Single-cell sequencing to quantify genomic integrity in cancervan den Bos, H., Bakker, B., Spierings, D. C. J., Lansdorp, P. M. & Foijer, F. 23-Sep-2017 In : International journal of biochemistry & cell biology.
Research output: Scientific - peer-review › Article
The use of single-cell DNA sequencing (sc-seq) techniques for the diagnosis, prognosis and treatment of cancer is a rapidly developing field. Sc-seq research is gaining momentum by decreased sequencing costs and continuous improvements in techniques. In this review, we provide an overview of recent advancements in the field of sc-seq in cancer and we discuss how sc-seq can contribute to improved care for cancer patients. Sc-seq has made it possible to study the genomes of individual cancer cells from primary tumors, metastases and circulating tumor cells, revealing inter- and intra-tumor heterogeneity, which cannot be detected using other methods We review studies on individual human cancer cells in relation to prognosis and treatment response. Finally, future perspectives of sc-seq in cancer diagnosis and treatment are discussed with a focus on the use of circulating tumor cells to monitor therapy response and the development of personalized treatments based on knowledge about the genomic heterogeneity.
|Journal||International journal of biochemistry & cell biology|
|State||E-pub ahead of print - 23-Sep-2017|
- Journal Article