Publication

Does oxidative stress shorten telomeres?

Boonekamp, J. J., Bauch, C., Mulder, E. & Verhulst, S. May-2017 In : Biology Letters. 13, 5, 5 p., 20170164

Research output: Scientific - peer-reviewArticle

Oxidative stress shortens telomeres in cell culture, but whether oxidative stress explains variation in telomere shortening in vivo at physiological oxidative stress levels is not well known. We therefore tested for correlations between six oxidative stress markers and telomere attrition in nestling birds (jackdaws Corvus monedula) that show a high rate of telomere attrition in early life. Telomere attrition was measured between ages 5 and 30 days, and was highly variable (average telomere loss: 323 bp, CV = 45%). Oxidative stress markers were measured in blood at age 20 days and included markers of oxidative damage (TBARS, dROMs and GSSG) and markers of antioxidant protection (GSH, redox state, uric acid). Variation in telomere attrition was not significantly related to these oxidative stress markers (vertical bar r vertical bar

Original languageEnglish
Article number20170164
Number of pages5
JournalBiology Letters
Volume13
Issue number5
StatePublished - May-2017

    Keywords

  • somatic damage, telomere attrition, development, molecular ecology, nestlings, LENGTH

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