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Over ons Praktische zaken Waar vindt u ons dr. F.J. (Frank) Dekker

dr. F.J. (Frank) Dekker

Universitair Hoofd Docent Farmaceutische Epigenetica

Profielfoto van dr. F.J. (Frank) Dekker

Faculteit Science and Engineering

Telefoon:

06 3192 1118 (0031-6-31921118)

E-mail:

f.j.dekker rug.nl

Homepage ORCID Research Portal

Publicaties

Allosteric Inhibitors of Macrophage Migration Inhibitory Factor (MIF) Interfere with Apoptosis-Inducing Factor (AIF) Co-Localization to Prevent Parthanatos

Chen, D., Osipyan, A., Adriana, J., Kader, M., Gureev, M., Knol, C. W. J., Sigmund, M. C., Xiao, Z., van der Wouden, P. E., Cool, R. H., Poelarends, G. J. & Dekker, F. J., 13-jul.-2023, In: Journal of Medicinal Chemistry. 66, 13, blz. 8767-8781 15 blz.

Onderzoeksoutput › › peer review

Discovery of highly potent HDAC8 PROTACs with anti-tumor activity

Zhao, C., Chen, D., Suo, F., Setroikromo, R., Quax, W. J. & Dekker, F., jul.-2023, In: Bioorganic Chemistry. 136, 16 blz., 106546.

Onderzoeksoutput › › peer review

First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8

Fiorentino, F., Sementilli, S., Menna, M., Turrisi, F., Tomassi, S., Pellegrini, F. R., Iuzzolino, A., D’Acunzo, F., Feoli, A., Wapenaar, H., Taraglio, S., Fraschetti, C., Del Bufalo, D., Sbardella, G., Dekker, F. J., Paiardini, A., Trisciuoglio, D., Mai, A. & Rotili, D., 8-mei-2023, In: Journal of Medicinal Chemistry. 66, 10, blz. 6591–6616 26 blz.

Onderzoeksoutput › › peer review

Histone Deacetylase 3-Directed PROTACs Have Anti-inflammatory Potential by Blocking Polarization of M0-like into M1-like Macrophages

Zhao, C., Chen, S., Chen, D., Río-Bergé, C., Zhang, J., Ettema, P., Daemen, T. & Dekker, F. J., 16-okt.-2023, In: Angewandte Chemie (International ed. in English). 62, 42, 11 blz., e202310059.

Onderzoeksoutput › › peer review

Identification and Characterization of a Small Molecule that Activates Thiosulfate Sulfurtransferase and Stimulates Mitochondrial Respiration

Al-Dahmani, Z. M., Hadian, M., Ruiz-Moreno, A. J., Maria, S-G. A., Batista, F. A., Zhang, R., Luo, Y., Sadremomtaz, A., van der Straat, R., Spoor, M., Dolga, A. M., Dekker, F. J., S S, A. D., van Goor, H. & Groves, M. R., nov.-2023, In: Protein Science. 32, 11, 18 blz., e4794.

Onderzoeksoutput › › peer review

Novel inhibitors of histone deacetylase (hdac), and methods, compositions and uses related thereto

Zwinderman, R. H. & Dekker, F. J., 26-jan.-2023, Octrooi Nr. WO2023003468, 22-jul.-2022, Prioriteitsdatum 23-jul.-2021

Onderzoeksoutput

Protocol of the Double-Click Seq Method to Evaluate the Deposition Bias of Chromatin Proteins

van der Wouden, P. E., Zwinderman, M. R. H., Chen, D., Borghesan, M. & Dekker, F. J., jun.-2023, In: Current Protocols. 3, 6, 17 blz., e805.

Onderzoeksoutput › › peer review

Rational Design in Photopharmacology with Molecular Photoswitches

Kobauri, P., Dekker, F. J., Szymanski, W. & Feringa, B. L., 24-jul.-2023, In: Angewandte Chemie - International Edition. 62, 30, e202300681.

Onderzoeksoutput › peer review

Substituted thiophene compounds as d-dopachrome tautomerase inhibitors

Xiao, Z. & Dekker, F. J., 9-mrt.-2023, Octrooi Nr. WO2023031246, 31-aug.-2022, Prioriteitsdatum 1-sep.-2021

Onderzoeksoutput

4-Iodopyrimidine labeling reveals nuclear translocation and nuclease activity for both MIF and MIF2

Xiao, Z., Chen, D., Mulder, F., Song, S., van der Wouden, P. E., Cool, R. H., Melgert, B. N., Poelarends, G. J. & Dekker, F. J., 3-jan.-2022, In: Chemistry. 28, 1, e202103030.

Onderzoeksoutput › › peer review

Alle (131) publicaties

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