In the palm of your hand: prevalence, disease patterns and natural course of Dupuytren disease
|PhD ceremony:||Ms R. (Rosanne) Lanting|
|When:||December 17, 2014|
|Supervisors:||prof. dr. P.M.N. (Paul) Werker, E.R. van den Heuvel|
|Where:||Academy building RUG|
|Faculty:||Medical Sciences / UMCG|
Dupuytren Disease (DD) affects the palmar fascias of the hand and fingers and causes nodules and cords. Eventually this can lead to an extension deficit of the affected fingers. At present, it is impossible to cure or prevent DD.
The estimated prevalence of DD in the general population of Western countries is 0.6-31.6%. Furthermore, the prevalence of DD in The Netherlands is 22.1% in the general population of people older than 50 years. The prevalence of the disease increases with age, and males are more often affected than females. Other significant risk factors for DD include excessive alcohol consumption, previous hand injury, familial occurrence of DD, and presence of Ledderhose disease.
DD affects fingers in a variable fashion, and knowledge about specific disease patterns based on location and severity of the disease was lacking. The ring finger is most frequently affected. In addition, the disease occurs often simultaneously in the following fingers: thumb and index finger; middle and ring finger; and the middle and little finger.
The course of DD differs per person. We investigated the short term disease course every 3-6 months during 1.5 years in 247 patients with DD. The results show that the disease increases in some patients, but is stable in the majority of participants during 1.5 years. There is also a group of patients whose disease improved over time.