Publication

Spinocerebellar ataxia: miRNAs expose biological pathways underlying pervasive Purkinje cell degeneration

van der Stijl, R., Withoff, S. & Verbeek, D. S. 18-Aug-2017 In : Neurobiology of Disease. 108, p. 148-158 11 p.

Research output: Scientific - peer-reviewReview article

Documents

  • Spinocerebellar ataxia

    Final publisher's version, 885 KB, PDF-document

DOI

Recent work has demonstrated the importance of miRNAs in the pathogenesis of various brain disorders including the neurodegenerative disorder spinocerebellar ataxia (SCA). This review focuses on the role of miRNAs in the shared pathogenesis of the different SCA types. We examine the novel findings of a recent cell-type-specific RNA-sequencing study in mouse brain and discuss how the identification of Purkinje-cell-enriched miRNAs highlights biological pathways that expose the mechanisms behind pervasive Purkinje cell degeneration in SCA. These key pathways are likely to contain targets for therapeutic development and represent potential candidate genes for genetically unsolved SCAs.

Original languageEnglish
Pages (from-to)148-158
Number of pages11
JournalNeurobiology of Disease
Volume108
StateE-pub ahead of print - 18-Aug-2017

    Keywords

  • Journal Article, Review

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