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University Medical Center Groningen

prof. dr. F. (Folkert) Kuipers

Research interests Publicaties Pers/media

Research interests

 

- Physiology and pathophysiology of the enterohepatic circulation in humans and experimental animals: hepatic and intestinal transport systems, mechanisms of bile formation and cholestasis, (patho)physiology of biliary lipid secretion, metabolic control by bile acids via newly identified signaling cascades

- Hepatic lipid metabolism in humans and experimental animals: lipoprotein assembly and secretion, causes and consequences of hepatic steatosis, interactions between carbohydrate and lipid metabolism, inborn errors of metabolism, inflammatory pathways, role of nuclear receptors (LXR, CHREBP)

- Regulation of cholesterol synthesis and trafficking: transcription factors and nuclear receptors (SREBP/PPAR/FXR/LXR) and transporter proteins, perinatal development, metabolic programming, application of stable isotope approaches

- Quantification of metabolic fluxes by stable isotope procedures

 

Publicaties

Changes in bile acid composition are correlated with reduced intestinal cholesterol uptake in intestine-specific WASH-deficient mice

Heida, A., van Dijk, T., Smit, M., Koehorst, M., Koster, M., Kloosterhuis, N., Havinga, R., Bloks, V. W., Wolters, J. C., de Bruin, A., Kuivenhoven, J. A., de Boer, J. F., Kuipers, F. & van de Sluis, B., mrt.-2024, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1869, 2, 11 blz., 159445.

Onderzoeksoutput › › peer review

Characterization of milk oligosaccharide and sialic acid content and their influence on brain sialic acid in a lean mouse model for gestational diabetes

Liu, F., Tol, A. J. C., Kuipers, F., Oosterveer, M. H., van der Beek, E. M. & van Leeuwen, S. S., 15-feb.-2024, In: Heliyon. 10, 3, 13 blz., e24539.

Onderzoeksoutput › › peer review

Dietary cystine restriction increases the proliferative capacity of the small intestine of mice

de Jong, J. C. W., van Rooijen, K. S., Stigter, E. C. A., Gülersönmez, M. C., de Zoete, M. R., Top, J., Baars, M. J. D., Vercoulen, Y., Kuipers, F., van Mil, S. W. C. & Ijssennagger, N., 5-jan.-2024, In: PLoS ONE. 19, 1, 15 blz., e0290493.

Onderzoeksoutput › › peer review

Transmission and dynamics of mother-infant gut viruses during pregnancy and early life

Lifelines NEXT cohort study, Garmaeva, S., Sinha, T., Gulyaeva, A., Kuzub, N., Spreckels, J. E., Andreu-Sánchez, S., Gacesa, R., Vich Vila, A., Brushett, S., Kruk, M., Dekens, J., Sikkema, J., Kuipers, F., Shkoporov, A. N., Hill, C., Scherjon, S., Wijmenga, C., Fu, J., Kurilshikov, A., & 1 anderenZhernakova, A., 2-mrt.-2024, In: Nature Communications. 15, 1, 19 blz., 1945.

Onderzoeksoutput › › peer review

Absence of gut microbiota reduces neonatal survival and exacerbates liver disease in Cyp2c70-deficient mice with a human-like bile acid composition

Sjöland, W., Wahlström, A., Makki, K., Schöler, M., Molinaro, A., Olsson, L., Greiner, T. U., Caesar, R., de Boer, J. F., Kuipers, F., Bäckhed, F. & Marschall, H-U., 14-jul.-2023, In: Clinical Science. 137, 13, blz. 995-1011 17 blz.

Onderzoeksoutput › › peer review

Activation of Liver X Receptors and Peroxisome Proliferator-Activated Receptors by Lipid Extracts of Brown Seaweeds: A Potential Application in Alzheimer's Disease?

Martens, N., Zhan, N., Voortman, G., Leijten, F. P. J., van Rheenen, C., van Leerdam, S., Geng, X., Huybrechts, M., Liu, H., Jonker, J. W., Kuipers, F., Lütjohann, D., Vanmierlo, T. & Mulder, M. T., 30-jun.-2023, In: Nutrients. 15, 13, 24 blz., 3004.

Onderzoeksoutput › › peer review

Adipocyte-specific FXR-deficiency protects adipose tissue from oxidative stress and insulin resistance and improves glucose homeostasis

Dehondt, H., Marino, A., Butruille, L., Mogilenko, D. A., Nzoussi Loubota, A. C., Chávez-Talavera, O., Dorchies, E., Vallez, E., Haas, J., Derudas, B., Bongiovanni, A., Tardivel, M., Kuipers, F., Lefebvre, P., Lestavel, S., Tailleux, A., Dombrowicz, D., Caron, S. & Staels, B., mrt.-2023, In: Molecular metabolism. 69, 13 blz., 101686.

Onderzoeksoutput › › peer review

Bile Acid Sequestration via Colesevelam Reduces Bile Acid Hydrophobicity and Improves Liver Pathology in Cyp2c70-/- Mice with a Human-like Bile Acid Composition

Palmiotti, A., de Vries, H. D., Hovingh, M. V., Koehorst, M., Mulder, N. L., Verkade, E., Veentjer, M. K., van Dijk, T. H., Bloks, V. W., Havinga, R., Verkade, H. J., de Boer, J. F. & Kuipers, F., 8-sep.-2023, In: Biomedicines. 11, 9, 15 blz., 2495.

Onderzoeksoutput › › peer review

Bile proteome reveals biliary regeneration during normothermic preservation of human donor livers

Thorne, A. M., Wolters, J. C., Lascaris, B., Bodewes, S. B., Lantinga, V. A., van Leeuwen, O. B., de Jong, I. E. M., Ustyantsev, K., Berezikov, E., Lisman, T., Kuipers, F., Porte, R. J. & de Meijer, V. E., 2023, In: Nature Communications. 14, 1, 13 blz., 7880.

Onderzoeksoutput › › peer review

Characterization of a novel bile salt export pump deficiency mouse model with the p.E297g mutation

Felzen, A., Hovingh, M., Havinga, R., Mulder, N., Koehorst, M., van de Sluis, B., de Boer, J. F., Kuipers, F. & Verkade, H., jun.-2023, ESPGHAN 55th Annual Meeting Abstracts. Wolters Kluwer, Vol. 76. blz. 671-672 2 blz.

Onderzoeksoutput › › peer review

Lees meer

Pers/media

Journal News - From the Journals

Folkert Kuipers

01/10/2019

Pers / media: Overig ›

De rol van het microbioom bij het ontstaan van hart- en vaatziekten

Debby Koonen & Folkert Kuipers

01/05/2019

Pers / media: Onderzoek ›

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