Dijkhuizen, Prof. Lubbert
Lubbert Dijkhuizen (1951) is professor of Microbiology. He initiated many research projects into life processes in micro-organisms and relevant industrial and other applications of this fundamental knowledge. The main focus in this research is on the ability to use micro-organisms and enzymes in biotechnological processes, in particular in the conversion of carbohydrates. Dijkhuizen's research also focuses on tuberculosis.
Dijkhuizen is one of the initiators and joint founders of the Carbohydrate Competence Center (CCC), a public-private cooperation among 19 businesses and 6 knowledge institutions. Research is being conducted in 24 projects (total value € 28 million) on carbohydrates that play an important role in Nutrition and Health. The Dagblad van het Noorden has written an overview article about the CCC's research and its implications for healthy nutrition, for example.
Dijkhuizen has thus far supervised over 55 PhD students and written over 300 international scientific publications. His research is internationally renowned and is so fruitful that he is always able to acquire the necessary funds. He has a good eye for the possible products and processes that his research may yield. This has resulted, for example, in his being mentioned as the inventor or joint inventor in 25 patents and about 75% of his research group being financed by external funds, mainly by industrial parties. In late 2010, Dijkhuizen and his colleague Dijkstra caused an international stir with an article in PNAS about a possible solution to prevent caries. In 2012 Dijkhuizen was nominated as one of the three most enterprising researchers of The Netherlands. the same year, Dijkhuizen's CCC announced a breakthrough in carbohydrate research, as a result of which, among other things, French Fries can be made healthier.
Previously in the news
- Frisdrankfles uit suikerbiet (in Dutch)
- Breakthrough in research healthy French Fries (in Dutch)
- Breakthrough in dental plaque research
- Glucansucrase designated as Molecule of the Month by the Protein Data Bank (PDB)
- Groningen launches research centre for synthetic biology
Publications
2019
Valk-Weeber,
R. L., Eshuis-de Ruiter, T., Dijkhuizen, L., & van
Leeuwen, S. VAN. (2020). Dynamic temporal variations in
bovine lactoferrin glycan structures. Journal of
Agricultural and Food Chemistry, 68(2),
549-560. [acs.jafc.9b06762]. https://doi.org/10.1021/acs.jafc.9b06762
Boger,
M., van Leeuwen, S. S., van Bueren, A. L., & Dijkhuizen,
L. (2019). Structural Identity of
Galactooligosaccharide Molecules Selectively Utilized by Single
Cultures of Probiotic Bacterial Strains. Journal
of Agricultural and Food Chemistry, 67(50),
13969-13977. https://doi.org/10.1021/acs.jafc.9b05968
Valk-Weeber,
R. L., Dijkhuizen, L., & van Leeuwen, S. S.
(2019). Large-scale quantitative isolation of pure protein
N-linked glycans. Carbohydrate
Research, 479, 13-22. https://doi.org/10.1016/j.carres.2019.04.011
Pham,
H., Ten Kate, G. A., Dijkhuizen, L., & van
Leeuwen, S. S. (2019). Synthesis and characterization of
sialylated lactose- and lactulose-derived oligosaccharides by
Trypanosoma cruzi trans-sialidase. Journal of
Agricultural and Food Chemistry, 67(12),
3469–3479. https://doi.org/10.1021/acs.jafc.8b06974
Devlamynck,
T., Te Poele, E. M., Quataert, K., Gerwig, G.
J., Van de Walle, D., Dewettinck, K., ... Dijkhuizen,
L. (2019). Trans-α-glucosylation of stevioside by
the mutant glucansucrase enzyme Gtf180-ΔN-Q1140E improves its
taste profile. Food Chemistry,
272, 653-662. https://doi.org/10.1016/j.foodchem.2018.08.025
Böger,
M., Hekelaar, J., van Leeuwen, S. S.,
Dijkhuizen, L., & Lammerts van Bueren, A. (2019).
Structural and functional characterization of a family GH53
β-1,4-galactanase from Bacteroides thetaiotaomicron that
facilitates degradation of prebiotic
galactooligosaccharides. Journal of Structural
Biology, 205(1), 1-10. [j.jsb.2018.12.002]. https://doi.org/10.1016/j.jsb.2018.12.002
2020
Kittibunchakul,
S., van Leeuwen, S. S., Dijkhuizen, L., Haltrich, D.,
& Nguyen, T-H. (2020). Structural comparison of different
galacto-oligosaccharides mixtures formed by β-galactosidases
from lactic acid bacteria and bifidobacteria.
Journal of Agricultural and Food Chemistry.
https://doi.org/10.1021/acs.jafc.9b08156
2018
Pham,
H. T. T., Boger, M. C. L., Dijkhuizen, L., & van
Leeuwen, S. S. (2019). Stimulatory effects of novel
glucosylated lactose derivatives GL34 on growth of selected gut
bacteria. Applied Microbiology and
Biotechnology, 103(2), 707-718. https://doi.org/10.1007/s00253-018-9473-8
Gangoiti,
J., Corwin, S. F., Lamothe, L. M., Vafiadi, C., Hamaker, B.
R., & Dijkhuizen, L. (2018). Synthesis of
novel α-glucans with potential health benefits through
controlled glucose release in the human gastrointestinal
tract. Critical Reviews in Food Science and
Nutrition. https://doi.org/10.1080/10408398.2018.1516621
Pham,
H. T., Dijkhuizen, L., & van Leeuwen, S. S.
(2018). Structural characterization of glucosylated GOS
derivatives synthesized by the Lactobacillus reuteri GtfA and
Gtf180 glucansucrase enzymes. Carbohydrate
Research, 470, 57-63. https://doi.org/10.1016/j.carres.2018.10.003
Pham,
H., Pijning, T., Dijkhuizen, L., &
van Leeuwen, S. S. (2018). Mutational Analysis of the Role of
the Glucansucrase Gtf180-Delta N Active Site Residues in Product
and Linkage Specificity with Lactose as Acceptor Substrate.
Journal of Agricultural and Food Chemistry,
66(47), 12544-12554. [acs.jafc.8b04486]. https://doi.org/10.1021/acs.jafc.8b04486
van
Leeuwen, S. S., Stoutjesdijk, E., ten Kate, G. A., Schaafsma,
A., Dijck-Brouwer, J., Muskiet, F. A. J., &
Dijkhuizen, L. (2018). Regional variations in human
milk oligosaccharides in Vietnam suggest FucTx activity besides
FucT2 and FucT3. Scientific Reports,
8(1), [16790]. https://doi.org/10.1038/s41598-018-34882-x
Boger,
M. C. L., van Bueren, A. L., & Dijkhuizen, L.
(2018). Cross-Feeding among Probiotic Bacterial Strains on
Prebiotic Inulin Involves the Extracellular exo-Inulinase of
Lactobacillus paracasei Strain W20. Applied and
environmental microbiology, 84(21),
[e01539-18]. https://doi.org/10.1128/AEM.01539-18
Gangoiti
Muñecas, J., van Leeuwen, S. S., Pijning,
T., Dijkhuizen, L., Vafeiadi, C., & Duboux,
S. (2018). Branched alpha glucans.
(Patent No. WO2018167032).
Meng,
X., Gangoiti, J., Wang, X., Grijpstra, P., van
Leeuwen, S. S., Pijning, T., & Dijkhuizen,
L. (2018). Biochemical characterization of a GH70
protein from Lactobacillus kunkeei DSM 12361 with two catalytic
domains involving branching sucrase activity.
Applied Microbiology and Biotechnology,
102(18), 7935-7950. https://doi.org/10.1007/s00253-018-9236-6
Yin,
H., Dijkhuizen, L., & van Leeuwen, S. (2018).
Synthesis of galacto-oligosaccharides derived from lactulose
by wild-type and mutant β-galactosidase enzymes from Bacillus
circulans ATCC 31382. Carbohydrate
Research, 465, 58-65. [j.carres.2018.06.009].
https://doi.org/10.1016/j.carres.2018.06.009
Meng,
X., Gangoiti, J., de Kok, N., van Leeuwen, S.
S., Pijning, T., & Dijkhuizen, L.
(2018). Biochemical characterization of two GH70 family
4,6-α-glucanotransferases with distinct product specificity
from Lactobacillus aviarius subsp. aviarius DSM 20655.
Food Chemistry, 253, 236-246.
[j.foodchem.2018.01.154]. https://doi.org/10.1016/j.foodchem.2018.01.154
Lammerts
van Bueren-Brandt, A., & Dijkhuizen, L.
(2018). Prebiotic branched
galacto-oligosaccharides (gos). (Patent No.
WO2018048305).
Te
Poele, E. M., Devlamynck, T., Jäger, M., Gerwig,
G. J., Van de Walle, D., Dewettinck, K., ...
Dijkhuizen, L. (2018). Glucansucrase (mutant) enzymes
from Lactobacillus reuteri 180 efficiently transglucosylate Stevia
component rebaudioside A, resulting in a superior taste.
Scientific Reports, 8(1), [1516]. https://doi.org/10.1038/s41598-018-19622-5
2017
Gangoiti,
J., Pijning, T., & Dijkhuizen, L.
(2018). Biotechnological potential of novel glycoside
hydrolase family 70 enzymes synthesizing α-glucans from starch
and sucrose. Biotechnology Advances,
36, 196-207. https://doi.org/10.1016/j.biotechadv.2017.11.001
Figueroa-Lozano,
S., Valk-Weeber, R. L., van Leeuwen, S. S.,
Dijkhuizen, L., & de Vos, P. (2018).
Dietary N-glycans from Bovine Lactoferrin and TLR
Modulation. Molecular Nutrition & Food
Research, 62(2), [1700389]. https://doi.org/10.1002/mnfr.201700389
Ceniceros,
A., Dijkhuizen, L., & Petrusma, M. (2017).
Molecular characterization of a Rhodococcus jostii RHA1
γ-butyrolactone(-like) signalling molecule and its main
biosynthesis gene gblA. Scientific
Reports, 7(1), 1-13. [17743]. https://doi.org/10.1038/s41598-017-17853-6
Dijkhuizen,
L., Gangoiti Muñecas, J., van Leeuwen, S. S., Vafeiadi,
C., & Duboux, S. (2017). Alpha
glucans. (Patent No. WO2017207663).
Pham,
H. T. T., Dijkhuizen, L., & van Leeuwen, S. S.
(2017). Structural characterization of glucosylated lactose
derivatives synthesized by the Lactobacillus reuteri GtfA and
Gtf180 glucansucrase enzymes. Carbohydrate
Research, 449, 59-64. https://doi.org/10.1016/j.carres.2017.07.002
Gangoiti,
J., van Leeuwen, S. S., Meng, X., Duboux, S., Vafiadi, C.,
Pijning, T., & Dijkhuizen, L. (2017).
Mining novel starch-converting Glycoside Hydrolase 70 enzymes
from the Nestlé Culture Collection genome database: The
Lactobacillus reuteri NCC 2613 GtfB. Scientific
Reports, 7(1), [9947]. https://doi.org/10.1038/s41598-017-07190-z
Ceniceros,
A., Dijkhuizen, L., Petrusma, M., & Medema, M. H.
(2017). Genome-based exploration of the specialized metabolic
capacities of the genus Rhodococcus. BMC
Genomics, 18(1), 1-16. [593]. https://doi.org/10.1186/s12864-017-3966-1
Frasch,
H-J., Leeuwen, S. S. V., & Dijkhuizen, L. (2017).
Molecular and biochemical characteristics of the inulosucrase
HugO from Streptomyces viridochromogenes DSM40736
(Tü494). Microbiology-Reading,
163(7), 1030-1041. https://doi.org/10.1099/mic.0.000493
Montersino,
S., te Poele, E., Orru, R., Westphal, A. H.,
Barendregt, A., Heck, A. J. R., ... van Berkel, W. J. H. (2017).
3-Hydroxybenzoate 6-Hydroxylase from Rhodococcus jostii RHA1
Contains a Phosphatidylinositol Cofactor.
Frontiers in Microbiology, 8, 1-11.
[1110]. https://doi.org/10.3389/fmicb.2017.01110
Yin,
H., Bultema, J. B., Dijkhuizen, L., & van Leeuwen,
S. S. (2017). Reaction kinetics and galactooligosaccharide
product profiles of the β-galactosidases from Bacillus
circulans, Kluyveromyces lactis and Aspergillus oryzae.
Food Chemistry, 225, 230-238.
[j.foodchem.2017.01.030]. https://doi.org/10.1016/j.foodchem.2017.01.030
Gangoiti,
J., Lamothe, L., van Leeuwen, S. S., Vafiadi, C., &
Dijkhuizen, L. (2017). Characterization of the
Paenibacillus beijingensis DSM 24997 GtfD and its glucan polymer
products representing a new glycoside hydrolase 70 subfamily of
4,6-α-glucanotransferase enzymes. PLoS
ONE, 12(4), [e0172622]. https://doi.org/10.1371/journal.pone.0172622
Gangoiti
Muñecas, J., van Leeuwen, S. S., Dijkhuizen, L.,
Vafeiadi, C., & Lamothe, L. (2017). Branched alpha glucans. (Patent No.
WO2017046040).
te
Poele, E. M., Valk, V., Devlamynck, T., van Leeuwen, S.
S., & Dijkhuizen, L. (2017). Catechol
glucosides act as donor/acceptor substrates of glucansucrase
enzymes of Lactobacillus reuteri. Applied
Microbiology and Biotechnology, 101(11),
4495-4505. https://doi.org/10.1007/s00253-017-8190-z
Meng,
X., Pijning, T., Tietema, M., Dobruchowska, J. M.,
Yin, H., Gerwig, G. J., ... Dijkhuizen,
L. (2017). Characterization of the glucansucrase
GTF180 W1065 mutant enzymes producing polysaccharides and
oligosaccharides with altered linkage composition.
Food Chemistry, 217, 81-90. https://doi.org/10.1016/j.foodchem.2016.08.087
Gerwig,
G. J., Te Poele, E. M., Dijkhuizen,
L., & Kamerling, J. P. (2017). Structural analysis
of rebaudioside A derivatives obtained by Lactobacillus reuteri 180
glucansucrase-catalyzed trans-α-glucosylation.
Carbohydrate Research, 440-441,
51-62. https://doi.org/10.1016/j.carres.2017.01.008
Yin,
H., Pijning, T., Meng, X., Dijkhuizen,
L., & van Leeuwen, S. S. (2017). Engineering of
the Bacillus circulans β-galactosidase product
specificity. Biochemistry,
56(5), 704-711. https://doi.org/10.1021/acs.biochem.7b00032
Lammerts
van Bueren, A., Mulder, M., Leeuwen, S. V., &
Dijkhuizen, L. (2017). Prebiotic
galactooligosaccharides activate mucin and pectic galactan
utilization pathways in the human gut symbiont Bacteroides
thetaiotaomicron. Scientific Reports,
7, 1-13. [40478]. https://doi.org/10.1038/srep40478
Gangoiti
Muñecas, J., van Leeuwen, S. S., Gerwig, G. J.,
Duboux, S., Vafiadi, C., Pijning, T., &
Dijkhuizen, L. (2017). 4,3-α-Glucanotransferase,
a novel reaction specificity in glycoside hydrolase family 70 and
clan GH-H. Scientific Reports,
7, 1-15. [39761]. https://doi.org/10.1038/srep39761
Sarian,
F. D., Janeček, Š., Pijning, T., Ihsanawati,
Nurachman, Z., Radjasa, O. K., ... van der Maarel, M. J. E.
C. (2017). A new group of glycoside hydrolase family
13 α-amylases with an aberrant catalytic triad.
Scientific Reports, 7, [44230]. https://doi.org/10.1038/srep44230
Yin,
H., Pijning, T., Meng, X., Dijkhuizen,
L., & van Leeuwen, S. S. (2017). Biochemical
characterization of the functional roles of residues in the active
site of the β-galactosidase from Bacillus circulans ATCC
31382. Biochemistry, 56(24),
3109-3118. https://doi.org/10.1021/acs.biochem.7b00207
Gangoiti
Muñecas, J., Meng, X., Lamerts van Bueren,
A., & Dijkhuizen, L. (2017). Draft
Genome Sequence of Lactobacillus reuteri 121, a Source of
α-Glucan and β-Fructan Exopolysaccharides.
Genome Announcements, 5(10), 1-2.
[e01691-16]. https://doi.org/10.1128/genomeA.01691-16
2016
Bai,
Y., Gangoiti , J., Dijkstra, B. W., Dijkhuizen,
L., & Pijning, T. (2017). Crystal
Structure of 4,6-α-Glucanotransferase Supports Diet-Driven
Evolution of GH70 Enzymes from α-Amylases in Oral
Bacteria. Structure, 25(2),
231-242. https://doi.org/10.1016/j.str.2016.11.023
Dobruchowska,
J. M., Jonsson, J. O., Fridjonsson, O. H., Aevarsson, A.,
Kristjansson, J. K., Altenbuchner, J., ... Hreggvidsson, G. O.
(2016). Modification of linear (β1→3)-linked
gluco-oligosaccharides with a novel recombinant
β-glucosyltransferase (trans-β-glucosidase) enzyme from
Bradyrhizobium diazoefficiens.
Glycobiology, 26(11), 1157-1170. https://doi.org/10.1093/glycob/cww074
Valk,
V., van der Kaaij, R. M., & Dijkhuizen,
L. (2016). Characterization of the starch-acting
MaAmyB enzyme from Microbacterium aurum B8.A representing the novel
subfamily GH13_42 with an unusual, multi-domain
organization. Scientific Reports,
6, 1-12. [srep36100]. https://doi.org/10.1038/srep36100
te
Poele, E. M., Dijkhuizen, L., Gerwig, G.
J., & Kamerling, J. P. (2016). Methods for the enzymatic modification of steviol
glycosides, modified steviol glycosides obtainable thereby, and the
use thereof as sweeteners. (Patent No.
WO2016144175).
Pijning,
T., Bai, Y., Gangoiti Muñecas, J., &
Dijkhuizen, L. (2016). Crystal Structure of a
4,6-α-Glucanotransferase Supports Diet-Driven Evolution of
GH70 Enzymes from α-Amylases in Oral Bacteria.
Poster session presented at ALAMY, Smolenice, Slovakia.
Devlamynck,
T., Te Poele, E. M., Meng, X., van Leeuwen, S.
S., & Dijkhuizen, L. (2016). Glucansucrase
Gtf180-Delta N of Lactobacillus reuteri 180: enzyme and reaction
engineering for improved glycosylation of non-carbohydrate
molecules. Applied Microbiology and
Biotechnology, 100(17), 7529-7539. https://doi.org/10.1007/s00253-016-7476-x
Figueroa,
S., Dijkhuizen, L., Valk, R., van Leeuwen, S., &
de Vos, P. (2016). Dietary N- and O-glycans from cow milk and
TLR modulation. European Journal of
Immunology, 46, 479-479.
Meng,
X., Gangoiti, J., Bai, Y., Pijning, T., Van Leeuwen,
S. S., & Dijkhuizen, L. (2016).
Structure-function relationships of family GH70 glucansucrase
and 4,6-α-glucanotransferase enzymes, and their evolutionary
relationships with family GH13 enzymes. Cellular
and molecular life sciences, 73(14),
2681-2706. https://doi.org/10.1007/s00018-016-2245-7
Valk,
V., Lammerts van Bueren, A., van der Kaaij, R.
M., & Dijkhuizen, L. (2016).
Carbohydrate Binding Module 74 is a novel starch binding
domain associated with large and multi-domain α-amylase
enzymes. Febs Journal,
283(12), 2354-2368. [13745]. https://doi.org/10.1111/febs.13745
Gangoiti,
J., van Leeuwen, S. S., Vafiadi, C., & Dijkhuizen,
L. (2016). The gram-negative bacterium Azotobacter
chroococcum NCIMB 8003 employs a new glycoside hydrolase family 70
4,6-α-glucanotransferase enzyme (GtfD) to synthesize a
reuteran like polymer from maltodextrins and starch.
Biochimica et biophysica acta,
1860(6), 1224-1236. https://doi.org/10.1016/j.bbagen.2016.02.005
van
Leeuwen, S. S., Kuipers, B. J. H., Dijkhuizen, L.,
& Kamerling, J. P. (2016). Comparative structural
characterization of 7 commercial galacto-oligosaccharide (GOS)
products. Carbohydrate Research,
425, 48-58. https://doi.org/10.1016/j.carres.2016.03.006
Te
Poele, E. M., Grijpstra, P., van Leeuwen, S.
S., & Dijkhuizen, L. (2016). Glucosylation
of catechol with the GTFA glucansucrase enzyme from Lactobacillus
reuteri and sucrose as donor substrate.
BIOCONJUGATE CHEMISTRY, 27(4),
937-946. https://doi.org/10.1021/acs.bioconjchem.6b00018
van
Leeuwen, S. S., Kuipers, B. J. H., Dijkhuizen, L.,
& Kamerling, J. P. (2016). Corrigendum to “1H NMR
analysis of the lactose/β-galactosidase-derived
galacto-oligosaccharide components of Vivinal® GOS up to
DP5” [Carbohydr. Res. 400 (2014) 59–73].
Carbohydrate Research, 419, 69-70.
https://doi.org/10.1016/j.carres.2015.12.004
Bai,
Y., Böger, M., van der Kaaij, R. M.,
Woortman, A. J. J., Pijning, T., van Leeuwen,
S. S., ... Dijkhuizen, L. (2016). Lactobacillus
reuteri strains convert starch and maltodextrins into
homo-exopolysaccharides using an extracellular and cell-associated
4,6-α-glucanotransferase. Journal of
Agricultural and Food Chemistry, 64(14),
2941-2952. https://doi.org/10.1021/acs.jafc.6b00714
Gerwig,
G. J., Te Poele, E. M., Dijkhuizen,
L., & Kamerling, J. P. (2016). Stevia Glycosides:
Chemical and Enzymatic Modifications of Their Carbohydrate Moieties
to Improve the Sweet-Tasting Quality. Advances in
carbohydrate chemistry and biochemistry, 73,
1-72. https://doi.org/10.1016/bs.accb.2016.05.001
Bai,
Y., Dobruchowska, J. M., van der Kaaij, R. M.,
Gerwig, G. J., & Dijkhuizen, L. (2016).
Structural basis for the roles of starch and sucrose in
homo-exopolysaccharide formation by Lactobacillus reuteri
35-5. Carbohydrate Polymers,
151, 29-39. https://doi.org/10.1016/j.carbpol.2016.05.048
Meng,
X., Pijning, T., Dobruchowska, J. M., Yin, H.,
Gerwig, G. J., & Dijkhuizen, L. (2016).
Structural determinants of alternating
(α1 → 4) and (α1 → 6)
linkage specificity in reuteransucrase of Lactobacillus
reuteri. Scientific Reports,
6, [35261]. https://doi.org/10.1038/srep35261
2015
Meng,
X., Dobruchowska, J. M., Pijning, T., Gerwig, G.
J., & Dijkhuizen, L. (2016).
Synthesis of New Hyper-Branched α-Glucans from Sucrose
by Lactobacillus reuteri 180 Glucansucrase Mutants.
Journal of Agricultural and Food Chemistry,
64(2), 433-442. https://doi.org/10.1021/acs.jafc.5b05161
Meng,
X., Pijning, T., Dobruchowska, J. M., Gerwig, G.
J., & Dijkhuizen, L. (2015).
Characterization of the functional roles of amino acid
residues in acceptor binding subsite +1 in the active site of the
glucansucrase GTF180 enzyme of Lactobacillus reuteri 180.
The Journal of Biological Chemistry,
290(50), 30131-30141. https://doi.org/10.1074/jbc.M115.687558
Aalbers,
F., Turkenburg, J. P., Davies, G. J., Dijkhuizen,
L., & Lammerts van Bueren, A. (2015).
Structural and Functional Characterization of a Novel Family
GH115 4-O-Methyl-α-Glucuronidase with Specificity for
Decorated Arabinogalactans. Journal of Molecular
Biology, 427(24), 3935-3946. https://doi.org/10.1016/j.jmb.2015.07.006
Gangoiti,
J., Pijning, T., & Dijkhuizen, L.
(2015). The Exiguobacterium sibiricum 255-15 GtfC enzyme
representing a novel glycoside hydrolase 70 subfamily of
4,6-α-glucanotransferase enzymes. Applied and
environmental microbiology, 82(2), 756-766.
[AEM.03420-15]. https://doi.org/10.1128/AEM.03420-15
Meng,
X., Dobruchowska, J. M., Gerwig, G. J., Kamerling, J.
P., & Dijkhuizen, L. (2015). Synthesis of
oligo- and polysaccharides by Lactobacillus reuteri 121
reuteransucrase at high concentrations of sucrose.
Carbohydrate Research, 414, 85-92.
https://doi.org/10.1016/j.carres.2015.07.011
Dijkhuizen,
L., van der Maarel, M., Kamerling, H.,
Leemhuis, H., Kralj, S., & Dobruchowska, J. (2015). IPC No.
C12P 19/ 04 A I. Gluco-oligosaccharides
comprising (alpha 1-->4) and (alpha 1-->6) glycosidic bonds,
use thereof, and methods for providing them. (Patent No.
BRPI1011572).
Paul,
C. J., Leemhuis, H., Dobruchowska, J. M., Grey, C., Onnby, L., van
Leeuwen, S. S., ... Karlsson, E. N. (2015). A GH57
4-alpha-glucanotransferase of hyperthermophilic origin with
potential for alkyl glycoside production. Applied
Microbiology and Biotechnology, 99(17),
7101-7113. https://doi.org/10.1007/s00253-015-6435-2
Bai,
Y., van der Kaaij, R. M., Leemhuis, H., Pijning,
T., van Leeuwen, S. S., Jin, Z., & Dijkhuizen,
L. (2015). Biochemical characterization of
Lactobacillus reuteri Glycoside Hydrolase family 70 GTFB type of
4,6-α-Glucanotransferase enzymes that synthesize soluble
dietary starch fibers. Applied and environmental
microbiology, 81(20), 7223-7232. https://doi.org/10.1128/AEM.01860-15
Valk,
V., Eeuwema, W., Sarian, F. D., van der Kaaij, R.
M., & Dijkhuizen, L. (2015).
Degradation of granular starch by the bacterium
Microbacterium aurum B8.A involves a novel modular α-amylase
enzyme system with FNIII and CBM25 domains.
Applied and environmental microbiology,
81(19), 6610-6620. https://doi.org/10.1128/AEM.01029-15
Wilbrink,
M. H., Ten Kate, G. A., Sanders, P., Gerwig, G.
J., van Leeuwen, S. S., Sallomons, E., ... Kamerling, J. P.
(2015). Enzymatic Decoration of Prebiotic
Galacto-oligosaccharides (Vivinal® GOS) with Sialic Acid using
Trypanosoma cruzi Trans-Sialidase and Two Bovine
Sialoglycoconjugates as Donor Substrates. Journal
of Agricultural and Food Chemistry, 63(25),
5976-5984. https://doi.org/10.1021/acs.jafc.5b01505
Meng,
X., Dobruchowska, J. M., Pijning, T., Gerwig, G.
J., Kamerling, J. P., & Dijkhuizen, L.
(2015). Truncation of domain V of the multidomain
glucansucrase GTF180 of Lactobacillus reuteri 180 heavily impairs
its polysaccharide-synthesizing ability. Applied
Microbiology and Biotechnology, 99(14),
5885-5894. https://doi.org/10.1007/s00253-014-6361-8
Bai,
Y., van der Kaaij, R. M., Woortman, A. J.
J., Jin, Z., & Dijkhuizen, L. (2015).
Characterization of the 4,6-α-glucanotransferase GTFB
enzyme of Lactobacillus reuteri 121 isolated from inclusion
bodies. BMC Biotechnology,
15, [49]. https://doi.org/10.1186/s12896-015-0163-7
van
Munster, J. M., Sanders, P., ten Kate, G. A.,
Dijkhuizen, L., & van der Maarel, M. J. E.
C. (2015). Kinetic characterization of Aspergillus
niger chitinase CfcI using a HPAEC-PAD method for native chitin
oligosaccharides. Carbohydrate
Research, 407, 73-78. https://doi.org/10.1016/j.carres.2015.01.014
Lammerts
van Bueren, A., Saraf, A., Martens, E. C., &
Dijkhuizen, L. (2015). Differential metabolism of
Exopolysaccharides from probiotic Lactobacilli by the human gut
symbiont Bacteroides thetaiotaomicron. Applied and
environmental microbiology, 81(12), 3973-3983.
https://doi.org/10.1128/AEM.00149-15
van
Munster, J. M., Dobruchowska, J. M., Veloo, R., Dijkhuizen,
L., & van der Maarel, M. J. E. C. (2015).
Characterization of the starvation-induced chitinase CfcA and
α-1,3-glucanase AgnB of Aspergillus niger.
Applied Microbiology and Biotechnology,
99, 2209-2223. https://doi.org/10.1007/s00253-014-6062-3
van
Munster, J. M., Nitsche, B. M., Akeroyd, M., Dijkhuizen,
L., van der Maarel, M. J. E. C., & Ram, A.
F. J. (2015). Systems Approaches to Predict the Functions of
Glycoside Hydrolases during the Life Cycle of Aspergillus niger
Using Developmental Mutants ∆brlA and ∆flbA.
PLoS ONE, 10(1), [e0116269]. https://doi.org/10.1371/journal.pone.0116269
2014
Venkataraman,
H., Te Poele, E. M., Rosłoniec, K. Z., Vermeulen,
N., Commandeur, J. N. M., van der Geize, R., &
Dijkhuizen, L. (2015). Biosynthesis of a steroid
metabolite by an engineered Rhodococcus erythropolis strain
expressing a mutant cytochrome P450 BM3 enzyme.
Applied Microbiology and Biotechnology,
99(11), 4713-4721. https://doi.org/10.1007/s00253-014-6281-7
Leemhuis,
H., Dobruchowska, J. M., Ebbelaar, M., Faber, F., Buwalda, P.
L., van der Maarel, M. J. E. C., ... Dijkhuizen,
L. (2014). Isomalto/Malto-polysaccharide, a novel
soluble dietary fiber made via enzymatic conversion of
starch. Journal of Agricultural and Food
Chemistry, 62(49), 12034-12044. https://doi.org/10.1021/jf503970a
van
Leeuwen, S. S., Kuipers, B. J. H., Dijkhuizen, L.,
& Kamerling, J. P. (2014). Development of a H-1 NMR
structural-reporter-group concept for the analysis of prebiotic
galacto-oligosaccharides of the [beta-D-Galp-(1 -> x)](n)-D-Glcp
type. Carbohydrate Research,
400, 54-58. https://doi.org/10.1016/j.carres.2014.08.011
van
Leeuwen, S. S., Kuipers, B. J. H., Dijkhuizen, L.,
& Kamerling, J. P. (2014). H-1 NMR analysis of the
lactose/beta-galactosidase-derived galacto-oligosaccharide
components of Vivinal (R) GOS up to DP5.
Carbohydrate Research, 400, 59-73.
https://doi.org/10.1016/j.carres.2014.08.012
Meng,
X., Dobruchowska, J. M., Pijning, T., Lopez-Bautista,
C., Kamerling, J. P., & Dijkhuizen, L. (2014).
Residue Leu(940) Has a Crucial Role in the Linkage and
Reaction Specificity of the Glucansucrase GTF180 of the Probiotic
Bacterium Lactobacillus reuteri 180. The Journal
of Biological Chemistry, 289(47), 32773-32782.
https://doi.org/10.1074/jbc.M114.602524
Jonsson
Wheat, J. O., Hreggvidsson, G. O., Fridjonsson, O. H.,
Dobruchowska, J. M., Kamerling, J. P., & Dijkhuizen,
L. (2014). Glucan branching enzymes and
their methods of use. (Patent No.
Netherlands).
Wilbrink,
M. H., ten Kate, G. A., van Leeuwen, S. S., Sanders,
P., Sallomons, E., Hage, J. A., ... Kamerling, J. P. (2014).
Galactosyl-Lactose Sialylation Using Trypanosoma cruzi
trans-Sialidase as the Biocatalyst and Bovine kappa-Casein-Derived
Glycomacropeptide as the Donor Substrate. Applied
and environmental microbiology, 80(19),
5984-5991. https://doi.org/10.1128/AEM.01465-14
van
Leeuwen, S. S., Schoemaker, R. J. W., Gerwig, G. J.,
van Leusen-van Kan, E. J. M., Dijkhuizen, L., &
Kamerling, J. P. (2014). Rapid milk group classification by
1H NMR analysis of Le and H epitopes in human milk oligosaccharide
donor samples. Glycobiology,
24(8), 728-739. https://doi.org/10.1093/glycob/cwu036
Petrusma,
M., van der Geize, R., & Dijkhuizen, L. (2014).
3-Ketosteroid 9 alpha-hydroxylase enzymes: Rieske non-heme
monooxygenases essential for bacterial steroid degradation.
Antonie Van Leeuwenhoek: International Journal of General
and Molecular Microbiology, 106(1), 157-172.
https://doi.org/10.1007/s10482-014-0188-2
Pijning,
T., Vujicic - Zagar, A., Kralj, S., Dijkhuizen,
L., & Dijkstra, B. W. (2014). Flexibility of
truncated and full-length glucansucrase GTF180 enzymes from
Lactobacillus reuteri 180. Febs
Journal, 281(9), 2159-2171. https://doi.org/10.1111/febs.12769
Bultema,
J. B., Kuipers, B. J. H., & Dijkhuizen, L. (2014).
Biochemical characterization of mutants in the active site
residues of the beta-galactosidase enzyme of Bacillus circulans
ATCC 31382. FEBS Open Bio,
4(1), 1015-1020. https://doi.org/10.1016/j.fob.2014.11.002
Hill,
P., Piel, J., Aris‑Brosou, S., Krištůfek, V.,
Boddy, C. N., & Dijkhuizen, L. (2014).
Habitat‑specific type I polyketide synthases in soils
and street sediments. Journal of Industrial
Microbiology & Biotechnology, 41(1),
75-85. https://doi.org/10.1007/s10295-013-1362-7
2013
Timm,
M., Goerl, J., Kraus, M., Kralj, S., Hellmuth, H., Beine, R., ...
Seibel, J. (2013). An Unconventional Glycosyl Transfer
Reaction: Glucansucrase GTFA Functions as an Allosyltransferase
Enzyme. ChemBioChem, 14(18),
2423-2426. https://doi.org/10.1002/cbic.201300392
Bokhove,
M., Claessen, D., de Jong, W., Dijkhuizen, L.,
Boekema, E. J., & Oostergetel, G. T. (2013). Chaplins of
Streptomyces coelicolor self-assemble into two distinct functional
amyloids. Journal of Structural
Biology, 184(2), 301-309. https://doi.org/10.1016/j.jsb.2013.08.013
van
Munster, J. M., Nitsche, B. M., Krijgsheld, P., van Wijk,
A., Dijkhuizen, L., Wösten, H. A.,
... van der Maarel, M. J. E. C. (2013). Chitinases
CtcB and CfcI modify the cell wall in sporulating aerial mycelium
of Aspergillus niger.
Microbiology-Sgm, 159(9), 1853-1867.
https://doi.org/10.1099/mic.0.067967-0
Dobruchowska,
J. M., Meng, X., Leemhuis, H., Gerwig, G. J.,
Dijkhuizen, L., & Kamerling, J. P. (2013).
Gluco-oligomers initially formed by the reuteransucrase
enzyme of Lactobacillus reuteri 121 incubated with sucrose and
malto-oligosaccharides. Glycobiology,
23(9), 1084-1096. https://doi.org/10.1093/glycob/cwt048
Leemhuis,
H., Pijning, T., Dobruchowska, J. M., van Leeuwen, S.
S., Kralj, S., Dijkstra, B. W., & Dijkhuizen, L.
(2013). Glucansucrases: Three-dimensional structures,
reactions, mechanism, alpha-glucan analysis and their implications
in biotechnology and food applications. Journal of
Biotechnology, 163(2), 250-272. https://doi.org/10.1016/j.jbiotec.2012.06.037
Li,
B., Dobruchowska, J. M., Gerwig, G. J.,
Dijkhuizen, L., & Kamerling, J. P. (2013).
Structural investigation of water-soluble polysaccharides
extracted from the fruit bodies of Coprinus comatus.
Carbohydrate Polymers, 91(1),
314-321. https://doi.org/10.1016/j.carbpol.2012.08.045
Puspasari,
F., Radjasa, O. K., Noer, A. S., Nurachman, Z., Syah, Y. M.,
van der Maarel, M., ... Janeček, Š. (2013).
Raw starch-degrading alpha-amylase from Bacillus aquimaris
MKSC 6.2: isolation and expression of the gene, bioinformatics and
biochemical characterization of the recombinant enzyme.
Journal of Applied Microbiology,
114(1), 108-120. https://doi.org/10.1111/jam.12025
Leemhuis,
H., Dijkman, W. P., Dobruchowska, J. M., Pijning,
T., Grijpstra, P., Kralj, S., ... Gerwig,
G. J. (2013). 4,6-alpha-Glucanotransferase activity
occurs more widespread in Lactobacillus strains and constitutes a
separate GH70 subfamily. Applied Microbiology and
Biotechnology, 97(1), 181-193. https://doi.org/10.1007/s00253-012-3943-1
2012
van
Leeuwen, S. S., Schoemaker, R. J. W., Timmer, C. J. A. M.,
Kamerling, J. P., & Dijkhuizen, L. (2012).
N- and O-Glycosylation of a Commercial Bovine Whey Protein
Product. Journal of Agricultural and Food
Chemistry, 60(51), 12553-12564. https://doi.org/10.1021/jf304000b
Wilbrink,
M. H., van der Geize, R., & Dijkhuizen, L. (2012).
Molecular characterization of Itp3 and Itp4, essential for
C24-branched chain sterol-side-chain degradation in Rhodococcus
rhodochrous DSM 43269.
Microbiology-Sgm, 158(12),
3054-3062. https://doi.org/10.1099/mic.0.059501-0
Pijning,
T., Vujicic-Zagar, A., Kralj, S., Dijkhuizen,
L., & Dijkstra, B. W. (2012). Structure of the
alpha-1,6/alpha-1,4-specific glucansucrase GTFA from Lactobacillus
reuteri 121. Acta Crystallographica Section F:
Structural Biology and Crystallization Communications,
68(12), 1448-1454. https://doi.org/10.1107/S1744309112044168
Jacobs,
A. A. C., Grommen, R., Hessels, G., Dijkhuizen, L.,
& van der Geize, R. (2012). Studies on a new candidate
vaccine for Rhodococcus equi infections in foals.
Tieraerztliche umschau, 67(10),
394-400.
Anwar,
M. A., Leemhuis, H., Pijning, T., Kralj, S., Dijkstra,
B. W., & Dijkhuizen, L. (2012). The role of
conserved inulosucrase residues in the reaction and product
specificity of Lactobacillus reuteri inulosucrase.
Febs Journal, 279(19), 3612-3621. https://doi.org/10.1111/j.1742-4658.2012.08721.x
van
Oosterwijk, N., Knol, J., Dijkhuizen, L., van der
Geize, R., & Dijkstra, B. W. (2012). Structure and
Catalytic Mechanism of 3-Ketosteroid-Delta 4-(5
alpha)-dehydrogenase from Rhodococcus jostii RHA1 Genome.
The Journal of Biological Chemistry,
287(37), 30975-30983. https://doi.org/10.1074/jbc.M112.374306
Diemer,
S. K., Svensson, B., Babol, L. N., Cockburn, D., Grijpstra,
P., Dijkhuizen, L., ... Ipsen, R. H. (2012).
Binding Interactions Between alpha-glucans from Lactobacillus
reuteri and Milk Proteins Characterised by Surface Plasmon
Resonance. Food Biophysics,
7(3), 220-226. https://doi.org/10.1007/s11483-012-9260-5
van
Leeuwen, S. S., Schoemaker, R. J. W., Timmer, C. J. A. M.,
Kamerling, J. P., & Dijkhuizen, L. (2012).
Use of Wisteria floribunda agglutinin affinity chromatography
in the structural analysis of the bovine lactoferrin N-linked
glycosylation. Biochimica et Biophysica
Acta-General Subjects, 1820(9), 1444-1455. https://doi.org/10.1016/j.bbagen.2011.12.014
van
Munster, J. M., van der Kaaij, R. M.,
Dijkhuizen, L., & van der Maarel, M. J. E.
C. (2012). Biochemical characterization of Aspergillus
niger Cfcl, a glycoside hydrolase family 18 chitinase that releases
monomers during substrate hydrolysis.
Microbiology-Sgm, 158(8), 2168-2179.
https://doi.org/10.1099/mic.0.054650-0
Desmet,
T., Soetaert, W., Bojarova, P., Kren, V., Dijkhuizen,
L., Eastwick-Field, V., ... Křen, V. (2012).
Enzymatic Glycosylation of Small Molecules: Challenging
Substrates Require Tailored Catalysts. Chemistry :
a European Journal, 18(35), 10786-10801. https://doi.org/10.1002/chem.201103069
Dijkhuizen,
L., van der Maarel, M., Kamerling, P. J.,
Leemhuis, J. G., Kralj, S., & Dobruchowska, J. (2012). IPC No.
C12P 19/ 00 A I. Glucooligasaccharides
comprising (ALPHA 1->4) and (ALPHA 1->6) glycosidic
bonds, use thereof, and methods for providing them. (Patent
No. US2012165290).
Leemhuis,
H., Pijning, T., Dobruchowska, J. M., Dijkstra, B.
W., & Dijkhuizen, L. (2012). Glycosidic bond
specificity of glucansucrases: on the role of acceptor substrate
binding residues. Biocatalysis and
Biotransformation, 30(3), 366-376. https://doi.org/10.3109/10242422.2012.676301
de
Jong, W., Vijgenboom, E., Dijkhuizen, L., Wosten, H.
A. B., & Claessen, D. (2012). SapB and the rodlins are
required for development of Streptomyces coelicolor in high
osmolarity media. FEMS Microbiology
Letters, 329(2), 154-159. https://doi.org/10.1111/j.1574-6968.2012.02517.x
Dobruchowska,
J. M., Gerwig, G. J., Kralj, S., Grijpstra,
P., Leemhuis, H., Dijkhuizen, L., &
Kamerling, J. P. (2012). Structural characterization of
linear isomalto-/malto-oligomer products synthesized by the novel
GTFB 4,6-α-glucanotransferase enzyme from Lactobacillus
reuteri 121. Glycobiology,
22(4), 517-528. https://doi.org/10.1093/glycob/cwr167
van
der Geize, R., Dijkhuizen, L., Ostendorf, M., &
van der Meijden, P. (2012). IPC No. C07C 401/ 00 A I. Pharmaceutical compositions and methods for treating
tuberculosis. (Patent No. US2012058977).
Sarian,
F. D., van der Kaaij, R. M., Kralj, S., Wijbenga,
D-J., Binnema, D. J., van der Maarel, M. J. E.
C., & Dijkhuizen, L. (2012).
Enzymatic degradation of granular potato starch by
Microbacterium aurum strain B8.A. Applied
Microbiology and Biotechnology, 93(2),
645-654. https://doi.org/10.1007/s00253-011-3436-7
Petrusma,
M., Dijkhuizen, L., & van der Geize, R. (2012).
Structural Features in the KshA Terminal Oxygenase Protein
That Determine Substrate Preference of 3-Ketosteroid 9
alpha-Hydroxylase Enzymes. Journal of
Bacteriology, 194(1), 115-121. https://doi.org/10.1128/JB.05838-11
2011
Arnoldus,
C. J., van der Geize, R., & Dijkhuizen, L. (2011).
IPC No. C12N 1/ 20 A I. Pharmaceutical
composition to protect an animal against a disorder arising from an
infection with a bacterium that belongs to the group of
nocardioform actinomycetes. (Patent No.
US2011274660).
Kralj,
S., Grijpstra, P., van Leeuwen, S. S., Leemhuis, H.,
Dobruchowska, J. M., van der Kaaij, R. M., ...
Dijkhuizen, L. (2011). 4,6-alpha-Glucanotransferase, a
Novel Enzyme That Structurally and Functionally Provides an
Evolutionary Link between Glycoside Hydrolase Enzyme Families 13
and 70. Applied and environmental
microbiology, 77(22), 8154-8163. https://doi.org/10.1128/AEM.05735-11
van
Oosterwijk, N., Knol, J., Dijkhuizen, L., van der
Geize, R., & Dijkstra, B. W. (2011). Cloning,
overexpression, purification, crystallization and preliminary X-ray
analysis of 3-ketosteroid Delta(4)-(5 alpha)-dehydrogenase from
Rhodococcus jostii RHA1. Acta Crystallographica
Section F: Structural Biology and Crystallization
Communications, 67(10), 1269-1273. https://doi.org/10.1107/S1744309111028727
Pijning,
T., Anwar, M. A., Boger, M., Dobruchowska, J. M., Leemhuis,
H., Kralj, S., ... Dijkstra, B. W. (2011). Crystal Structure
of Inulosucrase from Lactobacillus: Insights into the Substrate
Specificity and Product Specificity of GH68 Fructansucrases.
Journal of Molecular Biology,
412(1), 80-93. https://doi.org/10.1016/j.jmb.2011.07.031
van
der Geize, R., Grommen, A. W. F., Hessels, G. I., Jacobs, A. A.
C., & Dijkhuizen, L. (2011). The Steroid
Catabolic Pathway of the Intracellular Pathogen Rhodococcus equi Is
Important for Pathogenesis and a Target for Vaccine
Development. PLoS Pathogens,
7(8), [1002181]. https://doi.org/10.1371/journal.ppat.1002181
Petrusma,
M., Hessels, G., Dijkhuizen, L., & van der Geize,
R. (2011). Multiplicity of 3-Ketosteroid-9 alpha-Hydroxylase
Enzymes in Rhodococcus rhodochrous DSM43269 for Specific
Degradation of Different Classes of Steroids.
Journal of Bacteriology, 193(15),
3931-3940. https://doi.org/10.1128/JB.00274-11
Wilbrink,
M. H., Petrusma, M., Dijkhuizen, L., & van der
Geize, R. (2011). FadD19 of Rhodococcus rhodochrous DSM43269,
a Steroid-Coenzyme A Ligase Essential for Degradation of C-24
Branched Sterol Side Chains. Applied and
environmental microbiology, 77(13), 4455-4464.
https://doi.org/10.1128/AEM.00380-11
van
Keulen, G., Siebring, J., & Dijkhuizen, L. (2011).
Central Carbon Metabolic Pathways in Streptomyces. In
P. Dyson (Ed.), Streptomyces: Molecular Biology and
Biotechnology (1 ed., Vol. 1, pp. 105-124). Norfolk: Caister
Academic Press.
Palomo,
M., Pijning, T., Booiman, T., Dobruchowska, J. M.,
Vlist, J. V. D., Kralj, S., ... Leemhuis, H. (2011). Thermus
thermophilus Glycoside Hydrolase Family 57 Branching Enzyme:
Crystal Structure, Mechanism of Action, and Products Formed.
The Journal of Biological Chemistry,
286(5), 3520-3530. https://doi.org/10.1074/jbc.M110.179515
Hill,
P., Krištůfek, V., Dijkhuizen, L., Boddy,
C., Kroetsch, D., & van Elsas, J. D. (2011).
Land use intensity controls actinobacterial community
structure. Microbial ecology,
61(2), 286-302. https://doi.org/10.1007/s00248-010-9752-0
Claessen,
D., & Dijkhuizen, L. (2011). Streptomyceten:
van antibiotica to Alzheimer. In H. Smit, & P. Willemsen
(Eds.), De Microcanon [Hoofdstuk 43] VBK Media.
2010
van
der Kaaij, R., van der Maarel, M., &
Dijkhuizen, L. (2010). IPC No. C12N 15/ 63 A I. Glucanotransferase. (Patent No.
US2010317065).
Vujičić-Žagar,
A., Pijning, T., Kralj, S., López, C. A.,
Eeuwema, W., Dijkhuizen, L., & Dijkstra, B. W.
(2010). Crystal structure of a 117 kDa glucansucrase fragment
provides insight into evolution and product specificity of GH70
enzymes. Proceedings of the National Academy of
Sciences of the United States of America,
107(50), 21406-21411. https://doi.org/10.1073/pnas.1007531107
Dijkhuizen,
L., van der Maarel, M., Kamerling, J. P.,
Leemhuis, JG., Kralj, S., & Dobruchowska, J. (2010). IPC No.
C12P 19/ 04 A I. Glucose-oligosaccharides
comprising (al?6) and (al?4) glycosidic bonds, use thereof , and
methods for providing them. (Patent No.
WO2010128859).
van
der Geize, R., Dijkhuizen, L., Ostendorf, M., &
van der Meijden, P. (2010). IPC No. A61P 31/ 06 A I. Pharmaceutical compositions and methods for treating
tuberculosis. (Patent No. WO2010094810).
Anwar,
M. A., Kralj, S., Pique, A. V., Leemhuis, H., van der Maarel,
M. J. E. C., & Dijkhuizen, L. (2010).
Inulin and levan synthesis by probiotic Lactobacillus gasseri
strains: Characterization of three novel fructansucrase enzymes and
their fructan products.
Microbiology-Sgm, 156(4), 1264-1274.
https://doi.org/10.1099/mic.0.036616-0
Kol,
S., Merlo, M. E., Scheltema, R. A., de Vries,
M., Vonk, R. J., Kikkert, N. A., ... Takano, E. (2010).
Metabolomic Characterization of the Salt Stress Response in
Streptomyces coelicolor. Applied and environmental
microbiology, 76(8), 2574-2581. https://doi.org/10.1128/AEM.01992-09
van
der Maarel, M., Palomo Reixach, M., Booiman, T., &
Dijkhuizen, L. (2010). IPC No. C12N 9/ 10 A I. Method for altering starch using a microbial
branching enzyme. (Patent No. WO2010030185).
Nieselt,
K., Battke, F., Herbig, A., Bruheim, P., Wentzel, A., Jakobsen, O.
M., ... Morrisey, E. R. (2010). The dynamic architecture of
the metabolic switch in Streptomyces coelicolor.
BMC Genomics, 11, [10]. https://doi.org/10.1186/1471-2164-11-10
Leemhuis,
H., Kelly, R. M., & Dijkhuizen, L. (2010).
Engineering of cyclodextrin glucanotransferases and the
impact for biotechnological applications. Applied
Microbiology and Biotechnology, 85(4),
823-835. https://doi.org/10.1007/s00253-009-2221-3
2009
Rosloniec,
K. Z., Wilbrink, M. H., Capyk, J. K., Mohn, W. W., Ostendorf, M.,
van der Geize, R., ... Rosłoniec, K. Z. (2009).
Cytochrome P450 125 (CYP125) catalyses C26-hydroxylation to
initiate sterol side-chain degradation in Rhodococcus jostii
RHA1. Molecular Microbiology,
74(5), 1031-1043. https://doi.org/10.1111/j.1365-2958.2009.06915.x
Lopez,
C. A., Rzepiela, A. J., de Vries, A. H.,
Dijkhuizen, L., Huenenberger, P. H., & Marrink, S.
J. (2009). Martini Coarse-Grained Force Field:
Extension to Carbohydrates. Journal of Chemical
Theory and Computation, 5(12), 3195-3210. https://doi.org/10.1021/ct900313w
Malik,
A., Radji, M., Kralj, S., & Dijkhuizen, L. (2009).
Screening of lactic acid bacteria from Indonesia reveals
glucansucrase and fructansucrase genes in two different Weissella
confusa strains from soya. FEMS Microbiology
Letters, 300(1), 131-138. https://doi.org/10.1111/j.1574-6968.2009.01772.x
de
Jong, W., Wosten, H. A. B., Dijkhuizen, L., &
Claessen, D. (2009). Attachment of Streptomyces coelicolor is
mediated by amyloidal fimbriae that are anchored to the cell
surface via cellulose. Molecular
Microbiology, 73(6), 1128-1140. https://doi.org/10.1111/j.1365-2958.2009.06838.x
Petrusma,
M., Dijkhuizen, L., & van der Geize, R. (2009).
Rhodococcus rhodochrous DSM 43269 3-Ketosteroid 9
alpha-Hydroxylase, a Two-Component Iron-Sulfur-Containing
Monooxygenase with Subtle Steroid Substrate Specificity.
Applied and environmental microbiology,
75(16), 5300-5307. https://doi.org/10.1128/AEM.00066-09
Kelly,
R. M., Dijkhuizen, L., & Leemhuis, H. (2009).
The evolution of cyclodextrin glucanotransferase product
specificity. Applied Microbiology and
Biotechnology, 84(1), 119-133. https://doi.org/10.1007/s00253-009-1988-6
Kelly,
R. M., Dijkhuizen, L., & Leemhuis, H. (2009).
Starch and alpha-glucan acting enzymes, modulating their
properties by directed evolution. Journal of
Biotechnology, 140(3-4), 184-193. https://doi.org/10.1016/j.jbiotec.2009.01.020
Palomo,
M., Kralj, S., van der Maarel, M. J. E. C.,
& Dijkhuizen, L. (2009). The unique branching
patterns of Deinococcus glycogen branching enzymes are determined
by their N-terminal domains. Applied and
environmental microbiology, 75(5), 1355-1362.
https://doi.org/10.1128/AEM.02141-08
Leemhuis,
H., Kelly, R. M., & Dijkhuizen, L. (2009).
Directed Evolution of Enzymes: Library Screening
Strategies. Iubmb Life,
61(3), 222-228. https://doi.org/10.1002/iub.165
de
Jong, W., Manteca, A., Sanchez, J., Bucca, G., Smith, C. P.,
Dijkhuizen, L., ... Wosten, H. A. B. (2009). NepA is a
structural cell wall protein involved in maintenance of spore
dormancy in Streptomyces coelicolor. Molecular
Microbiology, 71(6), 1591-1603. https://doi.org/10.1111/j.1365-2958.2009.06633.x
van
Leeuwen, S. S., Kralj, S., Eeuwema, W., Gerwig, G.
J., Dijkhuizen, L., & Kamerling, J. P.
(2009). Structural Characterization of Bioengineered
alpha-D-Glucans Produced by Mutant Glucansucrase GTF180 Enzymes of
Lactobacillus reuteri Strain 180.
Biomacromolecules, 10(3), 580-588.
https://doi.org/10.1021/bm801240r
van
der Geize, R., Hessels, G. I., & Dijkhuizen, L.
(2009). IPC No. C12P 33/ 00 A I. Method for
the production of modified steroid degrading microorganisms and
there use. (Patent No. WO2009024572).
2008
Mohn,
W. W., van der Geize, R., Stewart, G. R., Okamoto, S., Liu,
J., Dijkhuizen, L., & Eltis, L. D. (2008).
The Actinobacterial mce4 Locus Encodes a Steroid
Transporter. The Journal of Biological
Chemistry, 283(51), 35368-35374. https://doi.org/10.1074/jbc.M805496200
van
der Geize, R., de Jong, W., Hessels, G. I., Grommen, A. W. F.,
Jacobs, A. A. C., & Dijkhuizen, L. (2008). A
novel method to generate unmarked gene deletions in the
intracellular pathogen Rhodococcus equi using 5-fluorocytosine
conditional lethality. Nucleic Acids
Research, 36(22), [151]. https://doi.org/10.1093/nar/gkn811
van
der Geize, R., Hessels, G. I., Nienhuis-Kuiper, M., &
Dijkhuizen, L. (2008). Characterization of a Second
Rhodococcus erythropolis SQ1 3-Ketosteroid 9 alpha-Hydroxylase
Activity Comprising a Terminal Oxygenase Homologue, KshA2, Active
with Oxygenase-Reductase Component KshB. Applied
and environmental microbiology, 74(23),
7197-7203. https://doi.org/10.1128/AEM.00888-08
Kralj,
S., van Leeuwen, S. S., Valk, V., Eeuwema, W., Kamerling, J.
P., & Dijkhuizen, L. (2008). Hybrid
reuteransucrase enzymes reveal regions important for glucosidic
linkage specificity and the transglucosylation/hydrolysis
ratio. Febs Journal, 275(23),
6002-6010. https://doi.org/10.1111/j.1742-4658.2008.06729.x
Borodina,
I., Siebring, J., Zhang, J., Smith, C. P., van Keulen, G.,
Dijkhuizen, L., & Nielsen, J. (2008). Antibiotic
overproduction in Streptomyces coelicolor A3(2) mediated by
phosphofructokinase deletion. The Journal of
Biological Chemistry, 283(37), 25186-25199. https://doi.org/10.1074/jbc.M803105200
Wieringa,
N. F., van der Windt, H. J., Zuiker, R. R.
M., Dijkhuizen, L., Verkerk, M. A., Vonk,
R. J., & Swart, J. A. A. (2008). Positioning functional
foods in an ecological approach to the prevention of overweight and
obesity. Obesity Reviews,
9(5), 464-473. https://doi.org/10.1111/j.1467-789X.2008.00470.x
Kelly,
R. M., Leemhuis, H., Rozeboom, H. J., van Oosterwijk,
N., Dijkstra, B. W., & Dijkhuizen, L. (2008).
Elimination of competing hydrolysis and coupling side
reactions of a cyclodextrin glucanotransferase by directed
evolution. Biochemical Journal,
413(3), 517-525. https://doi.org/10.1042/BJ20080353
van
der Vlist, J., Reixach, M. P., van der Maarel,
M., Dijkhuizen, L., Schouten, A. J.,
& Loos, K. (2008). Synthesis of branched
polyglucans by the tandem action of potato phosphorylase and
Deinococcus geothermalis glycogen branching enzyme.
Macromolecular Rapid Communications,
29(15), 1293-1297. https://doi.org/10.1002/marc.200800248
van
Leeuwen, S. S., Kralj, S., Gerwig, G. J.,
Dijkhuizen, L., & Kamerling, J. P. (2008).
Structural analysis of bioengineered alpha-D-glucan produced
by a triple mutant of the glucansucrase GTF180 enzyme from
Lactobacillus reuteri strain 180: Generation of (alpha 1 -> 4)
linkages in a native (1 -> 3)(1 -> 6)-alpha-D-glucan.
Biomacromolecules, 9(8), 2251-2258.
https://doi.org/10.1021/bm800410w
Hellmuth,
H., Wittrock, S., Kralj, S., Dijkhuizen, L., Hofer,
B., Seibel, J., & Seibel, J. (2008). Engineering the
glucansucrase GTFR enzyme reaction and glycosidic bond specificity:
Toward tailor-made polymer and oligosaccharide products.
Biochemistry, 47(25), 6678-6684. https://doi.org/10.1021/bi800563r
Poele,
E. M. T., Bolhuis, H., & Dijkhuizen, L. (2008).
Actinomycete integrative and conjugative elements.
Antonie Van Leeuwenhoek: International Journal of General
and Molecular Microbiology, 94(1), 127-143. https://doi.org/10.1007/s10482-008-9255-x
Dijkhuizen,
L., Goodfellow, M., Hoskisson, P., & Sutcliffe, I.
(2008). Actinomycetologists: a vibrant and strong scientific
community. Papers from the 14th International Symposium on the
Biology of Actinomycetes. Antonie Van Leeuwenhoek:
International Journal of General and Molecular
Microbiology, 94(1), 1-2. https://doi.org/10.1007/s10482-008-9245-z
Yuan,
X-L., van der Kaaij, R. M., van den Hondel, C. A. M.
J. J., Punt, P. J., van der Maarel, M. J. E. C.,
Dijkhuizen, L., ... van der Hondel, C. A. M. J. J. (2008).
Aspergillus niger genome-wide analysis reveals a large number
of novel alpha-glucan acting enzymes with unexpected expression
profiles. MOLECULAR GENETICS AND
GENOMICS, 279(6), 545-561. https://doi.org/10.1007/s00438-008-0332-7
Anwar,
M. A., Kralj, S., van der Maarel, M. J. E. C.,
& Dijkhuizen, L. (2008). The Probiotic
Lactobacillus johnsonii NCC 533 produces high-molecular-mass inulin
from sucrose by using an inulosucrase enzyme.
Applied and environmental microbiology,
74(11), 3426-3433. https://doi.org/10.1128/AEM.00377-08
van
Leeuwen, S., Kralj, S., van Geel-Schutten, G. H., Gerwig,
G., Dijkhuizen, L., & Kamerling, J. P.
(2008). Structural analysis of the alpha-D-glucan (EPS180)
produced by the Lactobacillus reuteri strain 180 glucansucrase
GTF180 enzyme. Carbohydrate Research,
343(7), 1237-1250. https://doi.org/10.1016/j.carres.2008.01.042
van
Leeuwen, S., Kralj, S., van Geel-Schutten, G. H., Gerwig,
G., Dijkhuizen, L., & Kamerling, J. P.
(2008). Structural analysis of the alpha-D-glucan (EPS35-5)
produced by the Lactobacillus reuteri strain 35-5 glucansucrase
GTFA enzyme. Carbohydrate Research,
343(7), 1251-1265. https://doi.org/10.1016/j.carres.2008.01.044
Poele,
E. M. T., Samborskyy, M., Oliynyk, M., Leadlay, P. F., Bolhuis,
H., & Dijkhuizen, L. (2008). Actinomycete
integrative and conjugative pMEA-like elements of Amycolatopsis and
Saccharopolyspora decoded. Plasmid,
59(3), 202-216. https://doi.org/10.1016/j.plasmid.2008.01.003
Kelly,
R. M., Leemhuis, H., Gatjen, L., Dijkhuizen, L., &
Gätjen, L. (2008). Evolution toward small molecule
inhibitor resistance affects native enzyme function and stability,
generating acarbose-insensitive cyclodextrin glucanotransferase
variants. The Journal of Biological
Chemistry, 283(16), 10727-10734. https://doi.org/10.1074/jbc.M709287200
Knol,
J., Bodewits, K., Hessels, G. I., Dijkhuizen, L.,
& Van der Geize, R. (2008). 3-Keto-5 alpha-steroid
Delta'-dehydrogenase from Rhodococcus erythropolis SQ1 and its
orthologue in Mycobacterium tuberculosis H37Rv are highly specific
enzymes that function in cholesterol catabolism.
Biochemical Journal, 410(2),
339-346. https://doi.org/10.1042/BJ20071130
Dijkhuizen,
L., Goodfellow, M., Hoskisson, P., & Sutcliffe, I.
(2008). Actinomycetologists: a vibrant and strong scientific
community. Papers from the 14th International Symposium on the
Biology of Actinomycetes. Antonie Van Leeuwenhoek:
International Journal of General and Molecular
Microbiology, 94, 1-2.
Pijning,
T., Vujicic-Zagar, A., Kralj, S., Eeuwema, W.,
Dijkhuizen, L., & Dijkstra, B. W. (2008).
Biochemical and crystallographic characterization of a
glucansucrase from Lactobacillus reuteri 180.
Biocatalysis and Biotransformation,
26(1-2), 12-17. https://doi.org/10.1080/10242420701789163
Goosen,
C., Van der Maarel, M. J. E. C., &
Dijkhuizen, L. (2008). Exo-inulinase of Aspergillus
niger N402: A hydrolytic enzyme with significant
transfructosylating activity. Biocatalysis and
Biotransformation, 26(1-2), 49-58. https://doi.org/10.1080/10242420701806686
Kralj,
S., Buchholz, K., Dijkhuizen, L., & Seibel, J.
(2008). Fructansucrase enzymes and sucrose analogues: A new
approach for the synthesis of unique
fructo-oligosaccharides. Biocatalysis and
Biotransformation, 26(1-2), 32-41. https://doi.org/10.1080/10242420701789478
2007
van
der Kaaij, R. M., Janecek, S., van der Maarel, M. J.
E. C., Dijkhuizen, L., & Janeček,
Š. (2007). Phylogenetic and biochemical characterization
of a novel cluster of intracellular fungal alpha-amylase
enzymes. Microbiology-Sgm,
153(12), 4003-4015. https://doi.org/10.1099/mic.0.2007/008607-0
Rohman,
A., van Oosterwijk, N., Kralj, S., Dijkhuizen, L.,
Dijkstra, B. W., & Puspaningsih, N. N. T. (2007).
Purification, crystallization and preliminary X-ray analysis
of a thermostable glycoside hydrolase family 43 beta-xylosidase
from Geobacillus thermoleovorans IT-08. Acta
Crystallographica Section F: Structural Biology and Crystallization
Communications, 63, 932-935. https://doi.org/10.1107/S1744309107046015
Kelly,
R. M., Leemhuis, H., & Dijkhuizen, L. (2007).
Conversion of a cyclodextrin glucanotransferase into an
alpha-amylase: Assessment of directed evolution strategies.
Biochemistry, 46(39), 11216-11222.
https://doi.org/10.1021/bi701160h
Poele,
E. M. T., Habets, M. N., Tan, G. Y. A., Ward, A. C., Goodfellow,
M., Bolhuis, H., & Dijkhuizen, L. (2007).
Prevalence and distribution of nucleotide sequences typical
for pMEA-like accessory genetic elements in the genus
Amycolatopsis. FEMS microbiology
ecology, 61(2), 285-294. https://doi.org/10.1111/j.1574-6941.2007.00334.x
Kaaij,
van der, R., Yuan, X-L., Franken, A., Ram, A. F. J., Punt,
P. J., Maarel, M. J. E. C. V. D., &
Dijkhuizen, L. (2007). Two novel, putatively cell
wall-associated and glycosylphosphatidylinositol-anchored
alpha-glucanotransferase enzymes of aspergillus niger.
Eukaryotic Cell, 6(7), 1178-1188. https://doi.org/10.1128/EC.00354-06
Barends,
T. R. M., Bultema, J. B., Kaper, T., van der Maarel, M. J. E.
C., Dijkhuizen, L., & Dijkstra, B. W.
(2007). Three-way stabilization of the covalent intermediate
in amylomaltase, an alpha-amylase-like transglycosylase.
The Journal of Biological Chemistry,
282(23), 17242-17249. https://doi.org/10.1074/jbc.M701444200
Kaper,
T., Leemhuis, H., Uitdehaag, J. C. M., van der Veen, B. A.,
Dijkstra, B. W., van der Maarel, M. J. E. C., ... van
Veen, B. (2007). Identification of acceptor substrate binding
subsites+2 and+3 in the amylomaltase from Thermus thermophilus
HB8. Biochemistry, 46(17),
5261-5269. https://doi.org/10.1021/bi602408j
Yuan,
X-L., van Munster, J. M., Ram, A. F. J., van der Maarel, M.
J. E. C., Dijkhuizen, L., & Goosen, C.
(2007). Molecular and biochemical characterization of a novel
intracellular invertase from Aspergillus niger with
transfructosylating activity. Eukaryotic
Cell, 6(4), 674-681. https://doi.org/10.1128/EC.00361-06
Pel,
H. J., de Winde, J. H., Archer, D. B., Dyer, P. S., Hofmann, G.,
Schaap, P. J., ... de Vries, R. P. (2007). Genome sequencing
and analysis of the versatile cell factory Aspergillus niger CBS
513.88. Nature Biotechnology,
25(2), 221-231. https://doi.org/10.1038/nbt1282
Geize,
R. V. D., Yam, K., Heuser, T., Wilbrink, M. H., Hara, H., Anderton,
M. C., ... Eltis, L. D. (2007). A gene cluster encoding
cholesterol catabolism in a soil actinomycete provides insight into
Mycobacterium tuberculosis survival in macrophages.
Proceedings of the National Academy of
Sciences, 104(6), 1947 - 1952. https://doi.org/10.1073/pnas.0605728104
Vrieling,
E. G., & Dijkhuizen, L. (2007).
Biomolecular Sciences: from systems biology to synthetic
biology. BIOforum Europe.
Biedendieck,
R., Beine, R., Gamer, M., Jordan, E., Buchholz, K., Seibel, J., ...
Jahn, D. (2007). Export, purification, and activities of
affinity tagged Lactobacillus reuteri levansucrase produced by
Bacillus megaterium. Applied Microbiology and
Biotechnology, 74(5), 1062 - 1073. https://doi.org/10.1007/s00253-006-0756-0
Hellmuth,
H., Hillringhaus, L., Höbbel, S., Kralj, S., Dijkhuizen,
L., Seibel, J., & Hobbel, S. (2007). Highly
Efficient Chemoenzymatic Synthesis of Novel Branched
Thiooligosaccharides by Substrate Direction with
Glucansucrases. ChemBioChem,
8(3), 273-276. https://doi.org/10.1002/cbic.200600444
Poele,
E. M. T., Habets, M. N., Tan, G. Y. A., Ward, A. C.,
Goodfellow, M., Bolhuis, H., & Dijkhuizen, L.
(2007). Prevalence and distribution of nucleotide sequences
typical for pMEA-like accessorygenetic elements in the genus
Amycolatopsis. FEMS microbiology
ecology, 61(2).
2006
Ozimek,
L. K., Kralj, S., Kaper, T., Maarel, M. J. E. C. V.
D., & Dijkhuizen, L. (2006). Single
amino acid residue changes in subsite -1 of inulosucrase from
Lactobacillus reuteri 121 strongly influence the size of products
synthesized. Febs Journal,
273(17), 4104-4113. https://doi.org/10.1111/j.1742-4658.2006.05411.x
Kralj,
S., Eeuwema, W., Eckhardt, T. H., & Dijkhuizen, L.
(2006). Role of asparagine 1134 in glucosidic bond and
transglycosylation specificity of reuteransucrase from
Lactobacillus reuteri 121. Febs
Journal, 273(16), 3735-3742. https://doi.org/10.1111/j.1742-4658.2006.05376.x
Claessen,
D., Jong, W. D., Dijkhuizen, L., & Wosten, H. A.
B. (2006). Regulation of Streptomyces development: Reach for
the sky! Trends in Microbiology,
14(7), 313 - 319. https://doi.org/10.1016/j.tim.2006.05.008
van
Hijum, S. A. F. T., Kralj, S., Ozimek, L. K., Dijkhuizen,
L., & van Geel-Schutten, I. G. H. (2006).
Structure-function relationships of glucansucrase and
fructansucrase enzymes from lactic acid bacteria.
Microbiology and Molecular Biology Reviews,
70(1), 157 - 176. https://doi.org/10.1128/MMBR.70.1.157-176.2006
Malten,
M., Biedendieck, R., Gamer, M., Drews, A. C., Stammen, S.,
Buchholz, K., ... Jahn, D. (2006). A Bacillus megaterium
plasmid system for the production, export, and one-step
purification of affinity-tagged heterologous levansucrase from
growth medium. Applied and environmental
microbiology, 72(2), 1677 - 1679. https://doi.org/10.1128/AEM.72.2.1677-1679.2006
Yuan,
X. L., Goosen, C., Kools, H., van der Maare, M. J. E. C., van den
Hondel, C. A. M. J., Dijkhuizen, L., ... Maarel,
M. J. E. C. V. D. (2006). Database mining and
transcriptional analysis of genes encoding inulin-modifying enzymes
of Aspergillus niger.
Microbiology-Sgm, 152(10), 3061 -
3073. https://doi.org/10.1099/mic.0.29051-0
Demain,
A. L., & Dijkhuizen, L. (2006). Ecology and
industrial microbiology. Current Opinion in
Microbiology, 9(3), 237 - 239. https://doi.org/10.1016/j.mib.2006.04.009
Schoondermark-Stolk,
S. A., Jansen, M., Verkleij, A. J., Verrips, C. T., Euverink,
G-J. W., Dijkhuizen, L., & Boonstra, J.
(2006). Genome-wide transcription survey on flavour
production in Saccharomyces cerevisiae. World
Journal of Microbiology and Biotechnology,
22(12), 1347-1356. https://doi.org/10.1007/s11274-006-9182-9
Schoondermark-Stolk,
S. A., Jansen, M., Veurink, J. H., Verkleij, A. J., Verrips, C.
T., Euverink, G-J. W., ... Dijkhuizen, L.
(2006). Rapid identification of target genes for
3-methyl-1-butanol production in Saccharomyces cerevisiae.
Applied Microbiology and Biotechnology,
70(2), 237-246. https://doi.org/10.1007/s00253-005-0070-2
Poele,
E. M. T., Kloosterman, H., Hessels, G. I., Bolhuis,
H., & Dijkhuizen, L. (2006). RepAM of the
Amycolatopsis methanolica integrative element pMEA300 belongs to a
novel class of replication initiator proteins.
Microbiology, 152(10), 2943 - 2950.
https://doi.org/10.1099/mic.0.28746-0
Ozimek,
L. K., Kralj, S., van der Maarel, M. J. E. C.,
& Dijkhuizen, L. (2006). The levansucrase and
inulosucrase enzymes of Lactobacillus reuteri 121 catalyse
processive and non-processive transglycosylation reactions.
Microbiology-Sgm, 152(4), 1187 -
1196. https://doi.org/10.1099/mic.0.28484-0
2005
Ozimek,
L. K., Euverink, G. J. W., Maarel, M. J. E. C.
V. D., & Dijkhuizen, L. (2005).
Mutational analysis of the role of calcium ions in the
Lactobacillus reuteri strain 121 fructosyltransferase (levansucrase
and inulosucrase) enzymes. FEBS
Letters, 579(5), 1124-1128. https://doi.org/10.1016/j.febslet.2004.11.113
Gebbink,
M. F. B. G., Claessen, D., Bouma, B., Dijkhuizen, L.,
& Wosten, H. A. B. (2005). Amyloids - A functional coat
for microorganisms. Nature Reviews
Microbiology, 3(4), 333 - 341. https://doi.org/10.1038/nrmicro1127
Kaper,
T., Talik, B., Ettema, T. J., Bos, H., van der Maarel, M. J.
E. C., & Dijkhuizen, L. (2005).
Amylomaltase of Pyrobaculum aerophilum IM2 produces
thermoreversible starch gels. Applied and
environmental microbiology, 71(9), 5098 -
5106. https://doi.org/10.1128/AEM.71.9.5098-5106.2005
Keulen,
G. V., Hopwood, D. A., Dijkhuizen, L., & Sawers,
R. G. (2005). Gas vesicles in actinomycetes: old buoys in
novel habitats? Trends in
Microbiology, 13(8), 350 - 354. https://doi.org/10.1016/j.tim.2005.06.006
Kralj,
S., Stripling, E., Sanders, P., van Geel-Schutten, G. H.,
& Dijkhuizen, L. (2005). Highly hydrolytic
reuteransucrase from probiotic Lactobacillus reuteri strain ATCC
55730. Applied and environmental
microbiology, 71(7), 3942 - 3950. https://doi.org/10.1128/AEM.71.7.3942-3950.2005
Kralj,
S., van Geel-Schutten, I. G. H., Faber, E. J., van der
Maarel, M. J. E. C., & Dijkhuizen, L.
(2005). Rational transformation of Lactobacillus reuteri 121
reuteransucrase into a dextransucrase.
Biochemistry, 44(25), 9206-9216. https://doi.org/10.1021/bi050447q
2004
Janssen,
M. I., van Leeuwen, M. B. M., van Kooten, R., de
Vries, J., Dijkhuizen, L., & Wosten, H. A.
B. (2004). Promotion of fibroblast activity by coating with
hydrophobins in the β-sheet end state.
Biomaterials, 25(14), 2731-2739. https://doi.org/10.1016/j.biomaterials.2003.09.060
van
Hijum, S. A. F. T., Szalowska, E., van der Maarel, M. J. E.
C., & Dijkhuizen, L. (2004).
Biochemical and molecular characterization of a levansucrase
from Lactobacillus reuteri.
Microbiology, 150(3), 621-630. https://doi.org/10.1099/mic.0.26671-0
Leemhuis,
H., Rozeboom, HJ., Dijkstra, BW., Dijkhuizen,
L., & Dijkstra, B. W. (2004). Improved
thermostability of Bacillus circulans cyclodextrin
glycosyltransferase by the introduction of a salt bridge.
Proteins-Structure Function and
Bioinformatics, 54(1), 128-134. https://doi.org/10.1002/prot.10516
Kralj,
S., van Geel-Schutten, G. H., van der Maarel, M. J. E.
C., & Dijkhuizen, L. (2004).
Biochemical and molecular characterization of Lactobacillus
reuteri 121 reuteransucrase.
Microbiology-Sgm, 150(7), 2099 -
2112. https://doi.org/10.1099/mic.0.27105-0
Kaper,
T., Maarel, M. J. E. C. V. D., Euverink, G. J.
W., & Dijkhuizen, L. (2004).
Exploring and exploiting starch-modifying amylomaltases from
thermophiles. Biochemical Society
Transactions, 32(2), 279-282. https://doi.org/10.1042/BST0320279
Kralj,
S., Geel-Schutten, G. H. V., Dondorff, M. M. G., Kirsanovs,
S., Maarel, M. J. E. C. V. D., & Dijkhuizen,
L. (2004). Glucan synthesis in the genus
Lactobacillus: isolation and characterization of glucansucrase
genes, enzymes and glucan products from six different
strains. Microbiology,
150(11), 3681 - 3690. https://doi.org/10.1099/mic.0.27321-0
van
der Geize, R., & Dijkhuizen, L. (2004).
Harnessing the catabolic diversity of rhodococci for
environmental and biotechnological applications.
Current Opinion in Microbiology,
7(3), 255 - 261. https://doi.org/10.1016/j.mib.2004.04.001
van
Keulen, G., Siebring, J., Rembacz, K., Hoogeveen, M.,
Tomczynska, M., & Dijkhuizen, L. (2004).
Improved method for the isolation of RNA from (standing
liquid cultures of) Streptomycetes. Journal of
microbiological methods, 58(1), 139 - 142. https://doi.org/10.1016/j.mimet.2004.03.014
Sosio,
M., Kloosterman, H., Bianchi, A., de Vreugd, P., Dijkhuizen,
L., & Donadio, S. (2004). Organization of the
teicoplanin gene cluster in Actinoplanes teichomyceticus.
Microbiology-Sgm, 150(1), 95 - 102.
https://doi.org/10.1099/mic.0.26507-0
Leemhuis,
H., Wehmeier, U. F., & Dijkhuizen, L. (2004).
Single amino acid mutations interchange the reaction
specificities of cyclodextrin glycosyltransferase and the
acarbose-modifying enzyme acarviosyl transferase.
Biochemistry, 43(41), 13204 - 13213.
https://doi.org/10.1021/bi049015q
Ozimek,
L. K., van Hijum, S. A. F. T., van Koningsveld, G. A., van
der Maarel, M. J. E. C., van Geel-Schutten, G. H.,
& Dijkhuizen, L. (2004). Site-directed mutagenesis
study of the three catalytic residues of the fructosyltransferases
of Lactobacillus reuteri 121. FEBS
Letters, 560(1-3), 131 - 133. https://doi.org/10.1016/S0014-5793(04)00085-7
Claessen,
D., Wosten, H. A. B., Dijkhuizen, L., & van
Keulen, G. (2004). Streptomyces coelicolor in an
oxygen-limited liquid environment: adapt and escape.
Microbiology Australia, 25(2), 22 -
23.
Claessen,
D., Stokroos, I., Deelstra, H. J., Penninga, N. A., Bormann, C.,
Salas, J. A., ... Wosten, H. A. B. (2004). The formation of
the rodlet layer of streptomycetes is the result of the interplay
between rodlins and chaplins. Molecular
Microbiology, 53(2), 433 - 443. https://doi.org/10.1111/j.1365-2958.2004.04143.x
2003
Kloosterman,
H., Hessels, G. I., Vrijbloed, J. W., Euverink, G.
J., & Dijkhuizen, L. (2003).
(De)regulation of key enzyme steps in the shikimate pathway
and phenylalanine-specific pathway of the actinomycete
Amycolatopsis methanolica.
Microbiology-Sgm, 149(11),
3321-3330. https://doi.org/10.1099/mic.0.26494-0
van
der Geize, R., van der Meijden, P., Hessels, G. I., &
Dijkhuizen, L. (2003). IPC No. C12P 33/ 18 A I. Identification of 3-Ketosteroid 9-Alfa-hydroxylase
genes and microorganisms bloked in 3-Ketosteroid 9-Alfa-hydroxylase
activity. (Patent No. WO03070925).
Leemhuis,
H., Kragh, KM., Dijkstra, BW., Dijkhuizen, L., Kragh,
K. M., & Dijkstra, B. W. (2003). Engineering cyclodextrin
glycosyltransferase into a starch hydrolase with a high
exo-specificity. Journal of
Biotechnology, 103(3), 203-212. https://doi.org/10.1016/S0168-1656(03)00126-3
Kralj,
S., van Geel-schutten, GH., van der Maarel,
MJEC., & Dijkhuizen, L. (2003).
Efficient screening methods for glucosyltransferase genes in
Lactobacillus strains. Biocatalysis and
Biotransformation, 21(4-5), 181-187. https://doi.org/10.1080/10242420310001618519
Leemhuis,
H., & Dijkhuizen, L. (2003). Engineering of
hydrolysis reaction specificity in the transglycosylase
cyclodextrin glycosyltransferase. Biocatalysis and
Biotransformation, 21(4-5), 261-270. https://doi.org/10.1080/10242420310001614333
Van
der Maarel, M. J. E. C., Vos, A.,
Sanders, P., & Dijkhuizen, L. (2003).
Properties of the glucan branching enzyme of the
hyperthermophilic bacterium Aquifex aeolicus.
Biocatalysis and Biotransformation,
21(4-5), 199-207. https://doi.org/10.1080/10242420310001618528
Dijkhuizen,
L. (2003). The Fifth Carbohydrate Bioengineering
Meeting was held in Groningen, The Netherlands, April 6-9,
2003. Biocatalysis and
Biotransformation, 21(4-5), 145. https://doi.org/10.1080/10242420310001621821
Claessen,
D., Rink, R., de Jong, W., Siebring, J., de Vreugd, P., Boersma, F.
G. H., ... Wosten, H. A. B. (2003). A novel class of secreted
hydrophobic proteins is involved in aerial hyphae formation in
Streptomyces coelicolor by forming amyloid-like fibrils.
Genes & Development, 17(14),
1714-1726. https://doi.org/10.1101/gad.264303
Leemhuis,
H., Rozeboom, H. J., Wilbrink, M., Euverink,
G-J. W., Dijkstra, B. W., & Dijkhuizen, L.
(2003). Conversion of cyclodextrin glycosyltransferase into a
starch hydrolase by directed evolution: The role of alanine 230 in
acceptor subsite+1. Biochemistry,
42(24), 7518-7526. https://doi.org/10.1021/bi034439q
Jansen,
M., Veurink, J. H., Euverink, G-J. W., &
Dijkhuizen, L. (2003). Growth of the salt-tolerant
yeast Zygosaccharomyces rouxii in microtiter plates: effects of
NaCl, pH and temperature on growth and fusel alcohol production
from branched-chain amino acids. Fems Yeast
Research, 3(3), 313-318. [PII
S1567-1356(02)00162-9]. https://doi.org/10.1016/S1567-1356(02)00162-9
Leemhuis,
H., Rozeboom, HJ., Dijkstra, BW., Dijkhuizen,
L., & Dijkstra, B. W. (2003). The fully conserved
Asp residue in conserved sequence region I of the alpha-amylase
family is crucial for the catalytic site architecture and
activity. FEBS Letters,
541(1-3), 47-51. https://doi.org/10.1016/S0014-5793(03)00286-2
van
Keulen, G., Ridder, ANJA., Dijkhuizen, L., Meijer,
WG., & Meijer, W. G. (2003). Analysis of DNA binding and
transcriptional activation by the LysR-type transcriptional
regulator CbbR of Xanthobacter flavus. Journal of
Bacteriology, 185(4), 1245-1252. https://doi.org/10.1128/JB.185.4.1245-1252.2003
Keulen,
G. V., Jonkers, H. M., Claessen, D., Dijkhuizen, L.,
& Wösten, H. A. B. (2003). Differentiation and
anaerobiosis in standing liquid cultures of Streptomyces
coelicolor. Journal of Bacteriology,
185(4), 1455-1458. https://doi.org/10.1128/JB.185.4.1455-1458.2003
van
Hijum, SAFT., van der Maarel, MJEC., &
Dijkhuizen, L. (2003). Kinetic properties of an
inulosucrase from Lactobacillus reuteri 121. FEBS
Letters, 534(1-3), 207-210. https://doi.org/10.1016/S0014-5793(02)03841-3
van
der Maarel, M., Dijkhuizen, L., Doeve, J. B.,
van der Veen, B. A., & Vos, A. (2003). IPC No. C12N 9/ 10 A I.
Prevenyion of retrogradation of starch.
(Patent No. WO03002728).
Leemhuis,
H., Dijkstra, BW., & Dijkhuizen, L. (2003).
Thermoanaerobacterium thermosulfurigenes cyclodextrin
glycosyltransferase - Mechanism and kinetics of inhibition by
acarbose and cyclodextrins. European Journal of
Biochemistry, 270(1), 155-162. https://doi.org/10.1046/j.1432-1033.2003.03376.x
Leemhuis,
H., Euverink, G-J. W., & Dijkhuizen,
L. (2003). High-throughput screening for gene
libraries expressing carbohydrate hydrolase activity.
Biotechnology Letters, 25(19),
1643-1645. https://doi.org/10.1023/A:1025646807840
Leemhuis,
H., Dijkstra, B. W., & Dijkhuizen, L. (2003).
Thermoanaerobacterium thermosulfurigenes cyclodextrin
glycosyltransferase. Mechanism and kinetics of inhibition by
acarbose and cyclodextrins. Proteins%3A
Structure%2C Function%2C and Bioinformatics,
54(1).
2002
Hektor,
HJ., Kloosterman, H., & Dijkhuizen,
L. (2002). Identification of a magnesium-dependent
NAD(P)(H)-binding domain in the nicotinoprotein methanol
dehydrogenase from Bacillus methanolicus. The
Journal of Biological Chemistry, 277(49),
46966-46973. https://doi.org/10.1074/jbc.M207547200
Janssen,
M. I., Leeuwen, M. B. M. V., Scholtmeijer,
K., Kooten, T. G. V., Dijkhuizen, L.,
& Wösten, H. A. B. (2002). Coating with genetic
engineered hydrophobin promotes growth of fibroblasts on a
hydrophobic solid. Biomaterials,
23(24), 4847-4854. [PII S0142-9612(02)00240-5]. https://doi.org/10.1016/S0142-9612(02)00240-5
van
Geel-Schutten, G. H., Dijkhuizen, L., Rahaoui, H.,
& Leer, R-J. (2002). IPC No. C12P 19/ 18 A I. Novel glucosyltransferases. (Patent No.
US2002155568).
Kloosterman,
H., Vrijbloed, JW., & Dijkhuizen, L.
(2002). Molecular, biochemical, and functional
characterization of a nudix hydrolase protein that stimulates the
activity of a nicotinoprotein alcohol dehydrogenase.
The Journal of Biological Chemistry,
277(38), 34785-34792. https://doi.org/10.1074/jbc.M205617200
van
Hijum, S., van Geel-Schutten, G. H., Dijkhuizen, L.,
& Rahaoui, H. (2002). IPC No. C12N 9/ 10 A I. Novel fructosyltransferases. (Patent No.
US2002127681).
Hijum,
S. A. F. T. V., Geel-Schutten, G. H. V., Rahaoui, H., Maarel,
M. J. E. C. V. D., & Dijkhuizen, L. (2002).
Characterization of a novel fructosyltransferase from
Lactobacillus reuteri that synthesizes high-molecular-weight inulin
and inulin oligosaccharides. Applied and
environmental microbiology, 68(9), 4390-4398.
https://doi.org/10.1128/AEM.68.9.4390-4398.2002
Kralj,
S., van Geel-Schutten, GH., Rahaoui, H., Leer, RJ., Faber,
EJ., van der Maarel, MJEC., & Dijkhuizen,
L. (2002). Molecular characterization of a novel
glucosyltransferase from Lactobacillus reuteri strain 121
synthesizing a unique, highly branched glucan with alpha-(1 ->
4) and alpha-(1 -> 6) glucosidic bonds. Applied
and environmental microbiology, 68(9),
4283-4291. https://doi.org/10.1128/AEM.68.9.4283-4291.2002
van
der Geize, R., Hessels, GI., van Gerwen, R., van der Meijden,
R., & Dijkhuizen, L. (2002). Molecular and
functional characterization of kshA and kshB, encoding two
components of 3-ketosteroid 9 alpha-hydroxylase, a class IA
monooxygenase, in Rhodococcus erythropolis strain SQ1.
Molecular Microbiology, 45(4),
1007-1018. https://doi.org/10.1046/j.1365-2958.2002.03069.x
Claessen,
D., Wösten, H. A. B., Keulen, G. V., Faber, O. G., Alves, A.
M. C. R., Meijer, W. G., & Dijkhuizen, L. (2002).
Two novel homologous proteins of Streptomyces coelicolor and
Streptomyces lividans are involved in the formation of the rodlet
layer and mediate attachment to a hydrophobic surface.
Molecular Microbiology, 44(6),
1483-1492. https://doi.org/10.1046/j.1365-2958.2002.02980.x
van
der Maarel, MJEC., van der Veen, B., Uitdehaag, JCM.,
Leemhuis, H., & Dijkhuizen, L. (2002).
Properties and applications of starch-converting enzymes of
the alpha-amylase family. Journal of
Biotechnology, 94(2), 137-155.
Uitdehaag,
JCM., van der Veen, BA., Dijkhuizen, L., &
Dijkstra, BW. (2002). Catalytic mechanism and product
specificity of cyclodextrin glycosyltransferase, a prototypical
transglycosylase from the alpha-amylase family.
Enzyme and Microbial Technology,
30(3), 295-304. [PII S0141-0229(01)00498-7].
Leemhuis,
H., Dijkstra, B. W., & Dijkhuizen, L. (2002).
Mutations converting cyclodextrin glycosyltransferase from a
transglycosylase into a starch hydrolase. FEBS
Letters, 514(2-3), 189-192. [PII
S0014-5793(02)02362-1]. https://doi.org/10.1016/S0014-5793(02)02362-1
Leemhuis,
H., Uitdehaag, JCM., Rozeboom, HJ., Dijkstra,
BW., Dijkhuizen, L., & Dijkstra, B. W. (2002).
The remote substrate binding subsite-6 in
cyclodextrin-glycosyltransferase controls the transferase activity
of the enzyme via an induced-fit mechanism. The
Journal of Biological Chemistry, 277(2),
1113-1119. https://doi.org/10.1074/jbc.M106667200
Uitdehaag,
J. C. M., Veen, B. A. V. D., Dijkhuizen, L., &
Dijkstra, B. W. (2002). Catalytic mechanism and product
specificity of cyclodextrin glycosyltransferase, a prototypical
transglycosylase from the α-amylase family.
Enzyme and Microbial Technology,
30(3). https://doi.org/10.1016/S0141-0229(01)00498-7
Uitdehaag,
JCM., Dijkhuizen, L., & Dijkstra, BW. (2002).
Cyclodextrin glycosyltransferase as a model enzyme to study
the reaction mechanism of the alpha-amylase family. In TT.
Teeri, B. Svensson, HJ. Gilbert, & T. Feizi (Eds.),
CARBOHYDRATE BIOENGINEERING: INTERDISCIPLINARY APPROACHES
(pp. 82-86). (ROYAL SOCIETY OF CHEMISTRY SPECIAL PUBLICATIONS).
CAMBRIDGE: ROYAL SOC CHEMISTRY.
Geize,
R. V. D., Hessels, G. I., & Dijkhuizen, L. (2002).
Molecular and functional characterization of the kstD2 gene
of Rhodococcus erythropolis SQ1 encoding a second 3-ketosteroid
Δ1-dehydrogenase isoenzyme. Molecular
Microbiology, 148, 3285-3292. https://doi.org/10.1099/00221287-148-10-3285
Maarel,
M. J. E. C. V. D., Veen, B. V. D., Uitdehaag, J. C. M.,
Leemhuis, H., & Dijkhuizen, L. (2002).
Properties and applications of starch-converting enzymes of
the α-amylase family. Journal of
Biotechnology, 94(2). https://doi.org/10.1016/S0168-1656(01)00407-2
2001
van
Hijum, SAFT., Bonting, K., van der Maarel,
MJEC., & Dijkhuizen, L. (2001).
Purification of a novel fructosyltransferase from
Lactobacillus reuteri strain 121 and characterization of the levan
produced. FEMS Microbiology Letters,
205(2), 323-328. https://doi.org/10.1111/j.1574-6968.2001.tb10967.x
van
der Geize, R., Hessels, GI., van Gerwen, R., van der Meijden,
P., & Dijkhuizen, L. (2001). Unmarked gene
deletion mutagenesis of kstD, encoding 3-ketosteroid
Delta(1)-dehydrogenase, in Rhodococcus erythropolis SQ1 using sacB
as counter-selectable marker. FEMS Microbiology
Letters, 205(2), 197-202.
Veen,
B. A. V. D., Leemhuis, H., Kralj, S., Uitdehaag, J. C. M.,
Dijkstra, B. W., & Dijkhuizen, L. (2001).
Hydrophobic amino acid residues in the acceptor binding site
are main determinants for reaction mechanism and specificity of
cyclodextrin-glycosyltransferase. The Journal of
Biological Chemistry, 276(48), 44557-44562. https://doi.org/10.1074/jbc.M107533200
van
Geel-Schutten, G. H., Dijkhuizen, L., Rahaoui, H.,
& Leer, R-J. (2001). IPC No. C12P 19/ 18 A I. Lactobacillus reuteri glucosyltransferase.
(Patent No. WO0190372).
Woesten,
H. A. B., Claessen, D., Faber, O. H., Meijer, W. G., &
Dijkhuizen, L. (2001). IPC No. C07K 14/ 36 A I. Protein capable of self-assembly at a
hydrophobic-hydrophilic interface and uses threof. (Patent
No. WO0174864).
Uitdehaag,
J. C. M., Veen, B. A. V. D., Dijkhuizen, L., Elber,
R., & Dijkstra, B. W. (2001). Enzymatic circularization
of a malto-octaose linear chain studied by stochastic reaction path
calculations on cyclodextrin glycosyltransferase.
Proteins-Structure Function and
Bioinformatics, 43(3), 327-335. https://doi.org/10.1002/prot.1044
van
der Geize, R., Hessels, G. I., & Dijkhuizen, L.
(2001). IPC No. C12P 33/ 06 A I. Microbial 9
alpha -hydroxylation of steroids. (Patent No.
WO0131050).
Alves,
A. M. C. R., Euverink, G. J. W., Santos, H.,
& Dijkhuizen, L. (2001). Different Physiological
Roles of ATP- and PPi-Dependent Phosphofructokinase Isoenzymes in
the Methylotrophic Actinomycete Amycolatopsis methanolica.
Journal of Bacteriology, 183(24),
7231-7240. https://doi.org/10.1128/JB.183.24.7231-7240.2001
Martin,
MT., Alcalde, M., Plou, FJ., Dijkhuizen, L.,
Ballesteros, A., & Plou, F. J. (2001). Synthesis of
malto-oligosaccharides via the acceptor reaction catalyzed by
cyclodextrin glycosyltransferases. Biocatalysis
and Biotransformation, 19(1), 21-35. https://doi.org/10.3109/10242420109103514
2000
Veen,
B. A. V. D., Uitdehaag, J. C. M., Dijkstra, B. W., &
Dijkhuizen, L. (2000). Engineering of cyclodextrin
glycosyltransferase reaction and product specificity.
Biochimica et biophysica acta-Protein structure and
molecular enzymology, 1543(2), 336-360. https://doi.org/10.1016/S0167-4838(00)00233-8
van
Keulen, G., Dijkhuizen, L., & Meijer, WG. (2000).
Effects of the calvin cycle on nicotinamide adenine
dinucleotide concentrations and redox balances of Xantobacter
flavus. Journal of Bacteriology,
182(16), 4637-4639.
Uitdehaag,
JCM., van Alebeek, GJWM., Dijkhuizen, L., Dijkstra,
BW., Alebeek, G-J. W. M. V., & Dijkstra, B. W. (2000).
Structures of maltohexaose and maltoheptaose bound at the
donor sites of cyclodextrin glycosyltransferase give insight into
the mechanisms of transglycosylation activity and cyclodextrin size
specificity. Biochemistry,
39(26), 7772-7780. https://doi.org/10.1021/bi000340x
van
der Veen, B. A., Uitdehaag, J. C. M., Dijkstra, B. W., &
Dijkhuizen, L. (2000). The role of arginine 47 in the
cyclization and coupling reactions of cyclodextrin
glycosyltransferase from Bacillus circulans strain 251 -
Implications for product inhibition and product specificity.
European Journal of Biochemistry,
267(12), 3432-3441. https://doi.org/10.1046/j.1432-1327.2000.01353.x
van
der Geize, R., Hessels, GI., van Gerwen, R., Vrijbloed, JW., van
der Meijden, P., & Dijkhuizen, L. (2000).
Targeted disruption of the kstD gene encoding a 3-ketosteroid
Delta(1)-dehydrogenase isoenzyme of Rhodococcus erythropolis strain
SQ1. Applied and environmental
microbiology, 66(5), 2029-2036. https://doi.org/10.1128/AEM.66.5.2029-2036.2000
Veen,
B. A. V. D., Uitdehaag, J. C. M., Penninga, D., van Alebeek, G. J.
W. M., Smith, L. M., Dijkstra, B. W., & Dijkhuizen,
L. (2000). Rational Design of Cyclodextrin
Glycosyltransferase from Bacillus circulans Strain 251 to Increase
α-Cyclodextrin Production. Journal of
Molecular Biology, 296(4), 1027-1038. https://doi.org/10.1006/jmbi.2000.3528
Veen,
B. A. V. D., Alebeek, G-J. W. M. V., Uitdehaag, J. C. M., Dijkstra,
B. W., & Dijkhuizen, L. (2000). The three
transglycosylation reactions catalyzed by cyclodextrin
glycosyltransferase from Bacillus circulans (strain 251) proceed
via different kinetic mechanisms. European Journal
of Biochemistry, 267(3), 658-665. https://doi.org/10.1046/j.1432-1327.2000.01031.x
Hektor,
H. J., Kloosterman, H., & Dijkhuizen, L. (2000).
Nicotinoprotein methanol dehydrogenase enzymes in
Gram-positive methylotrophic bacteria. Journal of
Molecular Catalysis B: Enzymatic, 8(1-3),
103-109. https://doi.org/10.1016/S1381-1177(99)00073-9
van
Geel-Schutten, GH., van Hijum, S., Kralj, S., Rahaoui, H., Leer,
RJ., & Dijkhuizen, L. (2000).
Exopolysaccharide production by Lactobacillus reuteri,
involving sucrase type of enzymes. Mededelingen -
Faculteit Landbouwkundige en Toegepaste Biologische Wetenschappen,
Universiteit Gent, 65(3A), 197-201.
1999
Uitdehaag,
J. C. M., Kalk, K. H., Veen, B. A. V. D., Dijkhuizen,
L., & Dijkstra, B. W. (1999). The Cyclization
Mechanism of Cyclodextrin Glycosyltransferase (CGTase) as Revealed
by a γ-Cyclodextrin-CGTase Complex at 1.8-Å
Resolution. The Journal of Biological
Chemistry, 274(49), 34868-34876. https://doi.org/10.1074/jbc.274.49.34868
Uitdehaag,
JCM., Kalk, KH., Dijkhuizen, L., & Dijkstra, BW.
(1999). The cyclization mechanism of cyclodextrin
glycosyltransferase (CGTase) as revealed by a
gamma-cyclodextrin-CGTase complex at 1.8-angstrom
resolution. The Journal of Biological
Chemistry, 274(49), 34868-34876.
Geel-Schutten,
G. H. V., Faber, E. J., Smit, E., Bonting, K., Smith, M. R., Brink,
B. T., ... Dijkhuizen, L. (1999). Biochemical
and structural characterization of the glucan and fructan
exopolysaccharides synthesized by the Lactobacillus reuteri
wild-type strain and by mutant strains. Applied
and environmental microbiology, 65(7),
3008-3014.
Uitdehaag,
JCM., Mosi, R., Kalk, KH., Dijkhuizen, L., Withers,
SG., & Dijkstra, BW. (1999). X-ray structures along the
reaction pathway of cyclodextrin glycosyltransferase elucidate
catalysis in the alpha-amylase family. Nature
Structural Biology, 6(5), 432-436.
Dijkhuizen,
L., Uitdehaag, J., & Dijkstra, BW. (1999).
Engineering of cyclodextrin glycosyltransferase. In
HJ. Gilbert, GJ. Davies, B. Henrissat, & B. Svensson (Eds.),
RECENT ADVANCES IN CARBOHYDRATE BIOENGINEERING (pp.
263-271). (ROYAL SOCIETY OF CHEMISTRY SPECIAL PUBLICATIONS).
CAMBRIDGE: ROYAL SOC CHEMISTRY.
Uitdehaag,
J. C. M., Mosi, R., Kalk, K. H., Veen, B. A. V. D.,
Dijkhuizen, L., Withers, S. G., & Dijkstra, B. W.
(1999). X-ray structures along the reaction pathway of
cyclodextrin glycosyltransferase elucidate catalysis in the
α-amylase family. Nature Structural
Biology, 6(5). https://doi.org/10.1038/8235
1998
Breedveld,
M., Bonting, K., & Dijkhuizen, L. (1998).
Mutational analysis of exopolysaccharide biosynthesis by
Lactobacillus sakei 0-1. FEMS Microbiology
Letters, 169(2), 241-249. https://doi.org/10.1111/j.1574-6968.1998.tb13324.x
Geel-Schutten,
G. H. V., Flesch, F., Brink, B. T., Smith, M. R., &
Dijkhuizen, L. (1998). Screening and characterization
of Lactobacillus strains producing large amounts of
exopolysaccharides. Applied Microbiology and
Biotechnology, 50(6), 697 - 703. https://doi.org/10.1007/s002530051353
Wind,
RD., Buitelaar, RM., & Dijkhuizen, L. (1998).
Engineering of factors determining alpha-amylase and
cyclodextrin glycosyltransferase specificity in the cyclodextrin
glycosyltransferase from Thermoanaerobacterium thermosulfurigenes
EM1. European Journal of Biochemistry,
253(3), 598-605.
Wind,
R. D., Uitdehaag, J. C. M., Buitelaar, R. M., Dijkstra, B.
W., & Dijkhuizen, L. (1998). Engineering of
cyclodextrin product specificity and pH optima of the thermostable
cyclodextrin glycosyltransferase from Thermoanaerobacterium
thermosulfurigenes EM1. The Journal of Biological
Chemistry, 273(10), 5771 - 5779. https://doi.org/10.1074/jbc.273.10.5771
van
Keulen, G., Girbal, L., van den Bergh, E. R. E., Dijkhuizen,
L., & Meijer, W. G. (1998). The LysR-type
transcriptional regulator CbbR controlling autotrophic CO2 fixation
by Xanthobacter flavus is an NADPH sensor. Journal
of Bacteriology, 180(6), 1411-1417.
Wind,
R. D., Uitdehaag, J. C. M., Buitelaar, R. M., Dijkstra, B.
W., & Dijkhuizen, L. (1998). Engineering of
cyclodextrin product specifity and pH optima of the thermostable
cyclodextrin glycosyltransferase from Thermoanaerobacterium
thermosulfurigenes EM1. The Journal of Biological
Chemistry, 273, 5771 - 5779.
Wind,
R. D., Buitelaar, R. M., & Dijkhuizen, L. (1998).
Engineering of factors determining alpha-amylase and
cyclodextrin glycosyltranferase specificity in the cyclodextrin
glycosyltransferase form Thermoanaerobacterium thermosulfurigenes
EM1. European Journal of Biochemistry,
253(3), 598 - 605. https://doi.org/10.1046/j.1432-1327.1998.2530598.x
1997
Bystrykh,
LV., Govorukhina, NI., Dijkhuizen,
L., & Duine, J. A. (1997). Tetrazolium-dye-linked
alcohol dehydrogenase of the methylotrophic actinomycete
Amycolatopsis methanolica is a three-component complex.
European Journal of Biochemistry,
247(1), 280-287. https://doi.org/10.1111/j.1432-1033.1997.00280.x
Arfman,
N., Hektor, H. J., Bystrykh, L. V., Govorukhina,
N. I., Dijkhuizen, L., & Frank, J. (1997).
Properties of an NAD(H)-containing methanol dehydrogenase and
its activator protein from Bacillus methanolicus.
European Journal of Biochemistry,
244(2), 426-433. https://doi.org/10.1111/j.1432-1033.1997.00426.x
Alves,
AMCR., Euverink, GJW., Bibb, MJ., &
Dijkhuizen, L. (1997). Identification of ATP-dependent
phosphofructokinase as a regulatory step in the glycolytic pathway
of the actinomycete Streptomyces coelicolor A 3(2).
Applied and environmental microbiology,
63(3), 956-961.
Osinga,
R., deVries, KA., Lewis, WE., vanRaaphorst, W., Dijkhuizen,
L., & vanDuyl, FC. (1997). Aerobic degradation of
phytoplankton debris dominated by Phaeocystis sp in different
physiological stages of growth. Aquatic Microbial
Ecology, 12(1), 11-19. https://doi.org/10.3354/ame012011
Alves,
A. M. C. R., Euverink, G. J. W., Bibb, M. J.,
& Dijkhuizen, L. (1997). Identification of
ATP-Dependent Phosphofructokinase as a Regulatory Step in the
Glycolytic Pathway of the Actinomycete Streptomyces coelicolor
A3(2). Applied and environmental
microbiology, 63(3), 956-961.
1996
Kwint,
R. L. J., Quist, P., Hansen, T. A., Dijkhuizen, L.,
& Kramer, K. J. M. (1996). Turnover of
dimethylsulfoniopropionate and dimethylsulfide in the marine
environment: A mesocosm experiment. Marine Ecology
Progress Series, 145(1-3), 223-232. https://doi.org/10.3354/meps145223
Penninga,
D., Veen, B. A. V. D., Knegtel, R. M. A., Hijum, S. A. F. T.
V., Rozeboom, H. J., Kalk, K. H., ...
Dijkhuizen, L. (1996). The raw starch binding domain
of cyclodextrin glycosyltransferase from Bacillus circulans strain
251. The Journal of Biological
Chemistry, 271(51), 32777-32784. https://doi.org/10.1074/jbc.271.51.32777
Bornaghi,
L., Utille, J-P., Penninga, D., Schmidt, A. K., Dijkhuizen,
L., Schulz, G. E., & Driguez, H. (1996). Enzymic
synthesis of cyclothiomaltins. Chemical
Communications, 41(22), 2541 - 2542. https://doi.org/10.1039/cc9960002541
Dijkhuizen,
L., Dijkstra, B. W., Andersen, C., & von der Osten, C.
(1996). IPC No. C12R 1/ 19 A N. Cyclomaltodextrin glucanotransferase
variants. (Patent No. WO9633267).
Hektor,
H. J., & Dijkhuizen, L. (1996). Mutational
analysis of primary alcohol metabolism in the methylotrophic
actinomycete Amycolatopsis methanolica. FEMS
Microbiology Letters, 144(1), 73 - 79. https://doi.org/10.1016/0378-1097(96)00341-2
Strokopytov,
B., Knegtel, R. M. A., Penninga, D., Rozeboom, H. J.,
Kalk, K. H., Dijkhuizen, L., & Dijkstra, B. W.
(1996). Structure of Cyclodextrin Glycosyltransferase
Complexed with a Maltononaose Inhibitor at 2.6 Å Resolution.
Implications for Product Specificity.
Biochemistry, 35(13), 4241-4249. https://doi.org/10.1021/bi952339h
Bystrykh,
LV., FernandezMoreno, MA., Herrema, JK., Malpartida, F.,
Hopwood, DA., & Dijkhuizen, L. (1996).
Production of actinorhodin-related ''blue pigments'' by
Streptomyces coelicolor A3(2). Journal of
Bacteriology, 178(8), 2238-2244.
Knegtel,
RMA., Wind, RD., Rozeboom, HJ., Kalk, KH., Buitelaar,
RM., Dijkhuizen, L., & Dijkstra, BW. (1996).
Crystal Structure at 2.3 Å Resolution and Revised
Nucleotide Sequence of the Thermostable Cyclodextrin
Glycosyltransferase from Thermoanaerobacterium thermosulfurigenes
EM1. Journal of Molecular Biology,
256(3), 611-622. https://doi.org/10.1006/jmbi.1996.0113
Euverink,
G. J. W., Vrijbloed, J. W., Hessels, G. I., &
Dijkhuizen, L. (1996). Isolation and analysis of
mutants of the methylotrophic actinomycete Amycolatopsis
methanolica blocked in aromatic amino acid biosynthesis.
FEMS Microbiology Letters, 136(3),
275-281. https://doi.org/10.1111/j.1574-6968.1996.tb08061.x
Smith,
L. M., Meijer, W. G., Dijkhuizen, L., & Goodwin,
P. M. (1996). A protein having similarity with
methylmalonyl-CoA mutase is required for the assimilation of
methanol and ethanol by Methylobacterium extorquens AM1.
Microbiology, 142(3), 675 - 684. https://doi.org/10.1099/13500872-142-3-675
Stefels,
J., & Dijkhuizen, L. (1996).
Characteristics of DMSP-lyase in Phaeocystis sp
(Prymnesiophyceae). Marine Ecology Progress
Series, 131(1-3), 307-313. https://doi.org/10.3354/meps131307
Bergh,
E. R. E. V. D., Baker, S. C., Raggers, R. J., Terpstra, P.,
Woudstra, E. C., Dijkhuizen, L., & Meijer, W. G.
(1996). Primary Structure and Phylogeny of the Calvin Cycle
Enzymes Transketolase and Fructosebisphosphate Aldolase of
Xanthobacter flavus. Journal of
Bacteriology, 178(3), 888 - 893.
Alves,
A. M. C. R., Meijer, W. G., Vrijbloed, J. W., &
Dijkhuizen, L. (1996). Characterization and Phylogeny
of the pfp Gene of Amycolatopsis methanolica Encoding PPi-Dependent
Phosphofructokinase. Journal of
Bacteriology, 178(1), 149 - 155.
Dijkhuizen,
L. (1996). Evolution of metabolic pathways. In
D. M. Roberts, P. Sharp, G. Alderson, & M. Collins (Eds.),
Evolution of microbial life (pp. 243 - 265). Cambridge:
Cambridge University Press.
Dijkhuizen,
L. (1996). Intriguing functionality of the production
and conversion of DMSP in Phaeocystis sp. In RP. Kiene, PT.
Visscher, MD. Keller, & GO. Kirst (Eds.), BIOLOGICAL AND
ENVIRONMENTAL CHEMISTRY OF DMSP AND RELATED SULFONIUM
COMPOUNDS (pp. 305 - 315). NEW YORK: Plenum Press.
Dijkhuizen,
L. (1996). Metabolic regulation in the actinomycete
Amycolatopsis methanolica, a facultative methylotroph employing the
rump ccucle for formaldehyde assimilation. In M. E.
Lidstrom, & F. R. Tabita (Eds.), Microbial growth on C1
compounds (pp. 9 - 15). Dordrecht/Boston/London: Kluwer
Academic Publishers.
Dijkhuizen,
L. (1996). Metabolic regulation in the actinomycete
Amycolatopsis methanolica, a facultative methylotroph employing the
rump cycle for formaldehyde assimilation. In ME. Lidstrom,
& FR. Tabita (Eds.), MICROBIAL GROWTH ON C(1)
COMPOUNDS (pp. 9-15). DORDRECHT: Kluwer Academic
Publishers.
Uitdehaag,
J. C. M., Penninga, D., Alebeek, G., Veen, B. V. D.,
Rozeboom, H., Kalk, K. H., ... Dijkstra, B. W. (1996).
Residues in Cyclodextrin Glycosyl Transferase that
Determine Product Specificity.
1995
KNEGTEL,
RMK., STROKOPYTOV, B., PENNINGA, D., FABER, OG., ROZEBOOM,
HJ., KALK, KH., ... DIJKSTRA, BW. (1995).
CRYSTALLOGRAPHIC STUDIES OF THE INTERACTION OF CYCLODEXTRIN
GLYCOSYLTRANSFERASE FROM BACILLUS-CIRCULANS STRAIN-251 WITH NATURAL
SUBSTRATES AND PRODUCTS. The Journal of Biological
Chemistry, 270(49), 29256-29264. https://doi.org/10.1074/jbc.270.49.29256
Pedersen,
S., Dijkhuizen, L., Dijkstra, BW., Jensen, BF., &
Jorgensen, ST. (1995). A better enzyme for
cyclodextrins. Chemtech,
25(12), 19-25.
Euverink,
G. J. W., Hessels, G. I., Franke, C., &
Dijkhuizen, L. (1995). Chorismate Mutase and
3-Deoxy-D-arabino-Heptulosonate 7-Phosphate Synthase of the
Methylotrophic Actinomycete Amycolatopsis methanolica.
Applied and environmental microbiology,
61(11), 3796-3803.
VRIJBLOED,
JW., VANDERPUT, NMJ., & DIJKHUIZEN, L. (1995).
IDENTIFICATION AND FUNCTIONAL-ANALYSIS OF THE TRANSFER REGION
OF PLASMID PMEA300 OF THE METHYLOTROPHIC ACTINOMYCETE
AMYCOLATOPSIS-METHANOLICA. Journal of
Bacteriology, 177(22), 6499-6505.
Vrijbloed,
J. W., Hylckama Vlieg, J. V., Put, N. M. J. V. D., Hessels, G.
I., & Dijkhuizen, L. (1995). Molecular
Cloning with a pMEA300-Derived Shuttle Vector and Characterization
of the Amycolatopsis methanolica Prephenate Dehydratase
Gene. Journal of Bacteriology,
177(22), 6666-6669.
Bergh,
E. R. E. V. D., Kooij, T. A. W. V. D., Dijkhuizen, L.,
& Meijer, W. (1995). Fructosebisphosphatase Isoenzymes of
the Chemoautotroph Xanthobacter flavus. Journal of
Bacteriology, 177(20), 5860-5864.
Vrijbloed,
J. W., Jelínková, M., Hessels, G. I., &
Dijkhuizen, L. (1995). Identification of the minimal
replicon of plasmid pMEA300 of the methylotrophic actinomycete
Amycolatopsis methanolica. Molecular
Microbiology, 18(1), 21-31. https://doi.org/10.1111/j.1365-2958.1995.mmi_18010021.x
Vrijbloed,
J. W., Madoń, J., & Dijkhuizen, L. (1995).
Transformation of the Methylotrophic Actinomycete
Amycolatopis methanolica with Plasmid DNA: Stimulatory Effect of a
pMEA300-Encoded Gene. Plasmid,
34(2), 96-104. https://doi.org/10.1006/plas.1995.9997
Stefels,
J., Dijkhuizen, L., & Gieskes, WWC. (1995).
DMSP-lyase activity in a spring phytoplankton bloom off the
Dutch coast, related to Phaeocystis sp. abundance.
Marine Ecology Progress Series,
123(1-3), 235-243. https://doi.org/10.3354/meps123235
Euverink,
G. J. W., Wolters, D. J., & Dijkhuizen, L.
(1995). Prephenate dehydratase of the actinomycete
Amycolatopsis methanolica: purification and characterization of
wild-type and deregulated mutant proteins.
Biochemical Journal, 308,
313-320.
Abou-Zeid,
A., Euverink, G. J. W., Hessels, G. I., Jensen, R.
A., & Dijkhuizen, L. (1995). Biosynthesis of
L-Phenylalanine and L-Tyrosine in the Actinomycete Amycolatopsis
methanolica. Applied and environmental
microbiology, 61(4), 1298-1302.
WIND,
RD., LIEBL, W., BUITELAAR, RM., PENNINGA, D., SPREINAT, A.,
DIJKHUIZEN, L., & BAHL, H. (1995). CYCLODEXTRIN
FORMATION BY THE THERMOSTABLE ALPHA-AMYLASE OF
THERMOANAEROBACTERIUM THERMOSULFURIGENES EM1 AND RECLASSIFICATION
OF THE ENZYME AS A CYCLODEXTRIN GLYCOSYLTRANSFERASE.
Applied and environmental microbiology,
61(4), 1257-1265.
Wind,
R. D., Liebl, W., Buitelaar, R. M., Penninga, D., Spreinat,
A., Dijkhuizen, L., & Bahl, H. (1995).
Cyclodextrin Formation by the Thermostable α-Amylase of
Thermoanaerobacterium thermosulfurigenes EM1 and Reclassification
of the Enzyme as a Cyclodextrin Glycosyltransferase.
Applied and environmental microbiology,
61(4), [ 692573].
PENNINGA,
D., STROKOPYTOV, B., ROZEBOOM, HJ., LAWSON, CL.,
DIJKSTRA, BW., & DIJKHUIZEN, L. (1995).
Site-Directed Mutations in Tyrosine 195 of Cyclodextrin
Glycosyltransferase from Bacillus circulans Strain 251 Affect
Activity and Product Specificity.
Biochemistry, 34(10), 3368-3376. https://doi.org/10.1021/bi00010a028
STROKOPYTOV,
B., PENNINGA, D., ROZEBOOM, HJ., KALK, KH.,
DIJKHUIZEN, L., & DIJKSTRA, BW. (1995). X-ray
Structure of Cyclodextrin Glycosyltransferase Complexed with
Acarbose. Implications for the Catalytic Mechanism of
Glycosidases. Biochemistry,
34(7), 2234-2240. https://doi.org/10.1021/bi00007a018
Dijkhuizen,
L., Penninga, D., Rozeboom, HJ., Strokopytov,
B., & Dijkstra, BW. (1995). Protein engineering of
cyclodextrin glycosyltransferase from Bacillus circulans strain
251. In SB. Petersen, B. Svensson, & S. Pedersen (Eds.),
CARBOHYDRATE BIOENGINEERING (pp. 165-174). (PROGRESS IN
BIOTECHNOLOGY; Vol. 10). AMSTERDAM: Elsevier.
Dijkhuizen,
L., Penninga, D., Rozeboom, H. J., Strokopytov,
B., & Dijkstra, B. W. (1995). Protein engineering of
cyclodextrin glycosyltransferase from Bacillus circulans strain
251. Progress in Biotechnology,
10(1), 165-174. https://doi.org/10.1016/S0921-0423(06)80101-2
Dijkhuizen,
L., Penninga, D., Rozeboom, H. J., Strokopytov,
B., & Dijkstra, B. W. (1995). Protein engineering of
cyclodextrin glycosyltransferase from Bacillus circulans strain
251. In Proceedings of an International Conference on
Carbohydrate Bioengineering (10 ed., pp. 165-174).
Elsevier.
Stefels,
J., Dijkhuizen, L., & Gieskes, WWC. (1995).
The marine sulfur-cycle: Importance of Phaeocystis sp in
DMS-production during a nearshore springbloom. In S.
Zwerver, RSA. vanRompaey, MTJ. Kok, & MM. Berk (Eds.),
Proceedings of the International Climate Change Research
Conference: Evaluation and Policy Implications (pp. 241-243).
(STUDIES IN ENVIRONMENTAL SCIENCE; Vol. 65). AMSTERDAM:
Elsevier.
1994
VRIJBLOED,
JW., MADON, J., & DIJKHUIZEN, L. (1994). A
plasmid from the methylotrophic actinomycete
amycolatopsis-methanolica capable of site-specific
integration. Journal of Bacteriology,
176(22), 7087-7090.
Alves,
A. M. C. R., Euverink, G. J. W., Hektor, H. J.,
Hessels, G. I., Vlag, J. V. D., Vrijbloed, J. W., ...
Dijkhuizen, L. (1994). Enzymes of Glucose and Methanol
Metabolism in the Actinomycete Amycolatopsis methanolica.
Journal of Bacteriology, 176(22),
6827-6835.
WIND,
RD., BUITELAAR, RM., EGGINK, G., HUIZING, HJ., &
DIJKHUIZEN, L. (1994). Characterization of a new
bacillus-stearothermophilus isolate - a highly thermostable
alpha-amylase-producing strain. Applied
Microbiology and Biotechnology, 41(2),
155-162.
LAWSON,
CL., VANMONTFORT, R., STROKOPYTOV, B., ROZEBOOM, HJ.,
KALK, KH., DEVRIES, GE., ... DIJKSTRA, BW. (1994). Nucleotide
Sequence and X-ray Structure of Cyclodextrin Glycosyltransferase
from Bacillus circulans Strain 251 in a Maltose-dependent Crystal
Form. Journal of Molecular Biology,
236(2), 590-600. https://doi.org/10.1006/jmbi.1994.1168
Hermes,
H. F. M., Tandler, R. F., Sonke, T., Dijkhuizen, L.,
& Meijer, E. M. (1994). Purification and Characterization
of an L-Amino Amidase from Mycobacterium neoaurum ATCC
25795. Applied and environmental
microbiology, 60(1), 153-159.
Wind,
R. D., Buitelaar, B. M., Eggink, G., Huizing, H. J., &
Dijkhuizen, L. (1994). Characterization of a new
Bacillus stearothermophilus isolate: A highly thermostable
alfa-amylase-producing strain. Applied
Microbiological Biotechnology, 41, 155 -
162.
Wind,
R. D., Buitelaar, R. M., Eggink, G., Huizing, H. J., &
Dijkhuizen, L. (1994). Characterization of a new
Bacillus stearothermophilus isolate: a highly thermostable
α-amylase-producing strain. Applied
Microbiology and Biotechnology, 41(2). https://doi.org/10.1007/BF00186953
1993
Hermes,
H. F. M., Croes, L. M., Peeters, W. P. H., Peters, P. J. H.,
& Dijkhuizen, L. (1993). Metabolism of amino acid
amides in Pseudomonas putida ATCC 12633. Applied
Microbiology and Biotechnology, 40(4),
519-525. https://doi.org/10.1007/BF00175742
Hermes,
H. F. M., Sonke, T., Peters, P. J. H., Balken, J. A. M. V.,
Kamphuis, J., Dijkhuizen, L., & Meijer, E. M.
(1993). Purification and Characterization of an
L-Aminopeptidase from Pseudomonas putida ATCC 12633.
Applied and environmental microbiology,
59(12), 4330-4334.
VANDERMAAREL,
MJEC., QUIST, P., DIJKHUIZEN, L., & HANSEN,
TA. (1993). ANAEROBIC DEGRADATION OF
DIMETHYLSULFONIOPROPIONATE TO 3-S-METHYLMERCAPTOPROPIONATE BY A
MARINE DESULFOBACTERIUM STRAIN. Archives of
Microbiology, 160(5), 411-412. https://doi.org/10.1007/BF00252230
van
den Bergh, E., Dijkhuizen, L., & Meijer, W.
(1993). CbbR, a LysR-Type Transcriptional Activator, Is
Required for Expression of the Autotrophic CO2 Fixation Enzymes of
Xanthobacter flavus. Journal of
Bacteriology, 175(19), 6097-6104.
BYSTRYKH,
L. V., Govorukhina, N. I., van Ophem, P. W.,
Hektor, H. J., Dijkhuizen, L., & Duine, J. A.
(1993). Formaldehyde dismutase activities in Gram-positive
bacteria oxidizing methanol. Journal of general
microbiology, 139(9), 1979-1985. https://doi.org/10.1099/00221287-139-9-1979
Bystrykh,
L. V., Vonck, J., Bruggen, E. F. J. V., Beeumen, J. V.,
Samyn, B., Govorukhina, N. I., ... Dijkhuizen,
L. (1993). Electron Microscopic Analysis and
Structural Characterization of Novel NADP(H)-Containing Methanol:
N,N'-Dimethyl-4-Nitrosoaniline Oxidoreductases from the
Gram-Positive Methylotrophic Bacteria Amycolatopsis methanolica and
Mycobacterium gastri MB19. Journal of
Bacteriology, 175(6), 1814-1822.
HANSEN,
TA., QUIST, P., VANDERMAAREL, MJEC., &
DIJKHUIZEN, L. (1993). ISOLATION OF MARINE
DIMETHYLSULFIDE-OXIDIZING BACTERIA. In G. Restelli, & G.
Angeletti (Eds.), DIMETHYLSULFIDE: OCEANS, ATMOSPHERE AND
CLIMATE (pp. 37-41). DORDRECHT: Kluwer Academic
Publishers.
1992
Tabita,
F. R., Gibson, J. L., Bowien, B., Dijkhuizen, L.,
& Meijer, W. (1992). Uniform designation for genes of the
Calvin-Benson-Bassham reductive pentose phosphate pathway of
bacteria. FEMS Microbiology Letters,
99(2-3), 107-110. https://doi.org/10.1111/j.1574-6968.1992.tb05551.x
Euverink,
G. J. W., Hessels, G. I., Vrijbloed, J. W., Coggins, J.
R., & Dijkhuizen, L. (1992). Purification
and characterization of a dual function 3-dehydroquinate
dehydratase from Amycolatopsis methanolica.
Journal of general microbiology,
138(11), 2449-2457. https://doi.org/10.1099/00221287-138-11-2449
Attwood,
M. M., Arfman, N., Weusthuis, R. A., & Dijkhuizen,
L. (1992). Purification and characterization of an
NAD+-linked formaldehyde dehydrogenase from the facultative RuMP
cycle methylotroph Arthrobacter P1. Antonie Van
Leeuwenhoek: International Journal of General and Molecular
Microbiology, 62(3), 201-207. https://doi.org/10.1007/BF00582580
de
Vries, G., Arfman, N., Terpstra, P., & Dijkhuizen,
L. (1992). Cloning, Expression, and Sequence Analysis
of the Bacillus methanolicus C1 Methanol Dehydrogenase Gene.
Journal of Bacteriology, 174(16),
5346-5353.
Kellogg,
R. M., Kruizinga, W., Bystrykh, L. V.,
Dijkhuizen, L., & Harder, W. (1992). Structural
Analysis of a Stereochemical Modification of Flavin Adenine
Dinucleotide in Alcohol Oxidase from Methylotrophic Yeasts.
Tetrahedron, 48(20), 4147-4162. https://doi.org/10.1016/S0040-4020(01)92193-3
Reding,
H. K., Croes, G. L. M., Dijkhuizen, L., & Wiegel,
J. (1992). Emendation of Xanthobacter flavus as a Motile
Species. International Journal of Systematic
Bacteriology, 42(2), 309-311. https://doi.org/10.1099/00207713-42-2-309
Arfman,
N., Moezelaar, H. R., Attwood, M. M., Robinson, G. K., Geel, M.
V., & Dijkhuizen, L. (1992). Environmental
regulation of alcohol metabolism in thermotolerant methylotrophic
Bacillus strains. Archives of
Microbiology, 157(3), 272-278. https://doi.org/10.1007/BF00245161
Arfman,
N., Dijkhuizen, L., Kirchhof, G., Ludwig, W.,
Schleifer, K-H., Bulygina, E. S., ... Sharp, R. J. (1992).
Bacillus methanolicus sp. nov., a New Species of
Thermotolerant, Methanol-Utilizing, Endospore-Forming
Bacteria. International Journal of Systematic
Bacteriology, 42(3), 439-445. https://doi.org/10.1099/00207713-42-3-439
Sani,
A., & Dijkhuizen, L. (1992). Regulation of
ribulose-bisphosphate carboxylase activity and synthesis in
Rhodopseudomonas blastica grown in continuous culture.
Nigerian Journal of Botany, 5,
27-34.
1991
Bystrykh,
L. V., Dijkhuizen, L., & Harder, W. (1991).
Modification of flavin adenine dinucleotide in alcohol
oxidase of the yeast Hansenula polymorpha. Journal
of general microbiology, 137(10), 2381-2386.
https://doi.org/10.1099/00221287-137-10-2381
VANOPHEM,
PW., Euverink, G-J., Dijkhuizen, L.,
& DUINE, JA. (1991). A novel dye-linked alcohol
dehydrogenase activity present in some Gram-positive
bacteria. FEMS Microbiology Letters,
80(1), 57-63. https://doi.org/10.1111/j.1574-6968.1991.tb04636.x
Vonck,
J., Arfman, N., de Vries, G. E., Beeumen, J. V., Bruggen, E. F. J.
V., & Dijkhuizen, L. (1991).
ELECTRON-MICROSCOPIC ANALYSIS AND
BIOCHEMICAL-CHARACTERIZATION OF A NOVEL METHANOL DEHYDROGENASE FROM
THE THERMOTOLERANT BACILLUS-SP C1. The Journal of
Biological Chemistry, 266(6), 3949-3954.
Arfman,
N., Beeumen, J. V., Vries, G. E. D., Harder, W., &
Dijkhuizen, L. (1991). PURIFICATION AND
CHARACTERIZATION OF AN ACTIVATOR PROTEIN FOR METHANOL DEHYDROGENASE
FROM THERMOTOLERANT BACILLUS SPP. The Journal of
Biological Chemistry, 266(6), 3955-3960.
Meijer,
W. G., Arnberg, A., Enequist, H. G., Terpstra, P., Lidstrom, M.
E., & Dijkhuizen, L. (1991). Identification
and organization of carbon dioxide fixation genes in Xanthobacter
flavus H4-14. Molecular and General
Genetics, 225(2), 320-330. https://doi.org/10.1007/BF00269865
Croes,
L. M., Meijer, W., & Dijkhuizen, L. (1991).
Regulation of methanol oxidation and carbon dioxide fixation
in Xanthobacter strain 25a grown in continuous culture.
Archives of Microbiology, 155(2),
159-163. https://doi.org/10.1007/BF00248611
1990
Dijkhuizen,
L., & Arfman, N. (1990). Methanol metabolism in
thermotolerant methylotrophic Bacillus species.
FEMS Microbiology Reviews, 87(3-4),
215-219. https://doi.org/10.1016/0378-1097(90)90457-2
Meijer,
W., Enequist, H. G., Terpstra, P., & Dijkhuizen,
L. (1990). Nucleotide sequences of the genes encoding
fructosebisphosphatase and phosphoribulokinase from Xanthobacter
flavus H4-14. Journal of general
microbiology, 136(11), 2225-2230. https://doi.org/10.1099/00221287-136-11-2225
Lawson,
C. L., Bergsma, J., Bruinenberg, P. M., Vries, G. D.,
Dijkhuizen, L., & Dijkstra, B. W. (1990).
Maltodextrin-dependent Crystallization of Cyclomaltodextrin
Glucanotransferase from Bacillus circulans.
Journal of Molecular Biology,
214(4), 807-809. https://doi.org/10.1016/0022-2836(90)90335-J
DEBOER,
L., GROBBEN, G., VRIJBLOED, JW., & DIJKHUIZEN, L.
(1990). BIOSYNTHESIS OF AROMATIC-AMINO-ACIDS IN NOCARDIA SP
239 - EFFECTS OF AMINO-ACID-ANALOGS ON GROWTH AND REGULATORY
ENZYMES. Applied Microbiology and
Biotechnology, 33(2), 183-189.
MEIJER,
WG., CROES, LM., JENNI, B., LEHMICKE, LG., LIDSTROM, ME.,
& DIJKHUIZEN, L. (1990). CHARACTERIZATION OF
XANTHOBACTER STRAINS H4-14 AND 25A AND ENZYME PROFILES AFTER GROWTH
UNDER AUTOTROPHIC AND HETEROTROPHIC CONDITIONS.
Archives of Microbiology, 153(4),
360-367. https://doi.org/10.1007/BF00249006
Koning,
W. D., Weusthuis, R. A., Harder, W., & Dijkhuizen,
L. (1990). Methanol-dependent production of
dihydroxyacetone and glycerol by mutants of the methylotrophic
yeast Hansenula polymorpha blocked in dihydroxyacetone kinase and
glycerol kinase. Applied Microbiology and
Biotechnology, 32(6), 693-698. https://doi.org/10.1007/BF00164742
Boer,
L. D., Euverink, G. J., Vlag, J. V. D., &
Dijkhuizen, L. (1990). Regulation of methanol
metabolism in the facultative methylotroph Nocardia sp. 239 during
growth on mixed substrates in batch- and continuous
cultures. Archives of Microbiology,
153(4), 337-343. https://doi.org/10.1007/BF00249002
Boer,
L. D., Dijkhuizen, L., Grobben, G., Goodfellow, M.,
Stackebrandt, E., Parlett, J. H., ... Witt, D. (1990).
Amycolatopsis methanolica sp. nov. a Facultatively
Methylotrophic Actinomycete. International Journal
of Systematic Bacteriology, 40(2), 194-204. https://doi.org/10.1099/00207713-40-2-194
Boer,
L. D., Grobben, G., Vrijbloed, J. W., & Dijkhuizen,
L. (1990). Biosynthesis of aromatic amino acids in
Nocardia sp. 239: effects of amino acid analogues on growth and
regulatory enzymes. Applied Microbiology and
Biotechnology, 33(2). https://doi.org/10.1007/BF00176522
DEKONING,
W., BONTING, K., HARDER, W., & DIJKHUIZEN, L.
(1990). CLASSICAL TRANSKETOLASE FUNCTIONS AS THE
FORMALDEHYDE-ASSIMILATING ENZYME DURING GROWTH OF A
DIHYDROXYACETONE SYNTHASE-NEGATIVE MUTANT OF THE METHYLOTROPHIC
YEAST HANSENULA-POLYMORPHA ON MIXTURES OF XYLOSE AND METHANOL IN
CONTINUOUS CULTURES. Yeast,
6(2), 117-125.
DE
KONING, W., WEUSTHUIS, RA., HARDER, W., & DIJKHUIZEN,
L. (1990). METABOLIC-REGULATION IN THE YEAST
HANSENULA-POLYMORPHA - GROWTH OF DIHYDROXYACETONE KINASE GLYCEROL
KINASE-NEGATIVE MUTANTS ON MIXTURES OF METHANOL AND XYLOSE IN
CONTINUOUS CULTURES. Yeast,
6(2), 107-115.
ARFMAN,
N., & DIJKHUIZEN, L. (1990). Methanol
dehydrogenase from thermotolerant methylotroph bacillus c1.
Methods in Enzymology, 188,
223-226.
LEVERING,
PR., & DIJKHUIZEN, L. (1990). Transaldolase
isoenzymes from arthrobacter p1. Methods in
Enzymology, 188, 405-411.
ARFMAN,
N., BYSTRYKH, L., GOVORUKHINA, NI.,
& DIJKHUIZEN, L. (1990). 3-HEXULOSE-6-PHOSPHATE
SYNTHASE FROM THERMOTOLERANT METHYLOTROPH BACILLUS C1.
Methods in Enzymology, 188,
391-397.
1989
Boer,
L. D., Rijssel, M. V., Euverink, G.
J., & Dijkhuizen, L. (1989).
Purification, characterization and regulation of a monomeric
L-phenylalanine dehydrogenase from the facultative methylotroph
Nocardia sp. 239. Archives of
Microbiology, 153(1), 12-18. https://doi.org/10.1007/BF00277534
de
Boer, L., Brouwer, J. W., Hassel, C. W. V., Levering, P.,
& Dijkhuizen, L. (1989). Nitrogen metabolism in
the facultative methylotroph Arthrobacter P1 grown with various
amines or ammonia as nitrogen sources. Antonie van
Leeuwenhoek: Journal of Microbiology, 56(3),
221-232. https://doi.org/10.1007/bf00418934
ARFMAN,
N., WATLING, EM., CLEMENT, W., VANOOSTERWIJK, RJ., DEVRIES, GE.,
HARDER, W., ... Vries, G. E. D. (1989). METHANOL METABOLISM
IN THERMOTOLERANT METHYLOTROPHIC BACILLUS STRAINS INVOLVING A NOVEL
CATABOLIC NAD-DEPENDENT METHANOL DEHYDROGENASE AS A KEY
ENZYME. Archives of Microbiology,
152(3), 280-288. https://doi.org/10.1007/BF00409664
Boer,
L. D., Vrijbloed, J. W., Grobben, G., & Dijkhuizen,
L. (1989). Regulation of aromatic amino acid
biosynthesis in the ribulose monophosphate cycle methylotroph
Nocardia sp. 239. Archives of
Microbiology, 151(4), 319-325. https://doi.org/10.1007/BF00406558
1988
Meijer,
W., & Dijkhuizen, L. (1988). Regulation of
Autotrophic Metabolism in Pseudomonas oxalaticus OX1 Wild-type and
an Isocitrate-lyase-deficient Mutant. Journal of
general microbiology, 134(12), 3231-3237. https://doi.org/10.1099/00221287-134-12-3231
DIJKHUIZEN,
L., ARFMAN, N., ATTWOOD, MM., BROOKE, AG., HARDER, W., &
WATLING, EM. (1988). ISOLATION AND INITIAL CHARACTERIZATION
OF THERMOTOLERANT METHYLOTROPHIC BACILLUS STRAINS.
FEMS Microbiology Letters, 52(3),
209-214. https://doi.org/10.1111/j.1574-6968.1988.tb02597.x
Levering,
P. R., Weenk, G., Olijve, W., Dijkhuizen, L., &
Harder, W. (1988). Regulation of gluconate and ketogluconate
production in Gluconobacter oxydans ATCC 621-H.
Archives of Microbiology, 149(6),
534-539. https://doi.org/10.1007/BF00446757
Boer,
L. D., Harder, W., & Dijkhuizen, L. (1988).
Phenylalanine and tyrosine metabolism in the facultative
methylotroph Nocardia sp. 239. Archives of
Microbiology, 149(5), 459-465. https://doi.org/10.1007/BF00425588
1987
SCHUTTEN,
N. V., HARDER, W., DIJKHUIZEN, L., & Schutten, I.
(1987). THERMOSTABILITY OF L-PHENYLALANINE AMINOTRANSFERASE
FROM THERMOPHILIC BACTERIA. Applied Microbiology
and Biotechnology, 27(3), 292-298. https://doi.org/10.1007/BF00252933
Koning,
W. D., Harder, W., & Dijkhuizen, L. (1987).
Glycerol metabolism in the methylotrophic yeast Hansenula
polymorpha: phosphorylation as the initial step.
Archives of Microbiology, 148(4),
314-320. https://doi.org/10.1007/bf00456710
Koning,
W. D., Gleeson, M. A. G., Harder, W., & Dijkhuizen,
L. (1987). Regulation of methanol metabolism in the
yeast Hansenula polymorpha. Isolation and characterization of
mutants blocked in methanol assimilatory enzymes.
Archives of Microbiology, 147(4),
375-382. https://doi.org/10.1007/bf00406136
Levering,
P. R., Tiesma, L., Woldendorp, J. P., & Dijkhuizen,
L. (1987). Isolation and characterization of mutants
of the facultative methylotroph Arthrobacter P1 blocked in
one-carbon metabolism. Archives of
Microbiology, 146(4), 346-352. https://doi.org/10.1007/BF00410934
1986
Brooke,
A. G., Dijkhuizen, L., & Harder, W. (1986).
Regulation of flavin biosynthesis in the methylotrophic yeast
Hansenula polymorpha. Archives of
Microbiology, 145(1), 62-70. https://doi.org/10.1007/BF00413028
Croes,
L. M., & Dijkhuizen, L. (1986). Regulation
of methylamine and formaldehyde metabolism in Arthrobacter P1.
Formaldehyde is the inducing signal for the synthesis of the RuMP
cycle enzyme hexulose phosphate synthase. Archives
of Microbiology, 144(3), 279-285. https://doi.org/10.1007/BF00410963
Levering,
P. R., & Dijkhuizen, L. (1986). Regulation
and function of transaldolase isoenzymes involved in sugar and
one-carbon metabolism in the ribulose monophosphate cycle
methylotroph Arthrobacter P1. Archives of
Microbiology, 144(2), 116-123. https://doi.org/10.1007/BF00414720
Croes,
L. M., Tiesma, L., & Dijkhuizen, L. (1986).
Regulation of methylamine and formaldehyde metabolism in
Arthrobacter P1. Effect of pulse-wise addition of "heterotrophic"
substrates to C1 substrate-limited continuous cultures.
Archives of Microbiology, 144(3),
272-278. https://doi.org/10.1007/bf00410962
1985
Janssen,
D. B., Scheper, A., Dijkhuizen, L., &
Witholt, B. (1985). Degradation of Halogenated Aliphatic
Compounds by Xanthobacter autotrophicus GJ10.
Applied and environmental microbiology,
49(3), 673-677.
DIJKHUIZEN,
L., HANSEN, T. A., & HARDER, W. (1985). METHANOL,
A POTENTIAL FEEDSTOCK FOR BIOTECHNOLOGICAL PROCESSES.
Trends in Biotechnology, 3(10),
262-267. https://doi.org/10.1016/0167-7799(85)90026-5
Boer,
L. D., Clement, W., Dijkhuizen, L., & Harder, W.
(1985). Methanol as a fermentation substrate for the
production of phenylalanine, tyrosine and tryptophan by the
facultative methylotroph Nocardia sp. 239. Antonie
van Leeuwenhoek: Journal of Microbiology,
51(5-6), 566-577.
LEVERING,
PR., & DIJKHUIZEN, L. (1985). Regulation of
methylotrophic and heterotrophic metabolism in Arthrobacter P1.
Growth on mixtures of methylamine and acetate in batch and
continuous cultures. Archives of
Microbiology, 142(2), 113-120. https://doi.org/10.1007/BF00447053
1984
Dijkhuizen,
L., & Harder, W. (1984). Current views on the
regulation of autotrophic carbon dioxide fixation via the Calvin
cycle in bacteria. Antonie van
Leeuwenhoek, 50(5-6), 473-487. https://doi.org/10.1007/BF02386221
Dijkhuizen,
L., Harder, W., Boer, L. D., Boven, A. V., Clement, W.,
Bron, S., & Venema, G. (1984). Genetic manipulation of
the restricted facultative methylotroph Hyphomicrobium X by the
R-plasmid-mediated introduction of the Escherichia coli pdh
genes. Archives of Microbiology,
139(4), 311-318. https://doi.org/10.1007/BF00408372
Dijkhuizen,
L., & Harder, W. (1984). Metabolic regulation in
the facultative methylotroph Arthrobacter P1. Growth on primary
amines as carbon and energy sources. Archives of
Microbiology, 139(2-3), 188-195. https://doi.org/10.1007/BF00401998
Dijkhuizen,
L., & Harder, W. (1984). Regulation of Autotrophic
and Heterotrophic Metabolism in Pseudomonas oxalaticus OX1. Growth
on Fructose and on Mixtures of Fructose and Formate in Batch and
Continuous Cultures. Microbiology,
130(3), 447-457. https://doi.org/10.1099/00221287-130-3-447
1983
Hiemstra,
H., Dijkhuizen, L., & Harder, W. (1983).
Diffusion of Oxygen in Alginate Gels Related to the Kinetics
of Methanol Oxidation by Immobilized Hansenula polymorpha
Cells. European Journal of Applied Microbiology
and Biotechnology, 18(4), 189-196. https://doi.org/10.1007/bf00501507
Harder,
W., & Dijkhuizen, L. (1983). Physiological
Responses to Nutrient Limitation. Annual Review of
Microbiology, 37(1), 1-23. https://doi.org/10.1146/annurev.mi.37.100183.000245
1982
LEVERING,
PR., DIJKHUIZEN, L., & HARDER, W. (1982).
ENZYMATIC EVIDENCE FOR THE OPERATION OF THE FBP ALDOLASE
CLEAVAGE AND TK TA REARRANGEMENT VARIANT OF THE RUMP CYCLE IN
ARTHROBACTER-P1. FEMS Microbiology
Letters, 14(4), 257-261.
Dijkhuizen,
L., & Harder, W. (1982). Enzymatic evidence for
the operation of the FBP aldolase cleavage and TK/TA re-arrangement
variant of the RuMP cycle in Arthrobacter P1. FEMS
Microbiology Letters, 14(4). https://doi.org/10.1111/j.1574-6968.1982.tb00009.x
HARDER,
W., & DIJKHUIZEN, L. (1982). STRATEGIES OF
MIXED SUBSTRATE UTILIZATION IN MICROORGANISMS.
Philosophical Transactions of the Royal Society of
London. Series B: Biological Sciences,
297(1088), 459-480.
Dijkhuizen,
L., Boer, L. D., Boers, R. H., Harder, W., & Konings, W.
(1982). Uptake of Methylamine Via an Inducible,
Energy-Dependent Transport System in the Facultative Methylotroph
Arthrobacter P1. Archives of
Microbiology, 133(4), 261-266. https://doi.org/10.1007/BF00521287
1981
DIJKHUIZEN,
L., KEIJER, L., WADDELL, VJC., PRIMROSE, SB., BARSTOW, D.,
& ATKINSON, A. (1981). THE RAPID ISOLATION OF MUTANTS OF
SOME GRAM-POSITIVE BACTERIA. FEMS Microbiology
Letters, 12(1), 51-53. https://doi.org/10.1111/j.1574-6968.1981.tb07610.x
1980
Dijkhuizen,
L., Werf, B. V. D., & Harder, W. (1980). Metabolic
Regulation in Pseudomonas oxalaticus OX1: Diauxic Growth on
Mixtures of Oxalate and Formate or Acetate.
Archives of Microbiology, 124(2-3),
261-268. https://doi.org/10.1007/BF00427736
1979
Dijkhuizen,
L., Timmerman, J. W. C., & Harder, W. (1979). A
Pyridine Nucleotide-Independent Membrane-Bound Formate
Dehydrogenase in Pseudomonas Oxalaticus OX1. FEMS
Microbiology Letters, 6(1), 53-56. https://doi.org/10.1016/0378-1097(79)90186-1
Dijkhuizen,
L. (1979). Regulation of autothrophic and
heterotrophic metabolism in Pseudomonas oxalaticus OX1.
s.n.
Dijkhuizen,
L., & Harder, W. (1979). Regulation of Autotrophic
and Heterotrophic Metabolism in Pseudomonas oxalaticus OX1: Growth
on Mixtures of Acetate and Formate in Continuous Culture.
Archives of Microbiology, 123(1),
47-53. https://doi.org/10.1007/BF00403501
Dijkhuizen,
L., & Harder, W. (1979). Regulation of Autotrophic
and Heterotrophic Metabolism in Pseudomonas oxalaticus OX1: Growth
on Mixtures of Oxalate and Formate in Continuous Culture.
Archives of Microbiology, 123(1),
55-63. https://doi.org/10.1007/BF00403502
1978
Knight,
M., Dijkhuizen, L., & Harder, W. (1978).
Metabolic Regulation in Pseudomonas oxalaticus OX1: Enzyme
and Coenzyme Concentration Changes during Substrate Transition
Experiments. Archives of Microbiology,
116(1), 85-90. https://doi.org/10.1007/BF00408737
Dijkhuizen,
L., Knight, M., & Harder, W. (1978). Metabolic
Regulation in Pseudomonas oxalaticus OX1: Autotrophic and
Heterotrophic Growth on Mixed Substrates. Archives
of Microbiology, 116(1), 77-83. https://doi.org/10.1007/bf00408736
1977
Dijkhuizen,
L., Harder, W., & Konings, W. N. (1977). Active
Transport of Oxalate by Pseudomonas oxalaticus OX1.
Archives of Microbiology, 115(2),
223-227. https://doi.org/10.1007/BF00406378
Dijkhuizen,
L., Wiersma, M., & Harder, W. (1977). Energy
Production and Growth of Pseudomonas oxalaticus OX1 on Oxalate and
Formate. Archives of Microbiology,
115(2), 229-236. https://doi.org/10.1007/BF00406379
1975
Dijkhuizen,
L., & Harder, W. (1975). Substrate inhibition in
Pseudomonas oxalaticus OX1: a kinetic study of growth inhibition by
oxalate and formate using extended cultures.
Antonie van Leeuwenhoek, 41(1). https://doi.org/10.1007/BF02565045
| Last modified: | 13 March 2020 4.04 p.m. |