Diagnostic and immunological aspects of the antibody response to human cytomegalvirus infection

Middeldorp, J. M. 1985 Groningen: s.n.. 151 p.

Research output: ScientificDoctoral Thesis


  • Jaap Michiel Middeldorp
The studies described in this thesis were initiated with three main aims: First, to develop a practical and sensitive method for serodiagnosis of Human cytomegoal virus ( CMV)-infections and to determine the relative diagnostic value of IgM and IgG antibody responses to distinct CMV-antigens. Second, to test the hypothesis that antibody responses directed against the CMV-MA complex Iocated on the outer surface of CMV-infected celIs would contribute to the recovery from infection, especially in patients receiving immune suppressive therapy and, in addition, to study the relation of the CMV-MA complex to other CMV-antigens. Third, to determine the molecular nature of CMV-antigens that are recognized by human serum antibodies during acute and latent CMV-infection. ... Zie: Summary and conclusions
Original languageEnglish
QualificationDoctor of Philosophy
  • The, Tjwan, Supervisor
  • Witholt, Bernard, Supervisor
Award date3-Jan-0002
Place of PublicationGroningen
StatePublished - 1985


  • Proefschriften (vorm), Cytomegalovirus , Infecties, Antistoffen, Immunologie

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ID: 3403969