Publication

The flexible clock: Predictive and reactive homeostasis, energy balance and the circadian regulation of sleep-wake timing

Riede, S. J., van der Vinne, V. & Hut, R. A. 1-Mar-2017 In : Journal of Experimental Biology. 220, 5, p. 738-749 12 p.

Research output: Scientific - peer-reviewLiterature review

The Darwinian fitness of mammals living in a rhythmic environment depends on endogenous daily (circadian) rhythms in behavior and physiology. Here, we discuss the mechanisms underlying the circadian regulation of physiology and behavior in mammals. We also review recent efforts to understand circadian flexibility, such as how the phase of activity and rest is altered depending on the encountered environment. We explain why shifting activity to the day is an adaptive strategy to cope with energetic challenges and show how this can reduce thermoregulatory costs. A framework is provided to make predictions about the optimal timing of activity and rest of non-model species for a wide range of habitats. This Review illustrates how the timing of daily rhythms is reciprocally linked to energy homeostasis, and it highlights the importance of this link in understanding daily rhythms in physiology and behavior.

Original languageEnglish
Pages (from-to)738-749
Number of pages12
JournalJournal of Experimental Biology
Volume220
Issue number5
StatePublished - 1-Mar-2017

    Keywords

  • Circadian rhythm flexibility, Adaptation, Peripheral, clock phase, Energy homeostasis, Circadian thermo-energetics, MAMMALIAN SUPRACHIASMATIC NUCLEUS, GENE-EXPRESSION, BODY-TEMPERATURE, PERIPHERAL-TISSUES, LOCOMOTOR-ACTIVITY, SIBERIAN HAMSTERS, ACTIVITY PATTERNS, FOOD-DEPRIVATION, PHASE PREFERENCE, NEURAL ACTIVITY

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