Publication

Aging rather than aneuploidy affects monoamine neurotransmitters in brain regions of Down syndrome mouse models

Dekker, A. D., Vermeiren, Y., Albac, C., Lana-Elola, E., Watson-Scales, S., Gibbins, D., Aerts, T., Van Dam, D., Fisher, E. M. C., Tybulewicz, V. L. J., Potier, M-C. & De Deyn, P. P. Sep-2017 In : Neurobiology of Disease. 105, p. 235-244 10 p.

Research output: Scientific - peer-reviewArticle

APA

Dekker, A. D., Vermeiren, Y., Albac, C., Lana-Elola, E., Watson-Scales, S., Gibbins, D., ... De Deyn, P. P. (2017). Aging rather than aneuploidy affects monoamine neurotransmitters in brain regions of Down syndrome mouse models. Neurobiology of Disease, 105, 235-244. DOI: 10.1016/j.nbd.2017.06.007

Author

Dekker, Alain D; Vermeiren, Yannick; Albac, Christelle; Lana-Elola, Eva; Watson-Scales, Sheona; Gibbins, Dorota; Aerts, Tony; Van Dam, Debby; Fisher, Elizabeth M C; Tybulewicz, Victor L J; Potier, Marie-Claude; De Deyn, Peter P / Aging rather than aneuploidy affects monoamine neurotransmitters in brain regions of Down syndrome mouse models.

In: Neurobiology of Disease, Vol. 105, 09.2017, p. 235-244.

Research output: Scientific - peer-reviewArticle

Harvard

Dekker, AD, Vermeiren, Y, Albac, C, Lana-Elola, E, Watson-Scales, S, Gibbins, D, Aerts, T, Van Dam, D, Fisher, EMC, Tybulewicz, VLJ, Potier, M-C & De Deyn, PP 2017, 'Aging rather than aneuploidy affects monoamine neurotransmitters in brain regions of Down syndrome mouse models' Neurobiology of Disease, vol 105, pp. 235-244. DOI: 10.1016/j.nbd.2017.06.007

Standard

Aging rather than aneuploidy affects monoamine neurotransmitters in brain regions of Down syndrome mouse models. / Dekker, Alain D; Vermeiren, Yannick; Albac, Christelle; Lana-Elola, Eva; Watson-Scales, Sheona; Gibbins, Dorota; Aerts, Tony; Van Dam, Debby; Fisher, Elizabeth M C; Tybulewicz, Victor L J; Potier, Marie-Claude; De Deyn, Peter P.

In: Neurobiology of Disease, Vol. 105, 09.2017, p. 235-244.

Research output: Scientific - peer-reviewArticle

Vancouver

Dekker AD, Vermeiren Y, Albac C, Lana-Elola E, Watson-Scales S, Gibbins D et al. Aging rather than aneuploidy affects monoamine neurotransmitters in brain regions of Down syndrome mouse models. Neurobiology of Disease. 2017 Sep;105:235-244. Available from, DOI: 10.1016/j.nbd.2017.06.007


BibTeX

@article{bdf32c929bbe414c96d172d1b0fc3202,
title = "Aging rather than aneuploidy affects monoamine neurotransmitters in brain regions of Down syndrome mouse models",
abstract = "Altered concentrations of monoamine neurotransmitters and metabolites have been repeatedly found in people with Down syndrome (DS, trisomy 21). Because of the limited availability of human post-mortem tissue, DS mouse models are of great interest to study these changes and the underlying neurobiological mechanisms. Although previous studies have shown the potential of Ts65Dn mice - the most widely used mouse model of DS to model noradrenergic changes, a comprehensive monoaminergic characterization in multiple brain regions has not been performed so far. Here, we used RP-HPLC with electrochemical detection to quantify (nor)adrenergic (NA, adrenaline and MHPG), dopaminergic (DA, HVA and DOPAC), and serotonergic compounds (tryptophan, 5-HT and 5-HIAA) in ten regionally dissected brain regions of Ts65Dn mice, as well as in Dp1Tyb mice - a novel DS mouse model. Comparing young adult aneuploid mice (2.5-5.5 months) with their euploid WT litter mates did not reveal generalized monoaminergic dysregulation, indicating that the genetic overload in these mice barely affected the absolute concentrations at this age. Moreover, we studied the effect of aging in Ts65Dn mice: comparing aged animals (12-13 months) with their younger counterparts revealed a large number of significant changes. In general, the (nor)adrenergic system appeared to be reduced, while serotonergic compounds were increased with aging. Dopaminergic alterations were less consistent. These overall patterns appeared to be relatively similar for Ts65Dn and WT mice, though more observed changes were regarded significant for WT mice. Similar human post-mortem studies are necessary to validate the monoaminergic construct validity of the Ts65Dn and Dp1Typ mouse models. (C) 2017 The Authors. Published by Elsevier Inc.",
keywords = "Journal Article",
author = "Dekker, {Alain D} and Yannick Vermeiren and Christelle Albac and Eva Lana-Elola and Sheona Watson-Scales and Dorota Gibbins and Tony Aerts and {Van Dam}, Debby and Fisher, {Elizabeth M C} and Tybulewicz, {Victor L J} and Marie-Claude Potier and {De Deyn}, {Peter P}",
note = "Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2017",
month = "9",
doi = "10.1016/j.nbd.2017.06.007",
volume = "105",
pages = "235--244",
journal = "Neurobiology of Disease",
issn = "0969-9961",
publisher = "ACADEMIC PRESS INC ELSEVIER SCIENCE",

}

RIS

TY - JOUR

T1 - Aging rather than aneuploidy affects monoamine neurotransmitters in brain regions of Down syndrome mouse models

AU - Dekker,Alain D

AU - Vermeiren,Yannick

AU - Albac,Christelle

AU - Lana-Elola,Eva

AU - Watson-Scales,Sheona

AU - Gibbins,Dorota

AU - Aerts,Tony

AU - Van Dam,Debby

AU - Fisher,Elizabeth M C

AU - Tybulewicz,Victor L J

AU - Potier,Marie-Claude

AU - De Deyn,Peter P

N1 - Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2017/9

Y1 - 2017/9

N2 - Altered concentrations of monoamine neurotransmitters and metabolites have been repeatedly found in people with Down syndrome (DS, trisomy 21). Because of the limited availability of human post-mortem tissue, DS mouse models are of great interest to study these changes and the underlying neurobiological mechanisms. Although previous studies have shown the potential of Ts65Dn mice - the most widely used mouse model of DS to model noradrenergic changes, a comprehensive monoaminergic characterization in multiple brain regions has not been performed so far. Here, we used RP-HPLC with electrochemical detection to quantify (nor)adrenergic (NA, adrenaline and MHPG), dopaminergic (DA, HVA and DOPAC), and serotonergic compounds (tryptophan, 5-HT and 5-HIAA) in ten regionally dissected brain regions of Ts65Dn mice, as well as in Dp1Tyb mice - a novel DS mouse model. Comparing young adult aneuploid mice (2.5-5.5 months) with their euploid WT litter mates did not reveal generalized monoaminergic dysregulation, indicating that the genetic overload in these mice barely affected the absolute concentrations at this age. Moreover, we studied the effect of aging in Ts65Dn mice: comparing aged animals (12-13 months) with their younger counterparts revealed a large number of significant changes. In general, the (nor)adrenergic system appeared to be reduced, while serotonergic compounds were increased with aging. Dopaminergic alterations were less consistent. These overall patterns appeared to be relatively similar for Ts65Dn and WT mice, though more observed changes were regarded significant for WT mice. Similar human post-mortem studies are necessary to validate the monoaminergic construct validity of the Ts65Dn and Dp1Typ mouse models. (C) 2017 The Authors. Published by Elsevier Inc.

AB - Altered concentrations of monoamine neurotransmitters and metabolites have been repeatedly found in people with Down syndrome (DS, trisomy 21). Because of the limited availability of human post-mortem tissue, DS mouse models are of great interest to study these changes and the underlying neurobiological mechanisms. Although previous studies have shown the potential of Ts65Dn mice - the most widely used mouse model of DS to model noradrenergic changes, a comprehensive monoaminergic characterization in multiple brain regions has not been performed so far. Here, we used RP-HPLC with electrochemical detection to quantify (nor)adrenergic (NA, adrenaline and MHPG), dopaminergic (DA, HVA and DOPAC), and serotonergic compounds (tryptophan, 5-HT and 5-HIAA) in ten regionally dissected brain regions of Ts65Dn mice, as well as in Dp1Tyb mice - a novel DS mouse model. Comparing young adult aneuploid mice (2.5-5.5 months) with their euploid WT litter mates did not reveal generalized monoaminergic dysregulation, indicating that the genetic overload in these mice barely affected the absolute concentrations at this age. Moreover, we studied the effect of aging in Ts65Dn mice: comparing aged animals (12-13 months) with their younger counterparts revealed a large number of significant changes. In general, the (nor)adrenergic system appeared to be reduced, while serotonergic compounds were increased with aging. Dopaminergic alterations were less consistent. These overall patterns appeared to be relatively similar for Ts65Dn and WT mice, though more observed changes were regarded significant for WT mice. Similar human post-mortem studies are necessary to validate the monoaminergic construct validity of the Ts65Dn and Dp1Typ mouse models. (C) 2017 The Authors. Published by Elsevier Inc.

KW - Journal Article

U2 - 10.1016/j.nbd.2017.06.007

DO - 10.1016/j.nbd.2017.06.007

M3 - Article

VL - 105

SP - 235

EP - 244

JO - Neurobiology of Disease

T2 - Neurobiology of Disease

JF - Neurobiology of Disease

SN - 0969-9961

ER -

ID: 46040161