Publication

Surface-modified electrodes in the mimicry of oxidative drug metabolism

Yuan, T., Permentier, H. & Bischoff, R. 1-Jul-2015 In : TrAC-Trends in Analytical Chemistry. 70, p. 50-57

Research output: Scientific - peer-reviewArticle

This review discusses different approaches that have been taken to mimic oxidative drug metabolism as executed by members of the Cytochrome P450 (CYP450) family of enzymes in humans. Non-modified electrodes can be used to produce some of the oxidative drug metabolites observed in vivo but their scope is rather limited. Modifying electrodes with simple cofactors in analogy to those observed in CYP450 but without the protein scaffold extends these possibilities and notably allows driving reactions following a CYP450-like mechanism. The review ends with approaches to immobilize CYP450s or analogs thereof on electrodes to mimic the in vivo drug metabolism fully. We discuss future perspectives with respect to the advantages and the disadvantages of each level of complexity and possible ways forward.
Original languageEnglish
Pages (from-to)50-57
JournalTrAC-Trends in Analytical Chemistry
Volume70
StatePublished - 1-Jul-2015

    Keywords

  • Carbon-based electrode Cytochrome P450 Electrochemistry Gold electrode Metalloporphyrin Modified electrode Oxidative drug metabolism Self-assembly monolayer Surface modification Surface-modified electrode

View graph of relations

ID: 21996596