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Beneficial effect of medicinal plants on the contractility of post-hypoxic isolated guinea pig atria - Potential implications for the treatment of ischemic-reperfusion injury

Bipat, R., Toelsie, J. R., Magali, I., Soekhoe, R., Stender, K., Wangsawirana, A., Oedairadjsingh, K., Pawirodihardjo, J. & Mans, D. R. A. Aug-2016 In : Pharmaceutical biology. 54, 8, p. 1483-1489 7 p.

Research output: Scientific - peer-reviewArticle

  • Robbert Bipat
  • Jerry R. Toelsie
  • Indira Magali
  • Rubaina Soekhoe
  • Karin Stender
  • Angelique Wangsawirana
  • Krishan Oedairadjsingh
  • Jennifer Pawirodihardjo
  • Dennis R. A. Mans

Context Ischemic-reperfusion injury is accompanied by a decreased contractility of the myocardium. Positive-inotropic agents have proven useful for treating this condition but may exert serious side-effects.Objective In this study, aqueous preparations from Abelmoschus esculentus L. Moench (Malvaceae), Annona muricata L. (Annonaceae), Bixa orellana L. (Bixaceae), Cecropia peltata L. (Moraceae), Erythrina fusca Lour. (Fabaceae), Psidium guajava L. (Myrtaceae) and Terminalia catappa L. (Combretaceae) were evaluated for their ability to improve the decreased contractility of isolated guinea pig atria after hypoxic stress.Materials and methods Guinea pig atria isolated in Ringer-Locke buffer gassed with 100% O-2 at 30 degrees C were exposed for 5min to hypoxia, then allowed to recover in oxygenated buffer alone or containing a single plant extract (0.001-1mg/mL). The contractility (g/s) and beating frequency (beats/min), as well as troponin C contents of the bathing solution (ng/mL), were determined and expressed as meansSDs.Results The extracts of A. muricata, B. orellana, C. peltata and T. catappa caused an increase in the contractility compared to untreated atria of 340 +/- 102%, 151 +/- 13%, 141 +/- 14% and 238 +/- 44%, respectively. However, the latter two preparations increased the troponin C contents of the bathing solution to 36 +/- 11 and 69 +/- 33, compared to the value of 11 +/- 3ng/mL found with untreated atria.Conclusions Preparations from A. muricata and B. orellana may possess positive-inotropic properties which may improve the contractility of the post-hypoxic myocardium. Studies to assess their usefulness in ischemic-reperfusion injury are warranted.

Original languageEnglish
Pages (from-to)1483-1489
Number of pages7
JournalPharmaceutical biology
Volume54
Issue number8
StatePublished - Aug-2016

    Keywords

  • Hypoxia, troponin C, positive-inotropism, TERMINALIA-ARJUNA, HEART-FAILURE, IN-VITRO, RAT, LEVOSIMENDAN, HIGENAMINE, EXTRACT, FORCE, MICE

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