Publication

Cross-cultural validation of the Quality of Life in Hand Eczema Questionnaire (QOLHEQ)

Ofenloch, R. F., Oosterhaven, J. A. F., Susitaival, P., Svensson, Å., Weisshaar, E., Minamoto, K., Onder, M., Schuttelaar, M-L. A., Bulbul Baskan, E., Diepgen, T. L. & Apfelbacher, C. Jul-2017 In : Journal of Investigative Dermatology. 137, 7, p. 1454-1460 7 p.

Research output: Scientific - peer-reviewArticle

The Quality of Life in Hand Eczema Questionnaire (QOLHEQ) is the only instrument assessing disease-specific Health-Related Quality of Life (HRQOL) in hand eczema patients. It is available in eight language versions. In this study we assessed if the items of different language versions of the QOLHEQ yield comparable values across countries. An international multi-center study was conducted with participating centers in Finland, Germany, Japan, the Netherlands, Sweden and Turkey. Methods of item response theory (IRT) were applied to each subscale to assess differential item functioning (DIF) for items between countries. Overall n=662 hand eczema patients were recruited into the study. Single items were removed or split according to the IRT model by country in order to resolve DIF. After this adjustment none of the four subscales of the QOLHEQ showed significant misfit to the IRT model (p<0.01) and a Person Separation Index of >0.7 showed good internal consistency for each subscale. By adapting the scoring of the QOLHEQ using the methods of IRT it was possible to obtain QOLHEQ-values which are comparable across countries. Cross-cultural variations in the interpretation of single items were resolved. The QOLHEQ is now ready to be used in international studies assessing the HRQOL impact of hand eczema.

Original languageEnglish
Pages (from-to)1454-1460
Number of pages7
JournalJournal of Investigative Dermatology
Volume137
Issue number7
StatePublished - Jul-2017

    Keywords

  • SEVERITY INDEX, GERMAN VERSION, RASCH MODEL, RESPONSIVENESS, RELIABILITY, INSTRUMENTS, POPULATION, DERMATITIS, PSORIASIS, VALIDITY

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