Haisma, Prof. Hidde
Hidde J. Haisma (1957) is professor of Pharmaceutic Gene Modulation at the Pharmacy department of the Faculty of Science and Engineering. He studied medical biology at Utrecht University and has worked in the US (including at Harvard Medical School) and at VU University Amsterdam. In 2000 he was appointed Professor of Pharmaceutic Gene Modulation at the University of Groningen.
Haisma conducts research into the development of drugs that can influence human genes in order to cure diseases. Haisma is editor of a number of journals in the field of gene therapy and has written over 100 publications and various patent applications in his field of study. Haisma is a board member of the Nederlandse Vereniging voor Gen- en Celtherapie (Dutch Society for Gene and Cell Therapy) and of the European Society of Gene and Cell Therapy. He is also a member of the Gene Doping Expert Group of the World Anti-Doping Agency (WADA). October 2016 he received a 100,000 US dollar grant from the WADA for his research project that will focus on the development of a gene doping detection assay based on next generation sequencing.
Video
- Haisma in NPO's Sportlab Sedoc on sport and genes (Dutch tv)
- Golden genes (Dutch tv, Labyrint)
- Haisma in TV programme Zembla: The Doping Theatre
Previously in the news
- Suspicious genes, fast legs
- Research grant from the World Anti-Doping Agency for professor Hidde Haisma
- Controleurs kunnen gendoping detecteren bij Winterspelen [Inspectors will be able to detect gene doping at Winter Games - in Dutch, source: de Volkskrant; infographic by Izaak Besuijen]
- Gene doping? No way back (in Dutch)
- With your genes? Try swimming (article in NRC on selection of sporters)
Publications
2021
Chen,
S., Chen, D., Liu, B., & Haisma, H.
J. (2022). Modulating CRISPR/Cas9 genome-editing
activity by small molecules. Drug Discovery
Today, 27(4), 951-966. https://doi.org/10.1016/j.drudis.2021.11.018
Diaz
Arguello, O. A., & Haisma, H. J. (2021).
Apoptosis-Inducing TNF Superfamily Ligands for Cancer
Therapy. Cancers, 13(7),
[1543]. https://doi.org/10.3390/cancers13071543
Wiggers,
T. G., Winters, M., Van den Boom, N. A., Haisma, H.
J., & Moen, M. H. (2021). Autologous stem cell
therapy in knee osteoarthritis: A systematic review of randomised
controlled trials. British Journal of Sports
Medicine, 55(20), 1161-1169. https://doi.org/10.1136/bjsports-2020-103671
Song,
S., Liu, B., Habibie, H., Van den Bor, J.,
Smit, M. J., Gosens, R., Wu, X.,
Brandsma, C-A., Cool, R. H., Haisma, H.
J., Poelarends, G. J., & Melgert, B.
N. (2021). D-dopachrome tautomerase contributes to
lung epithelial repair via ACKR3-dependent Akt signaling.
European Respiratory Journal, 58. https://doi.org/10.1183/13993003.congress-2021.OA2700
Song,
S., Liu, B., Habibie, H., van den Bor, J.,
Smit, M. J., Gosens, R., Wu, X.,
Brandsma, C-A., Cool, R. H., Haisma, H.
J., Poelarends, G. J., & Melgert, B.
N. (2021). D-dopachrome tautomerase contributes to
lung epithelial repair via atypical chemokine receptor 3-dependent
Akt signaling. EBioMedicine,
68, [103412]. https://doi.org/10.1016/j.ebiom.2021.103412
Cao,
F., Xiao, Z., Chen, S.,
Zhao, C., Chen, D., Haisma, H.
J., & Dekker, F. J. (2021). HDAC/MIF
dual inhibitor inhibits NSCLC cell survival and proliferation by
blocking the AKT pathway. Bioorganic
Chemistry, 117, [105396]. https://doi.org/10.1016/j.bioorg.2021.105396
Dömling,
A., Haisma, H., & Liu, B. (2021). Small molecule inhibitors of RNA guided
endonucleases. (Patent No. WO2021198275).
2020
Liu,
B., Diaz Arguello, O. A., Chen, D., Chen,
S., Saber, A., & Haisma, H. J. (2020).
CRISPR-mediated ablation of overexpressed EGFR in combination
with sunitinib significantly suppresses renal cell carcinoma
proliferation. PLoS ONE,
15(5), [0232985]. https://doi.org/10.1371/journal.pone.0232985
van
den Boom, N. A. C., Winters, M., Haisma, H. J., &
Moen, M. H. (2020). Efficacy of Stem Cell Therapy for Tendon
Disorders: A Systematic Review. Orthopaedic
journal of sports medicine, 8(4). https://doi.org/10.1177/2325967120915857
Liu,
B., Chen, D., Chen, S., Saber, A.,
& Haisma, H. (2020). Transcriptional activation of
cyclin D1 via HER2/HER3 contributes to EGFR-TKI resistance in lung
cancer. Biochemical Pharmacology,
178, [114095]. https://doi.org/10.1016/j.bcp.2020.114095
2019
Saber,
A., Liu, B., Ebrahimi, P., & Haisma, H. J. (2020).
CRISPR/Cas9 for overcoming drug resistance in solid
tumors. Daru : journal of Faculty of Pharmacy,
Tehran University of Medical Sciences, 28(1),
295-304. https://doi.org/10.1007/s40199-019-00240-z
Liu,
B., Chen, S., Chen, D., Cao,
F., Zwinderman, M., Kiemel, D., Aïssi, M.,
Dekker, F. J., Haisma, H. J., & La Rose, A.
(2020). Inhibition of histone deacetylase 1 (HDAC1) and HDAC2
enhances CRISPR/Cas9 genome editing. Nucleic Acids
Research, 48(2), 517-532. https://doi.org/10.1093/nar/gkz1136
de
Boer, E. N., van der Wouden, P. E.,
Johansson, L. F., van Diemen, C. C.,
& Haisma, H. J. (2019). A next-generation
sequencing method for gene doping detection that distinguishes low
levels of plasmid DNA against a background of genomic DNA.
Gene Therapy, 26(7-8), 338-346. https://doi.org/10.1038/s41434-019-0091-6
Liu,
B., Saber, A., & Haisma, H. J. (2019).
CRISPR/Cas9: A powerful tool for identification of new
targets for cancer treatment. Drug Discovery
Today, 24(4), 955-970. https://doi.org/10.1016/j.drudis.2019.02.011
Liu,
B., Song, S., Setroikromo, R.,
Chen, S., Hu, W., Chen, D., van der Wekken, A.
J., Melgert, B. N., Timens,
W., van den Berg, A., Saber, A., &
Haisma, H. J. (2019). CX Chemokine Receptor 7
Contributes to Survival of KRAS-Mutant Non-Small Cell Lung Cancer
upon Loss of Epidermal Growth Factor Receptor.
Cancers, 11(4), [455]. https://doi.org/10.3390/cancers11040455
Zhang,
B., Liu, B., Chen, D., Setroikromo, R.,
Haisma, H. J., & Quax, W. J. (2019).
Histone Deacetylase Inhibitors Sensitize TRAIL-Induced
Apoptosis in Colon Cancer Cells.
Cancers, 11(5), [645]. https://doi.org/10.3390/cancers11050645
2017
Bosch,
van den, T., Leus, N. G. J., Wapenaar, H., Boichenko, A.,
Hermans, J., Bischoff, R., Haisma, H.
J., & Dekker, F. J. (2017). A
6-alkylsalicylate histone acetyltransferase inhibitor inhibits
histone acetylation and pro-inflammatory gene expression in murine
precision-cut lung slices. Pulmonary Pharmacology
& Therapeutics, 44, 88-95. https://doi.org/10.1016/j.pupt.2017.03.006
Leus,
N. G. J., van den Bosch, T., van der Wouden, P. E.,
Krist, K., Ourailidou, M. E., Eleftheriadis, N., Kistemaker, L. E.
M., Bos, S., Gjaltema, R. A. F.,
Mekonnen, S. A., Bischoff, R., Gosens,
R., Haisma, H. J., & Dekker, F.
J. (2017). HDAC1-3 inhibitor MS-275 enhances IL10
expression in RAW264.7 macrophages and reduces cigarette
smoke-induced airway inflammation in mice.
Scientific Reports, 7, [45047]. https://doi.org/10.1038/srep45047
Pas,
H. I. M. F. L., Moen, M. H., Haisma, H. J., &
Winters, M. (2017). No evidence for the use of stem cell
therapy for tendon disorders: a systematic review.
British Journal of Sports Medicine,
51(13), 996-1004. https://doi.org/10.1136/bjsports-2016-096794
Pas,
H. I. M. F. L., Winters, M., Haisma, H. J., Koenis, M.
J. J., Tol, J. L., & Moen, M. H. (2017). Stem cell
injections in knee osteoarthritis: a systematic review.
British Journal of Sports Medicine,
51(15), 1125-1133. https://doi.org/10.1136/bjsports-2016-096793
Wapenaar,
H., van den Bosch, T., Leus, N. G. J., van der Wouden, P.
E., Eleftheriadis, N., Hermans, J., Hailu, G.
S., Rotili, D., Mai, A., Domling, A., Bischoff,
R., Haisma, H. J., & Dekker, F.
J. (2017). The relevance of K-i calculation for
bi-substrate enzymes illustrated by kinetic evaluation of a novel
lysine (K) acetyltransferase 8 inhibitor. European
Journal of Medicinal Chemistry, 136, 480-486.
https://doi.org/10.1016/j.ejmech.2017.05.015
2016
Arabpour,
M., Cool, R., Faber, K. N., Quax,
W. J., & Haisma, H. J. (2017).
Receptor-specific TRAIL as a means to achieve targeted
elimination of activated hepatic stellate cells.
Journal of Drug Targeting, 25(4),
360-369. https://doi.org/10.1080/1061186X.2016.1262867
Haisma,
H., & Schalekamp, T. (2016). Apothekersopleidingen
klaar voor de toekomst: Domeinspecifiek referentiekader en Raamplan
Farmacie geven onderwijs richting. Pharmaceutisch
Weekblad, 151(24), 18-19. http://www.pw.nl/achtergrond/2016/apothekersopleidingen-klaar-voor-de-toekomst
Haisma,
H., & Schalekamp, T. (2016, May 10).
Domeinspecifiek referentiekader & Raam plan Farmacie
2016. https://www.knmp.nl/downloads/domeinspecifiek-referentiekader-en-raamplan-farmacie-2016.pdf/view
Leus,
N. G. J., van der Wouden, P. E., van den Bosch, T.,
Hooghiemstra, W. T. R., Ourailidou, M. E., Kistemaker, L. E.
M., Bischoff, R., Gosens, R.,
Haisma, H. J., & Dekker, F. J. (2016).
HDAC 3-selective inhibitor RGFP966 demonstrates
anti-inflammatory properties in RAW 264.7 macrophages and mouse
precision-cut lung slices by attenuating NF-κB p65
transcriptional activity. Biochemical
Pharmacology, 58-74. https://doi.org/10.1016/j.bcp.2016.03.010
Haisma,
H. (2016). Nederlands farmaceutisch onderwijs
wereldwijd voorop. Pharmaceutisch
Weekblad, 151(50), 21.
van
den Bosch, T., Boichenko, A., Leus, N. G. J., Ourailidou, M. E.,
Wapenaar, H., Rotili, D., Mai, A., Imhof, A., Bischoff,
R., Haisma, H. J., & Dekker, F.
J. (2016). The histone acetyltransferase p300
inhibitor C646 reduces pro-inflammatory gene expression and
inhibits histone deacetylases. Biochemical
Pharmacology, 102, 130-140. https://doi.org/10.1016/j.bcp.2015.12.010
2014
Haisma,
H. (2014). Assessment of preclinical gene therapy
studies worldwide. (3 ed.) COGEM.
Haisma,
H. (2014). Sport: vliegensvlugge genen. In
Genen en Gezondheid (Vol. Cahier 1). Stichting
Biowetenschappen en Maatschappij.
Arabpour,
M., Poelstra, K., Helfrich, W.,
Bremer, E., & Haisma, H. J. (2014).
Targeted elimination of activated hepatic stellate cells by
an anti-epidermal growth factor-receptor single chain fragment
variable antibody-tumor necrosis factor-related apoptosis-inducing
ligand (scFv425-sTRAIL). Journal of gene
medicine, 16(9-10), 281-290. https://doi.org/10.1002/jgm.2776
Arabpour,
M., Poelstra, K., Helfrich, W.,
Bremer, E., & Haisma, H. J. (2014).
Targeted Elimination of Activated Hepatic Stellate Cells by
Anti-EGF-Receptor scFv-sTRAIL Fusion Protein.
Molecular Therapy, 22(suppl. 1),
S121-S121.
2013
Wisastra,
R., Kok, P. A. M., Eleftheriadis, N., Baumgartner, M. P., Camacho,
C. J., Haisma, H. J., & Dekker, F. J.
(2013). Discovery of a novel activator of 5-lipoxygenase from
an anacardic acid derived compound collection.
Bioorganic & Medicinal Chemistry,
21(24), 7763-7778. https://doi.org/10.1016/j.bmc.2013.10.015
van
der Gronde, T., de Hon, O., Haisma, H. J., &
Pieters, T. (2013). Gene doping: An overview and current
implications for athletes. British Journal of
Sports Medicine, 47(11), 670-678. https://doi.org/10.1136/bjsports-2012-091288
van
Dijk, R., Miranda, P. S. M., Riviere, C., ten Bloemendaal, L., van
Gorp, J., Duijst, S., de Waart, D. R., Beuers, U., Haisma, H.
J., & Bosma, P. J. (2013). Polyinosinic acid
blocks adeno-associated virus macrophage endocytosis in vitro and
enhances adeno-associated virus liver directed gene therapy in
vivo. Human Gene Therapy,
24(12), A135.
van
Dijk, R., Montenegro-Miranda, P. S., Riviere, C., Schilderink, R.,
ten Bloemendaal, L., van Gorp, J., Duijst, S., de Waart, D. R.,
Beuers, U., Haisma, H. J., & Bosma, P. J. (2013).
Polyinosinic Acid Blocks Adeno-Associated Virus Macrophage
Endocytosis In Vitro and Enhances Adeno-Associated Virus
Liver-Directed Gene Therapy In Vivo. Human Gene
Therapy, 24(9), 807-813. https://doi.org/10.1089/hum.2013.086
Kuldo,
J. M., Asgeirsdottir, S. A., Zwiers, P. J., Bellu, A.
R., Rots, M. G., Schalk, J. A. C., Ogawara, K. I.,
Trautwein, C., Banas, B., Haisma, H. J., Molema,
G., & Kamps, J. A. A. M. (2013).
Targeted adenovirus mediated inhibition of NF-kappa
B-dependent inflammatory gene expression in endothelial cells in
vitro and in vivo. Journal of Controlled
Release, 166(1), 57-65. https://doi.org/10.1016/j.jconrel.2012.12.016
2012
Ghizzoni,
M., Wu, J., Gao, T., Haisma, H. J., Dekker, F.
J., & Zheng, Y. G. (2012). 6-alkylsalicylates are
selective Tip60 inhibitors and target the acetyl-CoA binding
site. European Journal of Medicinal
Chemistry, 47(1), 337-344. https://doi.org/10.1016/j.ejmech.2011.11.001
Wisastra,
R., Ghizzoni, M., Boltjes, A., Haisma, H.
J., & Dekker, F. J. (2012). Anacardic
acid derived salicylates are inhibitors or activators of
lipoxygenases. Bioorganic & Medicinal
Chemistry, 20(16), 5027-5032. https://doi.org/10.1016/j.bmc.2012.06.019
Farinha
Antunes, I., Doorduin, J., Haisma, H.
J., Elsinga, P. H., van Waarde,
A., Willemsen, A. T. M., Dierckx, R.
A., & de Vries, E. F. J. (2012).
F-18-FEAnGA for PET of beta-Glucuronidase Activity in
Neuroinflammation. Journal of Nuclear
Medicine, 53(3), 451-458. https://doi.org/10.2967/jnumed.111.096388
Farinha
Antunes, I., Haisma, H. J., Elsinga, P.
H., Di Gialleonardo, V., van Waarde, A.,
Willemsen, A. T. M., Dierckx, R. A.,
& de Vries, E. F. J. (2012). Induction of
beta-Glucuronidase Release by Cytostatic Agents in Small
Tumors. Molecular pharmaceutics,
9(11), 3277-3285. https://doi.org/10.1021/mp300327w
Farinha
Antunes, I., Haisma, H. J., Elsinga, P.
H., van Waarde, A., Willemsen, A. T.
M., Dierckx, R. A., & de Vries, E. F.
J. (2012). In Vivo Evaluation of
1-O-(4-(2-Fluoroethyl-Carbamoyloxymethyl)-2-Nitrophenyl)-O-beta-D-Glucopyronuronate:
A Positron Emission Tomographic Tracer for Imaging
beta-Glucuronidase Activity in a Tumor/Inflammation Rodent
Model. Molecular imaging,
11(1), 77-87. https://doi.org/10.2310/7290.2011.00029
Antunes,
I. F., Haisma, H. J., Elsinga, P.
H., Sijbesma, J. W. A., van Waarde, A.,
Willemsen, A. T. M., Dierckx, R. A.,
& de Vries, E. F. J. (2012). In vivo evaluation of
[F-18]FEAnGA-Me: a PET tracer for imaging beta-glucuronidase
(beta-GUS) activity in a tumor/inflammation rodent model.
Nuclear Medicine and Biology, 39(6),
854-863. https://doi.org/10.1016/j.nucmedbio.2012.02.002
Haisma,
H. J. (2012). Physical Enhancement. In J.
Savulescu, R. ter Meulen, & G. Kahane (Eds.), Enhancing
human capacities (pp. 257-265). Wiley-Blackwell.
2011
Wisastra,
R., Poelstra, K., Bischoff, R.,
Maarsingh, H., Haisma, H. J., & Dekker, F.
J. (2011). Antibody-Free Detection of Protein Tyrosine
Nitration in Tissue Sections.
ChemBioChem, 12(13), 2016-2020. https://doi.org/10.1002/cbic.201100148
Varkouhi,
A. K., Scholte, M., Storm, G., & Haisma, H. J.
(2011). Endosomal escape pathways for delivery of
biologicals. Journal of Controlled
Release, 151(3), 220-228. https://doi.org/10.1016/j.jconrel.2010.11.004
Ghizzoni,
M., Haisma, H. J., Maarsingh, H., & Dekker,
F. J. (2011). Histone acetyltransferases are crucial
regulators in NF-kappa B mediated inflammation.
Drug Discovery Today, 16(11-12),
504-511. https://doi.org/10.1016/j.drudis.2011.03.009
Wisastra,
R., Ghizzoni, M., Maarsingh, H., Minnaard, A.
J., Haisma, H. J., & Dekker, F.
J. (2011). Isothiazolones; thiol-reactive inhibitors
of cysteine protease cathepsin B and histone acetyltransferase
PCAF. Organic and Biomolecular
Chemistry, 9(6), 1817-1822. https://doi.org/10.1039/c0ob00464b
Haisma,
H. J., & Bellu, A. R. (2011). Pharmacological
Interventions for Improving Adenovirus Usage in Gene
Therapy. Molecular pharmaceutics,
8(1), 50-55. https://doi.org/10.1021/mp100310h
2010
van
Zeeburg, H. J. T., van Beusechem, V. W., Huizenga, A.,
Haisma, H. J., Korokhov, N., Gibbs, S., Leemans, C. R.,
& Brakenhoff, R. H. (2010). Adenovirus retargeting to
surface expressed antigens on oral mucosa. Journal
of gene medicine, 12(4), 365-376. https://doi.org/10.1002/jgm.1447
Ghizzoni,
M., Boltjes, A., de Graaf, C.,
Haisma, H. J., & Dekker, F. J. (2010).
Improved inhibition of the histone acetyltransferase PCAF by
an anacardic acid derivative. Bioorganic &
Medicinal Chemistry, 18(16), 5826-5834. https://doi.org/10.1016/j.bmc.2010.06.089
Haisma,
H. J., Kamps, G. K., Bouma, A., Geel, T. M., Rots, M.
G., Kariath, A., & Bellu, A. R. (2010). Selective
targeting of adenovirus to alpha(v)beta(3) integrins, VEGFR2 and
Tie2 endothelial receptors by angio-adenobodies.
International Journal of Pharmaceutics,
391(1-2), 155-161. https://doi.org/10.1016/j.ijpharm.2010.02.032
Farinha
Antunes, I., Haisma, H. J., Elsinga, P.
H., Dierckx, R. A., & de Vries, E. F.
J. (2010). Synthesis and Evaluation of [F-18]-FEAnGA
as a PET Tracer for beta-Glucuronidase Activity.
BIOCONJUGATE CHEMISTRY, 21(5),
911-920. https://doi.org/10.1021/bc9004602
2009
ABEN
RENE WILHELMUS, MARIE., SCHEEREN JOHAN, WILHELM., CORNELISSEN
JEROEN JOHANNES LAMBERTUS, MARIA., DE VOS, DICK., &
Haisma, H. (2009). ESTER OF GLUCURONIDE
PRODRUG OF ANTHRACYCLINE AND METHOD OF PREPARATION AND USE IN
TUMOR-SELECTIVE CHEMOTHERAPY. (Patent No.
JP2009215295).
Aben,
R. W. M., de Vos, D., Haisma, H. J., Cornelissen, J.
J. L. M., & Scheeren, J. W. (2009, Mar 1). Esters of
glucuronide prodrugs of anthracyclines and method of preparation
and use in tumor-selective chemotherapy. Google
Patents.
Dekker,
F. J., & Haisma, H. J. (2009).
Histone acetyl transferases as emerging drug targets.
Drug Discovery Today, 14(19-20),
942-948. https://doi.org/10.1016/j.drudis.2009.06.008
Dekker,
F. J., Ghizzoni, M., van der Meer, N., Wisastra, R.,
& Haisma, H. J. (2009). Inhibition of the PCAF
histone acetyl transferase and cell proliferation by
isothiazolones. Bioorganic & Medicinal
Chemistry, 17(2), 460-466. https://doi.org/10.1016/j.bmc.2008.12.008
Ghizzoni,
M., Haisma, H. J., & Dekker, F. J.
(2009). Reactivity of isothiazolones and
isothiazolone-1-oxides in the inhibition of the PCAF histone
acetyltransferase. European Journal of Medicinal
Chemistry, 44(12), 4855-4861. https://doi.org/10.1016/j.ejmech.2009.07.025
Haisma,
H. J., Boesjes, M., Beerens, A. M., van der Strate, B.
W. A., Curiel, D. T., Plueddemann, A., Gordon, S., &
Bellu, A. R. (2009). Scavenger Receptor A: A New Route for
Adenovirus 5. Molecular pharmaceutics,
6(2), 366-374. https://doi.org/10.1021/mp8000974
2008
Riezebos-Brilman,
A., Walczak, M., Regts, J., Rots, M. G., Kamps, G.,
Dontje, B., Haisma, H. Y., Wilschut,
J., & Daemen, T. (2008). Erratum: A
comparative study on the immunotherapeutic efficacy of recombinant
Semliki Forest virus and adenovirus vector systems in a murine
model for cervical cancer (vol 14, pg 1695, 2007).
Gene Therapy, 15(1), 66. https://doi.org/10.1038/sj.gt.3303084
Johnson,
T. S., Mahnke, K., Storn, V., Schoenfeld, K., Ring, S., Nettelbeck,
D. M., Haisma, H. J., Le Gall, F., Kontermann, R. E.,
& Enk, A. H. (2008). Inhibition of Melanoma Growth by
Targeting of Antigen to Dendritic Cells via an Anti-DEC-205
Single-Chain Fragment Variable Molecule. Clinical
Cancer Research, 14(24), 8169-8177. https://doi.org/10.1158/1078-0432.CCR-08-1474
Schoemaker,
M. H., Rots, M. G., Beljaars, L., Ypma,
A. Y., Jansen, P. L. M., Poelstra, K., Moshage,
A., & Haisma, H. J. (2008).
PDGF-receptor beta-targeted adenovirus redirects gene
transfer from hepatocytes to activated stellate cells.
Molecular pharmaceutics, 5(3),
399-406. https://doi.org/10.1021/mp700118p
Haisma,
H. J., Kamps, J. A. A. M., Plantinga, J.
A., Rots, M. G., Bellu, A. R., & Kamps, G.
(2008). Polyinosinic acid enhances delivery of adenovirus
vectors in vivo by preventing sequestration in liver
macrophages. Journal of general
virology, 89, 1097-1105. https://doi.org/10.1099/vir.0.83495-0
Bremer,
E., van Dam, G. M., de Bruyn, M.,
van Riezen, M., Dijkstra, M., Kamps, G., Helfrich,
W., & Haisma, H. (2008). Potent
Systemic Anticancer Activity of Adenovirally Expressed
EGFR-Selective TRAIL Fusion Protein. Molecular
Therapy, 16(12), 1919-1926. https://doi.org/10.1038/mt.2008.203
Beerens,
A. M. J., Rots, M. G., Bermudez, B., De Vries,
E. F. J., & Haisma, H. J. (2008).
Secretion of thymidine kinase to increase the effectivity of
suicide gene therapy results in the loss of enzymatic
activity. Journal of Drug Targeting,
16(1), 26-35.
Farinha
Antunes, I., Haisma, H. J., & de
Vries, E. F. J. (2008). Tumor-specific activation of
prodrugs: Is there a role for nuclear medicine?
Nuclear Medicine Communications,
29(10), 845-846. https://doi.org/10.1097/MNM.0b013e3283094efc
2007
Riezebos-Brilman,
A., Walczak, M., Regts, J., Rots, M., Kamps, G.,
Dontje, B., Haisma, H., Wilschut,
J., & Daemen, T. (2007). A
comparative study on the immunotherapeutic efficacy of recombinant
Semliki Forest virus and adenovirus vector systems in a murine
model for cervical cancer. Gene
Therapy, 14(24), 1695-1704. https://doi.org/10.1038/sj.gt.3303036
Carette,
J. E., Graat, H. C. A., Schagen, F. H. E., Mastenbroek, D. C.
J., Rots, M. G., Haisma, H. J.,
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