Skip to ContentSkip to Navigation
OnderzoekZernike (ZIAM)News

Organized but intermittent: a liquid mimicking disordered proteins

18 mei 2017

Proteins, the engines of life, form the basis for all vital functions in all living systems. Most commonly, the biological functions of the proteins are imposed by their well-defined structures. This is not the case, however, for the so-called intrinsically disordered proteins (IDP), which e.g. are involved in DNA repair. In IDPs, the structural motifs are labile, rapidly fluctuating between conformations, which makes them very challenging to study.

A liquid mimicking disordered proteins
A liquid mimicking disordered proteins

The Theory of Condensed Matter and Optical Condensed Matter Physics groups (both Zernike Institute for Advanced Materials) together with colleagues from the University of Amsterdam joined efforts to mimic the properties of IDPs with a liquid consisting of the building block of proteins, the molecule N-methylacetamide (NMA). The dynamical properties of NMA were studied using combined computational and experimental ultrafast spectroscopy, which probes fast phenomena from a femto- to the pico-second timescale. Surprisingly, NMA molecules interacting via hydrogen bonds form fragile transient chain-like structures, which have been identified from their unique spectroscopic signature. Our ability to distinguish such chains provides the excellent potential for identifying similar organized but intermittent structures in IDPs.

The results of this work are published in the Journal of Physical Chemistry Letters (A. V. Cunha, E.  Salamatova, R. Bloem, S. Roeters, S. Woutersen, M. S. Pshenichnikov, and T.L.C Jansen, “Interplay Between Hydrogen Bonding and Vibrational Coupling in Liquid N-Methylacetamide”, J. Phys. Chem. Lett., 2017, 8, 2438–2444 DOI: 10.1021/acs.jpclett.7b00731

http://pubs.acs.org/doi/abs/10.1021/acs.jpclett.7b00731).

You may also want to have a look at the JPC Letters Spotlight related to the article.

Laatst gewijzigd:12 juni 2017 13:37

Meer nieuws

  • 17 oktober 2017

    iGEM-team tegen melkverspilling: fermentatiebacterie als virusverklikker?

    Met behulp van bacteriën kan melk fermenteren en ontstaat er bijvoorbeeld kaas of yoghurt. Helaas zijn deze bacteriën erg gevoelig voor virale infecties, waardoor het fermentatieproces kan mislukken. Gevolg is dat er jaarlijks grote hoeveelheden melk...

  • 12 oktober 2017

    Groen licht voor University College Fryslân in Leeuwarden

    Het nieuwe driejarige bachelorprogramma Global Responsibility & Leadership van de Rijksuniversiteit Groningen/Campus Fryslân heeft haar accreditatie verworven. Voor de opleiding is bij het Ministerie van Onderwijs het label ‘kleinschalig en intensief...

  • 06 oktober 2017

    Kwaliteit van nationaliteit in kaart gebracht

    Op woensdag 20 september heeft Prof. Dimitry Kochenov, Adjunct Hoogleraar Europees Constitutioneel Recht, de tweede editie van de Quality of Nationality Index (QNI) gepresenteerd. De publicatie kwam tot stand in samenwerking met Henley and Partners,...