1002/app.31854
Saluja, V., Amorij, J-P., Kapteyn, J. C., de Boer, A. H., Frijlink, H. W., & Hinrichs, W. L. J. (2010). A comparison between spray drying and spray freeze drying to produce an influenza subunit vaccine powder for inhalation. Journal of Controlled Release, 144(2), 127-133. DOI: 10.1016/j.jconrel.2010.02.025
Saluja, V., Amorij, J. P., van Roosmalen, M. L., Leenhouts, K., Huckriede, A., Hinrichs, W. L. J., & Frijlink, H. W. (2010). Intranasal delivery of influenza subunit vaccine formulated with GEM particles as an adjuvant. Aaps journal, 12(2), 109-116. DOI: 10.1208/s12248-009-9168-2
Geeraedts, F., Saluja, V., ter Veer, W., Amorij, J-P., Frijlink, H. W., Wilschut, J., ... Huckriede, A. (2010). Preservation of the immunogenicity of dry-powder influenza H5N1 whole inactivated virus vaccine at elevated storage temperatures. Aaps journal, 12(2), 215-222. DOI: 10.1208/s12248-010-9179-z
Willemsz, T. A., Oostra, W., Hooijmaijers, R., de Vegt, O., Morad, N., Vromans, H., ... Van der Voort Maarschalk, K. (2010). Blending of agglomerates into powders 1: Quantification of abrasion rate. International Journal of Pharmaceutics, 387(1-2), 87-92. DOI: 10.1016/j.ijpharm.2009.12.006
Van Der Steen, K. C., Frijlink, H. W., Schipper, C. M. A., & Barends, D. M. (2010). Prediction of the ease of subdivision of scored tablets from their physical parameters. Aaps pharmscitech, 11(1), 126-132. DOI: 10.1208/s12249-009-9365-4
Visser, M. R., Baert, L., Klooster, G. V. ., Schueller, L., Geldof, M., Vanwelkenhuysen, I., ... Hinrichs, W. L. J. (2010). Inulin solid dispersion technology to improve the absorption of the BCS Class IV drug TMC240. European Journal of Pharmaceutics and Biopharmaceutics, 74(2), 233-238. DOI: 10.1016/j.ejpb.2009.10.004
de Waard, H., Amani, A., Kendrick, J., Hinrichs, W. L. J., Frijlink, H. W., & Anwar, J. (2010). Evaluation and optimization of a force field for crystalline forms of mannitol and sorbitol. Journal of Physical Chemistry B, 114(1), 429-436. DOI: 10.1021/jp9052665

2009

Munnik, P., de Boer, A. H., Wissink, J., Hagedoorn, P., Heskamp, I., de Kruijf, W., ... Zanen, P. (2009). In vivo performance testing of the novel Medspray wet aerosol inhaler. Journal of aerosol medicine and pulmonary drug delivery, 22(4), 317-321. DOI: 10.1089/jamp.2008.0723
de Waard, H., Grasmeijer, N., Hinrichs, W. L. J., Eissens, A. C., Pfaffenbach, P. P. F., & Frijlink, H. W. (2009). Preparation of drug nanocrystals by controlled crystallization: Application of a 3-way nozzle to prevent premature crystallization for large scale production. European Journal of Pharmaceutical Sciences, 38(3), 224-229. DOI: 10.1016/j.ejps.2009.07.005
Rasyid, H. N., van der Mei, H. C., Frijlink, H. W., Soegijoko, S., Van Horn, J. R., Busscher, H., & Neut, D. (2009). Concepts for increasing gentamicin release from handmade bone cement beads. Acta Orthopaedica, 80(5), 508-513. DOI: 10.3109/17453670903389782
Schellekens, R. C. A., Olsder, G. G., Langenberg, S. M. C. H., Boer, T., Woerdenbag, H. J., Frijlink, H. W., ... Stellaard, F. (2009). Proof-of-concept study on the suitability of 13C-urea as a marker substance for assessment of in vivo behaviour of oral colon-targeted dosage forms. British Journal of Pharmacology, 158(2), 532-540. DOI: 10.1111/j.1476-5381.2009.00302.x
Rottier, B. L., van Erp, C. J. P., Sluyter, T. S., Heijerman, H. G. M., Frijlink, H. W., & Boer, A. H. D. (2009). Changes in performance of the Pari eFlow rapid and Pari LC Plus during 6 months use by CF patients. Journal of aerosol medicine and pulmonary drug delivery, 22(3), 263-269. DOI: 10.1089/jamp.2008.0712
Srinarong, P., Faber, J. H., Visser, M. R., Hinrichs, W. L. J., & Frijlink, H. W. (2009). Strongly enhanced dissolution rate of fenofibrate solid dispersion tablets by incorporation of superdisintegrants. European Journal of Pharmaceutics and Biopharmaceutics, 73(1), 154-161. DOI: 10.1016/j.ejpb.2009.05.006
Laksmana, F. L., Hartman Kok, P. J. A., Vromans, H., Frijlink, H. W., & Van Der Voort Maarschalk, K. (2009). Development and application of a process window for achieving high-quality coating in a fluidized bed coating process. Aaps pharmscitech, 10(3), 732-742. DOI: 10.1208/s12249-009-9250-1
Heijerman, H., Westerman, E., Conway, S., Touw, D., Döring, G., consensus working group, & Frijlink, H. (2009). Inhaled medication and inhalation devices for lung disease in patients with cystic fibrosis: A European consensus. Journal of Cystic Fibrosis, 8(5), 295-315. DOI: 10.1016/j.jcf.2009.04.005
de Vries, T. W., Rottier, B. L., Gjaltema, D., Hagedoorn, P., Frijlink, H. W., & de Boer, A. H. (2009). Comparative in vitro evaluation of four corticosteroid metered dose inhalers: Consistency of delivered dose and particle size distribution. Respiratory Medicine, 103(8), 1167-1173. DOI: 10.1016/j.rmed.2009.02.010
Zijlstra, G. S., Wolting, J., Prop, J., Petersen, A. H., Hinrichs, W. L. J., Uges, D. R. A., ... Frijlink, H. W. (2009). Efficacy of a new pulmonary cyclosporine a powder formulation for prevention of transplant rejection in rats. The Journal of Heart and Lung Transplantation, 28(5), 486-492. DOI: 10.1016/j.healun.2009.02.001
Laksmana, F. L., Van Vliet, L. J., Hartman Kok, P. J. A., Vromans, H., Frijlink, H. W., & Van der Voort Maarschalk, K. (2009). Quantitative Image Analysis for Evaluating the Coating Thickness and Pore Distribution in Coated Small Particles. Pharmaceutical Research, 26(4), 965-976. DOI: 10.1007/s11095-008-9805-y
Zijlstra, G. S., Ponsioen, B. J., Hummel, S. A., Sanders, N., Hinrichs, W. L. J., de Boer, A. H., & Frijlink, H. W. (2009). Formulation and process development of (recombinant human) deoxyribonuclease I as a powder for inhalation. Pharmaceutical development and technology, 14(4), 358-368. DOI: 10.1080/10837450802662820

2008

Schellekens, R. C. A., Stellaard, F., Mitrovic, D., Stuurman, F. E., Kosterink, J. G. W., & Frijlink, H. W. (2008). Pulsatile drug delivery to ileo-colonic segments by structured incorporation of disintegrants in pH-responsive polymer coatings. Journal of Controlled Release, 132(2), 91-98. DOI: 10.1016/j.jconrel.2008.08.008
Amorij, J-P., & Frijlink, H. W. (2008). Influenzavaccinatie met een droogpoederinhalator: Inhalatie griepvaccin beter dan injectie. Pharmaceutisch Weekblad, 143(41), 30-33.
Wu, Y. S., Frijlink, H. W., van Vliet, L. J., & van der Voort Maarschalk, K. (2008). Pore shape in the sodium chloride matrix of tablets after the addition of starch as a second component. European Journal of Pharmaceutics and Biopharmaceutics, 70(2), 539-543. DOI: 10.1016/j.ejpb.2008.05.028
Westerman, E. M., Boer, A. H. D., Touw, D. J., Brun, P. P. H. L., Roldaan, A. C., Frijlink, H. W., & Heijerman, H. G. M. (2008). Aerosolization of tobramycin (TOBI) with the PARI LC PLUS reusable nebulizer: which compressor to use? Comparison of the CR60 to the PortaNeb compressor. Journal of aerosol medicine and pulmonary drug delivery, 21(3), 269-280. DOI: 10.1089/jamp.2007.0674
Moes, J. J., Ruijken, M. M., Gout, E., Frijlink, H. W., & Ugwoke, M. I. (2008). Application of process analytical technology in tablet process development using NIR spectroscopy: Blend uniformity, content uniformity and coating thickness measurements. International Journal of Pharmaceutics, 357(1-2), 108-118. DOI: 10.1016/j.ijpharm.2008.01.062
de Waard, H., Hinrichs, W. L. J., & Frijlink, H. W. (2008). A novel bottom-up process to produce drug nanocrystals: Controlled crystallization during freeze-drying. Journal of controlled release : official journal of the Controlled Release Society, 128(2), 179-183. DOI: 10.1016/j.jconrel.2008.03.002
Amorij, J-P., Huckriede, A., Wilschut, J., Frijlink, H. W., & Hinrichs, W. L. J. (2008). Development of stable influenza vaccine powder formulations: Challenges and possibilities. Pharmaceutical Research, 25(6), 1256-1273. DOI: 10.1007/s11095-008-9559-6
Wu, Y. S., van Vliet, L. J., Frijlink, H. W., Stokroos, I., & van der Voort Maarschalk, K. (2008). Pore direction in relation to anisotropy of mechanical strength in a cubic starch compact. Aaps pharmscitech, 9(2), 528-535. DOI: 10.1208/s12249-008-9074-4
de Boer, A. H., Wissink, J., Hagedoorn, P., Heskamp, I., de Kruijf, W., Bünder, R., ... Frijlink, H. W. (2008). In vitro performance testing of the novel Medspray wet aerosol inhaler based on the principle of Rayleigh break-up. Pharmaceutical Research, 25(5), 1186-1192. DOI: 10.1007/s11095-007-9503-1
Weda, M., Zanen, P., De Boer, A. H., Barends, D. M., & Frijlink, H. W. (2008). The therapeutic index of locally acting inhaled drugs as a function of their fine particle mass and particle size distribution - A literature review. Current Drug Delivery, 5(2), 142-147. DOI: 10.2174/156720108783954897
de Waard, H., Hinrichs, W. L. J., Visser, M. R., Bologna, C., & Frijlink, H. W. (2008). Unexpected differences in dissolution behavior of tablets prepared from solid dispersions with a surfactant physically mixed or incorporated. International Journal of Pharmaceutics, 349(1-2), 66-73. DOI: 10.1016/j.ijpharm.2007.07.023
Laksmana, F. L., Kok, P. J. A. H., Frijlink, H. W., Vromans, H., & Van der Voort Maarschalk, K. (2008). Using the internal stress concept to assess the importance of moisture sorption-induced swelling on the moisture transport through the glassy HPMC films. Aaps pharmscitech, 9(3), 891-898. DOI: 10.1208/s12249-008-9128-7
Frijlink, H. Quantitative Image Analysis for Evaluating the Coating Thickness and Pore Distribution in Coated Small Particles

2007

Amorij, J-P., Westra, T. A., Hinrichs, W. L. J., Huckriede, A., & Frijlink, H. W. (2007). Towards an oral influenza vaccine: Comparison between intragastric and intracolonic delivery of influenza subunit vaccine in a murine model. Vaccine, 26(1), 67-76. DOI: 10.1016/j.vaccine.2007.10.045
Amorij, J-P., Saluja, V., Petersen, A. H., Hinrichs, W. L. J., Huckriede, A., & Frijlink, H. W. (2007). Pulmonary delivery of an inulin-stabilized influenza subunit vaccine prepared by spray-freeze drying induces systemic, mucosal humoral as well as cell-mediated immune responses in BALB/c mice. Vaccine, 25(52), 8707-8717. DOI: 10.1016/j.vaccine.2007.10.035
Zijlstra, G. S., Brandsma, C., Harpe, M. F. H., Van Dam, G. M., Slebos, D. J., Kerstjens, H. A. M., ... Frijlink, H. W. (2007). Dry powder inhalation of hemin to induce heme oxygenase expression in the lung. European Journal of Pharmaceutics and Biopharmaceutics, 67(3), 667-675. DOI: 10.1016/j.ejpb.2007.03.021
Wu, Y. S., van Vliet, L. J., Frijlink, H. W., & van der Voort Maarschalk, K. (2007). Pore size distribution in tablets measured with a morphological sieve. International Journal of Pharmaceutics, 342(1-2), 176-183. DOI: 10.1016/j.ijpharm.2007.05.011
de Jonge, J., Amorij, J-P., Hinrichs, W. L. J., Wilschut, J., Huckriede, A., & Frijlink, H. W. (2007). Inulin sugar glasses preserve the structural integrity and biological activity of influenza virosomes during freeze-drying and storage. European Journal of Pharmaceutical Sciences, 32(1), 33-44. DOI: 10.1016/j.ejps.2007.05.112
Amorij, J-P., Meulenaar, J., Hinrichs, W. L. J., Stegmann, T., Huckriede, A., Coenen, F., & Frijlink, H. W. (2007). Rational design of an influenza subunit vaccine powder with sugar glass technology: preventing conformational changes of haemagglutinin during freezing and freeze-drying. Vaccine, 25(35), 6447-6457. DOI: 10.1016/j.vaccine.2007.06.054
Westerman, E. M., de Boer, A. H., Le Brun, P. P. H., Touw, D. J., Roldaan, A. C., Frijlink, H. W., & Heijerman, H. G. M. (2007). Dry powder inhalation of colistin in cystic fibrosis patients: A single dose pilot study. Journal of Cystic Fibrosis, 6(4), 284-292. DOI: 10.1016/j.jcf.2006.10.010
Zijlstra, G. S., Rijkeboer, M., van Drooge, D., Sutter, M., Jiskoot, W., van de Weert, M., ... Frijlink, H. W. (2007). Characterization of a cyclosporine solid dispersion for inhalation. Aaps journal, 9(2), E190-E199. [21]. DOI: 10.1208/aapsj0902021
Westerman, E. M., de Boer, A. H., Le Brun, P. P. H., Touw, D. J., Frijlink, H. W., & Heijerman, H. G. M. (2007). Dry powder inhalation of colistin sulphomethate in healthy volunteers: A pilot study. International Journal of Pharmaceutics, 335(1-2), 41-45. DOI: 10.1016/j.ijpharm.2006.11.021
Westerman, E. M., Heijerman, H. G. M., & Frijlink, H. W. (2007). Dry powder inhalation versus wet nebulisation delivery of antibiotics in cystic fibrosis patients. Expert Opinion on Drug Delivery, 4(2), 91-94. DOI: 10.1517/17425247.4.2.91
Schellekens, R. C. A., Stuurman, F. E., van der Weert, F. H. J., Kosterink, J. G. W., & Frijlink, H. W. (2007). A novel dissolution method relevant to intestinal release behaviour and its application in the evaluation of modified release mesalazine products. European Journal of Pharmaceutical Sciences, 30(1), 15-20. DOI: 10.1016/j.ejps.2006.09.004
Wilschut, J., De Jonge, J., Huckriede, A., Amorij, J-P., Hinrichs, W. L. J., & Frijlink, H. W. (2007). Preservation of influenza Virosome structure and function during freeze-drying and storage. Journal of Liposome Research, 17(3-4), 173-182. DOI: 10.1080/08982100701536883

2006

Dickhoff, B. H. J., de Boer, A. H., Lambregts, D., & Frijlink, H. W. (2006). The effect of carrier surface treatment on drug particle detachment from crystalline carriers in adhesive mixtures for inhalation. International Journal of Pharmaceutics, 327(1-2), 17-25. DOI: 10.1016/j.ijpharm.2006.07.017
Barends, D. M., Groot, D. W., van der Steen, J. C., de Kaste, D., & Frijlink, H. W. (2006). Results of a market surveillance study in The Netherlands on break-mark tablets. Pharmeuropa Scientific Notes, 2006(2), 1-7.
Bouwman, A. M., Visser, M. R., Meesters, G. M. H., & Frijlink, H. W. (2006). The use of Stokes deformation number as a predictive tool for material exchange behaviour of granules in the 'equilibrium phase' in high shear granulation. International Journal of Pharmaceutics, 318(1-2), 78-85. DOI: 10.1016/j.ijpharm.2006.03.038
Wu, Y. S., van Vliet, L. J., Frijlink, H. W., & van der Voort Maarschalk, K. (2006). The determination of relative path length as a measure for tortuosity in compacts using image analysis. European Journal of Pharmaceutical Sciences, 28(5), 433-440. DOI: 10.1016/j.ejps.2006.05.006
van Drooge, D. J., Braeckmans, K., Hinrichs, W. L. J., Remaut, K., De Smedt, S. C., & Frijlink, H. W. (2006). Characterization of the mode of incorporation of lipophilic compounds in solid dispersions at the nanoscale using fluorescence resonance energy transfer (FRET). Macromolecular Rapid Communications, 27(14), 1149-1155. DOI: 10.1002/marc.200600177
de Boer, A. H., Hagedoorn, P., Westerman, E. M., Le Brun, P. P. H., Heijerman, H. G. M., & Frijlink, H. W. (2006). Design and in vitro performance testing of multiple air classifier technology in a new disposable inhaler concept (Twincer (R)) for high powder doses. European Journal of Pharmaceutical Sciences, 28(3), 171-178. DOI: 10.1016/j.ejps.2005.11.013
Hinrichs, W., Manceñido, F. A., Sanders, N. N., Braeckmans, K., De Smedt, S. C., Demeester, J., & Frijlink, H. W. (2006). The choice of a suitable oligosaccharide to prevent aggregation of PEGylated nanoparticles during freeze thawing and freeze drying. International Journal of Pharmaceutics, 311(1-2), 237-244. DOI: 10.1016/j.ijpharm.2005.12.032
de Boer, A. H., Hagedoorn, P., Gjaltema, D., Goede, J., & Frijlink, H. W. (2006). Air classifier technology (ACT) in dry powder inhalation - Part 3. Design and development of an air classifier family for the Novolizer (R) multi-dose dry powder inhaler. International Journal of Pharmaceutics, 310(1-2), 72-80. DOI: 10.1016/j.ijpharm.2005.11.030
de Boer, A. H., Hagedoorn, P., Gjaltema, D., Goede, J., & Frijlink, H. W. (2006). Air classifier technology (ACT) in dry powder inhalation - Part 4. Performance of air classifier technology in the Novolizer (R) multi-dose dry powder inhaler. International Journal of Pharmaceutics, 310(1-2), 81-89. DOI: 10.1016/j.ijpharm.2005.11.029
van Drooge, D. J., Hinrichs, W. L. J., Visser, M. R., & Frijlink, H. W. (2006). Characterization of the molecular distribution of drugs in glassy solid dispersions at the nano-meter scale, using differential scanning calorimetry and gravimetric water vapour sorption techniques. International Journal of Pharmaceutics, 310(1-2), 220-229. DOI: 10.1016/j.ijpharm.2005.12.007
Coenen, F., Tolboom, J. T. B. M., & Frijlink, H. W. (2006). Stability of influenza sub-unit vaccine. Does a couple of days outside the refrigerator matter? Vaccine, 24(4), 525-531. DOI: 10.1016/j.vaccine.2005.07.081

2005

Van Veen, B., Pajander, J., Zuurman, K., Lappalainen, R., Poso, A., Frijlink, H. W., & Ketolainen, J. (2005). The effect of powder blend and tablet structure on drug release mechanisms of hydrophobic starch acetate matrix tablets. European Journal of Pharmaceutics and Biopharmaceutics, 61(3), 149-157. DOI: 10.1016/j.ejpb.2005.04.007
van Drooge, D-J., Hinrichs, W. L. J., Dickhoff, B. H. J., Elli, M. N. A., Visser, M. R., Zijlstra, G. S., & Frijlink, H. W. (2005). Spray freeze drying to produce a stable Delta(9)-tetrahydrocannabinol containing inulin-based solid dispersion powder suitable for inhalation. European Journal of Pharmaceutical Sciences, 26(2), 231-240. DOI: 10.1016/j.ejps.2005.06.007
Van Waarde, A., Maas, B., Doze, P., Slart, R. H., Frijlink, H. W., Vaalburg, W., & Elsinga, P. (2005). Positron emission tomography studies of human airways using an inhaled beta-adrenoceptor antagonist, S-11C-CGP 12388. Chest, 128(4), 3020-3027. DOI: 10.1378/chest.128.4.3020
Wu, Y. S., Frijlink, H. W., van Vliet, L. J., Stokroos, I., & van der Voort Maarschalk, K. (2005). Location-dependent analysis of porosity and pore direction in tablets. Pharmaceutical Research, 22(8), 1399-1405. DOI: 10.1007/s11095-005-5280-x
Barends, D. M., Groot, D. W., Frijlink, H. W., Rodenhuis, N., & van der Steen, J. C. (2005). Development of an in vivo test procedure for the ease of breaking of scored tablets. Pharmeuropa Scientific Notes, 2005(1), 27-30.
de Boer, A. H., Dickhoff, B. H. J., Hagedoorn, P., Gjaltema, D., Goede, J., Lambregts, D., & Frijlink, H. W. (2005). A critical evaluation of the relevant parameters for drug redispersion from adhesive mixtures during inhalation. International Journal of Pharmaceutics, 294(1-2), 173-184. DOI: 10.1016/j.ijpharm.2005.01.035
Hinrichs, W. L. J., Sanders, N. N., De Smedt, S. C., Demeester, J., & Frijlink, H. W. (2005). Inulin is a promising cryo- and lyoprotectant for PEGylated lipoplexes. Journal of Controlled Release, 103(2), 465-479. DOI: 10.1016/j.jconrel.2004.12.011
Schellekens, R. C. A., Stuurman, F. E., Frijlink, H. W., & Kosterink, J. G. W. (2005). Ontwikkeling van orale toedieningsvorm met colonspecifieke afgifte: Nieuwe aanpak van onderzoek naar lactose-intolerantie. Pharmaceutisch Weekblad, 140(11), 366-368.
Bouwman, A. M., Henstra, M. J., Westerman, D., Chung, J. T., Zhang, Z., Ingram, A., ... Frijlink, H. W. (2005). The effect of the amount of binder liquid on the granulation mechanisms and structure of microcrystalline cellulose granules prepared by high shear granulation. International Journal of Pharmaceutics, 290(1-2), 129-136. DOI: 10.1016/j.ijpharm.2004.11.024
Bouwman, A. M., Henstra, M. J., Hegge, J. J. M. E., Zhang, Z., Ingram, A., Seville, J. P. K., & Frijlink, H. W. (2005). The relation between granule size, granule stickiness, and torque in the high-shear granulation process. Pharmaceutical Research, 22(2), 270-275. DOI: 10.1007/s11095-004-1194-2
Dickhoff, B. H. J., de Boer, A., Lambregts, D., & Frijlink, H. W. (2005). The interaction between carrier rugosity and carrier payload, and its effect on drug particle redispersion from adhesive mixtures during inhalation. European Journal of Pharmaceutics and Biopharmaceutics, 59(1), 197-205. DOI: 10.1016/j.ejpb.2004.07.005
van Veen, B., Bolhuis, G. K., Wu, Y. S., Zuurman, K., & Frijlink, H. W. (2005). Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) microcrystalline cellulose. European Journal of Pharmaceutics and Biopharmaceutics, 59(1), 133-138. DOI: 10.1016/j.ejpb.2004.05.009
Barends, D. M., de Groot, D. J. A., Frijlink, E., Rodenburg, N., & van der Steen, J. C. (2005). Development of an in vivo test procedure for the easy of breaking scored tablets. Pharmeuropa Scientific Notes, 1, 1 - 4.
Frijlink, E., & de Boer, A. H. (2005). Trends in the technology-driven development of new inhalation devices. Drug Discovery Today: Technologies, 2(1), 47-57. DOI: 10.1016/j.ddtec.2005.05.020
van Drooge, D. J., Dickhoff, B., Eli, M. N. A., Visser, M. R., & Frijlink, E. (2005). Spray freeze drying to procedure a stable D9-tetrahydrocannabinol containing inulin-based solid dispersion powder suitable for inhalation. European Journal Pharmaceutical Sciences, 26, 231 - 240.

2004

Weda, M., Zanen, P., de Boer, A. H., Barends, D. M., & Frijlink, H. W. (2004). An investigation into the predictive value of cascade impactor results for side effects of inhaled salbutamol. International Journal of Pharmaceutics, 287(1-2), 79-87. DOI: 10.1016/j.ijpharm.2004.08.017
de Boer, A. H., Hagedoorn, P., Gjaltema, D., Lambregts, D., Irngartinger, M., & Frijlink, H. W. (2004). The mode of drug particle detachment from carrier crystals in an air classifier-based inhaler. Pharmaceutical Research, 21(12), 2167-2174. DOI: 10.1007/s11095-004-5171-6
de Boer, A. H., Hagedoorn, P., Gjaltema, D., Lambregts, D., Irngartinger, M., & Frijlink, H. W. (2004). The rate of drug particle detachment from carrier crystals in an air classifier-based inhaler. Pharmaceutical Research, 21(12), 2158-2166. DOI: 10.1007/s11095-004-7668-4
Frijlink, H. W., & De Boer, A. H. (2004). Dry powder inhalers for pulmonary drug delivery. Expert Opinion on Drug Delivery, 1(1), 67-86. DOI: 10.1517/17425247.1.1.67
Bouwman, A. M., Visser, M. R., Eissens, A. C., Wesselingh, J. A., & Frijlink, H. W. (2004). The effect of vessel material on granules produced in a high-shear mixer. European Journal of Pharmaceutical Sciences, 23(2), 169-179. DOI: 10.1016/j.ejps.2004.07.008
Zijlstra, G. S., Hinrichs, W. L. J., de Boer, A. H., & Frijlink, H. W. (2004). The role of particle engineering in relation to formulation and de-agglomeration principle in the development of a dry powder formulation for inhalation of cetrorelix. European Journal of Pharmaceutical Sciences, 23(2), 139-149. DOI: 10.1016/j.ejps.2004.06.005
de Boer, A. H., Hagedoorn, P., Gjaltema, D., Le Brun, P. P. H., & Frijlink, E. (2004). Meer mogelijkheden met '(multiple) air classifier'-technologie. Pharmaceutisch Weekblad, 139(36), 1171-1175.
Frijlink, H. W., & de Boer, A. (2004). Systemische toediening van geneesmiddelen via de long. Pharmaceutisch Weekblad, 139(36), 1176-1179.
Le Brun, P. P. H., de Boer, A. H., & Frijlink, E. (2004). Werkingsprincipes en eigenschappen van toedieningsvormen voor inhalatie. Pharmaceutisch Weekblad, 139(36), 1157-1161.
de Boer, A. H., Gjaltema, D., Hagedoorn, P., & Frijlink, H. W. (2004). Comparative in vitro performance evaluation of the Novopulmon® 200 Novolizer® and Budesonid-ratiopharm® Jethaler: Two novel budesonide dry powder inhalers. Die Pharmazie, 59(9), 692-699.
Bouwman, A. M., Bosma, J. C., Vonk, P., Wesselingh, J. A., & Frijlink, H. W. (2004). Which shape factor(s) best describe granules? Powder Technology, 146(1-2), 66-72. DOI: 10.1016/j.powtec.2004.04.044
Van Drooge, D. J., Hinrichs, W. L. J., & Frijlink, H. W. (2004). Anomalous dissolution behaviour of tablets prepared from sugar glass-based solid dispersions. Journal of Controlled Release, 97(3), 441-452. DOI: 10.1016/j.jconrel.2004.03.018
Frijlink, H. W., Le Brun, P. P. H., & Brouwers, J. R. B. J. (2004). Farmacokinetiek en toedieningsvormen: Waarom geavanceerd ook zinvol is. Pharmaceutisch Weekblad, 139(26), 921-926.
Rigter, I. M., Schipper, H. G., Koopmans, R. P., van Kan, H. J. M., Frijlink, H. W., Kager, P. A., & Guchelaar, H-J. (2004). Relative bioavailability of three newly developed albendazole formulations: a randomized crossover study with healthy volunteers. Antimicrobial Agents and Chemotherapy, 48(3), 1051-1054. DOI: 10.1128/aac.48.3.1051-1054.2004
Van Drooge, D. J., Hinrichs, W. L. J., & Frijlink, H. W. (2004). Incorporation of lipophilic drugs in sugar glasses by lyophilization using a mixture of water and tertiary butyl alcohol as solvent. Journal of Pharmaceutical Sciences, 93(3), 713-725. DOI: 10.1002/jps.10590
van Drooge, D. J., Hinrichs, W. L. J., Wegman, K. A. M., Visser, M. R., Eissens, A. C., & Frijlink, H. W. (2004). Solid dispersions based on inulin for the stabilisation and formulation of delta 9-tetrahydrocannabinol. European Journal of Pharmaceutical Sciences, 21(4), 511-518. DOI: 10.1016/j.ejps.2003.11.014
Westerman, E. M., Le Brun, P. P. H., Touw, D. J., Frijlink, H. W., & Heijerman, H. G. M. (2004). Effect of nebulized colistin sulphate and colistin sulphomethate on lung function in patients with cystic fibrosis: A pilot study. Journal of Cystic Fibrosis, 3(1), 23-28. DOI: 10.1016/j.jcf.2003.12.005
Zijlstra, G., Boersma, C., Frijlink, H. W., & Postma, M. J. (2004). Pharmacoeconomic review of recombinant human DNase in the management of cystic fibrosis. Expert review of pharmacoeconomics & outcomes research, 4(1), 49-59. DOI: 10.1586/14737167.4.1.49
van Veen, B., van der Voort Maarschalk, K., Bolhuis, G. K., & Frijlink, H. W. (2004). Predicting mechanical properties of compacts containing two components. Powder Technology, 139(2), 156-164. DOI: 10.1016/j.powtec.2003.11.003
Eriksson, J. H. C., Mol, R., Somsen, G. W., Hinrichs, W. L. J., Frijlink, H. W., & de Jong, G. J. (2004). Feasibility of nonvolatile buffers in capillary electrophoresis-electrospray ionization-mass spectrometry of proteins. Electrophoresis, 25(1), 43-49. DOI: 10.1002/elps.200305695
de Boer, A. H., Hagedoorn, P., & Frijlink, E. (2004). Dry powder inhaler and method for pulmonary inhalation dry powder. (Patent No. WO 2004/110538.)
de Boer, A. H., Frijlink, E., Gjaltema, D., Goede, J., & Hagedoorn, P. (2004). Powder formulation disintegrating system and method for dry powder inhalers (Patent No. US 6,681,768 B2.)
de Boer, A. H., Gjaltema, D., Hagedoorn, P., & Frijlink, E. (2004). Comparative in vitro performance evaluation of the Novopulomr 200 Novolizerr and Budesonid-ratiopharmr Jethaler: two novel budesonide dry powder inhalers. Pharmazie, 59, 692 - 699.
de Boer, A., Hagedoorn, P., Le Brun, P. P. H., & Frijlink, H. W. (2004). Instructies bij het gebruik van inhalatoren. Pharmaceutisch Weekblad, 139(36), 1162-1166.
Dickhoff, B., de Boer, A. H., & Frijlink, E. (2004). Granular versus crystalline carrier particles in adhesive mixtures for inhalation. In Proceedings Respiratory Drug Delivery IX (pp. 772 - 796). (Proceedings Respiratory Drug Delivery IX, Davis Healthcare, Int.Publishing, LLC).
van Drooge, D. J., Zijlstra, G. S., Dickhoff, B., & Frijlink, E. (2004). A process for preparing formulations of lypophilic active substances by spray freeze drying. (Patent No. EP 041056661.5.)
Frijlink, E., Le Brun, P. P. H., & Brouwers, J. R. B. J. (2004). Waarom geavanceeerd ook zinvol is. P.W., 139(26), 921 - 926.
Frijlink, E. (2004). Vernevelapparatuur/Werkgroep vernevelapparatuur. HulpmiddelenKompas, 1 - 112.
Irngartinger, M., Camuglia, V., Damm, M., Goede, J., & Frijlink, H. W. (2004). Pulmonary delivery of therapeutic peptides via dry powder inhalation: effects of micronisation and manufacturing. European Journal of Pharmaceutics and Biopharmaceutics, 58(1), 7-14. DOI: 10.1016/j.ejpb.2004.03.016
van der Steen, J. C., Frijlink, E., Rodenhuis, N., & Barends, D. M. (2004). The Ph. Eur. Requirement for scored tablets: Sampling procedure and test. Pharmeuropa, 16(1), 51 - 55.

2003

de Boer, A. H., Hagedoorn, P., & Frijlink, H. W. (2003). The choice of a compressor for the aerosolisation of tobramycin (TOBI) with the PARI LC PLUS reusable nebuliser. International Journal of Pharmaceutics, 268(1-2), 59-69. DOI: 10.1016/j.ijpharm.2003.09.004
Dickhoff, B. H. J., de Boer, A., Lambregts, D., & Frijlink, H. W. (2003). The effect of carrier surface and bulk properties on drug particle detachment from crystalline lactose carrier particles during inhalation, as function of carrier payload and mixing time. European Journal of Pharmaceutics and Biopharmaceutics, 56(2), 291-302. DOI: 10.1016/S0939-6411(03)00109-7
Frijlink, H. W. (2003). Benefits of different drug formulations in psychopharmacology. European Neuropsychopharmacology, 13(SUPPL. 3), S77-S84. DOI: 10.1016/S0924-977X(03)00096-8
Eriksson, J. H. C., Hinrichs, W. L. J., de Jong, G. J., Somsen, G. W., & Frijlink, H. W. (2003). Investigations into the stabilization of drugs by sugar glasses: III. The influence of various high-pH buffers. Pharmaceutical Research, 20(9), 1437-1443. DOI: 10.1023/A:1025762328267
de Boer, A. H., Hagedoorn, P., Gjaltema, D., Goede, J., Kussendrager, K. D., & Frijlink, H. W. (2003). Air classifier technology (ACT) in dry powder inhalation. Part 2: The effect of lactose carrier surface properties on the drug-to-carrier interaction in adhesive mixtures for inhalation. International Journal of Pharmaceutics, 260(2), 201-216. DOI: 10.1016/S0378-5173(03)00264-3
de Boer, A. H., Hagedoorn, P., Gjaltema, D., Goede, J., & Frijlink, H. W. (2003). Air classifier technology (ACT) in dry powder inhalation. Part 1: Introduction of a novel force distribution concept (FDC) explaining the performance of a basic air classifier on adhesive mixtures. International Journal of Pharmaceutics, 260(2), 187-200. DOI: 10.1016/S0378-5173(03)00250-3
Rigter, I. M., Schipper, H. G., Koopmans, R. P., Frijlink, H. W., Kager, P. A., & Guchelaar, H. J. (2003). Open gerandomiseerd onderzoek met vier verschillende farmaceutische formuleringen: Biologische beschikbaarheid van alhendazol. Pharmaceutisch Weekblad, 138(29), 1031-1033.
Westerman, E. M., Le Brun, P. P. H., Frijlink, H. W., & Heijerman, H. G. M. (2003). Effect van verneveling van colistinesulfaat en colistinesulfomethaat op de longfunctie van patiënten met cystische fibrose: Sulfaat voldoet niet. Pharmaceutisch Weekblad, 138(20), 703-707.
Diederik, H., Le Brun, P. P. H., Frijlink, H. W., Vitányi, P. M. B., Weda, M., & Barends, D. M. (2003). Drug output of unvented jet nebulizers as a function of time. International Journal of Pharmaceutics, 257(1-2), 33-39. DOI: 10.1016/S0378-5173(03)00109-1
Eriksson, H. J. C., Verweij, W. R., Poelstra, K., Hinrichs, W. L. J., de Jong, G. J., Somsen, G. W., & Frijlink, H. W. (2003). Investigations into the stabilisation of drugs by sugar glasses: II: Delivery of an inulin-stabilised alkaline phosphatase in the intestinal lumen via the oral route. International Journal of Pharmaceutics, 257(1-2), 273-281. DOI: 10.1016/S0378-5173(03)00152-2
Bolhuis, G. K., Eissens, A. C., Adrichem, T. P., Wesselingh, J. A., & Frijlink, H. W. (2003). Hollow filler-binders as excipients for direct compaction. Pharmaceutical Research, 20(3), 515-518. DOI: 10.1023/A:1022637028221
Eriksson, H. J. C., Wijngaard, M., Hinrichs, W. L. J., Frijlink, H. W., Somsen, G. W., & De Jong, G. J. (2003). Potential of capillary electrophoresis for the monitoring of the stability of placental alkaline phosphatase. Journal of Pharmaceutical and Biomedical Analysis, 31(2), 351-357. DOI: 10.1016/S0731-7085(02)00646-5
de Boer, A. H., Frijlink, E., Gjaltema, D., Goede, J., & Hagedoorn, P. (2003). Powder formulation disintegrating system and method for dry powder inhalers (Patent No. WO 03/000325 A1.)
Bolhuis, G. K., Eissens, A. C., Adrichem, T. P., Wesselingh, J. A., & Frijlink, E. (2003). Hollow filler-binders as excipients for direct compression. Pharm.Res., 20(3), 515 - 518.
van Drooge, D. J., Eissens, A. C., & Frijlink, E. (2003). Stabilized natural cannabinoid formulation (Patent No. PCT/EP03/50087.)
Eriksson, J., Wijngaard, M., Frijlink, E., Somsen, G. W., & de Jong, G. J. (2003). Potential of capillary electrophoresis for the monitoring of the stability of placental alkaline phosphate. J.Pharm.Biomedical Analysis, 31, 351 - 357.
Rigter, I. M., Schipper, H. G., Koopmans, R. P., Frijlink, E., Kager, P. A., & Guchelaar, H. J. (2003). Biologische beschikbaarheid van albendazol. P.W., 138(29), 1031 - 1033.
Westerman, E., Le Brun, P. P. H., Touw, D. J., Frijlink, E., & Heijerman, H. G. M. (2003). Sulfaat voldoet niet. P.W., 138(20), 703 - 707.

2002

de Boer, A., Gjaltema, D., Hagedoorn, P., & Frijlink, H. W. (2002). Characterization of inhalation aerosols: a critical evaluation of cascade impactor analysis and laser diffraction technique. International Journal of Pharmaceutics, 249(1-2), 219-231. [PII S0378-5173(02)00526-4]. DOI: 10.1016/S0378-5173(02)00526-4
de Boer, A., Gjaltema, D., Hagedoorn, P., Schaller, M., Witt, W., & Frijlink, H. W. (2002). Design and application of a new modular adapter for laser diffraction characterization of inhalation aerosols. International Journal of Pharmaceutics, 249(1-2), 233-245. [PII S0378-5173(02)00527-6]. DOI: 10.1016/S0378-5173(02)00527-6
Weda, M., Zanen, P., de Boer, A., Gjaltema, D., Ajaoud, A., Barends, D. M., & Frijlink, H. W. (2002). Equivalence testing of salbutamol dry powder inhalers: in vitro impaction results versus in vivo efficacy. International Journal of Pharmaceutics, 249(1-2), 247-255. [PII S0378-5173(02)00533-1]. DOI: 10.1016/S0378-5173(02)00533-1
Eriksson, H. J. C., Hinrichs, W. L. J., van Veen, B., Somsen, G. W., de Jong, G. J., & Frijlink, H. W. (2002). Investigations into the stabilisation of drugs by sugar glasses: I. Tablets prepared from stabilised alkaline phosphatase. International Journal of Pharmaceutics, 249(1-2), 59-70. [PII S0378-5173(02)00531-8]. DOI: 10.1016/S0378-5173(02)00531-8
Van Veen, B., van der Voort Maarschalk, K., Bolhuis, G. K., Gons, M., Zuurman, K., & Frijlink, H. W. (2002). The influence of particles of a minor component on the matrix strength of sodium chloride. European Journal of Pharmaceutical Sciences, 16(4-5), 229-235. [PII S0928-0987(02)00105-7]. DOI: 10.1016/S0928-0987(02)00105-7
de Boer, A. H., Le Brun, P. P. H., van der Woude, H. G., Hagedoorn, P., Heijerman, H. G. M., & Frijlink, H. W. (2002). Dry powder inhalation of antibiotics in cystic fibrosis therapy, part 1: development of a powder formulation with colistin sulfate for a special test inhaler with an air classifier as de-agglomeration principle. European Journal of Pharmaceutics and Biopharmaceutics, 54(1), 17-24. [PII S0939-6411(02)00043-7]. DOI: 10.1016/S0939-6411(02)00043-7
Le Brun, P. P. H., de Boer, A. H., Mannes, G. P. M., de Fraîture, D. M. I., Brimicombe, R. W., Touw, D., ... Heijerman, H. G. M. (2002). Dry powder inhalation of antibiotics in cystic fibrosis therapy: Part 2. Inhalation of a novel colistin dry powder formulation: A feasibility study in healthy volunteers and patients. European Journal of Pharmaceutics and Biopharmaceutics, 54(1), 25-32. [PII S0939-6411(02)00044-9]. DOI: 10.1016/S0939-6411(02)00044-9
Eissens, A. C., Bolhuis, G. K., Hinrichs, W. L. J., & Frijlink, H. W. (2002). Inulin as filler-binder for tablets prepared by direct compaction. European Journal of Pharmaceutical Sciences, 15(1), 31-38. [PII S0928-0987(01)00201-9]. DOI: 10.1016/S0928-0987(01)00201-9
Van Veen, B., van der Voort Maarschalk, K., Bolhuis, G. K., Visser, M. R., Zuurman, K., & Frijlink, H. W. (2002). Pore formation in tablets compressed from binary mixtures as a result of deformation and relaxation of particles. European Journal of Pharmaceutical Sciences, 15(2), 171-177. [PII S0928-0987(01)00216-0]. DOI: 10.1016/S0928-0987(01)00216-0
de Koning, J. P., van der Mark, T. W., Coenegracht, P. M. J., Tromp, T. F. J., & Frijlink, H. W. (2002). Effect of an external resistance to airflow on the inspiratory flow curve. International Journal of Pharmaceutics, 234(1-2), 257-266. [PII S0378-5173(01)00969-3]. DOI: 10.1016/S0378-5173(01)00969-3
van Santen, E., Barends, D. M., & Frijlink, H. W. (2002). Breaking of scored tablets: a review. European Journal of Pharmaceutics and Biopharmaceutics, 53(2), 139-145. [PII S0939-6411(01)00228-4]. DOI: 10.1016/S0939-6411(01)00228-4
Kuipers, M. E., Heegsma, J., Bakker, H. I., Meijer, D., Swart, P. J., Frijlink, E. W., ... van den Berg, J. J. M. (2002). Design and fungicidal activity of mucoadhesive lactoferrin tablets for the treatment of oropharyngeal candidosis. Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents, 9(1), 31-38. DOI: 10.1080/107175402753413154

2001

Steendam, R., Frijlink, H. W., & Lerk, C. F. (2001). Plasticisation of amylodextrin by moisture. Consequences for compaction behaviour and tablet properties. European Journal of Pharmaceutical Sciences, 14(3), 245-254. DOI: 10.1016/S0928-0987(01)00171-3
Dickhoff, B. H. J., Ellison, M. J. H., de Boer, A., & Frijlink, H. W. (2001). The effect of budesonide particle mass on drug particle detachment from carrier crystals in adhesive mixtures during inhalation. European Journal of Pharmaceutics and Biopharmaceutics, 54(2), 245-248. [PII S0939-6411(02)00082-6]. DOI: 10.1016/S0939-6411(02)00082-6
Eriksson, H. J., Somsen, G. W., Hinrichs, W. L., Frijlink, H. W., & de Jong, G. J. (2001). Characterization of human placental alkaline phosphatase by activity and protein assays, capillary electrophoresis and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Journal of Chromatography B: Biomedical Sciences and Applications, 755(1-2), 311-319. DOI: 10.1016/S0378-4347(01)00136-0
Hinrichs, W. L. J., Prinsen, M. G., & Frijlink, H. W. (2001). Inulin glasses for the stabilization of therapeutic proteins. International Journal of Pharmaceutics, 215(1-2), 163-174. DOI: 10.1016/S0378-5173(00)00677-3
Steendam, R., Van Steenbergen, M. J., Hennink, W. E., Frijlink, H. W., & Lerk, C. F. (2001). Effect of molecular weight and glass transition on relaxation and release behaviour of poly(DL-lactic acid) tablets. Journal of Controlled Release, 70(1-2), 71-82. DOI: 10.1016/S0168-3659(00)00342-4
Eriksson, J., Somsen, G. W., Frijlink, E., & de Jong, G. J. (2001). Characterization of human placental alkaline phosphatase by activity and protein assays, capillary electrophoresis and matrix-assisted laser desorption/ionizaiton time-of-flight mass spectrometry. Journal of Chromatography B, 311 - 319.

2000

Van Veen, B., van der Voort Maarschalk, K., Bolhuis, G. K., Zuurman, K., & Frijlink, H. W. (2000). Tensile strength of tablets containing two materials with a different compaction behaviour. International Journal of Pharmaceutics, 203(1-2), 71-79. DOI: 10.1016/S0378-5173(00)00450-6
Le Brun, P. P., de Boer, A. H., Frijlink, H. W., & Heijerman, H. G. (2000). A review of the technical aspects of drug nebulization. Pharmacy World & Science, 22(3), 75-81. DOI: 10.1023/A:1008786600530
Steendam, R., Eissens, A. C. E., Frijlink, H. W., & Lerk, C. F. (2000). Plasticisation of amylodextrin by moisture: Consequences for drug release from tablets. International Journal of Pharmaceutics, 204(1-2), 23-33. DOI: 10.1016/S0378-5173(00)00456-7
Moolenaar, F., Meijler, W. J., Frijlink, H. W., Visser, J., & Proost, J. H. (2000). Clinical efficacy, safety and pharmacokinetics of a newly developed controlled release morphine sulphate suppository in patients with cancer pain. European Journal of Clinical Pharmacology, 56(3), 219-223. DOI: 10.1007/s002280000133
Frijlink, H. W., & Franke, J. P. (2000). De visie van de opleiding. Voorbereiden op bereiden. Pharmaceutisch Weekblad, 135(1), 36-40.

1999

Le Brun, P. P., Vinks, A. A., Touw, D. J., Hekelaar, N., Mannes, G. P., Brimicombe, R. W., ... Heijerman, H. G. (1999). Can tobramycin inhalation be improved with a jet nebulizer? Therapeutic Drug Monitoring, 21(6), 618-624. DOI: 10.1097/00007691-199912000-00007
Le Brun, P. P. H., de Boer, A. H., Gjaltema, D., Hagedoorn, P., Heijerman, H. G. M., & Frijlink, H. W. (1999). Inhalation of tobramycin in cystic fibrosis. Part 1: The choice of a nebulizer. International Journal of Pharmaceutics, 189(2), 205-214.
Le Brun, P. P. H., Boer, de, A., Gjaltema, D., Hagedoorn, P., Heijerman, H. G. M., & Frijlink, H. W. (1999). Inhalation of tobramycin in cystic fibrosis. Part 2: Optimization of the tobramycin solution for a jet and an ultrasonic nebulizer. International Journal of Pharmaceutics, 189(2), 215-225. DOI: 10.1016/S0378-5173(99)00252-5
Frijlink, H. W. (1999). Geneesmiddelontwikkeling stopt niet bij de werkzame stof: Toedieningsvorm voegt waarde toe. Pharmaceutisch Weekblad, 134(30), 1009-1012.
Frijlink, E. (1999). Toedieningsvorm voegt waarde toe. Pharmaceutisch Weekblad, 30, 1009 - 1012.
Frijlink, E. (1999). Bij ons draait het om poedertechnologie. Pharmaceutisch Weekblad, 51/52, 1798 - 1801.

1998

Frijlink, E. (1998). Over toedienen, toevoegen en produceren. Conceptuur, 6 - 8.

1995

Moolenaar, F., Meyler, P., Frijlink, E., Jauw, T. H., Visser, J., & Proost, J. (1995). Rectal absorption of morphine from controlled release suppositories. International Journal of Pharmaceutics, 114(1), 117-120. DOI: 10.1016/0378-5173(94)00219-U

1994

Frijlink, H. W. (1994). VERBETERD VOORSCHRIFT FENOBARBITALDRANK (V). Pharmaceutisch Weekblad, 129(27), 678-679.

1992

Frijlink, H. W., Paiotti, S., Eissens, A., & Lerk, C. F. (1992). The effects of cyclodextrins on drug release from fatty suppository bases: III. Application of cyclodextrin derivatives. European Journal of Pharmaceutics and Biopharmaceutics, 38(5), 174-179.

1991

Frijlink, H. W., Eissens, A., Schoonen, A., & Lerk, C. F. (1991). The effects of cyclodextrins on drug release from fatty suppository bases: I. In vitro observations. European Journal of Pharmaceutics and Biopharmaceutics, 37(3), 178-182.
Frijlink, H. W., Eissens, A., Schoonen, A., & Lerk, C. F. (1991). The effects of cyclodextrins on drug release from fatty suppository bases: II. In vivo observations. European Journal of Pharmaceutics and Biopharmaceutics, 37(3), 183-187.
Frijlink, H. W., Franssen, E. J., Eissens, A., Oosting, R., Lerk, C. F., & Meijer, D. K. (1991). The effects of cyclodextrins on the disposition of intravenously injected drugs in the rat. Pharmaceutical Research, 8(3), 380-384. DOI: 10.1023/A:1015857902238
Frijlink, H. W., Eissens, A., Hefting, N. R., Poelstra, K., Lerk, C. F., & Meijer, D. K. F. (1991). The effect of parenterally administered cyclodextrins on cholesterol levels in the rat. Pharmaceutical Research, 8(1), 9-16. DOI: 10.1023/A:1015861719134

1990

Frijlink, H. W., Visser, J., Hefting, N. R., Oosting, R., Meijer, D. K. F., & Lerk, C. F. (1990). The pharmacokinetics of β-cyclodextrin and hydroxypropyl-β-cyclodextrin in the rat. Pharmaceutical Research, 7(12), 1248-1252. DOI: 10.1023/A:1015929720063
Frijlink, H. W., Eissens, A., Schoonen, A. J. M., & Lerk, C. F. (1990). The effects of cyclodextrins on drug absorption. II. In vivo observations. International Journal of Pharmaceutics, 64(2-3), 195-205. DOI: 10.1016/0378-5173(90)90269-A
Woerdenbag, H. J., Van Uden, W., Frijlink, H. W., Lerk, C. F., Pras, N., & Malingre, T. M. (1990). Increased podophyllotoxin production in Podophyllum hexandrum cell suspension cultures after feeding coniferyl alcohol as a β-cyclodextrin complex. Planta Medica, 56(6), 631. DOI: 10.1007/BF00231558
FRIJLINK, H. W., EISSENS, A. C., SCHOONEN, A. J. M., & LERK, C. F. (1990). THE EFFECTS OF CYCLODEXTRINS ON DRUG ABSORPTION .2. INVIVO OBSERVATIONS. International Journal of Pharmaceutics, 64(2-3), 195-205.
WOERDENBAG, H. J., VANUDEN, W., FRIJLINK, H. W., LERK, C. F., PRAS, N., & MALINGRE, T. M. (1990). INCREASED PODOPHYLLOTOXIN PRODUCTION IN PODOPHYLLUM-HEXANDRUM CELL-SUSPENSION CULTURES AFTER FEEDING CONIFERYL ALCOHOL AS A BETA-CYCLODEXTRIN COMPLEX. Plant Cell Reports, 9(2), 97-100.
Woerdenbag, H. J., van Uden, W., Frijlink, H. W., Lerk, C. F., Pras, N., & Malingré, T. M. (1990). Increased podophyllotoxin production in Podophyllum hexandrum cell suspension cultures after feeding coniferyl alcohol as a β-cyclodextrin complex. Plant Cell Reports, 9(2), 97-100. DOI: 10.1007/BF00231558
Woerdenbag, H. J., Pras, N., Frijlink, H. W., Lerk, C. F., & Malingré, T. M. (1990). Cyclodextrin-facilitated bioconversion of 17 beta-estradiol by a phenoloxidase from Mucuna pruriens cell cultures. Phytochemistry, 29(5), 1551-1554.
Frijlink, H. W. (1990). Biopharmaceutical aspects of cyclodextrins Groningen: Rijksuniversiteit Groningen/CPS

1989

Bootsma, H. P. R., Frijlink, H. W., Eissens, A., Proost, J. H., Van Doorne, H., & Lerk, C. F. (1989). β-Cyclodextrin as an excipient in solid oral dosage forms: In vitro and in vivo evaluation of spray-dried diazepam-β-cyclodextrin products. International Journal of Pharmaceutics, 51(3), 213-223. DOI: 10.1016/0378-5173(89)90194-4
FRIJLINK, H. W., SCHOONEN, A. J. M., & LERK, C. F. (1989). THE EFFECTS OF CYCLODEXTRINS ON DRUG ABSORPTION .1. INVITRO OBSERVATIONS. International Journal of Pharmaceutics, 49(2), 91-102.
Frijlink, H. W., Schoonen, A. J. M., & Lerk, C. F. (1989). The effects of cyclodextrins on drugs absorption. I. In vitro observations. International Journal of Pharmaceutics, 49(2), 91-102. DOI: 10.1016/0378-5173(89)90106-3

1987

FRIJLINK, H. W., VISSER, J., & DRENTH, B. F. H. (1987). DETERMINATION OF CYCLODEXTRINS IN BIOLOGICAL-FLUIDS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH NEGATIVE COLORIMETRIC DETECTION USING POSTCOLUMN COMPLEXATION WITH PHENOLPHTHALEIN. Journal of chromatography-Biomedical applications, 415(2), 325-333.
Frijlink, H. W., Visser, J., & Drenth, B. F. H. (1987). Determination of cyclodextrins in biological fluids by high-performance liquid chromatography with negative colorimetric detection using post-column complexation with phenolphthalein. Journal of Chromatography A, 415(2), 325-333.
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