Publication

Health economics of blood transfusion in Zimbabwe

Mafirakureva, N. 2016 [Groningen]: University of Groningen. 197 p.

Research output: ScientificDoctoral Thesis

Documents

  • Title and contents

    Final publisher's version, 644 KB, PDF-document

  • Chapter 1

    Final publisher's version, 570 KB, PDF-document

  • Chapter 2

    Final publisher's version, 1 MB, PDF-document

  • Chapter 3

    Final publisher's version, 719 KB, PDF-document

  • Chapter 4

    Final publisher's version, 633 KB, PDF-document

  • Chapter 5

    Final publisher's version, 770 KB, PDF-document

    Embargo ends: 09/12/2017

  • Chapter 6

    Final publisher's version, 1 MB, PDF-document

  • Chapter 7

    Final publisher's version, 1 MB, PDF-document

  • Chapter 8

    Final publisher's version, 631 KB, PDF-document

  • Chapter 9

    Final publisher's version, 625 KB, PDF-document

  • Executive Summary

    Final publisher's version, 547 KB, PDF-document

  • Samenvatting

    Final publisher's version, 536 KB, PDF-document

  • List of Publications

    Final publisher's version, 551 KB, PDF-document

  • Acknowledgements

    Final publisher's version, 571 KB, PDF-document

  • About the Author

    Final publisher's version, 528 KB, PDF-document

  • Complete thesis

    Final publisher's version, 3 MB, PDF-document

    Embargo ends: 09/12/2017

  • Propositions

    Final publisher's version, 502 KB, PDF-document

  • Nyashadzaishe Mafirakureva
Health economic analyses quantify the costs and benefits of specific public health choices or interventions compared to current practice, thus informing decisions on the responsible use of scarce health care resources. The application of health economic evaluations to inform blood safety decisions has been growing over the past 10 years, particularly in high income countries. However, in sub-Saharan Africa where there is a greater need for improvements in blood safety amid severe resource constraints, health economic evaluations are still limited. This thesis presents the health economics of blood transfusion in a resource-limited setting, with the aim of helping decision-makers understand the cost-effectiveness of introducing a blood safety measure, individual donation – nucleic acid testing (ID-NAT). In particular, it discusses the chronic challenges in the collection, availability, accessibility and quality of empirical data; and their impact in informing health economic models. The thesis begins by describing the characteristics of patients receiving, and the adverse events following blood transfusions. The health related quality of life and healthcare costs for patients infected with HIV are also described. The screening costs for the serology tests currently implemented in Zimbabwe were estimated. All the data generated was collated and applied into a health economics model assessing the cost-effectiveness of introducing individual donation nucleic acid testing in addition to serologic testing in Zimbabwe. Despite further reducing the risk of viral transmission through blood transfusion, the introduction of nucleic acid testing in addition to the current serological screening, given the variables and underlying assumptions used, cannot be considered cost-effective for Zimbabwe. However, compared to high-income countries the cost-effectiveness is rather good.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
Supervisors/Advisors
  • Postma, Maarten, Supervisor
  • van Hulst, Marinus, Co-supervisor
  • Khoza, Star, Co-supervisor, External person
  • Donk, van, Dirk Pieter, Assessment committee
  • Meijer, K., Assessment committee, External person
  • Ullum, H., Assessment committee, External person
Award date9-Dec-2016
Place of Publication[Groningen]
Publisher
Print ISBNs978-90-367-9352-0
Electronic ISBNs978-90-367-9351-3
StatePublished - 2016

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