Onderzoek

• Eisel, U., Jarausch, W., Goretzki, G., Henschen, A., Engels, J., Weller, U., Hude l, M., Habermann, E., and Niemann, H. (1986). Tetanus toxin: primary structure, expression in E. coli, and homology with botulinum toxins. EMBO J , 5, 2495-2502.

 

• Demotz, S., Lanzavecchia, A., Eisel, U., Niemann, H., Widman, C., and Corradin, G. (1989). Delineation of several DR-restricted tetanus toxin T cell epitopes. J Immunol, 142 , 394-402.

 

• Andersen-Beckh, B., Binz, T., Kurazono, H., Mayer, T., Eisel, U., and Niemann, H., (1989). Tetanus toxin: Expression of subfragments in vitro and characterization of epitopes. Infect Immun , 57, 3498-3505.

 

• Orlik-Eisel, G., Lutz, F., Henschen, A., Eisel, U., Struckmeier, M., Kraeuter, J., and Niemann, H. (1990). The cytotoxin of Pseudomonas aeruginosa: Cytotoxicity requires proteolytic activation. Arch Microbiol, 153, 561-568.

 

• Mochida, S., Poulain, B., Eisel, U., Binz, T., Kurazono, H., Niemann, H., and Tauc, L. (1990). Exogenous mRNA encoding tetanus or botulinum neurotoxins expressed in Aplysia neurons. Proc Natl Acad Sci , USA, 87, 7844-7848.

 

• Mochida, S., Poulain, B., Eisel, U., Binz, T., Kurazono, H., Niemann, H., and Tauc., L. (1990). Molecular biology of clostridial toxins: Expression of mRNAs encoding tetanus and botulinum neurotoxins in Aplysia neurons. J Physiol (Paris), 84, 278-284.

 

• Niemann, H., Binz, T., Kurazono, H., Eisel, U., and Andersen-Beckh, B. (1991). Molekularbiologie clostridialer Neurotoxine. Nova acta Leopoldina , NF66, 279, 135 - 144.

 

• Kurazono, H., Mochida, S., Binz, T., Eisel, U., Quanz, M., Grebenstein, O., Wernars, K., Poulain, B., Tauc, L., and Niemann, H. (1992). Minimal essential domains specifying toxicity of the light chains of tetanus toxin and botulinum neurotoxin type A. J Biol Chem., 267, 14721-14729.

 

• Link, E., Edelmann, L., Chou, J.H., Binz, T., Yamasaki, S., Eisel, U., Baumert, M., Südhof, T.C., Niemann, H., and Jahn, R. (1992). Tetanus toxin action - inhibition of neurotransmitter release linked to synaptobrevin proteolysis. Biochem Biophys Res Commun, 189, 1017-1023.

 

• Eisel, U., Reynolds, K., Riddick, M., Zimmer, A., Niemann, H., and Zimmer, A. (1993). Tetanus toxin light chain expression in Sertoli cells of transgenic mice causes alterations of the actin cytoskeleton and disrupts spermatogenesis. EMBO J , 12, 3365-3372.

 

• Klein, M., Pieri, I., Uhlbach, F., Bayertz, C., van der Ploeg, A., Pfizenmeier, K., and Eisel, U. (1998). Cloning of the promoter region of the murine NMDA receptor subunit e 2: Evidence for alternative splicing of the 5’ non coding region. GENE , 208/2,259-269.

 

• Marvaud, J.C., Eisel, U., Binz, T., Niemann, H., and Popoff, M. R. (1998). TetR is a Positive Regulator of the Tetanus Toxin Gene in Clostridium tetani and is Homologous to BotR. Infect Immun 66(12),5698-5702.

 

• Pieri,I., Klein, M., Bayertz, C., Gerspach, J., van der Ploeg, A., Pfizenmaier, K., and Eisel, U.. (1999). Regulation of the Murine NMDA-Receptor-Subunit NR2C Promoter by Sp1 and fushi tarazu factor1 (FTZ-F1) homologues. Eur J Neurosci 11,2083-2092.
• Conzelmann, S., Levai, O., Bode, B., Eisel, U.,Raming, K.,Breer, H. and Strotmann, J.(2000) A novel brain receptor is expressed in a distinct population of olfactory sensory neurons. Eur J Neurosci , 12 (11),3926-34.

 

• Varju, P., Schlett, K., Eisel, U., and Madarasz, E. (2001) Schedule of NMDA receptor subunit expression and functional channel formation in the course of in vitro-induced neurogenesis. J Neurochem, 77, 1-14.

 

• Willuweit A.,Sass, G.,Schöneberg A., Eisel, U. ,Tiegs, G and Clauss, M. (2001) Chronic Inflammation and Protection from Acute Hepatitis in Transgenic Mice Expressing Tumor Necrosis Factor in Endothelial Cells. J Immunol, 167 (7), 3944-3952.

 

• Jelitai, M., Schlett, K., Varju, P., Eisel, U., and Madarasz, E. (2002) Regulated appearance of NMDA receptor subunits and channel functions during in vitro neuronal differentiation.J Neurobiol, 51(1):54-65.

 

• Fontaine, V., Mohand-Said, S., Hanoteau, N., Fuchs, C., Pfizenmaier, K., and Eisel, U. (2002) Neurodegenerative and neuroprotective effects of tumor necrosis factor in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2. J Neurosci, 22(7): RC216, 1-7.

 

• Marchetti L, M Klein, K Schlett, K Pfizenmaier and Eisel ULM (2004) TNF mediated neuroprotection against glutamate induced excitotoxicity is enhanced by NMDA receptor activation: essential role of a TNF receptor 2 mediated PI3 kinase dependent NF- k B gpathway. J Biol Chem, 279,32869-32881.

 

• Schlett, K., Pieri I., Metzger, F., Steigerwald, F., Dere, E., Kirilly, D., Barabás, B., Marchetti, L., Gerspach, J., Huston, J.P., Pfizenmaier, K., Köhr, G. and Eisel , U. (2004) Persistent NR2B expression in cerebellar granule cells decreases Purkinje cell innervation and motor performance. Mol Cell Neurosci, 27(3), 215-226.

 

• Metzger, F., Pieri, I., Eisel, U.L.M. (2005) NMDA receptor-dependent Purkinje cell dendritic development in cerebellar slice cultures. Dev Brain Res, 155: 165-168.

 

• Eisel ULM, Biber K, Luiten PGM.(2006) Life and death of nerve cells: therapeutic cytokine signaling pathways. Current Signal Transduction Therapy, 1, 133-146.

 

• De Souza Silva M. A., A. Dolga, I. Pieri, L. Marchetti,U.L.M. Eisel, J.P. Huston, and E. Dere (2006) Cholinergic cells in the nucleus basalis of mice express the N-methyl-D-aspartate-receptor subunit NR2C and its replacement by the NR2B subunit enhances frontal and amygdaloid acetylcholine levels. Genes Brain Behav, 5(7): 552-60.

 

• De Souza Silva MA, Dolga A, Pieri I, Marchetti L, Eisel UL, Huston JP, Dere E. (2007) NR2C by NR2B subunit exchange in juvenile mice affects emotionality and 5-HT in the frontal cortex. Genes Brain Behav, 6(5): 465-72.

 

• Ostroveanu A, Van der Zee EA, Dolga AM, Luiten PG, Eisel UL, Nijholt IM. (2007) A-kinase anchoring protein 150 in the mouse brain is concentrated in areas involved in learning and memory. Brain Res;1145: 97-107.

 

• Nijholt IM, Ostroveanu A, de Bruyn M, Luiten PG, Eisel UL, Van der Zee EA. (2007) Both exposure to a novel context and associative learning induce an upregulation of AKAP150 protein in mouse hippocampus.Neurobiol Learn Mem, 87(4):693-696.

 

• Havekes, R, Nijholt, IM, Visser, AK, Eisel., ULM, EA Van der Zee. (2008) Transgenic inhibition of neuronal calcineurin activity in the forebrain inhibits the extinction of contextual fear memory. Neurobiol Learn Mem, 89 (4) : 595-598.

 

• Biber, K., Pinto-Duarte, A., Wittendorp, M C,  Dolga, A M, Fernandes, CC, Von Frijtag J; Künzel, D, Keijser, JN, de Vries,R, Ijzerman, A P , Ribeiro, J A, Eisel,U,Sebastião A M  and HWGM  Boddeke (2008) Interleukin-6 Upregulates Neuronal Adenosine A₁ Receptors: Implications for Neuromodulation and Neuroprotection N europsychopharmacol, 33 :2237-2250.

 

• Dolga, AM; I M. Nijholt; A Ostroveanu; Q ten Bosch; P G M Luiten, and U L M Eisel (2008) Lovastatin induces neuroprotection through tumor necrosis factor receptor 2 signaling pathwaysJ Alz Dis, 13(2):1-12.

 

• Nijholt IM, Ostroveanu A,Luiten PG, Van der Zee EA and Eisel ULM (2008) Inhibition of PKA anchoring to A-kinase anchoring proteins impairs consolidation and facilitates extinction of contextual fear memories Neurobiol Learn Mem, 90 ( 1) : 223-229

 

• Nijholt IM, Dolga AM, Ostroveanu A, Luiten PG, Schmidt M, Eisel UL. Neuronal AKAP150 coordinates PKA and Epac-mediated PKB/Akt phosphorylation. Cell Signal . 2008 Oct;20(10):1715-24.

 

• Dolga AM, Granic I, Blank T, Knaus HG, Spiess J, Luiten PG, Eisel UL, Nijholt IM. TNF-alpha-mediates neuroprotection against glutamate-induced excitotoxicity via NF-kappaB-dependent up-regulation of K2.2 channels. J Neurochem . 2008 Nov;107(4):1158-67.

 

• Tárnok K, Kiss E, Luiten PG, Nyakas C, Tihanyi K, Schlett K, Eisel UL. Effects of Vinpocetine on mitochondrial function and neuroprotection in primary cortical neurons. Neurochem Int . 2008 Dec;53(6-8):289-95.

 

• van der Most PJ, Dolga AM, Nijholt IM, Luiten PG, Eisel UL. Statins: mechanisms of neuroprotection. Prog Neurobiol . 2009 May;88(1):64-75.

 

• Granic I, Dolga AM, Nijholt IM, van Dijk G, Eisel UL. Inflammation and NF-kappaB in Alzheimer's disease and diabetes. J Alzheimers Dis . 2009 Apr;16(4):809-21.

 

• Dolga AM, Granic I, Nijholt IM, Nyakas C, van der Zee EA, Luiten PG, Eisel UL.(2009) Pretreatment with Lovastatin Prevents N-Methyl-D-Aspartate-Induced Neurodegeneration in the Magnocellular Nucleus Basalis and Behavioral Dysfunction. J Alzheimers Dis . 2009; 17(2): 327-336.

 

• Alves MM, Burzynski G, Delalande JM, Osinga J, van der Goot A, Dolga AM et al. KBP interacts with SCG10, linking Goldberg-Shprintzen syndrome to microtubule dynamics and neuronal differentiation. Hum Mol Genet 2010 Sep 15; 19(18): 3642-3651.

 

• Dobos N, Korf J, Luiten PG, Eisel UL. Neuroinflammation in Alzheimer's disease and major depression. Biol Psychiatry 2010 Mar 15; 67(6): 503-504.

 

• Granic I, Masman MF, Kees Mulder C, Nijholt IM, Naude PJ, de Haan A et al. LPYFDa neutralizes amyloid-beta-induced memory impairment and toxicity. J Alzheimers Dis 2010; 19(3): 991-1005.

 

• Granic I, Masman MF, Luiten PG, Eisel UL. Braak staging in mouse models of Alzheimer's disease. Am J Pathol 2010 Oct; 177(4): 1603-1605.

 

• Granic I, Nyakas C, Luiten PG, Eisel UL, Halmy LG, Gross G et al. Calpain inhibition prevents amyloid-beta-induced neurodegeneration and associated behavioral dysfunction in rats. Neuropharmacology 2010 Sep-Oct; 59(4-5): 334-342.

 

• Ostroveanu A, van der Zee EA, Eisel UL, Schmidt M, Nijholt IM. Exchange protein activated by cyclic AMP 2 (Epac2) plays a specific and time-limited role in memory retrieval. Hippocampus 2010 Sep; 20(9): 1018-1026.

 

• Vinet J, de Jong EK, Boddeke HW, Stanulovic V, Brouwer N, Granic I et al. Expression of CXCL10 in cultured cortical neurons. J Neurochem 2010 Feb; 112(3): 703-714.

 

• Nijholt, I.M., I. Granic, P.G.M. Luiten and U.L.M. Eisel.TNFR2 - target for therapeutics against neurodegenerative diseases? Cytokines and Growths Factor Reviews in press

 

Books/chapters

 

• Niemann, H., Andersen-Beckh, B., Binz, T., Eisel, U., Demotz, S., Mayer, T., and Widman, C. (1988). Tetanus toxin: evaluation of the primary sequence and potential applications. In: Fehrenbach et al. (eds.), Bacterial protein toxins. Zbl. Bakt. Suppl. 17, Gustav Fischer Verlag, Stuttgart, New York, pp. 29-38.

 

• Binz, T., Eisel, U., Kurazono, H., Binschek, T., Bigalke, H., and Niemann, H. (1990). Tetanus and botulinum A toxins: Comparison of sequences and microinjection of tetanus toxin A subunit-specific mRNA into bovine chromaffine cells. In: Rappuoli et al. (eds.), Bacterial Protein Toxins, Zbl. Bakt. Suppl. 19, Gustav Fischer Verlag, Stuttgart, New York, pp. 105-108.

 

• Binz, T., Grebenstein, O., Kurazono, H., Eisel, U., Wernars, K., Popoff, M., Mochida, S., Poulain, B, Tauc, L., and Niemann, H. (1992). Molecular biology of the L chains of clostridial neurotoxins. In: Witholt, B., et al. (Ed.) Zentralblatt für Bakteriology Suppl. 23 (International Journal of Medical Microbiology) Bacterial Protein Toxins. 5th European Workshop, Veldhoven, Netherlands, June 30th -July 5th 1991. XIV+513P. Gustav Fischer Verlag, Stuttgart, New York. 342-3;0: 56-65.

 

• Niemann, H., Binz, T., Grebenstein, O., Kurazono, H., Kalkuhl, A., Yamasaki, S., Eisel, U., Pohlner, J., Schneider, G., Krivan, V., Kozaki, S., Mochida, S., Tauc, L., and Poulain, B. (1993). Dissecting the L chains of clostridial neurotoxins. Botulinum, tetanus neurotoxins: Neurotransmission and Biomedical Aspects. (B. DasGupta, editor). Plenum Publication Corp. pp. 361-375.

 

• Eisel, U., Reynolds, K., Riddick, M., Zimmer, A., and Zimmer, A. (1994). Tetanus toxin expression in Sertoli cells of transgenic mice inhibits spermatogenesis. In Function of Somatic Cells in the Testis: (ed. Bartke, A) pp 195 - 201.Springer-Verlag, New York.

 

• Eisel, U. Cytokines in Brain Diseases: Lessons from Transgenic Animals. (2002) In: Current Topics in Microbiology and Immunology 265 (Springer Verlag, Berlin-Heidelberg-New York-Tokyo) Eds. J. Richt und B. Dietzschold. Protective and Pathological Immune Response in the CNS. pp. 49-62.

 

• Boddeke, HWGM, Eisel, U, Biber, K. (2009) Cytokine Receptors in Glia The New Encyclopedia of Neuroscience, edited by Larry Squire et al, Elsevier, publication date: MAY-2009,ISBN-13:978-0-08-044617-2,ISBN-10:0-08-044617-5 Imprint: ACADEMIC PRESS

 

• Eisel, U. L. M., Dobos; N., Luiten, P.G.M., Korf, J. (2010) Inflammatory mediators, stroke and neurodegenerative disease. In Neuroimmune Biology (Vol. 9) The Brain and Host Defence (Ed. I. Berczi). in press.