Publication

Use of antihypertensive drugs during pregnancy in the Netherlands

De Jong, J., Bos, J. H. J., Schuiling-Veninga, C. C. M. & De Jong-Van Den Berg, L. T. W. 24-Aug-2016 In : Pharmacoepidemiology and Drug Safety. 25, p. 324 1 p.

Research output: Scientific - peer-reviewArticle

Background: Antihypertensive drugs are used during pregnancy for both chronic hypertension and gestational hypertension. Methyldopa, labetalol and nifedipine are considered safe for the fetus during pregnancy and are therefore recommended in the Dutch guidelines. Objectives: To determine how often antihypertensive drugs are prescribed in pregnancy and whether recommended drugs are prescribed. Methods: Using IADB.nl, a database with prescription records of 500,000 people in the Netherlands we investigated the use of antihypertensive drugs of women in the 273 days before the birth of their child. Results: Antihypertensive drugs were used in 2.3% of the pregnancies. Of these 44% used a not recommended drug in the first trimester of pregnancy, 22% in the second trimester and 10% in the third trimester. Of the pregnant women with chronic hypertension 49% used a recommended drug already before the pregnancy, 23% stopped using antihypertensive drugs during pregnancy and 17% switched to a recommended drug. 10% used a not recommended antihypertensive drug during the whole pregnancy. Of the women who started an antihypertensive drug after the 20th week of pregnancy, probably the group with gestational hypertension, 94% used a recommended drug. Conclusions: In most pregnancies antihypertensive drugs were used which are recommended as safe for the unborn child by the Dutch guidelines. In the first trimester 44% used a not recommended drug. Of the women with chronic hypertension 10% continued using a not recommended drug. More information to and education of women with chronic hypertension in the fertile age, by GP's and pharmacists could decrease these percentages.
Original languageEnglish
Pages (from-to)324
Number of pages1
JournalPharmacoepidemiology and Drug Safety
Volume25
StatePublished - 24-Aug-2016
Event32nd International Conference on Pharmacoepidemiology & Therapeutic Risk Management, The Convention Centre Dublin, Dublin, Ireland August 25–28, 2016 - Dublin, Ireland

Event

32nd International Conference on Pharmacoepidemiology & Therapeutic Risk Management, The Convention Centre Dublin, Dublin, Ireland August 25–28, 2016

25/08/201628/08/2016

Dublin, Ireland

Event: Conference

    Keywords

  • antihypertensive agent, child, clinical study, data base, doctor patient relation, education, female, first trimester pregnancy, human, information processing, maternal hypertension, Netherlands, pharmacist, practice guideline, pregnant woman, prescription, second trimester pregnancy, third trimester pregnancy

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