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Haisma, Prof. Hidde

Hidde Haisma
Hidde Haisma

Hidde J. Haisma (1957) is professor of Pharmaceutic Gene Modulation at the Pharmacy department of the Faculty of Science and Engineering. He studied medical biology at Utrecht University and has worked in the US (including at Harvard Medical School) and at VU University Amsterdam. In 2000 he was appointed Professor of Pharmaceutic Gene Modulation at the University of Groningen.

Haisma conducts research into the development of drugs that can influence human genes in order to cure diseases. Haisma is editor of a number of journals in the field of gene therapy and has written over 100 publications and various patent applications in his field of study. Haisma is a board member of the Nederlandse Vereniging voor Gen- en Celtherapie (Dutch Society for Gene and Cell Therapy) and of the European Society of Gene and Cell Therapy. He is also a member of the Gene Doping Expert Group of the World Anti-Doping Agency (WADA). October 2016 he received a 100,000 US dollar grant from the WADA for his research project that will focus on the development of a gene doping detection assay based on next generation sequencing.

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Publications

2021

Diaz Arguello, O. A., & Haisma, H. J. (2021). Apoptosis-Inducing TNF Superfamily Ligands for Cancer Therapy. Cancers, 13(7), [1543]. https://doi.org/10.3390/cancers13071543
Wiggers, T. G., Winters, M., Van den Boom, N. A., Haisma, H. J., & Moen, M. H. (2021). Autologous stem cell therapy in knee osteoarthritis: A systematic review of randomised controlled trials. British Journal of Sports Medicine. https://doi.org/10.1136/bjsports-2020-103671
Song, S., Liu, B., Habibie, H., van den Bor, J., Smit, M. J., Gosens, R., Wu, X., Brandsma, C-A., Cool, R. H., Haisma, H. J., Poelarends, G. J., & Melgert, B. N. (2021). D-dopachrome tautomerase contributes to lung epithelial repair via atypical chemokine receptor 3-dependent Akt signaling. EBioMedicine, 68, [103412]. https://doi.org/10.1016/j.ebiom.2021.103412

2020

Liu, B., Diaz Arguello, O. A., Chen, D., Chen, S., Saber, A., & Haisma, H. J. (2020). CRISPR-mediated ablation of overexpressed EGFR in combination with sunitinib significantly suppresses renal cell carcinoma proliferation. PLoS ONE, 15(5), [0232985]. https://doi.org/10.1371/journal.pone.0232985
van den Boom, N. A. C., Winters, M., Haisma, H. J., & Moen, M. H. (2020). Efficacy of Stem Cell Therapy for Tendon Disorders: A Systematic Review. Orthopaedic journal of sports medicine, 8(4). https://doi.org/10.1177/2325967120915857
Liu, B., Chen, D., Chen, S., Saber, A., & Haisma, H. (2020). Transcriptional activation of cyclin D1 via HER2/HER3 contributes to EGFR-TKI resistance in lung cancer. Biochemical Pharmacology, 178, [114095]. https://doi.org/10.1016/j.bcp.2020.114095

2019

Saber, A., Liu, B., Ebrahimi, P., & Haisma, H. J. (2020). CRISPR/Cas9 for overcoming drug resistance in solid tumors. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 28(1), 295-304. https://doi.org/10.1007/s40199-019-00240-z
Liu, B., Chen, S., Chen, D., Cao, F., Zwinderman, M., Kiemel, D., Aïssi, M., Dekker, F. J., Haisma, H. J., & La Rose, A. (2020). Inhibition of histone deacetylase 1 (HDAC1) and HDAC2 enhances CRISPR/Cas9 genome editing. Nucleic Acids Research, 48(2), 517-532. https://doi.org/10.1093/nar/gkz1136
de Boer, E. N., van der Wouden, P. E., Johansson, L. F., van Diemen, C. C., & Haisma, H. J. (2019). A next-generation sequencing method for gene doping detection that distinguishes low levels of plasmid DNA against a background of genomic DNA. Gene Therapy, 26(7-8), 338-346. https://doi.org/10.1038/s41434-019-0091-6
Liu, B., Saber, A., & Haisma, H. J. (2019). CRISPR/Cas9: A powerful tool for identification of new targets for cancer treatment. Drug Discovery Today, 24(4), 955-970. https://doi.org/10.1016/j.drudis.2019.02.011
Liu, B., Song, S., Setroikromo, R., Chen, S., Hu, W., Chen, D., van der Wekken, A. J., Melgert, B. N., Timens, W., van den Berg, A., Saber, A., & Haisma, H. J. (2019). CX Chemokine Receptor 7 Contributes to Survival of KRAS-Mutant Non-Small Cell Lung Cancer upon Loss of Epidermal Growth Factor Receptor. Cancers, 11(4), [455]. https://doi.org/10.3390/cancers11040455
Zhang, B., Liu, B., Chen, D., Setroikromo, R., Haisma, H. J., & Quax, W. J. (2019). Histone Deacetylase Inhibitors Sensitize TRAIL-Induced Apoptosis in Colon Cancer Cells. Cancers, 11(5), [645]. https://doi.org/10.3390/cancers11050645

2017

Bosch, van den, T., Leus, N. G. J., Wapenaar, H., Boichenko, A., Hermans, J., Bischoff, R., Haisma, H. J., & Dekker, F. J. (2017). A 6-alkylsalicylate histone acetyltransferase inhibitor inhibits histone acetylation and pro-inflammatory gene expression in murine precision-cut lung slices. Pulmonary Pharmacology & Therapeutics, 44, 88-95. https://doi.org/10.1016/j.pupt.2017.03.006
Leus, N. G. J., van den Bosch, T., van der Wouden, P. E., Krist, K., Ourailidou, M. E., Eleftheriadis, N., Kistemaker, L. E. M., Bos, S., Gjaltema, R. A. F., Mekonnen, S. A., Bischoff, R., Gosens, R., Haisma, H. J., & Dekker, F. J. (2017). HDAC1-3 inhibitor MS-275 enhances IL10 expression in RAW264.7 macrophages and reduces cigarette smoke-induced airway inflammation in mice. Scientific Reports, 7, [45047]. https://doi.org/10.1038/srep45047
Pas, H. I. M. F. L., Moen, M. H., Haisma, H. J., & Winters, M. (2017). No evidence for the use of stem cell therapy for tendon disorders: a systematic review. British Journal of Sports Medicine, 51(13), 996-1004. https://doi.org/10.1136/bjsports-2016-096794
Pas, H. I. M. F. L., Winters, M., Haisma, H. J., Koenis, M. J. J., Tol, J. L., & Moen, M. H. (2017). Stem cell injections in knee osteoarthritis: a systematic review. British Journal of Sports Medicine, 51(15), 1125-1133. https://doi.org/10.1136/bjsports-2016-096793
Wapenaar, H., van den Bosch, T., Leus, N. G. J., van der Wouden, P. E., Eleftheriadis, N., Hermans, J., Hailu, G. S., Rotili, D., Mai, A., Domling, A., Bischoff, R., Haisma, H. J., & Dekker, F. J. (2017). The relevance of K-i calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor. European Journal of Medicinal Chemistry, 136, 480-486. https://doi.org/10.1016/j.ejmech.2017.05.015

2016

Arabpour, M., Cool, R., Faber, K. N., Quax, W. J., & Haisma, H. J. (2017). Receptor-specific TRAIL as a means to achieve targeted elimination of activated hepatic stellate cells. Journal of Drug Targeting, 25(4), 360-369. https://doi.org/10.1080/1061186X.2016.1262867
Haisma, H., & Schalekamp, T. (2016). Apothekersopleidingen klaar voor de toekomst: Domeinspecifiek referentiekader en Raamplan Farmacie geven onderwijs richting. Pharmaceutisch Weekblad, 151(24), 18-19. http://www.pw.nl/achtergrond/2016/apothekersopleidingen-klaar-voor-de-toekomst
Haisma, H., & Schalekamp, T. (2016, May 10). Domeinspecifiek referentiekader & Raam plan Farmacie 2016. https://www.knmp.nl/downloads/domeinspecifiek-referentiekader-en-raamplan-farmacie-2016.pdf/view
Leus, N. G. J., van der Wouden, P. E., van den Bosch, T., Hooghiemstra, W. T. R., Ourailidou, M. E., Kistemaker, L. E. M., Bischoff, R., Gosens, R., Haisma, H. J., & Dekker, F. J. (2016). HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity. Biochemical Pharmacology, 58-74. https://doi.org/10.1016/j.bcp.2016.03.010
Haisma, H. (2016). Nederlands farmaceutisch onderwijs wereldwijd voorop. Pharmaceutisch Weekblad, 151(50), 21.
van den Bosch, T., Boichenko, A., Leus, N. G. J., Ourailidou, M. E., Wapenaar, H., Rotili, D., Mai, A., Imhof, A., Bischoff, R., Haisma, H. J., & Dekker, F. J. (2016). The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases. Biochemical Pharmacology, 102, 130-140. https://doi.org/10.1016/j.bcp.2015.12.010

2014

Haisma, H. (2014). Assessment of preclinical gene therapy studies worldwide. (3 ed.) COGEM.
Haisma, H. (2014). Sport: vliegensvlugge genen. In Genen en Gezondheid (Vol. Cahier 1). Stichting Biowetenschappen en Maatschappij.
Arabpour, M., Poelstra, K., Helfrich, W., Bremer, E., & Haisma, H. J. (2014). Targeted elimination of activated hepatic stellate cells by an anti-epidermal growth factor-receptor single chain fragment variable antibody-tumor necrosis factor-related apoptosis-inducing ligand (scFv425-sTRAIL). Journal of gene medicine, 16(9-10), 281-290. https://doi.org/10.1002/jgm.2776
Arabpour, M., Poelstra, K., Helfrich, W., Bremer, E., & Haisma, H. J. (2014). Targeted Elimination of Activated Hepatic Stellate Cells by Anti-EGF-Receptor scFv-sTRAIL Fusion Protein. Molecular Therapy, 22(suppl. 1), S121-S121.

2013

Wisastra, R., Kok, P. A. M., Eleftheriadis, N., Baumgartner, M. P., Camacho, C. J., Haisma, H. J., & Dekker, F. J. (2013). Discovery of a novel activator of 5-lipoxygenase from an anacardic acid derived compound collection. Bioorganic & Medicinal Chemistry, 21(24), 7763-7778. https://doi.org/10.1016/j.bmc.2013.10.015
van der Gronde, T., de Hon, O., Haisma, H. J., & Pieters, T. (2013). Gene doping: An overview and current implications for athletes. British Journal of Sports Medicine, 47(11), 670-678. https://doi.org/10.1136/bjsports-2012-091288
van Dijk, R., Miranda, P. S. M., Riviere, C., ten Bloemendaal, L., van Gorp, J., Duijst, S., de Waart, D. R., Beuers, U., Haisma, H. J., & Bosma, P. J. (2013). Polyinosinic acid blocks adeno-associated virus macrophage endocytosis in vitro and enhances adeno-associated virus liver directed gene therapy in vivo. Human Gene Therapy, 24(12), A135.
van Dijk, R., Montenegro-Miranda, P. S., Riviere, C., Schilderink, R., ten Bloemendaal, L., van Gorp, J., Duijst, S., de Waart, D. R., Beuers, U., Haisma, H. J., & Bosma, P. J. (2013). Polyinosinic Acid Blocks Adeno-Associated Virus Macrophage Endocytosis In Vitro and Enhances Adeno-Associated Virus Liver-Directed Gene Therapy In Vivo. Human Gene Therapy, 24(9), 807-813. https://doi.org/10.1089/hum.2013.086
Kuldo, J. M., Asgeirsdottir, S. A., Zwiers, P. J., Bellu, A. R., Rots, M. G., Schalk, J. A. C., Ogawara, K. I., Trautwein, C., Banas, B., Haisma, H. J., Molema, G., & Kamps, J. A. A. M. (2013). Targeted adenovirus mediated inhibition of NF-kappa B-dependent inflammatory gene expression in endothelial cells in vitro and in vivo. Journal of Controlled Release, 166(1), 57-65. https://doi.org/10.1016/j.jconrel.2012.12.016

2012

Wisastra, R., Ghizzoni, M., Boltjes, A., Haisma, H. J., & Dekker, F. J. (2012). Anacardic acid derived salicylates are inhibitors or activators of lipoxygenases. Bioorganic & Medicinal Chemistry, 20(16), 5027-5032. https://doi.org/10.1016/j.bmc.2012.06.019
Farinha Antunes, I., Doorduin, J., Haisma, H. J., Elsinga, P. H., van Waarde, A., Willemsen, A. T. M., Dierckx, R. A., & de Vries, E. F. J. (2012). F-18-FEAnGA for PET of beta-Glucuronidase Activity in Neuroinflammation. Journal of Nuclear Medicine, 53(3), 451-458. https://doi.org/10.2967/jnumed.111.096388
Antunes, I. F., Haisma, H. J., Elsinga, P. H., Sijbesma, J. W. A., van Waarde, A., Willemsen, A. T. M., Dierckx, R. A., & de Vries, E. F. J. (2012). In vivo evaluation of [F-18]FEAnGA-Me: a PET tracer for imaging beta-glucuronidase (beta-GUS) activity in a tumor/inflammation rodent model. Nuclear Medicine and Biology, 39(6), 854-863. https://doi.org/10.1016/j.nucmedbio.2012.02.002
Farinha Antunes, I., Haisma, H. J., Elsinga, P. H., van Waarde, A., Willemsen, A. T. M., Dierckx, R. A., & de Vries, E. F. J. (2012). In Vivo Evaluation of 1-O-(4-(2-Fluoroethyl-Carbamoyloxymethyl)-2-Nitrophenyl)-O-beta-D-Glucopyronuronate: A Positron Emission Tomographic Tracer for Imaging beta-Glucuronidase Activity in a Tumor/Inflammation Rodent Model. Molecular imaging, 11(1), 77-87. https://doi.org/10.2310/7290.2011.00029
Farinha Antunes, I., Haisma, H. J., Elsinga, P. H., Di Gialleonardo, V., van Waarde, A., Willemsen, A. T. M., Dierckx, R. A., & de Vries, E. F. J. (2012). Induction of beta-Glucuronidase Release by Cytostatic Agents in Small Tumors. Molecular pharmaceutics, 9(11), 3277-3285. https://doi.org/10.1021/mp300327w
Haisma, H. J. (2012). Physical Enhancement. In J. Savulescu, R. ter Meulen, & G. Kahane (Eds.), Enhancing human capacities (pp. 257-265). Wiley-Blackwell.
Ghizzoni, M., Wu, J., Gao, T., Haisma, H. J., Dekker, F. J., & Zheng, Y. G. (2012). 6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site. European Journal of Medicinal Chemistry, 47(1), 337-344. https://doi.org/10.1016/j.ejmech.2011.11.001

2011

Wisastra, R., Poelstra, K., Bischoff, R., Maarsingh, H., Haisma, H. J., & Dekker, F. J. (2011). Antibody-Free Detection of Protein Tyrosine Nitration in Tissue Sections. ChemBioChem, 12(13), 2016-2020. https://doi.org/10.1002/cbic.201100148
Varkouhi, A. K., Scholte, M., Storm, G., & Haisma, H. J. (2011). Endosomal escape pathways for delivery of biologicals. Journal of Controlled Release, 151(3), 220-228. https://doi.org/10.1016/j.jconrel.2010.11.004
Ghizzoni, M., Haisma, H. J., Maarsingh, H., & Dekker, F. J. (2011). Histone acetyltransferases are crucial regulators in NF-kappa B mediated inflammation. Drug Discovery Today, 16(11-12), 504-511. https://doi.org/10.1016/j.drudis.2011.03.009
Wisastra, R., Ghizzoni, M., Maarsingh, H., Minnaard, A. J., Haisma, H. J., & Dekker, F. J. (2011). Isothiazolones; thiol-reactive inhibitors of cysteine protease cathepsin B and histone acetyltransferase PCAF. Organic and Biomolecular Chemistry, 9(6), 1817-1822. https://doi.org/10.1039/c0ob00464b
Haisma, H. J., & Bellu, A. R. (2011). Pharmacological Interventions for Improving Adenovirus Usage in Gene Therapy. Molecular pharmaceutics, 8(1), 50-55. https://doi.org/10.1021/mp100310h

2010

van Zeeburg, H. J. T., van Beusechem, V. W., Huizenga, A., Haisma, H. J., Korokhov, N., Gibbs, S., Leemans, C. R., & Brakenhoff, R. H. (2010). Adenovirus retargeting to surface expressed antigens on oral mucosa. Journal of gene medicine, 12(4), 365-376. https://doi.org/10.1002/jgm.1447
Ghizzoni, M., Boltjes, A., de Graaf, C., Haisma, H. J., & Dekker, F. J. (2010). Improved inhibition of the histone acetyltransferase PCAF by an anacardic acid derivative. Bioorganic & Medicinal Chemistry, 18(16), 5826-5834. https://doi.org/10.1016/j.bmc.2010.06.089
Haisma, H. J., Kamps, G. K., Bouma, A., Geel, T. M., Rots, M. G., Kariath, A., & Bellu, A. R. (2010). Selective targeting of adenovirus to alpha(v)beta(3) integrins, VEGFR2 and Tie2 endothelial receptors by angio-adenobodies. International Journal of Pharmaceutics, 391(1-2), 155-161. https://doi.org/10.1016/j.ijpharm.2010.02.032
Farinha Antunes, I., Haisma, H. J., Elsinga, P. H., Dierckx, R. A., & de Vries, E. F. J. (2010). Synthesis and Evaluation of [F-18]-FEAnGA as a PET Tracer for beta-Glucuronidase Activity. BIOCONJUGATE CHEMISTRY, 21(5), 911-920. https://doi.org/10.1021/bc9004602

2009

ABEN RENE WILHELMUS, MARIE., SCHEEREN JOHAN, WILHELM., CORNELISSEN JEROEN JOHANNES LAMBERTUS, MARIA., DE VOS, DICK., & Haisma, H. (2009). ESTER OF GLUCURONIDE PRODRUG OF ANTHRACYCLINE AND METHOD OF PREPARATION AND USE IN TUMOR-SELECTIVE CHEMOTHERAPY. (Patent No. JP2009215295).
Aben, R. W. M., de Vos, D., Haisma, H. J., Cornelissen, J. J. L. M., & Scheeren, J. W. (2009, Mar 1). Esters of glucuronide prodrugs of anthracyclines and method of preparation and use in tumor-selective chemotherapy. Google Patents.
Dekker, F. J., & Haisma, H. J. (2009). Histone acetyl transferases as emerging drug targets. Drug Discovery Today, 14(19-20), 942-948. https://doi.org/10.1016/j.drudis.2009.06.008
Dekker, F. J., Ghizzoni, M., van der Meer, N., Wisastra, R., & Haisma, H. J. (2009). Inhibition of the PCAF histone acetyl transferase and cell proliferation by isothiazolones. Bioorganic & Medicinal Chemistry, 17(2), 460-466. https://doi.org/10.1016/j.bmc.2008.12.008
Ghizzoni, M., Haisma, H. J., & Dekker, F. J. (2009). Reactivity of isothiazolones and isothiazolone-1-oxides in the inhibition of the PCAF histone acetyltransferase. European Journal of Medicinal Chemistry, 44(12), 4855-4861. https://doi.org/10.1016/j.ejmech.2009.07.025
Haisma, H. J., Boesjes, M., Beerens, A. M., van der Strate, B. W. A., Curiel, D. T., Plueddemann, A., Gordon, S., & Bellu, A. R. (2009). Scavenger Receptor A: A New Route for Adenovirus 5. Molecular pharmaceutics, 6(2), 366-374. https://doi.org/10.1021/mp8000974

2008

Riezebos-Brilman, A., Walczak, M., Regts, J., Rots, M. G., Kamps, G., Dontje, B., Haisma, H. Y., Wilschut, J., & Daemen, T. (2008). Erratum: A comparative study on the immunotherapeutic efficacy of recombinant Semliki Forest virus and adenovirus vector systems in a murine model for cervical cancer (vol 14, pg 1695, 2007). Gene Therapy, 15(1), 66. https://doi.org/10.1038/sj.gt.3303084
Johnson, T. S., Mahnke, K., Storn, V., Schoenfeld, K., Ring, S., Nettelbeck, D. M., Haisma, H. J., Le Gall, F., Kontermann, R. E., & Enk, A. H. (2008). Inhibition of Melanoma Growth by Targeting of Antigen to Dendritic Cells via an Anti-DEC-205 Single-Chain Fragment Variable Molecule. Clinical Cancer Research, 14(24), 8169-8177. https://doi.org/10.1158/1078-0432.CCR-08-1474
Schoemaker, M. H., Rots, M. G., Beljaars, L., Ypma, A. Y., Jansen, P. L. M., Poelstra, K., Moshage, A., & Haisma, H. J. (2008). PDGF-receptor beta-targeted adenovirus redirects gene transfer from hepatocytes to activated stellate cells. Molecular pharmaceutics, 5(3), 399-406. https://doi.org/10.1021/mp700118p
Haisma, H. J., Kamps, J. A. A. M., Plantinga, J. A., Rots, M. G., Bellu, A. R., & Kamps, G. (2008). Polyinosinic acid enhances delivery of adenovirus vectors in vivo by preventing sequestration in liver macrophages. Journal of general virology, 89, 1097-1105. https://doi.org/10.1099/vir.0.83495-0
Bremer, E., van Dam, G. M., de Bruyn, M., van Riezen, M., Dijkstra, M., Kamps, G., Helfrich, W., & Haisma, H. (2008). Potent Systemic Anticancer Activity of Adenovirally Expressed EGFR-Selective TRAIL Fusion Protein. Molecular Therapy, 16(12), 1919-1926. https://doi.org/10.1038/mt.2008.203
Beerens, A. M. J., Rots, M. G., Bermudez, B., De Vries, E. F. J., & Haisma, H. J. (2008). Secretion of thymidine kinase to increase the effectivity of suicide gene therapy results in the loss of enzymatic activity. Journal of Drug Targeting, 16(1), 26-35.
Farinha Antunes, I., Haisma, H. J., & de Vries, E. F. J. (2008). Tumor-specific activation of prodrugs: Is there a role for nuclear medicine? Nuclear Medicine Communications, 29(10), 845-846. https://doi.org/10.1097/MNM.0b013e3283094efc

2007

Riezebos-Brilman, A., Walczak, M., Regts, J., Rots, M., Kamps, G., Dontje, B., Haisma, H., Wilschut, J., & Daemen, T. (2007). A comparative study on the immunotherapeutic efficacy of recombinant Semliki Forest virus and adenovirus vector systems in a murine model for cervical cancer. Gene Therapy, 14(24), 1695-1704. https://doi.org/10.1038/sj.gt.3303036
Carette, J. E., Graat, H. C. A., Schagen, F. H. E., Mastenbroek, D. C. J., Rots, M. G., Haisma, H. J., Groothuis, G. M. M., Schaap, G. R., Bras, J., Kaspers, G. J. L., Wuisman, P. I. J. M., Gerritsen, W. R., & van Beusechem, V. W. (2007). A conditionally replicating adenovirus with strict selectivity in killing cells expressing epidermal growth factor receptor. Virology, 361(1), 56-67. https://doi.org/10.1016/j.virol.2006.11.011
Gommans, W. M., McLaughlin, P. M. J., Lindhout, B. I., Segal, D. J., Wiegman, D. J., Haisma, H. J., van der Zaal, B. J., & Rots, M. G. (2007). Engineering zinc finger protein transcription factors to downregulate the epithelial glycoprotein-2 promoter as a novel anti-cancer treatment. Molecular carcinogenesis, 46(5), 391-401. https://doi.org/10.1002/mc.20289
Beerens, A. M. J., Rots, M. G., de Vries, E. F. J., & Haisma, H. J. (2007). Fusion of herpes simplex virus thymidine kinase to VP22 does not result in intercellular trafficking of the protein. International journal of molecular medicine, 19(5), 841-849.
Gommans, W. M., McLaughlin, P. M. J., Schalk, J. A. C., Groothuis, G. M. M., Haisma, H. J., & Rots, M. G. (2007). Highly efficient and carcinoma-specific adenoviral replication restricted by the EGP-2 promoter. Journal of Controlled Release, 117(1), 1-10. https://doi.org/10.1016/j.jconrel.2006.10.006

2006

Rots, MG., Elferink, MGL., Gommans, WM., Oosterhuis, D., Schalk, JAC., Curiel, DT., Olinga, P., Haisma, HJ., & Groothuis, GMM. (2006). An ex vivo human model system to evaluate specificity of replicating and non-replicating gene therapy agents. Journal of gene medicine, 8(1), 35-41. https://doi.org/10.1002/jgm.815
Stoff-Khalili, M. A., Rivera, A. A., Le, L. P., Stoff, A., Everts, M., Contreras, J. L., Chen, D., Teng, L., Rots, M. G., Haisma, H. J., Rocconi, R. P., Bauerschmitz, G. J., Rein, D. T., Yamamoto, M., Siegal, G. P., Dall, P., Michael Mathis, J., & Curiel, D. T. (2006). Employment of liver tissue slice analysis to assay hepatotoxicity linked to replicative and nonreplicative adenoviral agents. Cancer Gene Therapy, 13(6), 606-618. https://doi.org/10.1038/sj.cgt.7700934
Ogawara, K., Kuldo, JM., Oosterhuis, K., Kroesen, BJ., Rots, MG., Trautwein, C., Kimura, T., Haisma, HJ., & Molema, G. (2006). Functional inhibition of NF-kappa B signal transduction in alpha v alpha beta 3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant I kappa B gene. Arthritis Research and Therapy, 8(1), [32]. https://doi.org/10.1186/ar1885
Haisma, HJ., & de Hon, O. (2006). Gene doping. International Journal of Sports Medicine, 27(4), 257-266. https://doi.org/10.1055/s-2006-923986
Haisma, HJ., De Hon, O., Sollie, P., & Vorstenbosch, J. (2006). Genetische doping. Nederlands Tijdschrift voor Klinische Chemie en Laboratoriumgeneeskunde, 31(1), 19.
Karpanen, T., Wirzenius, M., Mäkinen, T., Veikkola, T., Haisma, H. J., Achen, M. G., Stacker, S. A., Pytowski, B., Ylä-Herttuala, S., & Alitalo, K. (2006). Lymphangiogenic growth factor responsiveness is modulated by postnatal lymphatic vessel maturation. American Journal of Pathology, 169(2), 708-718. https://doi.org/10.2353/ajpath.2006.051200
Mahasreshti, PJ., Kataram, M., Wu, HJ., Yalavarthy, LP., Carey, D., Dent, P., Chada, S., Alvarez, RD., Haisma, HJ., Fisher, PB., & Curiel, DT. (2006). Ovarian cancer targeted adenoviral-mediated mda-7/IL-24 gene therapy. Gynecologic Oncology, 100(3), 521-532. https://doi.org/10.1016/j.ygyno.2005.08.042
Visser, A. E., Verschure, P. J., Gommans, W. M., Haisma, H. J., & Rots, M. G. (2006). Step into the Groove: Engineered Transcription Factors as Modulators of Gene Expression. In JC. Hall, JC. Dunlap, T. Friedmann, & VanHeyningen (Eds.), ADVANCES IN GENETICS (pp. 131-+). (Advances in Genetics; Vol. 56). Academic Press. https://doi.org/10.1016/S0065-2660(06)56004-3
Gommans, WM., van Eert, SJ., McLaughlin, PMJ., Harmsen, MC., Yamamoto, M., Curiel, DT., Haisma, HJ., & Rots, MG. (2006). The carcinoma-specific epithelial glycoprotein-2 promoter controls efficient and selective gene expression in an adenoviral context. Cancer Gene Therapy, 13(2), 150-158. https://doi.org/10.1038/sj.cgt.7700882
Gommans, W. M., Oosterhuis, D., Dmitriev, I., Schaack, J., Curiel, D. T., Haisma, H. J., & Rots, M. G. (2006). Towards a double controlled conditionally replicative adenovirus for potent and specific melanoma cell kill. Journal of Controlled Release, 116(2), E64-E66. https://doi.org/10.1016/j.jconrel.2006.09.052

2005

Oosterhoff, D., Overmeer, RM., de Graaf, M., van der Meulen, IH., Giaccone, G., van Beusechem, VW., Haisma, HJ., Pinedo, HM., & Gerritsen, WR. (2005). Adenoviral vector-mediated expression of a gene encoding secreted, EpCAM-targeted carboxylesterase-2 sensitises colon cancer spheroids to CPT-11. British Jounal of Cancer, 92(5), 882-887. https://doi.org/10.1038/sj.bjc.6602362
Roy, H., Bhardwaj, S., Babu, M., Jauhiainen, S., Herzig, KH., Bellu, AR., Haisma, HJ., Carmeliet, P., Alitalo, K., & Yla-Herttuala, S. (2005). Adenovirus-mediated gene transfer of placental growth factor to perivascular tissue induces angiogenesis via upregulation of the expression of endogenous vascular endothelial growth factor-A. Human Gene Therapy, 16(12), 1422-1428.
Gommans, WM., Haisma, HJ., & Rots, MG. (2005). Engineering zinc finger protein transcription factors: The therapeutic relevance of switching endogenous gene expression on or off at command. Journal of Molecular Biology, 354(3), 507-519. https://doi.org/10.1016/j.jmb.2005.06.082
Lu, B., Makhija, SK., Nettelbeck, DM., Rivera, AA., Komarova, S., Zhou, F., Yamamoto, M., Haisma, HJ., Alvarez, RD., Curiel, DT., & Zhu, ZB. (2005). Evaluation of tumor-specific promoter activities in melanoma. Gene Therapy, 12(4), 330-338. https://doi.org/10.1038/sj.gt.3302385
Kraaij, R., van Rijswijk, ALCT., Haisma, HJ., & Bangma, CH. (2005). Prostate specific membrane antigen (PSMA) is a tissue-specific target for adenoviral transduction of prostate cancer in vitro. Prostate, 62(3), 253-259. https://doi.org/10.1002/pros.20150
Buursma, A. R., Beerens, A., de Vries, E. F. J., van Waarde, A., Rots, M., Hospers, G. A. P., Vaalburg, W., & Haisma, H. J. (2005). The human norepinephrine transporter in combination with C-11-m-hydroxyephedrine as a reporter gene/reporter probe for PET of gene therapy. Journal of Nuclear Medicine, 46(12), 2068-2075.
Haisma, H. J., & de Hon, O. (2005). Ziek, beter, best: van gentherapie tot genetische doping. In Beter dan Goed, over Genetica en de toekomst van Topsport (pp. 120 - 137). Veen Magazines B.V..

2004

Nevalainen, T. J., Scheeren, H. W., Pinedo, H. M., Haisma, H. J., & Boven, E. (2004). A methylester of the glucuronide prodrug DOX-GA3 for improvement of tumor-selective chemotherapy. Biochemical Pharmacology, 68(11), 2273-2281. https://doi.org/10.1016/j.bcp.2004.08.004
Kirby, TO., Rivera, A., Rein, D., Ulasov, N. V., Breidenbach, M., Kataram, M., Contreras, JL., Krumdieck, C., Yamamoto, M., Rots, MG., Haisma, HJ., Alvarez, RD., Mahasreshti, PJ., & Curiel, DT. (2004). A novel ex vivo model system for evaluation of conditionally replicative adenoviruses therapeutic efficacy and toxicity. Clin.Cancer Res., 10(24), 8697 - 8703.
Ogawara, K., Rots, M., Kok, R. J., Moorlag, H. E., van Loenen - Weemaes, A., Meijer, D. K. F., Haisma, H. J., & Molema, I. (2004). A novel strategy to modify adenovirus tropism and enhance transgene delivery to activated vascular endothelial cells in vitro and in vivo. Human Gene Therapy, 15(5), 433 - 443. https://doi.org/10.1089/10430340460745766
Rots, M., Gommans, W. M., Dmitriev, I., Oosterhuis, D., Seki, T., Curiel, D. T., & Haisma, H. J. (2004). A platform for constucting infectivity-enhanced fiber-mosaic adenoviruses genetically modified to express two fiber types. Gene Therapy and Molecular Biology, 8, 1 - 8.
Leath, CA., Kataram, M., Bhagavatula, P., Gopalkrishnan, RV., Dent, P., Fisher, PB., Pereboev, A., Carey, D., Lebedeva, N. V., Haisma, HJ., Alvarez, RD., Curiel, DT., & Mahasreshti, PJ. (2004). Infectivity enhanced adenoviral-mediated mda-7/IL-24 gene therapy for ovarian carcinoma. Gynecologic Oncology, 94(2), 352 - 362. https://doi.org/10.1016/j.ygyno.2004.04.028
Pinedo, H. M., Oosterhoff, D., Van der Meulen-Muileman, I. H., Gerritsen, W. R., Haisma, H. J., & Boven, E. (2004). Pronounced antitumor efficacy by extracellular activation of a doxorubicin-glucuronide prodrug after adenoviral vector-mediated expression of a human antibody-enzyme fusion protein. Human Gene Therapy, 15(3), 229 - 238.
Schoemaker, M., Conde de la Rosa, L., Buist-Homan, M., Vrenken, T. E., Havinga, R., Poelstra, K., Haisma, H. J., Jansen, P. LM., & Moshage, A. J. H. (2004). Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways. Hepatology, 39(6), 1563 - 1573. https://doi.org/10.1002/hep.20246

2003

Brandao, JG., Scheper, RJ., Lougheed, SM., Curiel, DT., Tillman, BW., Gerritsen, WR., van den Eertwegh, AJM., Pinedo, HM., Haisma, HJ., & de Gruijl, TD. (2003). CD40-targeted adenoviral gene transfer to dendritic cells through the use of a novel bispecific single-chain Fv antibody enhances cytotoxic T cell activation. Vaccine, 21(19-20), 2268-2272. https://doi.org/10.1016/S0264-410X(03)00050-1
van Beusechem, V. W., Mastenbroek, D. C., Van den Doel, P. B., Lamfers, M. L., Grill, J., Wurdinger, T., Haisma, H. J., Pinedo, H. M., & Gerritsen, W. R. (2003). Conditionally replicative adenovirus expressing a targeting adapter molecule exhibits enhanced oncolytic potency on CAR-deficient tumors. Gene Therapy, 10(23), 1982-1991. https://doi.org/10.1038/sj.gt.3302103
Pinedo, H. M., Quadir, R., Haisma, H. J., & Boven, E. (2003). Cytosolic beta-glycosidases for activation of glycoside prodrugs of daunorubicin. Biochem.Pharmacol., 65(11), 1875-1881. https://doi.org/10.1016/S0006-2952(03)00183-7
Oosterhoff, D., Witlox, M. A., van Beusechem, V. W., Haisma, H. J., Schaap, G. R., Bras, J., Kruyt, W., Molenaar, B., Boven, E., Wuisman, P. I., Pinedo, H. M., & Gerritsen, W. R. (2003). Gene-directed enzyme prodrug therapy for osteosarcoma: Sensitization to CPT-11 in vitro and in vivo by adenoviral delivery of a gene encoding secreted carboxylesterase-2. Mol.Cancer Ther., 2(8), 765-771.
Mahasreshti, P. J., Kataram, M., Wang, M. H., Stockard, C. R., Grizzle, W. E., Carey, D., Siegal, G. P., Haisma, H. J., Alvarez, R. D., & Curiel, D. T. (2003). Intravenous delivery of adenovirus-mediated soluble FLT-1 results in liver toxicity. Clin.Cancer Res., 9(7), 2701 - 2710.
Fonseca, M. J., Jagtenberg, J. C., Haisma, H. J., & Storm, G. (2003). Liposome-mediated targeting of enzymes to cancer cells for site-specific activation of prodrugs: Comparison with the corresponding antibody-enzyme conjugate. Pharmaceutical Research, 20(3), 423-428.
Beerens, A. M., Al Hadithy, A. F., Rots, M., & Haisma, H. J. (2003). Protein transduction domains and their utility in gene therapy. Curr.Gene Ther., 3(5), 486 - 494.
Schoemaker, M., Gommans, W. M., Conde de la Rosa, L., Buist-Homan, M., Klok, P., Trautwein, C., van Goor, H., Poelstra, K., Haisma, H. J., Jansen, P. LM., & Moshage, A. J. H. (2003). Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation. Journal of Hepatology, 39(2), 153-161. https://doi.org/10.1016/S0168-8278(03)00214-9
Haisma, HJ., & Rots, MG. (2003). State of the art in gene therapy. In CTS. Sibinga, & LFM. DeLeij (Eds.), CELLULAR ENGINEERING AND CELLULAR THERAPIES (pp. 171-187). (DEVELOPMENTS IN HEMATOLOGY AND IMMUNOLOGY; Vol. 38). Springer.
Rots, MG., Curiel, DT., Gerritsen, WR., & Haisma, HJ. (2003). Targeted cancer gene therapy: the flexibility of adenoviral gene therapy vectors. J.Control Release, 87(1-3), 159-165. https://doi.org/10.1016/S0168-3659(02)00360-7
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