Publication

Sulfur-Switch Ugi Reaction for Macrocyclic Disulfide-Bridged Peptidomimetics

Vishwanatha, T. M., Bergamaschi, E. & Dömling, A. 16-Jun-2017 In : Organic letters. 19, 12, p. 3195-3198 4 p.

Research output: Scientific - peer-reviewLetter

A general strategy is introduced for the efficient synthetic access of disulfide linked artificial macrocycles via a Ugi four-component reaction (U4CR) followed by oxidative cyclization. The double-mercapto input is proposed for use in the Ugi reaction, thereby yielding all six topologically possible combinations. The protocol is convergent and short and enables the production of novel disulfide peptidomimetics in a highly general fashion.

Original languageEnglish
Pages (from-to)3195-3198
Number of pages4
JournalOrganic letters
Volume19
Issue number12
StatePublished - 16-Jun-2017

    Keywords

  • AMINO-ACIDS, DERIVATIVES, NATIVE CHEMICAL LIGATION, RICH CYCLIC-PEPTIDES, MULTICOMPONENT REACTIONS, BOND FORMATION, N-CHLOROSUCCINIMIDE, 3+2 CYCLOADDITION, PHASE SYNTHESIS, MALFORMIN-C

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