Publication

Gender differences and temporal variation in the incidence of type 1 diabetes: results of 8012 cases in the nationwide Diabetes Incidence Study in Sweden 1983-2002

Ostman, J., Lonnberg, G., Arnqvist, H. J., Blohme, G., Bolinder, J., Schnell, A. E., Eriksson, J. W., Gudbjornsdottir, S., Sundkvist, G. & Nystrom, L. Apr-2008 In : Journal of Internal Medicine. 263, 4, p. 386-394 9 p.

Research output: Scientific - peer-reviewArticle

APA

Ostman, J., Lonnberg, G., Arnqvist, H. J., Blohme, G., Bolinder, J., Schnell, A. E., ... Nystrom, L. (2008). Gender differences and temporal variation in the incidence of type 1 diabetes: results of 8012 cases in the nationwide Diabetes Incidence Study in Sweden 1983-2002. Journal of Internal Medicine, 263(4), 386-394. DOI: 10.1111/j.1365-2796.2007.01896.x

Author

Ostman, J.; Lonnberg, G.; Arnqvist, H. J.; Blohme, G.; Bolinder, J.; Schnell, A. Ekbom; Eriksson, J. W.; Gudbjornsdottir, S.; Sundkvist, G.; Nystrom, L. / Gender differences and temporal variation in the incidence of type 1 diabetes : results of 8012 cases in the nationwide Diabetes Incidence Study in Sweden 1983-2002.

In: Journal of Internal Medicine, Vol. 263, No. 4, 04.2008, p. 386-394.

Research output: Scientific - peer-reviewArticle

Harvard

Ostman, J, Lonnberg, G, Arnqvist, HJ, Blohme, G, Bolinder, J, Schnell, AE, Eriksson, JW, Gudbjornsdottir, S, Sundkvist, G & Nystrom, L 2008, 'Gender differences and temporal variation in the incidence of type 1 diabetes: results of 8012 cases in the nationwide Diabetes Incidence Study in Sweden 1983-2002' Journal of Internal Medicine, vol 263, no. 4, pp. 386-394. DOI: 10.1111/j.1365-2796.2007.01896.x

Standard

Gender differences and temporal variation in the incidence of type 1 diabetes : results of 8012 cases in the nationwide Diabetes Incidence Study in Sweden 1983-2002. / Ostman, J.; Lonnberg, G.; Arnqvist, H. J.; Blohme, G.; Bolinder, J.; Schnell, A. Ekbom; Eriksson, J. W.; Gudbjornsdottir, S.; Sundkvist, G.; Nystrom, L.

In: Journal of Internal Medicine, Vol. 263, No. 4, 04.2008, p. 386-394.

Research output: Scientific - peer-reviewArticle

Vancouver

Ostman J, Lonnberg G, Arnqvist HJ, Blohme G, Bolinder J, Schnell AE et al. Gender differences and temporal variation in the incidence of type 1 diabetes: results of 8012 cases in the nationwide Diabetes Incidence Study in Sweden 1983-2002. Journal of Internal Medicine. 2008 Apr;263(4):386-394. Available from, DOI: 10.1111/j.1365-2796.2007.01896.x


BibTeX

@article{c450e450e88b41598f8ebe4121b7f7ad,
title = "Gender differences and temporal variation in the incidence of type 1 diabetes: results of 8012 cases in the nationwide Diabetes Incidence Study in Sweden 1983-2002",
abstract = "Objectives. To establish the gender difference amongst newly diagnosed type 1 diabetic patients aged 15-34 years, considering age at diagnosis, temporal trend and seasonal variation at time of diagnosis.Study design. A population-based prospective study with a mean annual population at risk of 2.3 million.Setting. All departments of medicine, endocrinology and paediatrics and primary health care units in Sweden.Subjects. Incident cases of diabetes aged 15-34 years at diagnosis 1983-2002.Measure instrument. Basic characteristics of patients at diagnosis were reported by the diagnosing doctor on a standardized form. Level of ascertainment was estimated at 80-90%.Results. Amongst all incident cases (n = 8012), 74% was diagnosed with type 1 diabetes. The mean annual incidence rate of type 1 diabetes was 12.7/100 000, in men 16.4/100 000 and in women 8.9/100 000. The incidence of type 1 diabetes decreased slowly by increasing age but was in all age groups higher in men, yielding an overall male/female ratio of 1.8. In both genders the incidence of type 1 diabetes decreased in average of 1.0% per year. A seasonal pattern with significantly higher incidence during January-March and lower during May-July was seen in both genders.Conclusions. A clear male predominance of type 1 diabetes was seen in all ages. The temporal trend and the seasonal pattern was similar in men and women. Hence, internal factors related to the gender rather than differences in the exposure to environmental factors seem to explain the consistent male-female bias in the postpubertal risk of developing type 1 diabetes.",
keywords = "diabetes, gender, incidence, register, temporal, young adults, YOUNG-ADULT PEOPLE, BODY-MASS INDEX, AGE-GROUP, SEASONAL-VARIATION, ALLEGHENY-COUNTY, TIME TRENDS, INCREASED RISK, FEMALE EXCESS, WEIGHT-GAIN, MELLITUS",
author = "J. Ostman and G. Lonnberg and Arnqvist, {H. J.} and G. Blohme and J. Bolinder and Schnell, {A. Ekbom} and Eriksson, {J. W.} and S. Gudbjornsdottir and G. Sundkvist and L. Nystrom",
year = "2008",
month = "4",
doi = "10.1111/j.1365-2796.2007.01896.x",
volume = "263",
pages = "386--394",
journal = "Journal of Internal Medicine",
issn = "0954-6820",
publisher = "WILEY",
number = "4",

}

RIS

TY - JOUR

T1 - Gender differences and temporal variation in the incidence of type 1 diabetes

T2 - Journal of Internal Medicine

AU - Ostman,J.

AU - Lonnberg,G.

AU - Arnqvist,H. J.

AU - Blohme,G.

AU - Bolinder,J.

AU - Schnell,A. Ekbom

AU - Eriksson,J. W.

AU - Gudbjornsdottir,S.

AU - Sundkvist,G.

AU - Nystrom,L.

PY - 2008/4

Y1 - 2008/4

N2 - Objectives. To establish the gender difference amongst newly diagnosed type 1 diabetic patients aged 15-34 years, considering age at diagnosis, temporal trend and seasonal variation at time of diagnosis.Study design. A population-based prospective study with a mean annual population at risk of 2.3 million.Setting. All departments of medicine, endocrinology and paediatrics and primary health care units in Sweden.Subjects. Incident cases of diabetes aged 15-34 years at diagnosis 1983-2002.Measure instrument. Basic characteristics of patients at diagnosis were reported by the diagnosing doctor on a standardized form. Level of ascertainment was estimated at 80-90%.Results. Amongst all incident cases (n = 8012), 74% was diagnosed with type 1 diabetes. The mean annual incidence rate of type 1 diabetes was 12.7/100 000, in men 16.4/100 000 and in women 8.9/100 000. The incidence of type 1 diabetes decreased slowly by increasing age but was in all age groups higher in men, yielding an overall male/female ratio of 1.8. In both genders the incidence of type 1 diabetes decreased in average of 1.0% per year. A seasonal pattern with significantly higher incidence during January-March and lower during May-July was seen in both genders.Conclusions. A clear male predominance of type 1 diabetes was seen in all ages. The temporal trend and the seasonal pattern was similar in men and women. Hence, internal factors related to the gender rather than differences in the exposure to environmental factors seem to explain the consistent male-female bias in the postpubertal risk of developing type 1 diabetes.

AB - Objectives. To establish the gender difference amongst newly diagnosed type 1 diabetic patients aged 15-34 years, considering age at diagnosis, temporal trend and seasonal variation at time of diagnosis.Study design. A population-based prospective study with a mean annual population at risk of 2.3 million.Setting. All departments of medicine, endocrinology and paediatrics and primary health care units in Sweden.Subjects. Incident cases of diabetes aged 15-34 years at diagnosis 1983-2002.Measure instrument. Basic characteristics of patients at diagnosis were reported by the diagnosing doctor on a standardized form. Level of ascertainment was estimated at 80-90%.Results. Amongst all incident cases (n = 8012), 74% was diagnosed with type 1 diabetes. The mean annual incidence rate of type 1 diabetes was 12.7/100 000, in men 16.4/100 000 and in women 8.9/100 000. The incidence of type 1 diabetes decreased slowly by increasing age but was in all age groups higher in men, yielding an overall male/female ratio of 1.8. In both genders the incidence of type 1 diabetes decreased in average of 1.0% per year. A seasonal pattern with significantly higher incidence during January-March and lower during May-July was seen in both genders.Conclusions. A clear male predominance of type 1 diabetes was seen in all ages. The temporal trend and the seasonal pattern was similar in men and women. Hence, internal factors related to the gender rather than differences in the exposure to environmental factors seem to explain the consistent male-female bias in the postpubertal risk of developing type 1 diabetes.

KW - diabetes

KW - gender

KW - incidence

KW - register

KW - temporal

KW - young adults

KW - YOUNG-ADULT PEOPLE

KW - BODY-MASS INDEX

KW - AGE-GROUP

KW - SEASONAL-VARIATION

KW - ALLEGHENY-COUNTY

KW - TIME TRENDS

KW - INCREASED RISK

KW - FEMALE EXCESS

KW - WEIGHT-GAIN

KW - MELLITUS

U2 - 10.1111/j.1365-2796.2007.01896.x

DO - 10.1111/j.1365-2796.2007.01896.x

M3 - Article

VL - 263

SP - 386

EP - 394

JO - Journal of Internal Medicine

JF - Journal of Internal Medicine

SN - 0954-6820

IS - 4

ER -

ID: 4691703