Exploring the potential of flavoprotein oxidoreductases in natural product biosynthesis
This thesis explores how certain enzymes, called flavoenzymes, help living organisms such as bacteria and fungi create natural products. These chemical compounds often have useful properties and can serve as the basis for the development of new medicines. Flavoenzymes are special because they work with oxygen to carry out chemical reactions and can change or build molecules in precise ways.
This work focuses on understanding the structure and function of several flavoenzymes, three oxidases and one monooxygenase, that play key roles in how natural products are made. By studying how these enzymes function and interact, the research gives valuable insight into the step-by-step process nature uses to build complex molecules. These findings not only deepen our understanding of how nature catalyzes chemical reactions, but also open up possibilities for designing new therapeutics.