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Over ons Praktische zaken Waar vindt u ons A.C. (Fiona) Reijne, MSc

Research interests

My project included a multi-scale Systems Biology approach to unravel the relationship between calorie restriction, physical activity, and biological aging.

So far, the first results indicate that:

  • Eating a Western-style diet left‐shifted the survival curve of mice, compared to mice feeding a standard diet. This left shift was associated with increased energy intake, adiposity, liver triglycerides, plasma cholesterol, corticosterone, insulin resistance levels, and decreased adiponectin levels. Several of these health parameters improved by giving mice access to a running wheel, while other health parameters further deteriorated. Apart from these multiple and diverging health effects of having access to a running wheel, it did not affect survival curves.
  • Mice feeding a Western-style diet resulted in increased adiposity, triglyceride levels in plasma, insulin resistance, and resting metabolic rate compared to the standard diet group. This was accompanied by reduced survival in the Western-style diet group. Dietary restriction irrespective of diet type improved the abovementioned parameters. Lifelong restricted consumption of a Western-style diet led to improved metabolic and endocrine parameters, and increased survival compared to the ad libitum Western-style diet group. Interestingly, the survival was comparable in restricted Western-style and standard diet groups, suggesting that reduced food intake rather than diet composition plays a more important role in promoting longevity/survival.
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Publicaties

Age and diet modulate the insulin-sensitizing effects of exercise: a tracer-based oral glucose tolerance test

Western-style diet does not negatively affect the healthy aging benefits of lifelong restrictive feeding

Running wheel access fails to resolve impaired sustainable health in mice feeding a high fat sucrose diet

Low-fat diet with caloric restriction reduces white matter microglia activation during aging

Running-wheel activity delays mitochondrial respiratory flux decline in aging mouse muscle via a post-transcriptional mechanism

Lifelong dietary intervention does not affect hematopoietic stem cell function

Whole-body vibration partially reverses aging-induced increases in visceral adiposity and hepatic lipid storage in mice

Integrative neurobiology of metabolic diseases, neuroinflammation, and neurodegeneration

Behavioral traits are affected by selective breeding for increased wheel-running behavior in mice

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