Publication

Pathophysiological and behavioral effects of systemic inflammation in aged and diseased rodents with relevance to delirium: A systematic review

Schreuder, L., Eggen, B. J., Biber, K., Schoemaker, R. G., Laman, J. D. & Rooij, de, S. E. May-2017 In : Brain, Behavior, and Immunity. 62, p. 362-381 20 p.

Research output: Scientific - peer-reviewReview article

Delirium is a frequent outcome for aged and demented patients that suffer a systemic inflammatory insult. Animal models that reconstruct these etiological processes have potential to provide a better understanding of the pathophysiology of delirium. Therefore, we systematically reviewed animal studies in which systemic inflammation was superimposed on aged or diseased animal models. In total, 77 studies were identified. Aged animals were challenged with a bacterial endotoxin in 29 studies, 25 studies superimposed surgery on aged animals, and in 6 studies a bacterial infection, Escherichia coli (E. coli), was used. Diseased animals were challenged with a bacterial endotoxin in 15 studies, two studies examined effects of the cytokine IL-1 beta, and one study used polyinosinic:polycytidilic acid (poly I:C). This systematic review analyzed the impact of systemic inflammation on the production of inflammatory and neurotoxic mediators in peripheral blood, cerebrospinal fluid (CSF), and on the central nervous system (CNS). Moreover, concomitant behavioral and cognitive symptoms were also evaluated. Finally, outcomes of behavioral and cognitive tests from animal studies were compared to features and symptoms present in delirious patients. (C) 2017 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)362-381
Number of pages20
JournalBrain, Behavior, and Immunity
Volume62
StatePublished - May-2017

    Keywords

  • Acute cognitive dysfunction, Sickness behavior, Aging, Neuroinflammation, Microglia, Astrocytes, Cytokines, LPS, Surgery, Infection, POSTOPERATIVE COGNITIVE DYSFUNCTION, INDUCED SICKNESS BEHAVIOR, INNATE IMMUNE-SYSTEM, LIPOPOLYSACCHARIDE-INDUCED SICKNESS, DEPRESSIVE-LIKE BEHAVIOR, CYTOKINE MESSENGER-RNA, ACUTE-PHASE RESPONSE, CHRONIC NEURODEGENERATION, PERIPHERAL INFECTION, WORKING-MEMORY

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