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The 2008 ISMR Research Grant AwardNina Ariani, PhD student in the department of Biomedical Engineering at the UMCG, has been awarded the 2008 ISMR Research Grant Award. ISMR, the International Society for Maxillofacial Rehabilitation, awards research grants on a yearly basis to stimulate basic or applied head and neck related research through the Research Grants Program. Nina received the $1500,- award for her work on: “Structural and clinical aspects of biofilm formation on silicone maxillofacial prostheses. Knowledge leads to prevention!”. Nina accepted the award during the 8th annual International Congress on Maxillofacial Rehabilitation, held September 24-27, 2008 in Bangkok, Thailand. Nina is supervised at the UMCG by Dr. B.P. Krom and Dr. R.P. van Oort and her work is supported by a Bernoulli grant from the University of Groningen. In Indonesia Nina is supervised by Prof. Dr. Tri Budi from the University of Indonesia in Jakarta.
NANTICO
Nonadhesive, Antimicrobial Coatings for Biomedical Implants
Principal Investigator
Prof Henk J. Busscher, PhD, University Medical Center Groningen/University of Groningen, Department of BioMedical Engineering
Partners
Summary
Utilization of biomaterials implants has become an accepted and often life-saving procedure. Implant infection is the most feared and serious complication of the use of biomaterials implants. Bacterial contamination during surgery and subsequent adhesion onto biomaterial surfaces and colonization of the surrounding tissue initiates implant infection. Treatment of biomaterials-associated infections (BAI) is difficult and often infection is irreversible, requiring removal of the implant. Implantation of a second implant can only occur when infection of adjacent tissue has been eliminated, else revision surgery is doomed to fail. The consortium aims to develop new materials coatings that can prevent BAI or facilitate new treatment modalities employing on demand, antimicrobials releasing coatings. To this end, the consortium will:
1. converge state-of-the-art materials technology with fundamental knowledge on the pathogenesis of BAI.
2. further develop in vivo imaging systems as a tool for monitoring BAI, and evaluating combined effects of nonadhesive and antimicrobial coatings, systemic antibiotics and the host immune system.
Development of anti-BAI technologies implies combination of surface physics and chemistry, tailoring of antimicrobial compound surface-immobilization schemes, and the development and validation in in vitro and in vivo (animal) models. Finally, fundamental microbiology is required to unravel physicochemical mechanisms involved in bacterial adhesion, biofilm development and colonization of surrounding tissue, as to translate this knowledge in the design and development of polymer-based technologies that support prevention and treatment of BAI. Our consortium contains the required elements and coherence to optimize the chance of reaching the designated aims and will yield novel technologies to improve healthcare through prevention and better treatment of BAI, along with a reduction of the formidable costs associated with BAI.
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