Ellen Nollen, PhD

 

Study: MSc, Molecular Biology and Biochemical Engineering, University of Wageningen, 1994

PhD thesis: Hsp70 chaperone functions in stressed cells, University of Groningen, 2000

 

 

 

 

 

 

  

 

 

 

 

 

 

Email: Ellen Nollen

Phone +31 (0)50 361 7124 

 

Keywords
C. elegans, Parkinson’s disease. Alzheimer’s disease, Huntington’s disease, protein misfolding diseases, neurodegeneration, disease modifiers, protein quality control, aging

  

Short CV 

Ellen Nollen currently holds a Rosalind Franklin Fellowship at the Department of Genetics, University Medical Centre Groningen, in the Netherlands, where she is studying the molecular basis of Parkinson’s disease and other aging-associated neurodegenerative diseases. In July 2011 she was awarded an ERC Starting Independent Researcher Grant (€1.5 million) to work on ‘Protein damage control: regulation of toxic protein aggregation in aging-associated neurodegenerative diseases’, More and in November 2011 she was named as an EMBO Young Investigator. More

In 2007 she received an Alfred Tissières Young Investigator Award.

She previously worked as a postdoctoral fellow in the Dept. of Functional Genomics, Hubrecht Laboratory, Utrecht, under Prof. Ronald Plasterk, for which she had an NWO-VENI grant, and in the Dept. of Biochemistry, Northwestern University, Evanston, USA, under Prof. Rick Morimoto, during which she was supported by NWO-Talent and EMBO long-term fellowships. She completed her PhD thesis on “Hsp70 chaperone functions in stressed cells” in 2000 under Prof. Harm Kampinga at the University of Groningen.

 

Selected papers 

• Identification of MOAG-4/SERF as a conserved general regulator of age-related proteotoxicity. (2010) Van Ham TJ, Holmberg M, van der Goot A, Teuling E , Garcia-Arencibia M, Kim HE, Du D, Thijssen KL, Wiersma M, Burggraaff R, van Bergeijk P, van Rheenen J, van Veluw GJ, Hofstra RMW, Rubinsztein DC, and Nollen EAA.  Cell 142(4):601-12.

• Van Ham T.J., Thijssen K.L. Breitling R., Hofstra R.M.W., Plasterk R.H.A.& Nollen E.A.A. (2008) C. elegans model links alpha-synuclein inclusion formation to aging. PLoS Genet. 4(3):e1000027
• Nollen E.A.A., Garcia S.M., van Haaften G., Kim S., Chavez A., Morimoto R.I.& Plasterk R.H. (2004) Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation. Proc. Natl. Acad. Sci. USA 101(17):6403-8
• Kim S., Nollen E.A.A., Kitagawa K., Bindokas V.P. & Morimoto R.I. (2002) Polyglutamine protein aggregates are dynamic. Nat. Cell. Biol. 10:826-31
• Nollen E.A.A., Salomons F.A., Brunsting J.F., van der Want J.J.L., Sibon O.C.M & Kampinga, H.H. (2001) Dynamic changes in the localization of thermally unfolded nuclear proteins associated with chaperone dependent protection. Proc. Natl. Acad. Sci. USA, 21: 12038-43
• see also Frantz S. Stress Relief. (2001) Research Highlights, Nature Reviews Molecular Cell Biology , 2: 786-786