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Over ons Praktische zaken Waar vindt u ons dr. J.L. (Joost) Kluiver

Research interests

Over the last decade it has become clear that non-coding RNAs are important players in virtually all physiological processes. Deregulation of non-coding RNAs contributes to diseases including cancer.

In our studies we focus on understanding how small and long non-coding RNAs contribute to the pathogenesis of B-cell lymphoma. These include studies on MYC –regulated miRNAs and lncRNAs, miRNA-lncRNA interactions and the role of lncRNAs in epigenetics.

 

Keywords: B-cell lymphoma, non-coding RNAs, microRNA, lncRNAs

Publicaties

Circular ZDHHC11 supports Burkitt lymphoma growth independent of its miR-150 binding capacity

Detection of circulating tumor DNA in plasma of patients with primary CNS lymphoma by digital droplet PCR

Pinpointing Functionally Relevant miRNAs in Classical Hodgkin Lymphoma Pathogenesis

A population-based study of transformed marginal zone lymphoma: identifying outcome-related characteristics

CRISPR/Cas9 screen for genome-wide interrogation of essential MYC-bound E-boxes in cancer cells

Genomic profiling of post-transplant lymphoproliferative disorders using cell-free DNA

Inhibition of the glutamate-cysteine ligase catalytic subunit with buthionine sulfoximine enhances the cytotoxic effect of doxorubicin and cyclophosphamide in Burkitt lymphoma cells

Long non-coding RNAs associated with transcriptomic signatures and treatment outcome in diffuse large B-cell lymphoma

Proliferation-promoting roles of linear and circular PVT1 are independent of their ability to bind miRNAs in B-cell lymphoma

Actionability of on-target ALK Resistance Mutations in Patients With Non-Small Cell Lung Cancer: Local Experience and Review of the Literature

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Pers/media

Receiving funding from Lymph&Co